Lidocaine (hydrochloride)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lidocaine (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lidocaine (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.129237
EGFR epidermal growth factor receptor 0.119731
ACTG1 actin gamma 1 0.113192
TPT1 tumor protein, translationally-controlled 1 0.0986556
IER3 immediate early response 3 0.0876279
HMGA2 high mobility group AT-hook 2 0.087374
RPL3 ribosomal protein L3 0.0847405
SEPTIN9 septin 9 0.0791591
RCOR1 REST corepressor 1 0.0784356
LAMA4 laminin, alpha 4 0.0744586
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.069122
HSPA8 heat shock 70kDa protein 8 0.0679974
MYH9 myosin, heavy chain 9, non-muscle 0.0647524
NTSR1 neurotensin receptor 1 (high affinity) 0.061965
RPS12 ribosomal protein S12 0.0579994
SMAD3 SMAD family member 3 0.0575859
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0543898
AHNAK AHNAK nucleoprotein 0.0532029
H1-4 H1.4 linker histone, cluster member 0.0508501
ABR active BCR-related 0.0502784
RPS6 ribosomal protein S6 0.0499414
DSPP dentin sialophosphoprotein 0.049229
CLIP2 CAP-GLY domain containing linker protein 2 0.0469676
VCL vinculin 0.0461432
ATXN1 ataxin 1 0.0459991
EFNB2 ephrin-B2 0.0456139
RAD51B RAD51 paralog B 0.0435469
SGMS2 sphingomyelin synthase 2 0.0411406
PLEC plectin 0.0411061
FHL2 four and a half LIM domains 2 0.0409481
DOCK5 dedicator of cytokinesis 5 0.0409444
MPRIP myosin phosphatase Rho interacting protein 0.0398536
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0392181
LOC112694756 uncharaterized LOC112694756 0.0392076
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0391088
ZHX2 zinc fingers and homeoboxes 2 0.0375777
RPS8 ribosomal protein S8 0.0367384
JARID2 jumonji, AT rich interactive domain 2 0.0345177
RPLP2 ribosomal protein, large, P2 0.0343086
FLNA filamin A, alpha 0.0338709
GATAD2A GATA zinc finger domain containing 2A 0.0332337
SYNE2 spectrin repeat containing, nuclear envelope 2 0.032892
LOC102724023 ES1 protein homolog, mitochondrial 0.0326322
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0322789
RPS19 ribosomal protein S19 0.0318079
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0317344
H1-10 H1.10 linker histone 0.0313081
RRM2 ribonucleotide reductase M2 0.0311728
FHIT fragile histidine triad 0.0305935
ZNRF3 zinc and ring finger 3 0.0305319
RPLP0 ribosomal protein, large, P0 0.0305049
AKAP13 A kinase (PRKA) anchor protein 13 0.0302564
EIF4H eukaryotic translation initiation factor 4H 0.0298602
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0294182
WWOX WW domain containing oxidoreductase 0.0292782
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0290645
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0290418
MKI67 marker of proliferation Ki-67 0.028766
HDLBP high density lipoprotein binding protein 0.0287164
EPCAM epithelial cell adhesion molecule 0.0287148
RPL38 ribosomal protein L38 0.0285357
BCAR3 breast cancer anti-estrogen resistance 3 0.0285218
NACA nascent polypeptide-associated complex alpha subunit 0.0283453
NUP50 nucleoporin 50kDa 0.0282716
RPL5 ribosomal protein L5 0.0281205
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0278886
CPOX coproporphyrinogen oxidase 0.0275468
RPS24 ribosomal protein S24 0.0275297
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0272828
RPS11 ribosomal protein S11 0.0268576
ACTN4 actinin, alpha 4 0.0262215
RPS4X ribosomal protein S4, X-linked 0.0262048
RPS3 ribosomal protein S3 0.0261716
NCEH1 neutral cholesterol ester hydrolase 1 0.0261469
SLC30A10 solute carrier family 30, member 10 0.025891
RPL23 ribosomal protein L23 0.0258404
CMIP c-Maf inducing protein 0.0258019
HDAC4 histone deacetylase 4 0.0254161
MYH14 myosin, heavy chain 14, non-muscle 0.0253126
H1-2 H1.2 linker histone, cluster member 0.0250667
KLF12 Kruppel-like factor 12 0.0248353
RPL19 ribosomal protein L19 0.0246961
RPL4 ribosomal protein L4 0.0244664
ZSWIM6 zinc finger, SWIM-type containing 6 0.0243396
SMYD3 SET and MYND domain containing 3 0.0241679
RPL7A ribosomal protein L7a 0.0233509
MYO5B myosin VB 0.0231739
CSNK1A1 casein kinase 1, alpha 1 0.0231715
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0230764
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0229027
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.022687
MCL1 myeloid cell leukemia 1 0.0226449
OSBPL10 oxysterol binding protein-like 10 0.0225398
RPL37A ribosomal protein L37a 0.0225201
APLP2 amyloid beta (A4) precursor-like protein 2 0.0222778
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0217559
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0216931
RPLP1 ribosomal protein, large, P1 0.0216143
DOCK1 dedicator of cytokinesis 1 0.0214173
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0213632

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.202874
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.128559
CD36 CD36 molecule (thrombospondin receptor) -0.114413
