| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ligustrazine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ligustrazine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DST | dystonin | 0.0925669 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0902681 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0835155 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0812981 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0758688 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0637851 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0625393 |
| AHNAK | AHNAK nucleoprotein | 0.0590544 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0569128 |
| CANX | calnexin | 0.0561728 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0548863 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0433055 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0428807 |
| RAI1 | retinoic acid induced 1 | 0.0427708 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0411935 |
| ANXA1 | annexin A1 | 0.0364099 |
| TXNRD1 | thioredoxin reductase 1 | 0.0333424 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.032422 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0321431 |
| SET | SET nuclear proto-oncogene | 0.0315862 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0315551 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0313931 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0310536 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.031025 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0308728 |
| ENO1 | enolase 1, (alpha) | 0.0307646 |
| DOCK11 | dedicator of cytokinesis 11 | 0.0306019 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0304919 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0285467 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0285148 |
| RPS8 | ribosomal protein S8 | 0.0260457 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0255353 |
| CAPRIN2 | caprin family member 2 | 0.0252572 |
| LOXL2 | lysyl oxidase-like 2 | 0.0250853 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0250707 |
| YEATS2 | YEATS domain containing 2 | 0.0244128 |
| PHF3 | PHD finger protein 3 | 0.0240906 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0237353 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0236518 |
| HDLBP | high density lipoprotein binding protein | 0.0235513 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0235044 |
| EREG | epiregulin | 0.0234282 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.023221 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0229706 |
| OGA | O-GlcNAcase | 0.0228123 |
| SLK | STE20-like kinase | 0.0221936 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0221493 |
| EFNA5 | ephrin-A5 | 0.0221402 |
| RPL23 | ribosomal protein L23 | 0.0217871 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0217806 |
| PGK1 | phosphoglycerate kinase 1 | 0.0217559 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0215969 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0215966 |
| CCDC47 | coiled-coil domain containing 47 | 0.0213006 |
| PRELID2 | PRELI domain containing 2 | 0.0209236 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0203495 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.020131 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0200045 |
| GOLGB1 | golgin B1 | 0.0199643 |
| SERINC1 | serine incorporator 1 | 0.019813 |
| RPL37A | ribosomal protein L37a | 0.0197076 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0196728 |
| EXOC4 | exocyst complex component 4 | 0.0195483 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0193844 |
| DENND1A | DENN/MADD domain containing 1A | 0.0193298 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0193284 |
| MYOF | myoferlin | 0.0193204 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0192044 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0191384 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0190143 |
| RPL12 | ribosomal protein L12 | 0.0190056 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0189716 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0188158 |
| FMNL2 | formin-like 2 | 0.0187848 |
| NGLY1 | N-glycanase 1 | 0.0187225 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0186269 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0186201 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0184697 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0184107 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.018271 |
| PYGL | phosphorylase, glycogen, liver | 0.0180676 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0174502 |
| SQSTM1 | sequestosome 1 | 0.0173204 |
| RPS3 | ribosomal protein S3 | 0.0172567 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0171109 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0171048 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0169992 |
| ZNF217 | zinc finger protein 217 | 0.0168818 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0167651 |
| UPP1 | uridine phosphorylase 1 | 0.0166249 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0164993 |
| EMP1 | epithelial membrane protein 1 | 0.0163621 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0162346 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0161654 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | 0.01613 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0160045 |
| NAV2 | neuron navigator 2 | 0.0159983 |
| ARRDC3 | arrestin domain containing 3 | 0.0159073 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0158573 |
| SSR1 | signal sequence receptor, alpha | 0.0158166 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.252664 |
| POTEF | POTE ankyrin domain family, member F | -0.129609 |
| TP63 | tumor protein p63 | -0.0810747 |
| TMSB4X | thymosin beta 4, X-linked | -0.0729435 |
| HLA-B | major histocompatibility complex, class I, B | -0.072521 |
| MT1X | metallothionein 1X | -0.0666964 |
| EGR1 | early growth response 1 | -0.0526874 |
| TMSB10 | thymosin beta 10 | -0.0493547 |
| FTL | ferritin, light polypeptide | -0.0489156 |
| VIM | vimentin | -0.0475295 |
| ACTG1 | actin gamma 1 | -0.0472125 |
| HMGA1 | high mobility group AT-hook 1 | -0.0420783 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0412123 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0407102 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0389157 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0371047 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0366597 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0356637 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0355951 |
| SP100 | SP100 nuclear antigen | -0.0352544 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0344855 |
| MT2A | metallothionein 2A | -0.0343467 |
| RIGI | RNA sensor RIG-I | -0.0331098 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0315216 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0293603 |
| HLA-A | major histocompatibility complex, class I, A | -0.0288294 |
| CD44 | CD44 molecule (Indian blood group) | -0.0284805 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0272136 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0269833 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.026279 |
| PMP22 | peripheral myelin protein 22 | -0.0256132 |
| PFN1 | profilin 1 | -0.0251039 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0249648 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0245151 |
| MT1E | metallothionein 1E | -0.0243257 |
| BSG | basigin (Ok blood group) | -0.0239457 |
| RPL35A | ribosomal protein L35a | -0.0234821 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0231682 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0231353 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0226077 |
| TAPBP | TAP binding protein (tapasin) | -0.0224439 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0223536 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0223086 |
| RPL28 | ribosomal protein L28 | -0.0222979 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0220489 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0220372 |
| B2M | beta-2-microglobulin | -0.0218806 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0217747 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.020967 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0207826 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0203093 |
| GNAS | GNAS complex locus | -0.0200725 |
| PLSCR1 | phospholipid scramblase 1 | -0.018862 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0184536 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.018251 |
| SRPK2 | SRSF protein kinase 2 | -0.0181899 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0181739 |
| WASF2 | WAS protein family, member 2 | -0.0177519 |
| PARD3 | par-3 family cell polarity regulator | -0.0175817 |
| DEK | DEK proto-oncogene | -0.0174124 |
| MYADM | myeloid-associated differentiation marker | -0.0173477 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0171798 |
| S100A9 | S100 calcium binding protein A9 | -0.0170473 |
| H1-0 | H1.0 linker histone | -0.0169704 |
| RNF213 | ring finger protein 213 | -0.0167268 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0167212 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0166147 |
| RPS24 | ribosomal protein S24 | -0.0165332 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.016523 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0164187 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.016284 |
| CCNL1 | cyclin L1 | -0.0161589 |
| SMIM44 | small integral membrane protein 44 | -0.0161521 |
| FOSL1 | FOS-like antigen 1 | -0.0158862 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0153594 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0153043 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0152624 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0151712 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0150583 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0148885 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0147556 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0147545 |
| ATN1 | atrophin 1 | -0.0147245 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0147046 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0146398 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.014594 |
| SAMHD1 | SAM domain and HD domain 1 | -0.0144495 |
| THOC2 | THO complex 2 | -0.0143848 |
| BRD2 | bromodomain containing 2 | -0.0143307 |
| TRIM56 | tripartite motif containing 56 | -0.0142161 |
| RBM25 | RNA binding motif protein 25 | -0.0141016 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0140833 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | -0.0140512 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0140013 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0139267 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0139251 |
| PHIP | pleckstrin homology domain interacting protein | -0.0138864 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0138544 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0137777 |
| ZNF207 | zinc finger protein 207 | -0.013694 |
