| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ligustrazine perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ligustrazine_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.14743 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.113448 |
| PM20D1 | peptidase M20 domain containing 1 | 0.100535 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0872977 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0826683 |
| TPM3 | tropomyosin 3 | 0.0733619 |
| FGB | fibrinogen beta chain | 0.0590111 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0576059 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0474856 |
| PCBP2 | poly(rC) binding protein 2 | 0.0460635 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.044697 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0439224 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0426238 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0398949 |
| WDR43 | WD repeat domain 43 | 0.0398431 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0385025 |
| POTEF | POTE ankyrin domain family, member F | 0.0373163 |
| MCL1 | myeloid cell leukemia 1 | 0.0372105 |
| NUP58 | nucleoporin 58 | 0.0351929 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.034897 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0348063 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0341887 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0333873 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0332348 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0330239 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0329439 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0328068 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0327147 |
| CCNL1 | cyclin L1 | 0.0318553 |
| HDGF | hepatoma-derived growth factor | 0.031556 |
| MSN | moesin | 0.0313246 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0312178 |
| ECT2 | epithelial cell transforming 2 | 0.0293062 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0289527 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0285895 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.02855 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0280113 |
| TAGLN2 | transgelin 2 | 0.0276049 |
| RTN4 | reticulon 4 | 0.0271911 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0265819 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0260924 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0259289 |
| CALR | calreticulin | 0.0258152 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0253229 |
| PFN1 | profilin 1 | 0.0253006 |
| FAM168A | family with sequence similarity 168, member A | 0.024952 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0244013 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0242635 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0242016 |
| TFG | TRK-fused gene | 0.024138 |
| CBX5 | chromobox homolog 5 | 0.0238395 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0238289 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0236999 |
| USP3 | ubiquitin specific peptidase 3 | 0.0235402 |
| PLS3 | plastin 3 | 0.0234881 |
| HYOU1 | hypoxia up-regulated 1 | 0.0234772 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0234233 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0231803 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0231437 |
| PNN | pinin, desmosome associated protein | 0.0228068 |
| RRM2 | ribonucleotide reductase M2 | 0.0228042 |
| RPL3 | ribosomal protein L3 | 0.0223904 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0223896 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0222921 |
| FAT1 | FAT atypical cadherin 1 | 0.0221503 |
| YBX3 | Y box binding protein 3 | 0.0220754 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0219984 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0217962 |
| CENPF | centromere protein F, 350/400kDa | 0.0217293 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0216502 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0216144 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0215287 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.021443 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0213129 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0211519 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0211235 |
| YBX1 | Y box binding protein 1 | 0.0209482 |
| LDHB | lactate dehydrogenase B | 0.0208243 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0206503 |
| ANXA5 | annexin A5 | 0.0206301 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0203691 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0203073 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0202974 |
| CLU | clusterin | 0.0201955 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0200993 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.019992 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.019674 |
| AHR | aryl hydrocarbon receptor | 0.0196487 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.019532 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0194531 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0193183 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0193172 |
| CASC3 | cancer susceptibility candidate 3 | 0.0193024 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0192813 |
| SCAF4 | SR-related CTD-associated factor 4 | 0.01921 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0191268 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0190868 |
| MKI67 | marker of proliferation Ki-67 | 0.0190614 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0190597 |
| RNF145 | ring finger protein 145 | 0.0189743 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.315545 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.132236 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.129604 |
| VIM | vimentin | -0.122599 |
| IER3 | immediate early response 3 | -0.117769 |
| ACTG1 | actin gamma 1 | -0.0968735 |
| TMSB10 | thymosin beta 10 | -0.0911913 |
| FTL | ferritin, light polypeptide | -0.0911209 |
| CAVIN1 | caveolae associated protein 1 | -0.0792189 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0785894 |
| RPLP1 | ribosomal protein, large, P1 | -0.070456 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0682708 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0591215 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0576875 |
| PYGL | phosphorylase, glycogen, liver | -0.0536389 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0530927 |
| RPS8 | ribosomal protein S8 | -0.0498677 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0496615 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0469453 |
| STC1 | stanniocalcin 1 | -0.0464911 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0455463 |
| BICC1 | BicC family RNA binding protein 1 | -0.0453972 |
| GRAMD1B | GRAM domain containing 1B | -0.0442695 |
| RPL31 | ribosomal protein L31 | -0.0432098 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0430146 |
| RPL36 | ribosomal protein L36 | -0.042107 |
| EGFR | epidermal growth factor receptor | -0.0418841 |
| RPS29 | ribosomal protein S29 | -0.0415643 |
| RPL35A | ribosomal protein L35a | -0.04138 |
| SVIL | supervillin | -0.03967 |
| ZFHX3 | zinc finger homeobox 3 | -0.039365 |
| RPS27A | ribosomal protein S27a | -0.0393047 |
| PTMA | prothymosin, alpha | -0.0392626 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0370963 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0370706 |
| FLNB | filamin B, beta | -0.0368499 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0354542 |
| RPL19 | ribosomal protein L19 | -0.0352256 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0351735 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0340865 |
| NEBL | nebulette | -0.0340652 |
| HLA-E | major histocompatibility complex, class I, E | -0.0337619 |
| RPS19 | ribosomal protein S19 | -0.0337222 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0335522 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0330799 |
| S100A10 | S100 calcium binding protein A10 | -0.0326498 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0325776 |
| HLA-B | major histocompatibility complex, class I, B | -0.0323459 |
| IGF2 | insulin-like growth factor 2 | -0.032257 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0321886 |
| RPL37A | ribosomal protein L37a | -0.0321862 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0321812 |
| USP34 | ubiquitin specific peptidase 34 | -0.0317463 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0315705 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0302965 |
| VDAC1 | voltage-dependent anion channel 1 | -0.030222 |
| RPL34 | ribosomal protein L34 | -0.0300386 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0300163 |
| OSMR | oncostatin M receptor | -0.0296309 |
| CUX1 | cut-like homeobox 1 | -0.0288553 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0284976 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0284313 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0284002 |
| DST | dystonin | -0.0283838 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0282123 |
| NUMB | numb homolog (Drosophila) | -0.0282068 |
| RPS6 | ribosomal protein S6 | -0.0277949 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0276871 |
| EFNA5 | ephrin-A5 | -0.0276862 |
| SNX14 | sorting nexin 14 | -0.0273874 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0273471 |
| CMIP | c-Maf inducing protein | -0.027145 |
| RPS21 | ribosomal protein S21 | -0.0270916 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0264955 |
| EHBP1 | EH domain binding protein 1 | -0.0263148 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0262809 |
| RPL37 | ribosomal protein L37 | -0.0257304 |
| CDK13 | cyclin-dependent kinase 13 | -0.0257264 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0252833 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.025178 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0251102 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0244645 |
| RPS24 | ribosomal protein S24 | -0.0244191 |
| RPL30 | ribosomal protein L30 | -0.0242784 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0242438 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0236603 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0235464 |
| AHNAK | AHNAK nucleoprotein | -0.0234549 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0233409 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.022885 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0227424 |
| NHSL1 | NHS-like 1 | -0.0226321 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0225934 |
| RACK1 | receptor for activated C kinase 1 | -0.0223704 |
| GLIS3 | GLIS family zinc finger 3 | -0.0223116 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.022295 |
| RPS27 | ribosomal protein S27 | -0.0222752 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0220912 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0220098 |
| KIF13A | kinesin family member 13A | -0.0218664 |
