Ligustrazine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ligustrazine perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ligustrazine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.111476
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0941831
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0882172
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0848911
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0753233
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0737682
BTBD9 BTB (POZ) domain containing 9 0.0712707
MSI2 musashi RNA-binding protein 2 0.0703836
TRIO trio Rho guanine nucleotide exchange factor 0.0696237
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0684844
RNF149 ring finger protein 149 0.066608
GMDS GDP-mannose 4,6-dehydratase 0.0651366
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0628163
CANX calnexin 0.0623183
PRKCA protein kinase C, alpha 0.0620376
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0579115
FAT1 FAT atypical cadherin 1 0.0577325
ERRFI1 ERBB receptor feedback inhibitor 1 0.0557945
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.055361
AHNAK AHNAK nucleoprotein 0.054884
KIF16B kinesin family member 16B 0.0544555
MYH9 myosin, heavy chain 9, non-muscle 0.0540585
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0516293
NPEPPS aminopeptidase puromycin sensitive 0.0508369
PRELID2 PRELI domain containing 2 0.0505702
ESYT2 extended synaptotagmin-like protein 2 0.0504757
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0502646
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0492275
MBNL2 muscleblind-like splicing regulator 2 0.0490957
ARRDC3 arrestin domain containing 3 0.0482578
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0476706
NDRG1 N-myc downstream regulated 1 0.0455126
ARHGAP26 Rho GTPase activating protein 26 0.0454122
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0452346
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0445098
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0437032
HELZ helicase with zinc finger 0.0434051
SMAD3 SMAD family member 3 0.0419725
IGF1R insulin-like growth factor 1 receptor 0.0412086
MCTP2 multiple C2 domains, transmembrane 2 0.0408496
MYO5B myosin VB 0.0404335
ZMYM2 zinc finger, MYM-type 2 0.039986
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0394602
SORBS1 sorbin and SH3 domain containing 1 0.0389906
BIRC6 baculoviral IAP repeat containing 6 0.0388602
APP amyloid beta (A4) precursor protein 0.038832
STS steroid sulfatase (microsomal), isozyme S 0.0381004
ARHGAP32 Rho GTPase activating protein 32 0.0379951
TRIM2 tripartite motif containing 2 0.0378402
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0376197
RAB6A RAB6A, member RAS oncogene family 0.037368
FNIP1 folliculin interacting protein 1 0.0370043
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0362025
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0358718
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0352082
CTNND1 catenin (cadherin-associated protein), delta 1 0.034805
ARHGAP5 Rho GTPase activating protein 5 0.0347102
PGK1 phosphoglycerate kinase 1 0.0346977
PTK2 protein tyrosine kinase 2 0.0340275
KDM3A lysine (K)-specific demethylase 3A 0.0339169
GRK3 G protein-coupled receptor kinase 3 0.0338832
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0337693
RREB1 ras responsive element binding protein 1 0.0335145
PADI1 peptidyl arginine deiminase, type I 0.0333825
TBC1D22A TBC1 domain family, member 22A 0.0333372
CMIP c-Maf inducing protein 0.0332935
TM9SF2 transmembrane 9 superfamily member 2 0.0332333
ERBIN erbb2 interacting protein 0.0330466
MXD1 MAX dimerization protein 1 0.0324957
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0320341
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0319968
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.031838
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0314223
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.031353
LPP LIM domain containing preferred translocation partner in lipoma 0.0310643
SAMD12 sterile alpha motif domain containing 12 0.0310382
RICTOR RPTOR independent companion of MTOR, complex 2 0.0304306
MED13L mediator complex subunit 13-like 0.0300979
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0300814
SBF2 SET binding factor 2 0.0299373
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0297932
FNDC3A fibronectin type III domain containing 3A 0.029786
LCORL ligand dependent nuclear receptor corepressor-like 0.0297276
COPA coatomer protein complex, subunit alpha 0.029444
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0294407
NPSR1 neuropeptide S receptor 1 0.0288292
KDM6A lysine (K)-specific demethylase 6A 0.0285143
ENO1 enolase 1, (alpha) 0.0285105
TJP2 tight junction protein 2 0.0284225
YEATS2 YEATS domain containing 2 0.0282286
SETD5 SET domain containing 5 0.0281609
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0278344
DENND1A DENN/MADD domain containing 1A 0.0274941
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0274748
HDLBP high density lipoprotein binding protein 0.0272867
