Ligustrazine_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ligustrazine perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ligustrazine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.145309
RNF145 ring finger protein 145 0.0590507
GRB10 growth factor receptor-bound protein 10 0.0582604
KDM3A lysine (K)-specific demethylase 3A 0.0580181
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0554023
ANKRD11 ankyrin repeat domain 11 0.0535043
FAM13A family with sequence similarity 13, member A 0.0531273
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0514161
KDM6A lysine (K)-specific demethylase 6A 0.0501946
RAB1A RAB1A, member RAS oncogene family 0.0500019
WAC WW domain containing adaptor with coiled-coil 0.0489492
RBM39 RNA binding motif protein 39 0.0445344
EREG epiregulin 0.0445044
MED13L mediator complex subunit 13-like 0.0440261
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0418898
MYO5B myosin VB 0.0417706
FNDC3B fibronectin type III domain containing 3B 0.041363
GARS1 glycyl-tRNA synthetase 1 0.0411823
TFG TRK-fused gene 0.037434
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0370374
MARCHF6 membrane associated ring-CH-type finger 6 0.0365081
ZFAND3 zinc finger, AN1-type domain 3 0.0350482
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0330353
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0321895
RREB1 ras responsive element binding protein 1 0.0317163
NUP58 nucleoporin 58 0.0316086
CTBP2 C-terminal binding protein 2 0.031418
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0310356
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0308319
NCKAP1 NCK-associated protein 1 0.0302491
NAMPT nicotinamide phosphoribosyltransferase 0.0300398
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0293751
H2AC6 H2A clustered histone 6 0.029138
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0286213
PRRC1 proline-rich coiled-coil 1 0.0286157
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0282889
PUM2 pumilio RNA-binding family member 2 0.027929
TRA2A transformer 2 alpha homolog (Drosophila) 0.0272838
EWSR1 EWS RNA-binding protein 1 0.0272594
HELZ helicase with zinc finger 0.0272407
COPA coatomer protein complex, subunit alpha 0.0264766
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0254579
YME1L1 YME1-like 1 ATPase 0.0252846
PARD3 par-3 family cell polarity regulator 0.0252083
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0246807
LRRC1 leucine rich repeat containing 1 0.0245339
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0244061
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0242646
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0238605
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0234824
FUBP1 far upstream element (FUSE) binding protein 1 0.0232592
EPS8 epidermal growth factor receptor pathway substrate 8 0.0230518
MXD1 MAX dimerization protein 1 0.0224723
ADAM17 ADAM metallopeptidase domain 17 0.0224718
NDRG1 N-myc downstream regulated 1 0.0224538
OXSR1 oxidative stress responsive 1 0.0217726
SND1 staphylococcal nuclease and tudor domain containing 1 0.021685
FXR1 fragile X mental retardation, autosomal homolog 1 0.0215551
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0213422
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0212388
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0212386
YAP1 Yes-associated protein 1 0.0210837
YTHDC1 YTH domain containing 1 0.0208897
ARHGAP26 Rho GTPase activating protein 26 0.0208228
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 0.0207332
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0206843
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0206198
IARS1 isoleucyl-tRNA synthetase 1 0.0204195
PUM1 pumilio RNA-binding family member 1 0.0203832
EIF4B eukaryotic translation initiation factor 4B 0.0202047
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0201816
MBNL2 muscleblind-like splicing regulator 2 0.0201273
ARID4B AT rich interactive domain 4B (RBP1-like) 0.019948
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0198263
MPRIP myosin phosphatase Rho interacting protein 0.0198138
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0197072
SPAG9 sperm associated antigen 9 0.0196796
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.019661
VEGFA vascular endothelial growth factor A 0.0196388
TES testin LIM domain protein 0.0195447
CANX calnexin 0.019538
CCNY cyclin Y 0.019443
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0194168
APP amyloid beta (A4) precursor protein 0.0193591
RLF rearranged L-myc fusion 0.0192386
FNDC3A fibronectin type III domain containing 3A 0.0191668
NEK7 NIMA-related kinase 7 0.0189703
TMSB4X thymosin beta 4, X-linked 0.0189343
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0188465
ESRP1 epithelial splicing regulatory protein 1 0.0187901
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0187501
PDIA6 protein disulfide isomerase family A, member 6 0.0187218
CDC73 cell division cycle 73 0.0185943
