Ligustrazine_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ligustrazine perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ligustrazine_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.151136
SDK1 sidekick cell adhesion molecule 1 0.128506
NAMPT nicotinamide phosphoribosyltransferase 0.109493
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.107538
CXCL8 chemokine (C-X-C motif) ligand 8 0.0958479
CD44 CD44 molecule (Indian blood group) 0.0935699
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0889348
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0873855
SOD2 superoxide dismutase 2, mitochondrial 0.0855795
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0832507
RICTOR RPTOR independent companion of MTOR, complex 2 0.0756981
ELL2 elongation factor, RNA polymerase II, 2 0.0752658
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0744286
SMAD3 SMAD family member 3 0.0703104
AKAP12 A kinase (PRKA) anchor protein 12 0.066056
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0651522
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0624443
KDM3A lysine (K)-specific demethylase 3A 0.0606966
SIK3 SIK family kinase 3 0.0545674
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0533112
TFPI2 tissue factor pathway inhibitor 2 0.0524682
PARD3 par-3 family cell polarity regulator 0.0509626
ATP13A3 ATPase type 13A3 0.0506125
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0495981
WAC WW domain containing adaptor with coiled-coil 0.0488078
FAM13A family with sequence similarity 13, member A 0.0487377
ARHGAP5 Rho GTPase activating protein 5 0.0480434
RAB27B RAB27B, member RAS oncogene family 0.0443839
CDCP1 CUB domain containing protein 1 0.0436404
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0434806
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0430555
RUNX1 runt-related transcription factor 1 0.0416577
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0412825
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0412129
EFNA5 ephrin-A5 0.0401671
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.040007
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0398905
USP3 ubiquitin specific peptidase 3 0.0396236
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0385293
PTK2 protein tyrosine kinase 2 0.0384122
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0381694
ENO1 enolase 1, (alpha) 0.038071
STC1 stanniocalcin 1 0.0379693
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0376175
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0373662
BMAL2 basic helix-loop-helix ARNT like 2 0.0359735
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0358951
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0357503
MARCHF6 membrane associated ring-CH-type finger 6 0.0355652
NRP1 neuropilin 1 0.0355449
OGA O-GlcNAcase 0.0354916
MYO10 myosin X 0.0352207
MYH9 myosin, heavy chain 9, non-muscle 0.0352115
ZEB2 zinc finger E-box binding homeobox 2 0.0350449
FMNL2 formin-like 2 0.0350292
HELZ helicase with zinc finger 0.0348612
TGM2 transglutaminase 2 0.0344638
PELI1 pellino E3 ubiquitin protein ligase 1 0.0342597
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.033798
FAM20C family with sequence similarity 20, member C 0.0333167
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0330699
NRG1 neuregulin 1 0.0330062
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0329567
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0321984
TNIP1 TNFAIP3 interacting protein 1 0.0317195
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0315566
RAB8B RAB8B, member RAS oncogene family 0.0313905
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0313381
GLCCI1 glucocorticoid induced 1 0.0310311
FLNB filamin B, beta 0.0308892
MTSS1 metastasis suppressor 1 0.0307559
AHR aryl hydrocarbon receptor 0.0302975
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0302856
EPS8 epidermal growth factor receptor pathway substrate 8 0.0302196
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0301406
NAV2 neuron navigator 2 0.0301385
ZFAND3 zinc finger, AN1-type domain 3 0.0298042
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0295881
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0290984
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0290592
ZFAND6 zinc finger, AN1-type domain 6 0.0290392
GPAT3 glycerol-3-phosphate acyltransferase 3 0.028787
MSI2 musashi RNA-binding protein 2 0.0286037
MEF2A myocyte enhancer factor 2A 0.0286035
APP amyloid beta (A4) precursor protein 0.0285355
UGCG UDP-glucose ceramide glucosyltransferase 0.0284069
KYNU kynureninase 0.028361
AHNAK AHNAK nucleoprotein 0.0283085
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0282663
ANKRD11 ankyrin repeat domain 11 0.0281671
RNF145 ring finger protein 145 0.0276195
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0276065
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.027465
MAPK8 mitogen-activated protein kinase 8 0.0269719
WWTR1 WW domain containing transcription regulator 1 0.0269141
CDC73 cell division cycle 73 0.0268958
