| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lidocaine (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
199 genes differentially expressed following the Lidocaine (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.326775 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.172443 |
| ATXN1 | ataxin 1 | 0.150954 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.125578 |
| IGF1R | insulin-like growth factor 1 receptor | 0.114763 |
| INHBA | inhibin, beta A | 0.0996024 |
| RPLP0 | ribosomal protein, large, P0 | 0.0994851 |
| VIM | vimentin | 0.0939024 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0918723 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0884073 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0829299 |
| DST | dystonin | 0.0828446 |
| ASPH | aspartate beta-hydroxylase | 0.0797941 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0795004 |
| FN1 | fibronectin 1 | 0.0788018 |
| AFF1 | AF4/FMR2 family, member 1 | 0.074583 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0735671 |
| RPL37A | ribosomal protein L37a | 0.0713816 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0709989 |
| DSPP | dentin sialophosphoprotein | 0.0701949 |
| COL5A2 | collagen, type V, alpha 2 | 0.0691685 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0691382 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0678892 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0672724 |
| SIK3 | SIK family kinase 3 | 0.0634642 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0623379 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.061807 |
| NCKAP5 | NCK-associated protein 5 | 0.0608454 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0585815 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0581434 |
| HLA-B | major histocompatibility complex, class I, B | 0.0576148 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0573657 |
| RPS27A | ribosomal protein S27a | 0.0569723 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0562181 |
| CNKSR3 | CNKSR family member 3 | 0.0538463 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0531157 |
| B2M | beta-2-microglobulin | 0.0513379 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0509793 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0508362 |
| RPL31 | ribosomal protein L31 | 0.0496178 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0479353 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0478604 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0460744 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0460585 |
| TRIM44 | tripartite motif containing 44 | 0.045647 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0448333 |
| LMO7 | LIM domain 7 | 0.0394616 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0385909 |
| RPL19 | ribosomal protein L19 | 0.0370992 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0354604 |
| STC1 | stanniocalcin 1 | 0.0346294 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0343183 |
| RTN4 | reticulon 4 | 0.0340857 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0340747 |
| PTK2 | protein tyrosine kinase 2 | 0.0338894 |
| RPL26 | ribosomal protein L26 | 0.0336731 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0334063 |
| ENO1 | enolase 1, (alpha) | 0.0330069 |
| RBM33 | RNA binding motif protein 33 | 0.0316616 |
| RACK1 | receptor for activated C kinase 1 | 0.0285123 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0285032 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0282463 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0272439 |
| FRMD4A | FERM domain containing 4A | 0.0268731 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0264363 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0260487 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0244343 |
| USP34 | ubiquitin specific peptidase 34 | 0.0233253 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0231488 |
| MYO1E | myosin IE | 0.0221957 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0219807 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0212821 |
| CD44 | CD44 molecule (Indian blood group) | 0.021198 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.019979 |
| RPS16 | ribosomal protein S16 | 0.0199698 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.01948 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0192897 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0191643 |
| RPS23 | ribosomal protein S23 | 0.0189304 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0188255 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.018729 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.018042 |
| CDC73 | cell division cycle 73 | 0.0172917 |
| BTBD7 | BTB (POZ) domain containing 7 | 0.0171302 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0168364 |
| PKN2 | protein kinase N2 | 0.0165017 |
| VMP1 | vacuole membrane protein 1 | 0.0164535 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0162672 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0159972 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0159661 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0156265 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.015202 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0138475 |
| CDK12 | cyclin-dependent kinase 12 | 0.0138053 |
| SPAG9 | sperm associated antigen 9 | 0.013781 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0135375 |
| TPM3 | tropomyosin 3 | 0.0123957 |
| RAD51B | RAD51 paralog B | 0.011743 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0110752 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0109505 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.210142 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.195657 |
| CMIP | c-Maf inducing protein | -0.129134 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.1269 |
| NAV2 | neuron navigator 2 | -0.12221 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.112827 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.108824 |
| NDRG1 | N-myc downstream regulated 1 | -0.10742 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.107396 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.097303 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0971968 |
| SYT1 | synaptotagmin I | -0.0946535 |
| EFNA5 | ephrin-A5 | -0.0908641 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0864139 |
| HMGA2 | high mobility group AT-hook 2 | -0.0851681 |
| VCL | vinculin | -0.0829377 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0822791 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0801051 |
| INTS6 | integrator complex subunit 6 | -0.079207 |
| FNIP1 | folliculin interacting protein 1 | -0.0787734 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0770766 |
| COL5A1 | collagen, type V, alpha 1 | -0.0760766 |
| LDHA | lactate dehydrogenase A | -0.075194 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0747032 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0734992 |
| EGR1 | early growth response 1 | -0.0717084 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0699974 |
| PDE10A | phosphodiesterase 10A | -0.0685346 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0669935 |
| RPS19 | ribosomal protein S19 | -0.0655112 |
| DIAPH2 | diaphanous-related formin 2 | -0.0629935 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0609922 |
| RPS8 | ribosomal protein S8 | -0.0598987 |
| FLNB | filamin B, beta | -0.058972 |
| RPS12 | ribosomal protein S12 | -0.0584372 |
| AHNAK | AHNAK nucleoprotein | -0.056568 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0564213 |
| IGF2 | insulin-like growth factor 2 | -0.054939 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0535312 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0486875 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0484807 |
| LAMB3 | laminin, beta 3 | -0.0453617 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0452097 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0449498 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0430382 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.042884 |
| GOLGA4 | golgin A4 | -0.0411405 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0408515 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0399447 |
| RPL34 | ribosomal protein L34 | -0.0395544 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.038554 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0384914 |
| PARD3 | par-3 family cell polarity regulator | -0.03806 |
| PRKCA | protein kinase C, alpha | -0.0371303 |
| RPS25 | ribosomal protein S25 | -0.0350906 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0346324 |
| PKM | pyruvate kinase, muscle | -0.0344925 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0332117 |
| SMYD3 | SET and MYND domain containing 3 | -0.0331735 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0330961 |
| PGK1 | phosphoglycerate kinase 1 | -0.0330412 |
| CDH13 | cadherin 13 | -0.0311878 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0301289 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0299801 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0284002 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.0256406 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0238187 |
| ZNF292 | zinc finger protein 292 | -0.0226989 |
| TMSB10 | thymosin beta 10 | -0.0202737 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0201281 |
| RPLP1 | ribosomal protein, large, P1 | -0.0198263 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0186028 |
| RPS6 | ribosomal protein S6 | -0.0185826 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.016735 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0156382 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0149495 |
| PTMA | prothymosin, alpha | -0.0143194 |
| EVI5 | ecotropic viral integration site 5 | -0.0137724 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0125006 |
| CDK6 | cyclin-dependent kinase 6 | -0.0118964 |
| RPL15 | ribosomal protein L15 | -0.0117998 |
| RASAL2 | RAS protein activator like 2 | -0.0094033 |
| RPS3 | ribosomal protein S3 | -0.00926978 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.00906747 |
| ATM | ATM serine/threonine kinase | -0.00848664 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.00834283 |
| NRG1 | neuregulin 1 | -0.0066571 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.00652093 |
| RUNX1 | runt-related transcription factor 1 | -0.00575455 |
| FMN1 | formin 1 | -0.00508478 |
| MCL1 | myeloid cell leukemia 1 | -0.00473751 |
| PLEC | plectin | -0.00335633 |
| COL6A3 | collagen, type VI, alpha 3 | -0.00320126 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.00312807 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.00243752 |
| JMJD1C | jumonji domain containing 1C | -0.00206034 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.00181932 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.00164468 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0012008 |
