| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lidocaine (hydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lidocaine (hydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | 0.221609 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.107514 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0945739 |
| COL5A2 | collagen, type V, alpha 2 | 0.0804011 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0786493 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0782491 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0658515 |
| DST | dystonin | 0.0629409 |
| CALR | calreticulin | 0.0621454 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0613509 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0591488 |
| TENM3 | teneurin transmembrane protein 3 | 0.0560351 |
| CENPF | centromere protein F, 350/400kDa | 0.0551367 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0549957 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.051906 |
| H1-4 | H1.4 linker histone, cluster member | 0.0517004 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0511301 |
| PEG10 | paternally expressed 10 | 0.0505782 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0479738 |
| ENAH | enabled homolog (Drosophila) | 0.0471585 |
| ITGAV | integrin, alpha V | 0.0468322 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0460119 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0456172 |
| TMSB4X | thymosin beta 4, X-linked | 0.0453405 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0448423 |
| H1-0 | H1.0 linker histone | 0.0444869 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0444681 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0416375 |
| BBX | bobby sox homolog (Drosophila) | 0.0415497 |
| RPL3 | ribosomal protein L3 | 0.0413431 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0410783 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0406389 |
| LRRC4C | leucine rich repeat containing 4C | 0.0401766 |
| COL3A1 | collagen, type III, alpha 1 | 0.0394666 |
| TPM3 | tropomyosin 3 | 0.0384499 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0382624 |
| TXNRD1 | thioredoxin reductase 1 | 0.0380214 |
| TPX2 | TPX2, microtubule-associated | 0.0376625 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0376533 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0373994 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0367459 |
| RASAL2 | RAS protein activator like 2 | 0.0361478 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0361435 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0358461 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0354451 |
| CFL2 | cofilin 2 (muscle) | 0.035396 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.035065 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.034997 |
| TBC1D5 | TBC1 domain family, member 5 | 0.034919 |
| TEX11 | testis expressed 11 | 0.0345712 |
| MED13L | mediator complex subunit 13-like | 0.0344231 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.034167 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0337092 |
| ENO1 | enolase 1, (alpha) | 0.0327573 |
| SRPK2 | SRSF protein kinase 2 | 0.0327023 |
| RHOA | ras homolog family member A | 0.032356 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0321766 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.032056 |
| USP34 | ubiquitin specific peptidase 34 | 0.0316846 |
| PARD3 | par-3 family cell polarity regulator | 0.0313919 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0313327 |
| TNRC18 | trinucleotide repeat containing 18 | 0.03096 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0308867 |
| SETD5 | SET domain containing 5 | 0.0308018 |
| NCKAP1 | NCK-associated protein 1 | 0.0306278 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0305678 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0304216 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0303143 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0301037 |
| ZNF638 | zinc finger protein 638 | 0.0297264 |
| R3HDM1 | R3H domain containing 1 | 0.0293082 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0289255 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.028632 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.02844 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.028068 |
| CDC73 | cell division cycle 73 | 0.027991 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0278876 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0278814 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0277934 |
| B2M | beta-2-microglobulin | 0.027687 |
| PGK1 | phosphoglycerate kinase 1 | 0.0276053 |
| JMJD1C | jumonji domain containing 1C | 0.0274981 |
| GREB1L | growth regulation by estrogen in breast cancer-like | 0.0271849 |
| RNF213 | ring finger protein 213 | 0.0268013 |
| PCDH7 | protocadherin 7 | 0.0266686 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0266133 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0265099 |
| CCNL1 | cyclin L1 | 0.0264179 |
| LDHA | lactate dehydrogenase A | 0.0259854 |
| CADM2 | cell adhesion molecule 2 | 0.0259582 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0259571 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0258625 |
| ACTN4 | actinin, alpha 4 | 0.0257868 |
| AK1 | adenylate kinase 1 | 0.025396 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0253252 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0253053 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0252413 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0252139 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0252072 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0249312 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0780443 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0698538 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0585389 |
