| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ligustrazine perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ligustrazine_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0953612 |
| FBN1 | fibrillin 1 | 0.0826802 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.05848 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0584414 |
| OGA | O-GlcNAcase | 0.0579123 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.057492 |
| MT2A | metallothionein 2A | 0.0527167 |
| SQSTM1 | sequestosome 1 | 0.0516301 |
| COL3A1 | collagen, type III, alpha 1 | 0.0491026 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0472831 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0455961 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0390135 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0387968 |
| GPC6 | glypican 6 | 0.0363159 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0360732 |
| COL1A2 | collagen, type I, alpha 2 | 0.0355138 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0342388 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0318692 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0314913 |
| FMNL2 | formin-like 2 | 0.0313471 |
| SBF2 | SET binding factor 2 | 0.0307558 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.03029 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0297418 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0290757 |
| STC1 | stanniocalcin 1 | 0.0290153 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.028914 |
| PTMA | prothymosin, alpha | 0.0283568 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0282303 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0281765 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0279878 |
| CAVIN1 | caveolae associated protein 1 | 0.0279495 |
| ADM | adrenomedullin | 0.0279461 |
| ATP13A3 | ATPase type 13A3 | 0.0277659 |
| THBS2 | thrombospondin 2 | 0.0276856 |
| UBC | ubiquitin C | 0.0274428 |
| CD109 | CD109 molecule | 0.0270437 |
| GOLGA4 | golgin A4 | 0.0269864 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0267412 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.0266498 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0265678 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 0.0263595 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0256019 |
| ARRDC3 | arrestin domain containing 3 | 0.025321 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0251354 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0248788 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0244324 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0243888 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0243671 |
| OPTN | optineurin | 0.0242513 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0240394 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0228875 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0228472 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0227318 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.022719 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0223304 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0220342 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0217711 |
| NDRG1 | N-myc downstream regulated 1 | 0.0216936 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0216393 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0213433 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0207216 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0200465 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0200377 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0197694 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0197579 |
| HELZ | helicase with zinc finger | 0.0196558 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0195838 |
| TMOD1 | tropomodulin 1 | 0.019372 |
| WTAP | Wilms tumor 1 associated protein | 0.0190888 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0189358 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0188908 |
| NAV2 | neuron navigator 2 | 0.0187038 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0186328 |
| ANXA2 | annexin A2 | 0.0186209 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0181514 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0181495 |
| FNIP1 | folliculin interacting protein 1 | 0.0180748 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | 0.0179711 |
| SERINC1 | serine incorporator 1 | 0.017967 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0179101 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0176826 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0175955 |
| RPL12 | ribosomal protein L12 | 0.0174307 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0173786 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0173598 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0171219 |
| NEFL | neurofilament, light polypeptide | 0.0171157 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0170966 |
| ZNF292 | zinc finger protein 292 | 0.0170626 |
| XPO1 | exportin 1 | 0.0170012 |
| CLU | clusterin | 0.0167544 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.016677 |
| MATR3 | matrin 3 | 0.016611 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.016553 |
| PCGF5 | polycomb group ring finger 5 | 0.0165284 |
| ITSN2 | intersectin 2 | 0.0164785 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0163657 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0163125 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0162249 |
| KIAA1217 | KIAA1217 | 0.0161881 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.45616 |
| VIM | vimentin | -0.258962 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.237973 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.161999 |
| COL5A1 | collagen, type V, alpha 1 | -0.134428 |
| CDH13 | cadherin 13 | -0.124021 |
| FN1 | fibronectin 1 | -0.116299 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.101678 |
| MAP1B | microtubule-associated protein 1B | -0.101025 |
| NAV1 | neuron navigator 1 | -0.0986594 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0972823 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0932579 |
| SUCNR1 | succinate receptor 1 | -0.0834574 |
| TMSB10 | thymosin beta 10 | -0.0821375 |
| PODXL | podocalyxin-like | -0.0724322 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0687833 |
| EGFR | epidermal growth factor receptor | -0.0664554 |
| DCLK2 | doublecortin-like kinase 2 | -0.0625866 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0579376 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0543968 |
| EFNA5 | ephrin-A5 | -0.054116 |
| TPM1 | tropomyosin 1 (alpha) | -0.049854 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0494248 |
| CUX1 | cut-like homeobox 1 | -0.0490937 |
| MX2 | MX dynamin-like GTPase 2 | -0.0476608 |
| LOX | lysyl oxidase | -0.0471106 |
| PKM | pyruvate kinase, muscle | -0.0437338 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0428322 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0422775 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0422576 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0405797 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0396112 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0394271 |
| MEIS2 | Meis homeobox 2 | -0.0389674 |
| RUNX1 | runt-related transcription factor 1 | -0.0382821 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0378501 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0373478 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.035916 |
| VEGFC | vascular endothelial growth factor C | -0.0350516 |
| PLXNA2 | plexin A2 | -0.0340221 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0339699 |
| PRSS23 | protease, serine, 23 | -0.0335934 |
| BSG | basigin (Ok blood group) | -0.0335124 |
| PLAT | plasminogen activator, tissue | -0.0331706 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0328188 |
| FMN2 | formin 2 | -0.0322847 |
| PCDH7 | protocadherin 7 | -0.0320065 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0318838 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0316884 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0316221 |
| CYTH3 | cytohesin 3 | -0.0309456 |
| RNF213 | ring finger protein 213 | -0.0308905 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0307108 |
| CD99 | CD99 molecule | -0.0304096 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.030038 |
| TAGLN2 | transgelin 2 | -0.0297616 |
| COL5A2 | collagen, type V, alpha 2 | -0.0292579 |
| S100A6 | S100 calcium binding protein A6 | -0.0291734 |
| TENM3 | teneurin transmembrane protein 3 | -0.0290255 |
| SRPK2 | SRSF protein kinase 2 | -0.0285526 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0281581 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0281454 |
| TPM4 | tropomyosin 4 | -0.0280511 |
| TNS3 | tensin 3 | -0.0276204 |
| CALR | calreticulin | -0.0274544 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0272374 |
| PFN1 | profilin 1 | -0.0266434 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.02645 |
| POTEF | POTE ankyrin domain family, member F | -0.0250527 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0240963 |
| GSE1 | Gse1 coiled-coil protein | -0.0240803 |
| S100A10 | S100 calcium binding protein A10 | -0.0237466 |
| CEP112 | centrosomal protein 112kDa | -0.0237356 |
| KRT81 | keratin 81, type II | -0.0231462 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | -0.0231211 |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | -0.0229712 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0229079 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0228601 |
| MSN | moesin | -0.0226944 |
| MSI2 | musashi RNA-binding protein 2 | -0.0224173 |
| RIGI | RNA sensor RIG-I | -0.0219647 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0219302 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0218392 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0217536 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.021511 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0213931 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0211821 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0211717 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0211592 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.02083 |
| ACER3 | alkaline ceramidase 3 | -0.0207868 |
| AXL | AXL receptor tyrosine kinase | -0.0207866 |
| HLA-B | major histocompatibility complex, class I, B | -0.0206884 |
| CDK6 | cyclin-dependent kinase 6 | -0.020659 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0205406 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0205329 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0205249 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0202634 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0200942 |
| IL7R | interleukin 7 receptor | -0.0200908 |
