| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ligustrazine perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ligustrazine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.168829 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.16879 |
| ANXA1 | annexin A1 | 0.14163 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.12454 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0882259 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0821601 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0815029 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0756579 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0741126 |
| DST | dystonin | 0.0717331 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0710607 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0685537 |
| ECT2 | epithelial cell transforming 2 | 0.0652775 |
| PTMA | prothymosin, alpha | 0.0638238 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0631438 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0606883 |
| CALR | calreticulin | 0.0595146 |
| ENO1 | enolase 1, (alpha) | 0.0592059 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0560079 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.055125 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0542272 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0538855 |
| AHNAK | AHNAK nucleoprotein | 0.0521739 |
| MED13L | mediator complex subunit 13-like | 0.0504702 |
| FUS | FUS RNA binding protein | 0.0491267 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.048929 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0486027 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0484416 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0483835 |
| CANX | calnexin | 0.0442543 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0440092 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0435999 |
| GANAB | glucosidase, alpha; neutral AB | 0.0431014 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0427265 |
| RPL11 | ribosomal protein L11 | 0.0424961 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0424919 |
| USP53 | ubiquitin specific peptidase 53 | 0.0417664 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0414731 |
| ASPH | aspartate beta-hydroxylase | 0.0412702 |
| BCHE | butyrylcholinesterase | 0.0411898 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0409495 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0403324 |
| EZR | ezrin | 0.039797 |
| RPL23 | ribosomal protein L23 | 0.0393443 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0393384 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.039331 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0389967 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0386871 |
| TFG | TRK-fused gene | 0.0385269 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0384975 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0377893 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0374168 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | 0.0372665 |
| PDGFC | platelet derived growth factor C | 0.0371436 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0370114 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0368913 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0368496 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0364233 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0361186 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0360542 |
| PCBP2 | poly(rC) binding protein 2 | 0.0354676 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0353439 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0351076 |
| NCKAP1 | NCK-associated protein 1 | 0.0350216 |
| LMO7 | LIM domain 7 | 0.0343401 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0336166 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0334022 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0333929 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0333058 |
| ARRDC3 | arrestin domain containing 3 | 0.0332421 |
| PGK1 | phosphoglycerate kinase 1 | 0.0328961 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0328111 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0327977 |
| FMNL2 | formin-like 2 | 0.0326621 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0325205 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0325126 |
| FAT1 | FAT atypical cadherin 1 | 0.0320842 |
| RBM39 | RNA binding motif protein 39 | 0.0318901 |
| VCAN | versican | 0.0317815 |
| PLK2 | polo-like kinase 2 | 0.0314901 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0313741 |
| PTK2 | protein tyrosine kinase 2 | 0.0313504 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0313319 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0312347 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0306905 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0306052 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.030559 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0303269 |
| ANXA2 | annexin A2 | 0.0300321 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0295275 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0294233 |
| PARD3 | par-3 family cell polarity regulator | 0.0293245 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0293006 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0290026 |
| CLDN1 | claudin 1 | 0.0287379 |
| XPOT | exportin, tRNA | 0.028238 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0281987 |
| RPL12 | ribosomal protein L12 | 0.0281535 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0279566 |
| CCDC47 | coiled-coil domain containing 47 | 0.0278844 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.263175 |
| VIM | vimentin | -0.177831 |
| AREG | amphiregulin | -0.0944979 |
| ACTG1 | actin gamma 1 | -0.0702342 |
| RPS2 | ribosomal protein S2 | -0.0648935 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.063569 |
| PCDH7 | protocadherin 7 | -0.0547832 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0514697 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0456928 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0425284 |
| CCN2 | cellular communication network factor 2 | -0.0416889 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0414374 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0394572 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0380726 |
| FTL | ferritin, light polypeptide | -0.0377099 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0372489 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0369711 |
| EGR1 | early growth response 1 | -0.0368134 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0367244 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0363191 |
| TUBA1B | tubulin, alpha 1b | -0.0360583 |
| ATP11A | ATPase, class VI, type 11A | -0.0357251 |
| EXOC6B | exocyst complex component 6B | -0.0346245 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0342459 |
| EDN1 | endothelin 1 | -0.0334305 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0331501 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0329488 |
| CCND1 | cyclin D1 | -0.0328723 |
| CCDC88A | coiled-coil domain containing 88A | -0.032833 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0320101 |
| HMGA2 | high mobility group AT-hook 2 | -0.0300491 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0300367 |
| BPTF | bromodomain PHD finger transcription factor | -0.0300247 |
| ZNF804A | zinc finger protein 804A | -0.0296427 |
| PFN1 | profilin 1 | -0.0291937 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0291485 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0283226 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0278799 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0275184 |
| POTEF | POTE ankyrin domain family, member F | -0.027127 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0269872 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0267688 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0264671 |
| EHBP1 | EH domain binding protein 1 | -0.026393 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0250058 |
| GOLGB1 | golgin B1 | -0.0248026 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0246321 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0238225 |
| DUSP6 | dual specificity phosphatase 6 | -0.0233186 |
| MYADM | myeloid-associated differentiation marker | -0.0230676 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0229509 |
| UBXN4 | UBX domain protein 4 | -0.0228879 |
| ANKRD12 | ankyrin repeat domain 12 | -0.022625 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.022452 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0223614 |
| GNAS | GNAS complex locus | -0.0219969 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0219314 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.0218236 |
| ZNF638 | zinc finger protein 638 | -0.0217373 |
| YBX3 | Y box binding protein 3 | -0.0214327 |
| MYPN | myopalladin | -0.0213865 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0209653 |
| SMAD5 | SMAD family member 5 | -0.020919 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0205642 |
| RANBP17 | RAN binding protein 17 | -0.0202473 |
| GOLGA4 | golgin A4 | -0.020086 |
| BRD4 | bromodomain containing 4 | -0.0199803 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0199413 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.019555 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0194879 |
| ERBIN | erbb2 interacting protein | -0.0194518 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.019291 |
| NBEAL1 | neurobeachin-like 1 | -0.0192851 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0190264 |
| RTN3 | reticulon 3 | -0.0188755 |
| RPL28 | ribosomal protein L28 | -0.0187046 |
| MYO9A | myosin IXA | -0.0186677 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0186469 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0186093 |
| EFCAB14 | EF-hand calcium binding domain 14 | -0.0185742 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0183793 |
| S100A6 | S100 calcium binding protein A6 | -0.0181491 |
| RAB10 | RAB10, member RAS oncogene family | -0.0180906 |
| NABP1 | nucleic acid binding protein 1 | -0.0180579 |
| NCOA1 | nuclear receptor coactivator 1 | -0.0179379 |
| PPIP5K2 | diphosphoinositol pentakisphosphate kinase 2 | -0.0177247 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0176917 |
| NUP98 | nucleoporin 98kDa | -0.0173336 |
| SERTAD2 | SERTA domain containing 2 | -0.0172478 |
| RC3H1 | ring finger and CCCH-type domains 1 | -0.0167927 |
| KLF12 | Kruppel-like factor 12 | -0.0167173 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0166101 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0163338 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.0163113 |
| SSH2 | slingshot protein phosphatase 2 | -0.0162944 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0162822 |
| RPS21 | ribosomal protein S21 | -0.0159889 |
| ATXN2 | ataxin 2 | -0.0159401 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0158505 |
| NPHP3 | nephronophthisis 3 (adolescent) | -0.0158416 |