| TMSB10 | thymosin beta 10 | -0.0510613 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0503206 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0466579 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0427705 |
| NOP58 | NOP58 ribonucleoprotein | -0.0397372 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0388363 |
| WDR43 | WD repeat domain 43 | -0.0374724 |
| USP53 | ubiquitin specific peptidase 53 | -0.0373947 |
| SRP72 | signal recognition particle 72kDa | -0.0368094 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0360722 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.03555 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0355437 |
| ANK2 | ankyrin 2, neuronal | -0.0324615 |
| PLPP1 | phospholipid phosphatase 1 | -0.0322378 |
| RPS21 | ribosomal protein S21 | -0.0322338 |
| RPLP1 | ribosomal protein, large, P1 | -0.0318025 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0317689 |
| PFN1 | profilin 1 | -0.0316359 |
| GNAS | GNAS complex locus | -0.0314817 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0313993 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0313299 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0302664 |
| PRR16 | proline rich 16 | -0.0297049 |
| TUT4 | terminal uridylyl transferase 4 | -0.0292772 |
| RPLP2 | ribosomal protein, large, P2 | -0.0287556 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0287388 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.027931 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.027374 |
| RPS23 | ribosomal protein S23 | -0.0273219 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0273127 |
| PRTG | protogenin | -0.0272971 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0272868 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0270836 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | -0.026876 |
| CANX | calnexin | -0.0265808 |
| MTREX | Mtr4 exosome RNA helicase | -0.0263963 |
| RPL11 | ribosomal protein L11 | -0.0262263 |
| CRY1 | cryptochrome circadian clock 1 | -0.0261427 |
| VGLL3 | vestigial-like family member 3 | -0.0260433 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0260078 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0259191 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0254595 |
| HMGB1 | high mobility group box 1 | -0.0252995 |
| SMAP1 | small ArfGAP 1 | -0.0251853 |
| RPS8 | ribosomal protein S8 | -0.0250827 |
| USP15 | ubiquitin specific peptidase 15 | -0.0250762 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0249507 |
| QKI | QKI, KH domain containing, RNA binding | -0.0246451 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0246202 |
| RPL19 | ribosomal protein L19 | -0.0243129 |
| RPL13A | ribosomal protein L13a | -0.0241261 |
| PHF21A | PHD finger protein 21A | -0.0235586 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.023549 |
| SFRP4 | secreted frizzled-related protein 4 | -0.0235193 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0234334 |
| HBS1L | HBS1-like translational GTPase | -0.0232912 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | -0.0231931 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0228983 |
| RPL39 | ribosomal protein L39 | -0.0226623 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0224974 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.0224297 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0223593 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | -0.0223495 |
| TFRC | transferrin receptor | -0.0223307 |
| ZFR | zinc finger RNA binding protein | -0.022315 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.0220253 |
| FIP1L1 | factor interacting with PAPOLA and CPSF1 | -0.0217876 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0217259 |
| RPL12 | ribosomal protein L12 | -0.0216937 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0212495 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | -0.0212223 |
| WDR70 | WD repeat domain 70 | -0.021178 |
| RPL32 | ribosomal protein L32 | -0.0209965 |
| COX6B1 | cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) | -0.0208807 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0208597 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0207984 |
| RPS10 | ribosomal protein S10 | -0.0206496 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0206214 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.0205642 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0205193 |
| CCN2 | cellular communication network factor 2 | -0.0203226 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.0202875 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0202752 |
| CLSPN | claspin | -0.0201775 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0201443 |
| ZNF217 | zinc finger protein 217 | -0.0201149 |
| RPL18 | ribosomal protein L18 | -0.0200977 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0199911 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0199338 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0198261 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0195948 |
| FAM171B | family with sequence similarity 171, member B | -0.0195364 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0194766 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0193697 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0193384 |
| RPL10A | ribosomal protein L10a | -0.0192726 |
| ACTG1 | actin gamma 1 | -0.0188605 |
