| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ligustrazine perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ligustrazine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.226582 |
| HELZ | helicase with zinc finger | 0.105003 |
| FAM13A | family with sequence similarity 13, member A | 0.0920861 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0891851 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.065934 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0632379 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0610915 |
| MEF2A | myocyte enhancer factor 2A | 0.059679 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0553726 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0541586 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0538383 |
| LPIN1 | lipin 1 | 0.0530524 |
| SEPTIN9 | septin 9 | 0.0528972 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0524995 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0444517 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0425254 |
| NDRG1 | N-myc downstream regulated 1 | 0.0421667 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0415517 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0413299 |
| ZNF292 | zinc finger protein 292 | 0.0401673 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0397259 |
| NUP58 | nucleoporin 58 | 0.0376588 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0362792 |
| SMAD3 | SMAD family member 3 | 0.0355329 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0352858 |
| RNF145 | ring finger protein 145 | 0.0342284 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.033907 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0334837 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0334387 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.032453 |
| OGA | O-GlcNAcase | 0.0321214 |
| PCBP2 | poly(rC) binding protein 2 | 0.0317417 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.030734 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0306022 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.029908 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0296614 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0292497 |
| ASPH | aspartate beta-hydroxylase | 0.0291994 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0289522 |
| KIAA1217 | KIAA1217 | 0.0288584 |
| CASC3 | cancer susceptibility candidate 3 | 0.0285769 |
| SET | SET nuclear proto-oncogene | 0.027999 |
| MSI2 | musashi RNA-binding protein 2 | 0.0274749 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.027401 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0272141 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0271561 |
| XPO1 | exportin 1 | 0.0271179 |
| DTNA | dystrobrevin, alpha | 0.0269367 |
| NBAS | neuroblastoma amplified sequence | 0.0268477 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0266342 |
| ARRDC3 | arrestin domain containing 3 | 0.0264218 |
| APP | amyloid beta (A4) precursor protein | 0.026156 |
| PGK1 | phosphoglycerate kinase 1 | 0.0259668 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0259034 |
| TPR | translocated promoter region, nuclear basket protein | 0.0258693 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0257319 |
| FMNL2 | formin-like 2 | 0.0255478 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.025119 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0249433 |
| MED13L | mediator complex subunit 13-like | 0.0247305 |
| VEGFA | vascular endothelial growth factor A | 0.0246154 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0243265 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0242735 |
| CCNY | cyclin Y | 0.0241784 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0240687 |
| FAM168A | family with sequence similarity 168, member A | 0.0240498 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.023642 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0234205 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0233273 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0232914 |
| KCTD3 | potassium channel tetramerization domain containing 3 | 0.0230895 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0229999 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0229702 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0228704 |
| COG5 | component of oligomeric golgi complex 5 | 0.0227457 |
| ZNF148 | zinc finger protein 148 | 0.0224323 |
| DST | dystonin | 0.0222805 |
| COPA | coatomer protein complex, subunit alpha | 0.0222659 |
| PTK2 | protein tyrosine kinase 2 | 0.0221733 |
| INSIG2 | insulin induced gene 2 | 0.022151 |
| AFDN | afadin, adherens junction formation factor | 0.0218762 |
| RBM33 | RNA binding motif protein 33 | 0.0218356 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0217764 |
| MATR3 | matrin 3 | 0.0216366 |
| SLMAP | sarcolemma associated protein | 0.0214728 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0214006 |
| TOP1 | topoisomerase (DNA) I | 0.0209972 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0209924 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0207854 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0207755 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0207578 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0206817 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0206358 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 0.0206298 |
| USP3 | ubiquitin specific peptidase 3 | 0.0203468 |
| RANBP9 | RAN binding protein 9 | 0.0203071 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0201318 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0199106 |
