Ligustrazine_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ligustrazine perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ligustrazine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.106106
FN1 fibronectin 1 0.0649422
LRMDA leucine rich melanocyte differentiation associated 0.0606992
SPTBN1 spectrin, beta, non-erythrocytic 1 0.059959
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0525692
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0520017
ELL2 elongation factor, RNA polymerase II, 2 0.0469022
ERRFI1 ERBB receptor feedback inhibitor 1 0.0437816
ENO1 enolase 1, (alpha) 0.0430993
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0400075
FMNL2 formin-like 2 0.0393599
MYH9 myosin, heavy chain 9, non-muscle 0.0391038
INSIG2 insulin induced gene 2 0.0358913
SOD2 superoxide dismutase 2, mitochondrial 0.0357506
MACF1 microtubule-actin crosslinking factor 1 0.034731
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0341997
MSI2 musashi RNA-binding protein 2 0.0329092
APOB apolipoprotein B 0.0316195
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0303317
AFDN afadin, adherens junction formation factor 0.0292235
ZNF292 zinc finger protein 292 0.0291906
MYO1B myosin IB 0.0288425
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0283524
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0283304
FAT1 FAT atypical cadherin 1 0.0282531
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0281893
DSPP dentin sialophosphoprotein 0.0278137
PDE8A phosphodiesterase 8A 0.0277738
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.026993
DST dystonin 0.0266162
PEG3 paternally expressed 3 0.0265759
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0264253
DDIT4 DNA-damage-inducible transcript 4 0.0256053
IGFBP1 insulin-like growth factor binding protein 1 0.0252233
KIF1B kinesin family member 1B 0.0244537
FBF1 Fas (TNFRSF6) binding factor 1 0.0244216
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0243372
BIRC3 baculoviral IAP repeat containing 3 0.02422
ASPH aspartate beta-hydroxylase 0.0239416
GRK3 G protein-coupled receptor kinase 3 0.0233092
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0230004
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0229713
GMDS GDP-mannose 4,6-dehydratase 0.022947
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0229318
EEF2 eukaryotic translation elongation factor 2 0.0226919
SOX5 SRY (sex determining region Y)-box 5 0.0224721
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0221294
EIF4B eukaryotic translation initiation factor 4B 0.0216254
PTK2 protein tyrosine kinase 2 0.0215708
BHLHE40 basic helix-loop-helix family, member e40 0.021543
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0209508
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0208926
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0207682
TF transferrin 0.0204305
ARHGAP12 Rho GTPase activating protein 12 0.0200869
KIAA1217 KIAA1217 0.0198383
WAC WW domain containing adaptor with coiled-coil 0.019606
DTNA dystrobrevin, alpha 0.0195951
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0195189
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0194674
KRT18 keratin 18, type I 0.0194064
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0191429
NBAS neuroblastoma amplified sequence 0.0188496
KDM6A lysine (K)-specific demethylase 6A 0.0188276
LRRC1 leucine rich repeat containing 1 0.0185193
TNS1 tensin 1 0.018286
ANXA5 annexin A5 0.0181989
DENND1A DENN/MADD domain containing 1A 0.0180969
CORO1C coronin, actin binding protein, 1C 0.0179408
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0176384
IQSEC1 IQ motif and Sec7 domain 1 0.0172819
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0170442
TNIP1 TNFAIP3 interacting protein 1 0.016962
A2M alpha-2-macroglobulin 0.016945
KDM7A lysine (K)-specific demethylase 7A 0.0169342
FNIP1 folliculin interacting protein 1 0.0168366
AKAP13 A kinase (PRKA) anchor protein 13 0.01673
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0165868
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0165241
SAMD4A sterile alpha motif domain containing 4A 0.016357
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0157438
SLMAP sarcolemma associated protein 0.0156425
USP6NL USP6 N-terminal like 0.0153586
MAP2K1 mitogen-activated protein kinase kinase 1 0.0152998
HOOK2 hook microtubule-tethering protein 2 0.015297
DSCAM Down syndrome cell adhesion molecule 0.0152831
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0150515
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0149736
PRELID2 PRELI domain containing 2 0.0149314
XPO1 exportin 1 0.014822
PDZD8 PDZ domain containing 8 0.0147807
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0146699
PTPRM protein tyrosine phosphatase, receptor type, M 0.0146381
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0145957
