| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ligustrazine perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ligustrazine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.172337 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.11859 |
| ARRDC3 | arrestin domain containing 3 | 0.0880479 |
| CES1 | carboxylesterase 1 | 0.0814628 |
| TOP1 | topoisomerase (DNA) I | 0.0810828 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.079219 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0745191 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0741682 |
| FAM13A | family with sequence similarity 13, member A | 0.070294 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0701816 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0679659 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0664558 |
| HELZ | helicase with zinc finger | 0.0643442 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0594284 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.058563 |
| SMAD3 | SMAD family member 3 | 0.0522582 |
| RNF145 | ring finger protein 145 | 0.0512815 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0507052 |
| RUNX1 | runt-related transcription factor 1 | 0.0506073 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0499343 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0493067 |
| NUP58 | nucleoporin 58 | 0.0492543 |
| PGK1 | phosphoglycerate kinase 1 | 0.0489592 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0481059 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0477977 |
| HYOU1 | hypoxia up-regulated 1 | 0.0459354 |
| NCKAP1 | NCK-associated protein 1 | 0.0451296 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0446539 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0444283 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0438238 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.04292 |
| NPTN | neuroplastin | 0.041291 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0412725 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0410587 |
| ANXA5 | annexin A5 | 0.0408347 |
| PLEC | plectin | 0.0396996 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0393847 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0393424 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0392757 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0390684 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0389086 |
| TFG | TRK-fused gene | 0.0381155 |
| ARL8B | ADP-ribosylation factor-like 8B | 0.0379429 |
| SLTM | SAFB-like, transcription modulator | 0.0376016 |
| TMEM165 | transmembrane protein 165 | 0.0367524 |
| TPD52 | tumor protein D52 | 0.0360273 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0359354 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0342693 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0337805 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 0.0337401 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0331967 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0331067 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0326827 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.032578 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0306519 |
| ATP13A3 | ATPase type 13A3 | 0.0305085 |
| ANXA2 | annexin A2 | 0.0303272 |
| PCBP2 | poly(rC) binding protein 2 | 0.0296578 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0291007 |
| CCNY | cyclin Y | 0.0288519 |
| ZNF292 | zinc finger protein 292 | 0.0284251 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0283071 |
| SLMAP | sarcolemma associated protein | 0.028218 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0279837 |
| CD109 | CD109 molecule | 0.0276987 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0275693 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0274868 |
| MYO5B | myosin VB | 0.0269153 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0264988 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0262506 |
| USP3 | ubiquitin specific peptidase 3 | 0.0262103 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0260397 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0251384 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0247722 |
| WDR45B | WD repeat domain 45B | 0.0247675 |
| COLEC11 | collectin sub-family member 11 | 0.0245221 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0245147 |
| MYO1B | myosin IB | 0.0243431 |
| NBAS | neuroblastoma amplified sequence | 0.0241463 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0239029 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0236973 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0235242 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.023307 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0232562 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0232529 |
| ECT2 | epithelial cell transforming 2 | 0.0232231 |
| PDE8A | phosphodiesterase 8A | 0.0230842 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0229458 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0224337 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0223353 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.022319 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0222997 |
| CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like | 0.0221386 |
| ANO6 | anoctamin 6 | 0.0219784 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0219116 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0210489 |
| LAMB3 | laminin, beta 3 | 0.020925 |
| CCNL1 | cyclin L1 | 0.0209217 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | 0.0208774 |
| INSIG2 | insulin induced gene 2 | 0.0207802 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.432056 |
| MT2A | metallothionein 2A | -0.125052 |
| TMSB10 | thymosin beta 10 | -0.107925 |
| EGFR | epidermal growth factor receptor | -0.106109 |
| TXNRD1 | thioredoxin reductase 1 | -0.0969877 |
| UBC | ubiquitin C | -0.0774106 |
| PTMA | prothymosin, alpha | -0.0710611 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0710467 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0697184 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0662492 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0631328 |
| FTL | ferritin, light polypeptide | -0.0630889 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0609638 |
| ACTG1 | actin gamma 1 | -0.0602447 |
| RPLP1 | ribosomal protein, large, P1 | -0.0525346 |
| H1-0 | H1.0 linker histone | -0.0518173 |
| RPS27A | ribosomal protein S27a | -0.0500999 |
| MT1X | metallothionein 1X | -0.0488912 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0488567 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0472094 |
| S100A10 | S100 calcium binding protein A10 | -0.045173 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0412595 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0399893 |
| RPL35A | ribosomal protein L35a | -0.0398961 |
| EGR1 | early growth response 1 | -0.0396032 |
| RPS24 | ribosomal protein S24 | -0.0395854 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0389384 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0353476 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0350342 |
| CSTB | cystatin B (stefin B) | -0.0344983 |
| RPS8 | ribosomal protein S8 | -0.0337309 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0335808 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.032877 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0324045 |
| IER3 | immediate early response 3 | -0.0317652 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0306547 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0303198 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0302843 |
| STC1 | stanniocalcin 1 | -0.0300417 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0295637 |
| RPLP0 | ribosomal protein, large, P0 | -0.0294213 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0291439 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0289854 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0288223 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0287637 |
| MORF4L2 | mortality factor 4 like 2 | -0.0283572 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0278807 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0277872 |
| RPS12 | ribosomal protein S12 | -0.0272913 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0272042 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0270073 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.02664 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0262777 |
| RPS3 | ribosomal protein S3 | -0.0260082 |
| RPL34 | ribosomal protein L34 | -0.0258536 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.025803 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0257497 |
| GOLGB1 | golgin B1 | -0.0256122 |
| GNAS | GNAS complex locus | -0.0248431 |
| HLA-B | major histocompatibility complex, class I, B | -0.0247095 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0246427 |
| FBXO11 | F-box protein 11 | -0.0242862 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | -0.0241417 |
| RPS25 | ribosomal protein S25 | -0.0238227 |
| CCNI | cyclin I | -0.0237483 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0231719 |
| LDHA | lactate dehydrogenase A | -0.0228814 |
| NF1 | neurofibromin 1 | -0.0228697 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0228284 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0228246 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0226116 |
| MKI67 | marker of proliferation Ki-67 | -0.0225749 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0224571 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0221093 |
| AGR2 | anterior gradient 2 | -0.0220241 |
| RPS19 | ribosomal protein S19 | -0.0217833 |
| S100A11 | S100 calcium binding protein A11 | -0.0217698 |
| EMP1 | epithelial membrane protein 1 | -0.0216028 |
| NBEAL1 | neurobeachin-like 1 | -0.0215531 |
| RPL37A | ribosomal protein L37a | -0.0214819 |
| RPL5 | ribosomal protein L5 | -0.0213974 |
| CEP350 | centrosomal protein 350kDa | -0.0213143 |
| TUT4 | terminal uridylyl transferase 4 | -0.0210749 |
| RPL30 | ribosomal protein L30 | -0.021017 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0209518 |
| RPS21 | ribosomal protein S21 | -0.0204967 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0202799 |
| CST3 | cystatin C | -0.0202151 |
| RSF1 | remodeling and spacing factor 1 | -0.0201095 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0197508 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0196816 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0194761 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0194665 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0193912 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | -0.01936 |
| LAMA4 | laminin, alpha 4 | -0.019356 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0192525 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0192499 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0191454 |
| ECD | ecdysoneless homolog (Drosophila) | -0.0191385 |