UBA6 ubiquitin-like modifier activating enzyme 6 0.0268845
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0267114
TOP2B topoisomerase (DNA) II beta 180kDa 0.0264164
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0264009

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0957823
VIM vimentin -0.0860091
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0641562
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0629392
IGFBP3 insulin-like growth factor binding protein 3 -0.0597211
EGR1 early growth response 1 -0.0551317
SYT1 synaptotagmin I -0.0518923
SEC31A SEC31 homolog A (S. cerevisiae) -0.0510891
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0503476
DPYD dihydropyrimidine dehydrogenase -0.044644
DDIT3 DNA-damage-inducible transcript 3 -0.0431919
FNIP1 folliculin interacting protein 1 -0.0425444
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0424685
FTL ferritin, light polypeptide -0.0423049
ARF4 ADP-ribosylation factor 4 -0.0421333
BLZF1 basic leucine zipper nuclear factor 1 -0.0410953
AKAP9 A kinase (PRKA) anchor protein 9 -0.0380612
MBD5 methyl-CpG binding domain protein 5 -0.0367812
SOS1 son of sevenless homolog 1 (Drosophila) -0.0365393
MRPS6 mitochondrial ribosomal protein S6 -0.0365073
TTC3 tetratricopeptide repeat domain 3 -0.035827
CALU calumenin -0.0349551
SEC24A SEC24 family member A -0.0345431
GOLGA4 golgin A4 -0.0337641
USP34 ubiquitin specific peptidase 34 -0.0330265
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0329461
HM13 histocompatibility (minor) 13 -0.03197
RPS19 ribosomal protein S19 -0.0287476
C6ORF62 chromosome 6 open reading frame 62 -0.0286878
IER3 immediate early response 3 -0.0279565
HDAC9 histone deacetylase 9 -0.0278107
RAB7A RAB7A, member RAS oncogene family -0.0276068
MORF4L2 mortality factor 4 like 2 -0.0269518
SRP54 signal recognition particle 54kDa -0.0267824
MYADM myeloid-associated differentiation marker -0.0267701
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0265552
BPTF bromodomain PHD finger transcription factor -0.0263772
ZMYND8 zinc finger, MYND-type containing 8 -0.0257981
PTMA prothymosin, alpha -0.0255549
RPS6 ribosomal protein S6 -0.0248101
MYO9A myosin IXA -0.0247184
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0245874
EHBP1 EH domain binding protein 1 -0.0243898
EXOC4 exocyst complex component 4 -0.0243115
MON2 MON2 homolog (S. cerevisiae) -0.0242141
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0238956
ARHGAP24 Rho GTPase activating protein 24 -0.0236868
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0230404
PFN1 profilin 1 -0.0230084
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.022775
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0225502
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0220977
RPL36 ribosomal protein L36 -0.0220021
GOLGA3 golgin A3 -0.0219359
RAB5A RAB5A, member RAS oncogene family -0.0214092
HDLBP high density lipoprotein binding protein -0.0213845
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0211732
RPL35A ribosomal protein L35a -0.021161
GPC6 glypican 6 -0.0209931
TMEM263 transmembrane protein 263 -0.0209057
DLG1 discs, large homolog 1 (Drosophila) -0.0208506
RPS29 ribosomal protein S29 -0.0208033
GOLGB1 golgin B1 -0.0207684
GREB1L growth regulation by estrogen in breast cancer-like -0.0205509
SCFD2 sec1 family domain containing 2 -0.0205005
TMEM165 transmembrane protein 165 -0.0204393
RPS3 ribosomal protein S3 -0.0204345
SCFD1 sec1 family domain containing 1 -0.0202942
WASF2 WAS protein family, member 2 -0.0196892
SEPTIN2 septin 2 -0.0196695
ZNF804A zinc finger protein 804A -0.0195802
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0194701
RAI14 retinoic acid induced 14 -0.019467
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0193751
SERF2 small EDRK-rich factor 2 -0.0193208
RPLP2 ribosomal protein, large, P2 -0.0190771
MT2A metallothionein 2A -0.0186577
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0186234
RPTOR regulatory associated protein of MTOR, complex 1 -0.0185197
IARS1 isoleucyl-tRNA synthetase 1 -0.0185137
ANKRD28 ankyrin repeat domain 28 -0.0183978
ATM ATM serine/threonine kinase -0.0182523
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0181615
LOX lysyl oxidase -0.0181121
MAML2 mastermind-like 2 (Drosophila) -0.0179441
CDK13 cyclin-dependent kinase 13 -0.0178412
RASAL2 RAS protein activator like 2 -0.0177737
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0177363
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0177222
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0176938
PTPRK protein tyrosine phosphatase, receptor type, K -0.0176468
EIF1 eukaryotic translation initiation factor 1 -0.0176246
RAD51B RAD51 paralog B -0.0175316
TAS2R14 taste receptor, type 2, member 14 -0.0174404
RPL32 ribosomal protein L32 -0.0168848
SYAP1 synapse associated protein 1 -0.0168157
TRIP11 thyroid hormone receptor interactor 11 -0.0167175
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0165604
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0164622
WNK1 WNK lysine deficient protein kinase 1 -0.0164032