| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ligustrazine perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ligustrazine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.166741 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0958101 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0935035 |
| FN1 | fibronectin 1 | 0.0874572 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0838197 |
| CD44 | CD44 molecule (Indian blood group) | 0.0832699 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0773898 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0772445 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0736648 |
| PRELID2 | PRELI domain containing 2 | 0.0696327 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0681981 |
| ENO1 | enolase 1, (alpha) | 0.0666587 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0651051 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0593653 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0570112 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0564468 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0554151 |
| AHNAK | AHNAK nucleoprotein | 0.0551299 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0529976 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0501785 |
| CANX | calnexin | 0.0500913 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0495529 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0490191 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0488961 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0472414 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0455014 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0449736 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0439981 |
| ADM | adrenomedullin | 0.0438051 |
| GOLGB1 | golgin B1 | 0.043683 |
| DST | dystonin | 0.0403234 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0400657 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0377382 |
| ATXN1 | ataxin 1 | 0.0371052 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0368731 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.035957 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0344149 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0334611 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0321632 |
| BBX | bobby sox homolog (Drosophila) | 0.0317313 |
| VCL | vinculin | 0.0316104 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0306703 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0304009 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0296182 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0294792 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.029334 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0291873 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0286232 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0285535 |
| SMAD3 | SMAD family member 3 | 0.0284929 |
| ASPH | aspartate beta-hydroxylase | 0.0283639 |
| INHBA | inhibin, beta A | 0.0282405 |
| CADM1 | cell adhesion molecule 1 | 0.0280477 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0280282 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0274614 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0272604 |
| EGFR | epidermal growth factor receptor | 0.0268431 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0266859 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0264721 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0260448 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0260183 |
| NAV2 | neuron navigator 2 | 0.0259623 |
| ARRDC3 | arrestin domain containing 3 | 0.0259518 |
| SMYD3 | SET and MYND domain containing 3 | 0.025542 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0249141 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0248197 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0248034 |
| DSPP | dentin sialophosphoprotein | 0.024774 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0245692 |
| SQSTM1 | sequestosome 1 | 0.0239084 |
| MAP1B | microtubule-associated protein 1B | 0.0235845 |
| YEATS2 | YEATS domain containing 2 | 0.0235655 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0234502 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0230199 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0229258 |
| GANAB | glucosidase, alpha; neutral AB | 0.0228445 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.022029 |
| FBXO32 | F-box protein 32 | 0.0219403 |
| MKI67 | marker of proliferation Ki-67 | 0.0218693 |
| VCAN | versican | 0.0218508 |
| ANXA1 | annexin A1 | 0.0217943 |
| PDE10A | phosphodiesterase 10A | 0.0217461 |
| IL6ST | interleukin 6 signal transducer | 0.0217024 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0216541 |
| HDAC9 | histone deacetylase 9 | 0.0216407 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0215861 |
| CALR | calreticulin | 0.0215748 |
| SEPTIN9 | septin 9 | 0.0214247 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0212554 |
| MTSS1 | metastasis suppressor 1 | 0.0211377 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0211197 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0209304 |
| CDH13 | cadherin 13 | 0.0208011 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0204286 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0202605 |
| MYO1E | myosin IE | 0.0200521 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0198439 |
| ANO6 | anoctamin 6 | 0.0196041 |
| FNIP1 | folliculin interacting protein 1 | 0.0195682 |
| HYOU1 | hypoxia up-regulated 1 | 0.019478 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.285117 |
| COL1A1 | collagen, type I, alpha 1 | -0.260363 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.221591 |
| VIM | vimentin | -0.197087 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.175231 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.154585 |
| TMSB10 | thymosin beta 10 | -0.0929855 |
| MT1X | metallothionein 1X | -0.0912488 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0665327 |
| ACTG1 | actin gamma 1 | -0.0611779 |
| FTL | ferritin, light polypeptide | -0.0582129 |
| COL1A2 | collagen, type I, alpha 2 | -0.0559574 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0546791 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0545213 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.053772 |
| RPL35A | ribosomal protein L35a | -0.0469076 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0467582 |
| RPL28 | ribosomal protein L28 | -0.0444485 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0437768 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0436983 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0432184 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0404764 |
| NDRG1 | N-myc downstream regulated 1 | -0.038654 |
| TMSB4X | thymosin beta 4, X-linked | -0.0379153 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0365837 |
| IER3 | immediate early response 3 | -0.0364751 |
| S100A6 | S100 calcium binding protein A6 | -0.0357856 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0356697 |
| RPL8 | ribosomal protein L8 | -0.0355419 |
| HLA-B | major histocompatibility complex, class I, B | -0.034607 |
| HMGA2 | high mobility group AT-hook 2 | -0.0341782 |
| S100A10 | S100 calcium binding protein A10 | -0.0340274 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.033015 |
| POTEF | POTE ankyrin domain family, member F | -0.03154 |
| USP3 | ubiquitin specific peptidase 3 | -0.0314806 |
| GNAS | GNAS complex locus | -0.0314284 |
| S100A9 | S100 calcium binding protein A9 | -0.0313783 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.030365 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0278048 |
| LOX | lysyl oxidase | -0.0277974 |
| CD99 | CD99 molecule | -0.0272285 |
| CLMP | CXADR-like membrane protein | -0.0266952 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | -0.0266154 |
| MT2A | metallothionein 2A | -0.0264019 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0262154 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0260044 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0256916 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0255299 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0245914 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0242944 |
| RPLP1 | ribosomal protein, large, P1 | -0.0241779 |
| BSG | basigin (Ok blood group) | -0.023905 |
| EHD2 | EH-domain containing 2 | -0.0238833 |
| PFN1 | profilin 1 | -0.0238427 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0237615 |
| TGFB1 | transforming growth factor, beta 1 | -0.0231293 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0229413 |
| RPL30 | ribosomal protein L30 | -0.0229044 |
| WASF2 | WAS protein family, member 2 | -0.0224421 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0223421 |
| RACK1 | receptor for activated C kinase 1 | -0.0222861 |
| PXDN | peroxidasin | -0.0221601 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0221473 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0219641 |
| HLA-A | major histocompatibility complex, class I, A | -0.0219058 |
| TAPBP | TAP binding protein (tapasin) | -0.021734 |
| PTMA | prothymosin, alpha | -0.021695 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0215481 |
| RHEB | Ras homolog enriched in brain | -0.0212264 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0211385 |
| RPS20 | ribosomal protein S20 | -0.0208405 |
| TPM1 | tropomyosin 1 (alpha) | -0.0208228 |
| RPLP0 | ribosomal protein, large, P0 | -0.0207413 |
| SRPK2 | SRSF protein kinase 2 | -0.0207384 |
| RPS6 | ribosomal protein S6 | -0.0206167 |
| PKM | pyruvate kinase, muscle | -0.0205933 |
| QKI | QKI, KH domain containing, RNA binding | -0.0204431 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0200389 |
| CST3 | cystatin C | -0.0198513 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0198399 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0197687 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0196406 |
| WDR45B | WD repeat domain 45B | -0.0193747 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0192812 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0191128 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0191021 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0189973 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0189616 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0188856 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0187975 |
| FAM162A | family with sequence similarity 162, member A | -0.0185687 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | -0.0182326 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0181363 |
| SMIM44 | small integral membrane protein 44 | -0.0181172 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0181118 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0180781 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0179627 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.017943 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0179007 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.017444 |
