| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lidocaine (hydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lidocaine (hydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.127806 |
| PLEC | plectin | 0.117453 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.102463 |
| EZR | ezrin | 0.0931775 |
| AHNAK | AHNAK nucleoprotein | 0.0884572 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0864473 |
| ACTN4 | actinin, alpha 4 | 0.0826051 |
| RPL3 | ribosomal protein L3 | 0.073121 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0706459 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0702991 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.06787 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0624907 |
| DSPP | dentin sialophosphoprotein | 0.06218 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0580167 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0566747 |
| FLNA | filamin A, alpha | 0.0558494 |
| MSI2 | musashi RNA-binding protein 2 | 0.0534919 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.051456 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0505138 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0503687 |
| INTS6 | integrator complex subunit 6 | 0.0501499 |
| H1-4 | H1.4 linker histone, cluster member | 0.0490691 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.047908 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0464909 |
| NAV2 | neuron navigator 2 | 0.0445448 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0442238 |
| WWOX | WW domain containing oxidoreductase | 0.0434323 |
| PKM | pyruvate kinase, muscle | 0.042236 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0420188 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.041601 |
| SEPTIN9 | septin 9 | 0.0415103 |
| LMO7 | LIM domain 7 | 0.0412928 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0411187 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0409818 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0406952 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0404651 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0402316 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0396419 |
| HDAC4 | histone deacetylase 4 | 0.0391462 |
| BCL2L1 | BCL2-like 1 | 0.0385858 |
| MSN | moesin | 0.0383836 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0383562 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0383562 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0378754 |
| MKI67 | marker of proliferation Ki-67 | 0.0373897 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.037359 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.037094 |
| ATXN1 | ataxin 1 | 0.0370746 |
| RUNX1 | runt-related transcription factor 1 | 0.0367733 |
| VCL | vinculin | 0.0363521 |
| DST | dystonin | 0.0361688 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0360914 |
| TNS3 | tensin 3 | 0.0360553 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0359706 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0355689 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0351097 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0347561 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0346337 |
| SMAD3 | SMAD family member 3 | 0.0342619 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0340387 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0338608 |
| YAP1 | Yes-associated protein 1 | 0.0336015 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0334846 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0329379 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0328037 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.032583 |
| SYT1 | synaptotagmin I | 0.0325696 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0323951 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0323423 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0319468 |
| ACTN1 | actinin, alpha 1 | 0.0318853 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0318624 |
| ANO6 | anoctamin 6 | 0.0316967 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0312283 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0311708 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0311183 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0301638 |
| FAT1 | FAT atypical cadherin 1 | 0.0298848 |
| FLNB | filamin B, beta | 0.0298567 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0295252 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0294333 |
| H1-5 | H1.5 linker histone, cluster member | 0.029014 |
| SET | SET nuclear proto-oncogene | 0.0290121 |
| CENPF | centromere protein F, 350/400kDa | 0.0288998 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0288093 |
| MYO10 | myosin X | 0.0286065 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0276904 |
| TPX2 | TPX2, microtubule-associated | 0.0271786 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0271429 |
| RCOR1 | REST corepressor 1 | 0.0270982 |
| EXOC4 | exocyst complex component 4 | 0.0266956 |
| TOP1 | topoisomerase (DNA) I | 0.0265247 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0264271 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0263644 |
| RPS12 | ribosomal protein S12 | 0.0261425 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.026113 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0261058 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0256169 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0255896 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0254597 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL35A | ribosomal protein L35a | -0.10693 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0973027 |
