| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ligustrazine perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ligustrazine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | 0.156899 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.123481 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.103725 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0988966 |
| TOP1 | topoisomerase (DNA) I | 0.0957721 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0955386 |
| RPL26 | ribosomal protein L26 | 0.0949319 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0934751 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0862585 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0803227 |
| PRKCA | protein kinase C, alpha | 0.0784352 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0748208 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0732618 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0725546 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.071723 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.067492 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0631658 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0606212 |
| RPS24 | ribosomal protein S24 | 0.0603638 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0603234 |
| FAM13A | family with sequence similarity 13, member A | 0.0586692 |
| PRRC2C | proline-rich coiled-coil 2C | 0.057918 |
| RPS8 | ribosomal protein S8 | 0.0572574 |
| AREG | amphiregulin | 0.0562636 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0562207 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0551551 |
| RPL12 | ribosomal protein L12 | 0.0549414 |
| VMP1 | vacuole membrane protein 1 | 0.0532541 |
| RSF1 | remodeling and spacing factor 1 | 0.0504527 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0495519 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0494837 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0492757 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0488913 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.048417 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0478495 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0460577 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0458773 |
| FRY | furry homolog (Drosophila) | 0.0456544 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0452085 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0450264 |
| SLTM | SAFB-like, transcription modulator | 0.0445612 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0444501 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0436873 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.043208 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0431948 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0431213 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0422147 |
| CLTC | clathrin, heavy chain (Hc) | 0.0417106 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0414347 |
| CANX | calnexin | 0.0405285 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0401571 |
| MCL1 | myeloid cell leukemia 1 | 0.0395046 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0394283 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0392033 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0388643 |
| ATOSA | atos homolog A | 0.0385623 |
| MATR3 | matrin 3 | 0.0385037 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0378634 |
| RPS12 | ribosomal protein S12 | 0.0374488 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0372784 |
| NOP58 | NOP58 ribonucleoprotein | 0.0369103 |
| SIK3 | SIK family kinase 3 | 0.0367411 |
| RPL35A | ribosomal protein L35a | 0.0367008 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0366024 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0361476 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0360735 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0358642 |
| RPL19 | ribosomal protein L19 | 0.0354156 |
| CYTH1 | cytohesin 1 | 0.0351282 |
| EVI5 | ecotropic viral integration site 5 | 0.0341432 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.033069 |
| RREB1 | ras responsive element binding protein 1 | 0.032959 |
| TXNIP | thioredoxin interacting protein | 0.0326044 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0325666 |
| WWC2 | WW and C2 domain containing 2 | 0.0320916 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0318066 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0317046 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0314294 |
| TXNRD1 | thioredoxin reductase 1 | 0.0310988 |
| CENPF | centromere protein F, 350/400kDa | 0.0310052 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0309166 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0308723 |
| GOLGA4 | golgin A4 | 0.0306938 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.030608 |
| CUL3 | cullin 3 | 0.0297091 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0289818 |
| UBXN7 | UBX domain protein 7 | 0.0287495 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0286442 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.028486 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0284149 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0279323 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0278681 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0277072 |
| YBX3 | Y box binding protein 3 | 0.0276634 |
| CA12 | carbonic anhydrase XII | 0.027322 |
| USP34 | ubiquitin specific peptidase 34 | 0.0273089 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0272572 |
| RPS3 | ribosomal protein S3 | 0.02721 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.027092 |
| DST | dystonin | 0.0269035 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.175938 |
| FN1 | fibronectin 1 | -0.154048 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.123894 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.098754 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0789457 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0787454 |
| NAV2 | neuron navigator 2 | -0.0756403 |
| FLNB | filamin B, beta | -0.0721178 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0713032 |
| POTEF | POTE ankyrin domain family, member F | -0.070401 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0683708 |
| S100A10 | S100 calcium binding protein A10 | -0.0671537 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0629099 |
| CD109 | CD109 molecule | -0.0615681 |
| SPAG9 | sperm associated antigen 9 | -0.058729 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0586772 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0574009 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0549614 |
| B2M | beta-2-microglobulin | -0.0541631 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.053521 |
| LDHA | lactate dehydrogenase A | -0.052137 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0508769 |
| S100A6 | S100 calcium binding protein A6 | -0.0508689 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0488745 |
| C3 | complement component 3 | -0.0485917 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0483545 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0480211 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0469592 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0469313 |
| FOXO3 | forkhead box O3 | -0.0464429 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0460523 |
| SSH2 | slingshot protein phosphatase 2 | -0.0456317 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0455501 |
| ATP11B | ATPase, class VI, type 11B | -0.0454938 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0452027 |
| OGA | O-GlcNAcase | -0.0435545 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0434575 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0429939 |
| MYO1E | myosin IE | -0.0427907 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0424021 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0413501 |
| PDE10A | phosphodiesterase 10A | -0.0408883 |
| SETD5 | SET domain containing 5 | -0.0408614 |
| ZNF638 | zinc finger protein 638 | -0.0407397 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0397584 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0391427 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0390397 |
| SVIL | supervillin | -0.0389872 |
| SEPTIN11 | septin 11 | -0.0386947 |
| YAP1 | Yes-associated protein 1 | -0.0386309 |
| STC1 | stanniocalcin 1 | -0.0383381 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0383323 |
| CALR | calreticulin | -0.0376305 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0375193 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0375171 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0370667 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0370376 |
| FTL | ferritin, light polypeptide | -0.0370224 |
| TMSB10 | thymosin beta 10 | -0.0368255 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0367043 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0361991 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | -0.0361837 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | -0.0355658 |
| RPS15 | ribosomal protein S15 | -0.0350991 |
| CFDP1 | craniofacial development protein 1 | -0.0349895 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0349538 |
| KIF13A | kinesin family member 13A | -0.0349252 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0345872 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0344522 |
| DARS1 | aspartyl-tRNA synthetase 1 | -0.0344394 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0339163 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0338141 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0336963 |
| HLA-B | major histocompatibility complex, class I, B | -0.0336407 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.033638 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0335512 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0334486 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0333808 |
| EWSR1 | EWS RNA-binding protein 1 | -0.0331175 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0330094 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0327413 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0324293 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0324271 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0323791 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0323712 |
| LOXL2 | lysyl oxidase-like 2 | -0.0322055 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0317074 |
| RAB10 | RAB10, member RAS oncogene family | -0.0315168 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0313912 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0312268 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0311809 |
| SETD2 | SET domain containing 2 | -0.031056 |
| PERP | PERP, TP53 apoptosis effector | -0.0310502 |
| FBXO11 | F-box protein 11 | -0.0309882 |
| USP3 | ubiquitin specific peptidase 3 | -0.030915 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.030676 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0305904 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.030464 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0302175 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0299939 |