LPIN2 lipin 2 0.0145935
ZFAND3 zinc finger, AN1-type domain 3 0.0144252
HELZ helicase with zinc finger 0.0143986
RAB6A RAB6A, member RAS oncogene family 0.0142042
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0141556
CANX calnexin 0.0140679

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.658381
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.114991
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0902839
MT2A metallothionein 2A -0.0810444
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0778724
C3 complement component 3 -0.0715297
RPS6 ribosomal protein S6 -0.0647757
RPS12 ribosomal protein S12 -0.0553988
TPT1 tumor protein, translationally-controlled 1 -0.05367
RPL37A ribosomal protein L37a -0.050736
APOA2 apolipoprotein A-II -0.0481622
RPS8 ribosomal protein S8 -0.0466994
RPS3 ribosomal protein S3 -0.0420892
RPS19 ribosomal protein S19 -0.0410511
RPL11 ribosomal protein L11 -0.0402963
RPLP1 ribosomal protein, large, P1 -0.0400219
FTL ferritin, light polypeptide -0.0397898
RPS24 ribosomal protein S24 -0.0397488
RPL26 ribosomal protein L26 -0.0358615
RPLP2 ribosomal protein, large, P2 -0.0349536
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0343019
TRIM26 tripartite motif containing 26 -0.0342685
TIMP1 TIMP metallopeptidase inhibitor 1 -0.033949
NKD1 naked cuticle homolog 1 (Drosophila) -0.0338581
RPL35A ribosomal protein L35a -0.0330582
RPS29 ribosomal protein S29 -0.0328942
RPS27A ribosomal protein S27a -0.0318509
RPL9 ribosomal protein L9 -0.0309824
TMSB10 thymosin beta 10 -0.0300372
RACK1 receptor for activated C kinase 1 -0.029318
GNAS GNAS complex locus -0.0287631
EGR1 early growth response 1 -0.0283664
RPL5 ribosomal protein L5 -0.0280365
RBM39 RNA binding motif protein 39 -0.0275826
RPL31 ribosomal protein L31 -0.0272214
RPS16 ribosomal protein S16 -0.0270941
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.026436
RPS14 ribosomal protein S14 -0.0263118
RPLP0 ribosomal protein, large, P0 -0.025779
RPL34 ribosomal protein L34 -0.0255739
RPL12 ribosomal protein L12 -0.0252799
EIF1 eukaryotic translation initiation factor 1 -0.0241764
SLC38A2 solute carrier family 38, member 2 -0.023762
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0237306
PDGFB platelet-derived growth factor beta polypeptide -0.0236362
RPL36 ribosomal protein L36 -0.0231879
LOC112694756 uncharaterized LOC112694756 -0.022583
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0225745
DLC1 DLC1 Rho GTPase activating protein -0.0219653
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0219145
PTCHD4 patched domain containing 4 -0.0218553
RBM25 RNA binding motif protein 25 -0.0216495
FOXP1 forkhead box P1 -0.0211726
ZMYND8 zinc finger, MYND-type containing 8 -0.0210829
RPL19 ribosomal protein L19 -0.0206501
AHSG alpha-2-HS-glycoprotein -0.0200121
B2M beta-2-microglobulin -0.0200019
RPS21 ribosomal protein S21 -0.0197972
RPS11 ribosomal protein S11 -0.0195362
RPL30 ribosomal protein L30 -0.0194806
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0189145
RPS5 ribosomal protein S5 -0.0188856
RPS10 ribosomal protein S10 -0.0187945
PERP PERP, TP53 apoptosis effector -0.0187359
BCL2L1 BCL2-like 1 -0.0187075
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0186773
RPS13 ribosomal protein S13 -0.018632
HMGA1 high mobility group AT-hook 1 -0.0185325
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0185269
RPL32 ribosomal protein L32 -0.0182583
FAM107B family with sequence similarity 107, member B -0.0180437
RPS25 ribosomal protein S25 -0.0178565
RAB7A RAB7A, member RAS oncogene family -0.0176416
ATF4 activating transcription factor 4 -0.0176321
S100A9 S100 calcium binding protein A9 -0.017617
KIF21A kinesin family member 21A -0.0175851
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.0175285
RPL38 ribosomal protein L38 -0.017343
RPS2 ribosomal protein S2 -0.0172855
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0172074
RPL7A ribosomal protein L7a -0.0171657
UGDH UDP-glucose 6-dehydrogenase -0.016924
RPL18 ribosomal protein L18 -0.0169224
RPS17 ribosomal protein S17 -0.0168959
RPS23 ribosomal protein S23 -0.0168263
RPL37 ribosomal protein L37 -0.0166647
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0165893
EHBP1 EH domain binding protein 1 -0.0164689
AMBP alpha-1-microglobulin/bikunin precursor -0.0164117
SOS1 son of sevenless homolog 1 (Drosophila) -0.0158926
RPL7 ribosomal protein L7 -0.0158343
IFI6 interferon, alpha-inducible protein 6 -0.0157067
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0156226
ACYP2 acylphosphatase 2, muscle type -0.0155654
RPL13A ribosomal protein L13a -0.0154481
RPL10A ribosomal protein L10a -0.0154103
SOX4 SRY (sex determining region Y)-box 4 -0.0153931
EIF5B eukaryotic translation initiation factor 5B -0.015393
VMP1 vacuole membrane protein 1 -0.0153618
RPL28 ribosomal protein L28 -0.0152871