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0185086
WDR43 WD repeat domain 43 0.0179577
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0178159
HDLBP high density lipoprotein binding protein 0.0176242
RAD23B RAD23 homolog B (S. cerevisiae) 0.0176172
HSPA8 heat shock 70kDa protein 8 0.0173575
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0173163

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.326875
PTMA prothymosin, alpha -0.192518
TMSB10 thymosin beta 10 -0.118544
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.117422
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.10677
MUC6 mucin 6, oligomeric mucus/gel-forming -0.087863
RPS6 ribosomal protein S6 -0.0834137
TNS4 tensin 4 -0.0652773
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0630653
RPS27A ribosomal protein S27a -0.0619168
CEMIP cell migration inducing protein, hyaluronan binding -0.0615474
RPLP1 ribosomal protein, large, P1 -0.0603775
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0576681
FTL ferritin, light polypeptide -0.0548697
RPS8 ribosomal protein S8 -0.0535703
S100A6 S100 calcium binding protein A6 -0.0486057
PKM pyruvate kinase, muscle -0.0448237
LOC112694756 uncharaterized LOC112694756 -0.0437071
ACTG1 actin gamma 1 -0.0431697
PERP PERP, TP53 apoptosis effector -0.0426335
RPL9 ribosomal protein L9 -0.0408853
RPS19 ribosomal protein S19 -0.0403453
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0401935
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0395869
LDHA lactate dehydrogenase A -0.0394458
LOC102724023 ES1 protein homolog, mitochondrial -0.0391582
CADPS Ca++-dependent secretion activator -0.0387102
PTEN phosphatase and tensin homolog -0.0386653
RPL35A ribosomal protein L35a -0.0376938
RNF43 ring finger protein 43 -0.0369844
RPS3 ribosomal protein S3 -0.0365034
TXNIP thioredoxin interacting protein -0.0349829
SOX9 SRY (sex determining region Y)-box 9 -0.0348332
MYO1E myosin IE -0.0348029
RPL8 ribosomal protein L8 -0.0347982
RPL7A ribosomal protein L7a -0.034711
RPLP2 ribosomal protein, large, P2 -0.0339708
ZBTB20 zinc finger and BTB domain containing 20 -0.033809
S100A9 S100 calcium binding protein A9 -0.0334392
RPL34 ribosomal protein L34 -0.032277
RPS13 ribosomal protein S13 -0.0322348
EZR ezrin -0.0321357
RPL5 ribosomal protein L5 -0.0318707
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.031848
POTEF POTE ankyrin domain family, member F -0.0317945
UBC ubiquitin C -0.0316419
PATJ PATJ crumbs cell polarity complex component -0.0316041
RPL37A ribosomal protein L37a -0.0311375
MT1X metallothionein 1X -0.0309559
SMYD3 SET and MYND domain containing 3 -0.0308899
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0308036
RPL23 ribosomal protein L23 -0.0305657
RPLP0 ribosomal protein, large, P0 -0.0304735
FTH1 ferritin, heavy polypeptide 1 -0.0304009
BPTF bromodomain PHD finger transcription factor -0.0294037
AGR2 anterior gradient 2 -0.0293081
ANTXR2 anthrax toxin receptor 2 -0.0291952
RPL26 ribosomal protein L26 -0.0289001
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0288886
NALF1 NALCN channel auxiliary factor 1 -0.0288197
PRSS3 protease, serine, 3 -0.0287936
AREG amphiregulin -0.0283683
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0278907
MUC13 mucin 13, cell surface associated -0.0276055
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.027347
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0263956
EPCAM epithelial cell adhesion molecule -0.0262184
RPL27A ribosomal protein L27a -0.0257684
GCC2 GRIP and coiled-coil domain containing 2 -0.025653
RPL31 ribosomal protein L31 -0.0256453
CCNI cyclin I -0.025615
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0255818
TRIM2 tripartite motif containing 2 -0.0250522
RPL36 ribosomal protein L36 -0.0247809
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0247223
RPL18 ribosomal protein L18 -0.0244662
CD44 CD44 molecule (Indian blood group) -0.0244506
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.024284
TBC1D5 TBC1 domain family, member 5 -0.0242194
S100A10 S100 calcium binding protein A10 -0.0240539
TSC22D1 TSC22 domain family, member 1 -0.0239926
MT2A metallothionein 2A -0.0238459
ITGB4 integrin, beta 4 -0.0238268
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0237639
RPS23 ribosomal protein S23 -0.023648
RPL28 ribosomal protein L28 -0.0236441
LIMA1 LIM domain and actin binding 1 -0.0234998
LMNA lamin A/C -0.023464
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0233812
ATXN1 ataxin 1 -0.0232135
RPS12 ribosomal protein S12 -0.0230987
FHL2 four and a half LIM domains 2 -0.022888
RPL11 ribosomal protein L11 -0.0228421
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0227165
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0227087
FOXP1 forkhead box P1 -0.0226941
PFN1 profilin 1 -0.0226266
MBD5 methyl-CpG binding domain protein 5 -0.0223628
RPS25 ribosomal protein S25 -0.0222861
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0221157