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0920179
LMO7 LIM domain 7 -0.081985
OXR1 oxidation resistance 1 -0.0687813
GOLGA4 golgin A4 -0.0654345
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0599476
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0594746
COG5 component of oligomeric golgi complex 5 -0.0563956
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0542229
TOP1 topoisomerase (DNA) I -0.0493016
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.046988
AREG amphiregulin -0.0467613
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0452805
LDHA lactate dehydrogenase A -0.04372
IGFBP3 insulin-like growth factor binding protein 3 -0.0425661
PCBP2 poly(rC) binding protein 2 -0.0419285
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0412109
BRWD1 bromodomain and WD repeat domain containing 1 -0.0405875
RUNX2 runt-related transcription factor 2 -0.0392412
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0388146
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0381578
TXNRD1 thioredoxin reductase 1 -0.0378446
EREG epiregulin -0.0370811
NDRG1 N-myc downstream regulated 1 -0.0361662
RNF145 ring finger protein 145 -0.0358386
PUM2 pumilio RNA-binding family member 2 -0.0349724
BIRC6 baculoviral IAP repeat containing 6 -0.0322595
STRN3 striatin, calmodulin binding protein 3 -0.0322417
HDAC2 histone deacetylase 2 -0.0322261
KMT2C lysine (K)-specific methyltransferase 2C -0.0316687
EIF1 eukaryotic translation initiation factor 1 -0.031463
ESYT2 extended synaptotagmin-like protein 2 -0.0314179
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0311481
PNISR PNN-interacting serine/arginine-rich protein -0.0310007
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0309933
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.030851
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0308425
PTBP2 polypyrimidine tract binding protein 2 -0.0293128
FERMT1 fermitin family member 1 -0.0292183
FAR1 fatty acyl CoA reductase 1 -0.0291976
KDM6A lysine (K)-specific demethylase 6A -0.0290579
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0290554
PCNX1 pecanex 1 -0.0290451
TXNIP thioredoxin interacting protein -0.0289448
KMT2E lysine (K)-specific methyltransferase 2E -0.0283237
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0282239
NEK7 NIMA-related kinase 7 -0.028145
FAM3C family with sequence similarity 3, member C -0.027693
PHIP pleckstrin homology domain interacting protein -0.0275283
SRP54 signal recognition particle 54kDa -0.0273668
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0272642
UBC ubiquitin C -0.0269077
OSBPL3 oxysterol binding protein-like 3 -0.0268422
NFXL1 nuclear transcription factor, X-box binding-like 1 -0.0266557
GSK3B glycogen synthase kinase 3 beta -0.0263706
ESRP1 epithelial splicing regulatory protein 1 -0.0262074
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0260585
YTHDC1 YTH domain containing 1 -0.0257337
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0255172
NEMF nuclear export mediator factor -0.0251733
NCOR1 nuclear receptor corepressor 1 -0.0251413
RNF43 ring finger protein 43 -0.025099
PERP PERP, TP53 apoptosis effector -0.0250574
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0250491
RAB6A RAB6A, member RAS oncogene family -0.0249552
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0246721
WDR43 WD repeat domain 43 -0.0243545
USP3 ubiquitin specific peptidase 3 -0.0240559
GARS1 glycyl-tRNA synthetase 1 -0.0237637
MBNL1 muscleblind-like splicing regulator 1 -0.0235328
PDLIM5 PDZ and LIM domain 5 -0.0232956
SERINC5 serine incorporator 5 -0.02319
VMP1 vacuole membrane protein 1 -0.023059
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0230335
RBM39 RNA binding motif protein 39 -0.0229946
NAMPT nicotinamide phosphoribosyltransferase -0.0229911
CEP152 centrosomal protein 152kDa -0.0229113
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.022684
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0222916
ANKRD28 ankyrin repeat domain 28 -0.0222733
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0221816
HMGA1 high mobility group AT-hook 1 -0.0221649
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0221491
SLC38A1 solute carrier family 38, member 1 -0.021682
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0213977
ZNF292 zinc finger protein 292 -0.0213741
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0212349
MATR3 matrin 3 -0.0211572
ANLN anillin, actin binding protein -0.0211361
GDF15 growth differentiation factor 15 -0.0209135
USP24 ubiquitin specific peptidase 24 -0.0208181
NBAS neuroblastoma amplified sequence -0.0207249
ZMYM2 zinc finger, MYM-type 2 -0.0205744
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0204343
SLMAP sarcolemma associated protein -0.0204153
TCERG1 transcription elongation regulator 1 -0.0203954
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0203217
ITPRID2 ITPR interacting domain containing 2 -0.0200997