Lidocaine (hydrochloride)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lidocaine (hydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lidocaine (hydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.186492
SNAP25 synaptosomal-associated protein, 25kDa 0.0956647
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0855897
MCL1 myeloid cell leukemia 1 0.0825157
INHBA inhibin, beta A 0.0792122
FNDC3A fibronectin type III domain containing 3A 0.0767533
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0735247
MYH9 myosin, heavy chain 9, non-muscle 0.0732094
SLC38A2 solute carrier family 38, member 2 0.0721495
NCKAP5 NCK-associated protein 5 0.066817
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0650435
IRS2 insulin receptor substrate 2 0.064522
EXT1 exostosin glycosyltransferase 1 0.0629513
TRIO trio Rho guanine nucleotide exchange factor 0.0560015
PDE4D phosphodiesterase 4D, cAMP-specific 0.0557354
FGF14 fibroblast growth factor 14 0.0552832
ARHGAP26 Rho GTPase activating protein 26 0.0543466
PSD3 pleckstrin and Sec7 domain containing 3 0.0526125
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0494174
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.048536
LOC112694756 uncharaterized LOC112694756 0.0477266
PTCHD4 patched domain containing 4 0.0461147
CNKSR3 CNKSR family member 3 0.0459577
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like 0.0449788
RNF213 ring finger protein 213 0.0442077
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0441003
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0435299
SMYD3 SET and MYND domain containing 3 0.0429399
ASPH aspartate beta-hydroxylase 0.0424797
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0421077
TOX thymocyte selection-associated high mobility group box 0.0417429
MACF1 microtubule-actin crosslinking factor 1 0.0409172
DST dystonin 0.0403129
TENM1 teneurin transmembrane protein 1 0.0398702
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0398513
TXNRD1 thioredoxin reductase 1 0.0396948
WWOX WW domain containing oxidoreductase 0.0390751
NBEA neurobeachin 0.0378682
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0377623
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0375274
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0370105
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0362708
RPH3AL rabphilin 3A-like (without C2 domains) 0.0359249
FAT1 FAT atypical cadherin 1 0.0355297
TOP1 topoisomerase (DNA) I 0.0340395
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0326464
STC1 stanniocalcin 1 0.0312683
ANKRD36C ankyrin repeat domain 36C 0.0311308
TRIM9 tripartite motif containing 9 0.030486
DOCK5 dedicator of cytokinesis 5 0.0304227
TRAPPC9 trafficking protein particle complex 9 0.0301799
LCOR ligand dependent nuclear receptor corepressor 0.0300444
TACC2 transforming, acidic coiled-coil containing protein 2 0.029789
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0293668
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0292424
USP34 ubiquitin specific peptidase 34 0.0290683
BACE2 beta-site APP-cleaving enzyme 2 0.028944
SCFD2 sec1 family domain containing 2 0.02894
GDAP1 ganglioside induced differentiation associated protein 1 0.0289033
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.0287892
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0282421
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.028129
MAP7 microtubule-associated protein 7 0.0279528
RBM19 RNA binding motif protein 19 0.0277148
MACROD2 MACRO domain containing 2 0.0274463
CDK13 cyclin-dependent kinase 13 0.0274315
TBC1D22A TBC1 domain family, member 22A 0.0273487
ZFHX3 zinc finger homeobox 3 0.0270965
ST18 suppression of tumorigenicity 18, zinc finger 0.0269851
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0269351
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.0268923
SMOC1 SPARC related modular calcium binding 1 0.0268835
TTC19 tetratricopeptide repeat domain 19 0.0267503
GRAMD4 GRAM domain containing 4 0.0266529
SIK2 salt-inducible kinase 2 0.0265159
KIF26B kinesin family member 26B 0.0264674
ACTG1 actin gamma 1 0.0264081
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0264026
ANKH ANKH inorganic pyrophosphate transport regulator 0.0262551
EGFR epidermal growth factor receptor 0.0262364
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0259061
CEMIP cell migration inducing protein, hyaluronan binding 0.0256344
RHOA ras homolog family member A 0.0256046
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0255379
FHIT fragile histidine triad 0.0252059
FNDC3B fibronectin type III domain containing 3B 0.0251998
MARS1 methionyl-tRNA synthetase 1 0.0251911
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0251771
RIMS2 regulating synaptic membrane exocytosis 2 0.0249681
RNF144A ring finger protein 144A 0.024765
GOLGA3 golgin A3 0.0245354
LPP LIM domain containing preferred translocation partner in lipoma 0.0243135
RPTOR regulatory associated protein of MTOR, complex 1 0.0242647
ATF6 activating transcription factor 6 0.0241689
INTS6 integrator complex subunit 6 0.024062
EPHA4 EPH receptor A4 0.0238347