| PTMA | prothymosin, alpha | -0.0578957 |
| HMGA1 | high mobility group AT-hook 1 | -0.0471355 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0444806 |
| RPL9 | ribosomal protein L9 | -0.0425412 |
| TMSB10 | thymosin beta 10 | -0.0389331 |
| RPS8 | ribosomal protein S8 | -0.0372177 |
| CCND1 | cyclin D1 | -0.0341181 |
| RPS24 | ribosomal protein S24 | -0.0334247 |
| PERP | PERP, TP53 apoptosis effector | -0.0331996 |
| RPLP1 | ribosomal protein, large, P1 | -0.0302759 |
| VIM | vimentin | -0.0288664 |
| HMGB1 | high mobility group box 1 | -0.0284403 |
| CBX3 | chromobox homolog 3 | -0.0279525 |
| RPLP0 | ribosomal protein, large, P0 | -0.0270189 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0258888 |
| RPL12 | ribosomal protein L12 | -0.0254515 |
| RPL34 | ribosomal protein L34 | -0.025352 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0249385 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0242849 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0237463 |
| RPS13 | ribosomal protein S13 | -0.0229011 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0222136 |
| FTL | ferritin, light polypeptide | -0.0216938 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0211277 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0208209 |
| KRT19 | keratin 19, type I | -0.0203109 |
| THOC2 | THO complex 2 | -0.0196887 |
| S100A4 | S100 calcium binding protein A4 | -0.0195973 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0191059 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0188648 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0188544 |
| IGF2 | insulin-like growth factor 2 | -0.0182706 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0168563 |
| DEK | DEK proto-oncogene | -0.0161282 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0161259 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0159595 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0158497 |
| LDHB | lactate dehydrogenase B | -0.0157681 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0157266 |
| RPL11 | ribosomal protein L11 | -0.0156607 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0153801 |
| S100A6 | S100 calcium binding protein A6 | -0.0153697 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0152298 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0151329 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0150603 |
| TMEM123 | transmembrane protein 123 | -0.0149044 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0148163 |
| H3-3B | H3.3 histone B | -0.0148161 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0146543 |
| INHBB | inhibin, beta B | -0.0146346 |
| RPS6 | ribosomal protein S6 | -0.0146331 |
| EGR1 | early growth response 1 | -0.0146219 |
| TPM4 | tropomyosin 4 | -0.0144671 |
| RPL39 | ribosomal protein L39 | -0.014186 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.014045 |
| TMEM41B | transmembrane protein 41B | -0.0140062 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0139449 |
| PROX1 | prospero homeobox 1 | -0.0138784 |
| RPL27A | ribosomal protein L27a | -0.0138735 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0136913 |
| PFN1 | profilin 1 | -0.0136814 |
| APCDD1 | adenomatosis polyposis coli down-regulated 1 | -0.0136619 |
| GNAS | GNAS complex locus | -0.0135461 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0134041 |
| RPL7L1 | ribosomal protein L7-like 1 | -0.0133696 |
| ABLIM1 | actin binding LIM protein 1 | -0.0132051 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0130581 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0128563 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0127706 |
| IER3 | immediate early response 3 | -0.0123715 |
| ZNF33B | zinc finger protein 33B | -0.0122626 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0122561 |
| IFITM2 | interferon induced transmembrane protein 2 | -0.0122045 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0119464 |
| KHSRP | KH-type splicing regulatory protein | -0.0118459 |
| MEF2A | myocyte enhancer factor 2A | -0.0118393 |
| PARK7 | parkinson protein 7 | -0.0117928 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0117042 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0114762 |
| TXNIP | thioredoxin interacting protein | -0.0113595 |
| MT1E | metallothionein 1E | -0.0113254 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | -0.0112641 |
| YY1 | YY1 transcription factor | -0.0112402 |
| COX5A | cytochrome c oxidase subunit Va | -0.0112005 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0111988 |
| RPL30 | ribosomal protein L30 | -0.0111236 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0110402 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0110358 |
| RPL10A | ribosomal protein L10a | -0.0110145 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.0110101 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0109514 |
| CEP57 | centrosomal protein 57kDa | -0.0109131 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.010803 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0106921 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0105652 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0103647 |
| RPL36A | ribosomal protein L36a | -0.0103427 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0102857 |