| QKI | QKI, KH domain containing, RNA binding | 0.0198018 |
| RNF150 | ring finger protein 150 | 0.0197426 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.531077 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.223859 |
| SYT1 | synaptotagmin I | -0.135634 |
| VCL | vinculin | -0.0994517 |
| VIM | vimentin | -0.0843646 |
| ACTG1 | actin gamma 1 | -0.0818212 |
| PTMA | prothymosin, alpha | -0.0772591 |
| RPS6 | ribosomal protein S6 | -0.0726872 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0669082 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0590555 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0560084 |
| RPL19 | ribosomal protein L19 | -0.0535258 |
| FMN1 | formin 1 | -0.0523389 |
| RPL34 | ribosomal protein L34 | -0.0519793 |
| TMSB10 | thymosin beta 10 | -0.0518847 |
| TLE4 | transducin-like enhancer of split 4 | -0.051595 |
| RPLP1 | ribosomal protein, large, P1 | -0.0504363 |
| BPTF | bromodomain PHD finger transcription factor | -0.0469907 |
| RPL35A | ribosomal protein L35a | -0.046643 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0461992 |
| RPL23 | ribosomal protein L23 | -0.0460458 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0455832 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0445446 |
| RPS19 | ribosomal protein S19 | -0.044448 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | -0.0431189 |
| GPC5 | glypican 5 | -0.0429187 |
| ZNF804A | zinc finger protein 804A | -0.0424158 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0407839 |
| IER3 | immediate early response 3 | -0.0402511 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0397541 |
| GLCCI1 | glucocorticoid induced 1 | -0.0397434 |
| EGR1 | early growth response 1 | -0.0394348 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0390608 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0373983 |
| RPS24 | ribosomal protein S24 | -0.0367043 |
| COL1A1 | collagen, type I, alpha 1 | -0.0362075 |
| TPM1 | tropomyosin 1 (alpha) | -0.0357213 |
| FTL | ferritin, light polypeptide | -0.035214 |
| SIK2 | salt-inducible kinase 2 | -0.034006 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0337337 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0329456 |
| RPS3 | ribosomal protein S3 | -0.0326832 |
| RPL31 | ribosomal protein L31 | -0.0322034 |
| RPL38 | ribosomal protein L38 | -0.0319765 |
| RPL26 | ribosomal protein L26 | -0.0317262 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.031193 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0309112 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0308973 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0308821 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0305349 |
| RACK1 | receptor for activated C kinase 1 | -0.030172 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0301355 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0299112 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0299069 |
| PDZRN3 | PDZ domain containing ring finger 3 | -0.0297432 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0295967 |
| RPLP0 | ribosomal protein, large, P0 | -0.0295693 |
| RPS29 | ribosomal protein S29 | -0.0287845 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0287755 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0282871 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0281214 |
| GPATCH8 | G patch domain containing 8 | -0.0275123 |
| GNAS | GNAS complex locus | -0.0271926 |
| VMP1 | vacuole membrane protein 1 | -0.0261138 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0260281 |
| S100A6 | S100 calcium binding protein A6 | -0.0253789 |
| SP100 | SP100 nuclear antigen | -0.0253783 |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | -0.0250078 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.024982 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0248235 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0248132 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0246287 |
| RIGI | RNA sensor RIG-I | -0.0246205 |
| THBS1 | thrombospondin 1 | -0.0244755 |
| PLPP1 | phospholipid phosphatase 1 | -0.0243478 |
| RPL36 | ribosomal protein L36 | -0.0243371 |
| STK38L | serine/threonine kinase 38 like | -0.0242969 |
| FRMD4A | FERM domain containing 4A | -0.024239 |
| RPS14 | ribosomal protein S14 | -0.0241352 |
| RPL9 | ribosomal protein L9 | -0.0239688 |
| HAND2 | heart and neural crest derivatives expressed 2 | -0.0236534 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.023641 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0236013 |
| ATRNL1 | attractin-like 1 | -0.0231743 |
| RPS27 | ribosomal protein S27 | -0.0227417 |
| NCOA7 | nuclear receptor coactivator 7 | -0.022677 |
| GREM2 | gremlin 2, DAN family BMP antagonist | -0.0225208 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0223483 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0221849 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0220482 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | -0.022001 |
| RPS11 | ribosomal protein S11 | -0.021461 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0213944 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.0213724 |
| PLAT | plasminogen activator, tissue | -0.0212102 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0211347 |
| RPS8 | ribosomal protein S8 | -0.0211003 |
| RPL32 | ribosomal protein L32 | -0.020924 |
| RPS21 | ribosomal protein S21 | -0.0208693 |
| RPL7A | ribosomal protein L7a | -0.0207409 |