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.02724
SEC24D SEC24 family member D 0.0272316
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0271343
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0270583
FRK fyn-related Src family tyrosine kinase 0.0270333

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.164241
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.120375
EGR1 early growth response 1 -0.103583
LMO7 LIM domain 7 -0.0835703
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0802139
PERP PERP, TP53 apoptosis effector -0.0725349
PTMA prothymosin, alpha -0.0718076
TMC5 transmembrane channel-like 5 -0.0696532
LCN2 lipocalin 2 -0.0688412
HLA-B major histocompatibility complex, class I, B -0.0648682
RPS6 ribosomal protein S6 -0.0643236
NCKAP5 NCK-associated protein 5 -0.0639153
IRF1 interferon regulatory factor 1 -0.0603117
RAB7A RAB7A, member RAS oncogene family -0.060224
MYO1E myosin IE -0.0586559
IFI6 interferon, alpha-inducible protein 6 -0.0575854
C6ORF132 chromosome 6 open reading frame 132 -0.0570912
LOC102724023 ES1 protein homolog, mitochondrial -0.0535793
SQSTM1 sequestosome 1 -0.052213
FTL ferritin, light polypeptide -0.0521386
IFI27 interferon, alpha-inducible protein 27 -0.0515427
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0507876
PLSCR1 phospholipid scramblase 1 -0.0483242
IRS2 insulin receptor substrate 2 -0.0481003
EZR ezrin -0.0451512
DSTN destrin (actin depolymerizing factor) -0.0448134
BLZF1 basic leucine zipper nuclear factor 1 -0.0447679
RPL35A ribosomal protein L35a -0.043561
MX2 MX dynamin-like GTPase 2 -0.0428673
IL20RA interleukin 20 receptor, alpha -0.0416409
GOLGB1 golgin B1 -0.041419
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0408196
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0404714
GCLC glutamate-cysteine ligase, catalytic subunit -0.0399739
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0399535
PTBP3 polypyrimidine tract binding protein 3 -0.0394584
RBM25 RNA binding motif protein 25 -0.0393612
HM13 histocompatibility (minor) 13 -0.0393599
EIF1 eukaryotic translation initiation factor 1 -0.0388707
EFNB2 ephrin-B2 -0.0381519
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0380449
GCC2 GRIP and coiled-coil domain containing 2 -0.0375431
RRBP1 ribosome binding protein 1 -0.0371079
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.036376
MX1 MX dynamin-like GTPase 1 -0.0361363
UBC ubiquitin C -0.035501
MEIS2 Meis homeobox 2 -0.0353613
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0350346
EPCAM epithelial cell adhesion molecule -0.0346908
MPHOSPH8 M-phase phosphoprotein 8 -0.0345038
LOC112694756 uncharaterized LOC112694756 -0.0344569
ZSWIM6 zinc finger, SWIM-type containing 6 -0.03443
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0340804
DSCAM Down syndrome cell adhesion molecule -0.0340097
EPHB2 EPH receptor B2 -0.0339726
SRRM2 serine/arginine repetitive matrix 2 -0.0338388
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0332549
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0331444
FOXP1 forkhead box P1 -0.033029
ITPKC inositol-trisphosphate 3-kinase C -0.032487
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0322285
TMSB10 thymosin beta 10 -0.0316365
VMP1 vacuole membrane protein 1 -0.0315687
SLC38A1 solute carrier family 38, member 1 -0.0311525
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0300727
PKM pyruvate kinase, muscle -0.0300385
RBM39 RNA binding motif protein 39 -0.029996
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0299948
MT2A metallothionein 2A -0.0298988
RPL9 ribosomal protein L9 -0.0298105
ACTG1 actin gamma 1 -0.0295933
NUCB2 nucleobindin 2 -0.0295253
BPTF bromodomain PHD finger transcription factor -0.0287298
RPLP1 ribosomal protein, large, P1 -0.0286399
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0286327
PHACTR4 phosphatase and actin regulator 4 -0.0285649
RPS19 ribosomal protein S19 -0.0285034
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0284816
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -0.0284109
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0284028
AREG amphiregulin -0.0281854
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0278731
S100A10 S100 calcium binding protein A10 -0.0276009
PMP22 peripheral myelin protein 22 -0.0274265
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0273783
SMC4 structural maintenance of chromosomes 4 -0.0270785
RPL37 ribosomal protein L37 -0.0270319
RPL30 ribosomal protein L30 -0.0268031
ADNP activity-dependent neuroprotector homeobox -0.0267748
EPSTI1 epithelial stromal interaction 1 (breast) -0.0263896
S100A9 S100 calcium binding protein A9 -0.0261029
TJP1 tight junction protein 1 -0.026014
RPL12 ribosomal protein L12 -0.0255853
TRERF1 transcriptional regulating factor 1 -0.0254689
PRRC2C proline-rich coiled-coil 2C -0.0245012
GOLM2 golgi membrane protein 2 -0.0244588
MT1X metallothionein 1X -0.0244223
BTG1 B-cell translocation gene 1, anti-proliferative -0.0244069
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.0244067
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0243627