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 0.0238242
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.0235705
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0235236
SETX senataxin 0.023487

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.0577857
NDRG1 N-myc downstream regulated 1 -0.0526528
ZNF292 zinc finger protein 292 -0.045492
DTNA dystrobrevin, alpha -0.0433872
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.035731
MAP1B microtubule-associated protein 1B -0.0356949
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0354017
CHGB chromogranin B -0.0337672
ENO1 enolase 1, (alpha) -0.0332966
MATR3 matrin 3 -0.0309633
CALCA calcitonin-related polypeptide alpha -0.030084
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0297468
GRB10 growth factor receptor-bound protein 10 -0.0284101
PGAP1 post-GPI attachment to proteins 1 -0.0271597
RPS21 ribosomal protein S21 -0.0262823
MIS18BP1 MIS18 binding protein 1 -0.026273
GPC5 glypican 5 -0.0262277
EGR1 early growth response 1 -0.0261634
RPS19 ribosomal protein S19 -0.0251665
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0238946
NALF1 NALCN channel auxiliary factor 1 -0.0238065
RPS6 ribosomal protein S6 -0.0234004
FKBP9 FK506 binding protein 9, 63 kDa -0.0229788
SSBP2 single-stranded DNA binding protein 2 -0.022347
ESRRG estrogen-related receptor gamma -0.0218547
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0213292
DGKB diacylglycerol kinase, beta 90kDa -0.0212707
TPD52 tumor protein D52 -0.0212417
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0211796
SCAF11 SR-related CTD-associated factor 11 -0.0208858
CHD7 chromodomain helicase DNA binding protein 7 -0.0205654
RIT2 Ras-like without CAAX 2 -0.0203815
LMAN1 lectin, mannose-binding, 1 -0.0201101
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0200664
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0199272
RB1CC1 RB1-inducible coiled-coil 1 -0.0199052
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.019628
SINHCAF SIN3-HDAC complex associated factor -0.0195856
NIPSNAP2 nipsnap homolog 2 -0.019531
WDR45B WD repeat domain 45B -0.0187632
LCORL ligand dependent nuclear receptor corepressor-like -0.0187338
IGFBP5 insulin-like growth factor binding protein 5 -0.0183858
PIAS2 protein inhibitor of activated STAT, 2 -0.018348
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0182129
ISG15 ISG15 ubiquitin-like modifier -0.0180138
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.0179622
NCAM1 neural cell adhesion molecule 1 -0.0177259
ANKRD28 ankyrin repeat domain 28 -0.0176879
ELL2 elongation factor, RNA polymerase II, 2 -0.0176112
RPS14 ribosomal protein S14 -0.0175598
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0173906
PEG10 paternally expressed 10 -0.0172334
MRPS6 mitochondrial ribosomal protein S6 -0.0171801
CENPF centromere protein F, 350/400kDa -0.0171323
ECT2 epithelial cell transforming 2 -0.0166458
RNF145 ring finger protein 145 -0.01659
TFF3 trefoil factor 3 (intestinal) -0.0165077
RPLP1 ribosomal protein, large, P1 -0.0164103
SRP54 signal recognition particle 54kDa -0.0162012
NKTR natural killer cell triggering receptor -0.0161637
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0161511
ZNF395 zinc finger protein 395 -0.0161487
GPHN gephyrin -0.0161097
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0159649
JAM3 junctional adhesion molecule 3 -0.0157834
TNRC6B trinucleotide repeat containing 6B -0.0156363
GOLGA4 golgin A4 -0.0156044
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0155584
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0154229
TENT4A terminal nucleotidyltransferase 4A -0.0154011
BHLHE40 basic helix-loop-helix family, member e40 -0.0153481
GSR glutathione reductase -0.0152567
OGA O-GlcNAcase -0.0152407
LIFR leukemia inhibitory factor receptor alpha -0.0151006
SEPTIN7 septin 7 -0.015098
CCDC88A coiled-coil domain containing 88A -0.0150884
PHIP pleckstrin homology domain interacting protein -0.0150594
RPS27 ribosomal protein S27 -0.0150311
PPME1 protein phosphatase methylesterase 1 -0.0149755
ZEB1 zinc finger E-box binding homeobox 1 -0.0149685
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0149194
NEMF nuclear export mediator factor -0.0145227
FANCL Fanconi anemia, complementation group L -0.0145068
POGZ pogo transposable element with ZNF domain -0.0144794
PDIA6 protein disulfide isomerase family A, member 6 -0.0144669
ADNP activity-dependent neuroprotector homeobox -0.0144455
NOL4 nucleolar protein 4 -0.014375
ATP5F1E ATP synthase F1 subunit epsilon -0.0143422
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.014333
TPR translocated promoter region, nuclear basket protein -0.0142619
RPS29 ribosomal protein S29 -0.0142468
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0142275
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0142064
TENT5A terminal nucleotidyltransferase 5A -0.0141661
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 -0.0141356
NGLY1 N-glycanase 1 -0.0140473
CSMD3 CUB and Sushi multiple domains 3 -0.0140394
PFN1 profilin 1 -0.0140355
CDCA2 cell division cycle associated 2 -0.0140272
S100A9 S100 calcium binding protein A9 -0.0139965