Ligustrazine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ligustrazine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ligustrazine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.167957
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.108863
ERRFI1 ERBB receptor feedback inhibitor 1 0.0969446
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0904416
RAD51B RAD51 paralog B 0.083473
CSDE1 cold shock domain containing E1, RNA-binding 0.0800286
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0725165
TPM3 tropomyosin 3 0.0722511
AKAP12 A kinase (PRKA) anchor protein 12 0.0718645
TRIO trio Rho guanine nucleotide exchange factor 0.0654122
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0640015
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0617036
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0611632
XPO1 exportin 1 0.0518651
NAP1L1 nucleosome assembly protein 1-like 1 0.0515521
FMNL2 formin-like 2 0.0490801
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0477742
CANX calnexin 0.0473555
OGA O-GlcNAcase 0.046145
ANKRD36 ankyrin repeat domain 36 0.045872
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0455245
THSD4 thrombospondin, type I, domain containing 4 0.0451499
RBM39 RNA binding motif protein 39 0.0426819
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0426689
SMAD3 SMAD family member 3 0.0426043
BBX bobby sox homolog (Drosophila) 0.0422847
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0419089
KDM3A lysine (K)-specific demethylase 3A 0.0417528
EEF2 eukaryotic translation elongation factor 2 0.041027
XPOT exportin, tRNA 0.0406287
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0405993
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0405501
SET SET nuclear proto-oncogene 0.0403395
CSNK1A1 casein kinase 1, alpha 1 0.0400432
EXOC4 exocyst complex component 4 0.038943
MACF1 microtubule-actin crosslinking factor 1 0.0385733
AHNAK AHNAK nucleoprotein 0.0378272
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0367017
PTK2 protein tyrosine kinase 2 0.0366609
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0348923
CAMTA1 calmodulin binding transcription activator 1 0.0348322
KDM2A lysine (K)-specific demethylase 2A 0.0348086
USP9X ubiquitin specific peptidase 9, X-linked 0.0345601
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.034475
ANO6 anoctamin 6 0.0344159
TAS2R14 taste receptor, type 2, member 14 0.0343656
TRIP12 thyroid hormone receptor interactor 12 0.0340519
MYH9 myosin, heavy chain 9, non-muscle 0.0340197
EIF4B eukaryotic translation initiation factor 4B 0.0334148
ZFC3H1 zinc finger, C3H1-type containing 0.0333538
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0327863
CEP250 centrosomal protein 250kDa 0.032572
COPA coatomer protein complex, subunit alpha 0.0321309
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0320278
HSPA8 heat shock 70kDa protein 8 0.0318206
TFPI2 tissue factor pathway inhibitor 2 0.0315136
PUM2 pumilio RNA-binding family member 2 0.0314034
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0307342
PDIA3 protein disulfide isomerase family A, member 3 0.0306932
NIPBL Nipped-B homolog (Drosophila) 0.0305948
MKI67 marker of proliferation Ki-67 0.0305486
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0304137
ENO1 enolase 1, (alpha) 0.0304031
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0303333
TFG TRK-fused gene 0.0299673
PRELID2 PRELI domain containing 2 0.0298885
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0298763
PCBP2 poly(rC) binding protein 2 0.0296871
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0293299
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0293188
GOLGA4 golgin A4 0.0288906
PGK1 phosphoglycerate kinase 1 0.0288738
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0288653
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0284067
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0283064
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0280539
MED13L mediator complex subunit 13-like 0.0278266
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0277066
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0275926
RICTOR RPTOR independent companion of MTOR, complex 2 0.027498
ZNF292 zinc finger protein 292 0.0274489
NCKAP1 NCK-associated protein 1 0.0274146
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0273278
PDE4D phosphodiesterase 4D, cAMP-specific 0.0269984
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0267797
JMJD1C jumonji domain containing 1C 0.0266846
ZFAND3 zinc finger, AN1-type domain 3 0.0265023
ANKRD11 ankyrin repeat domain 11 0.0264206
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0263753
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0263309
BIRC6 baculoviral IAP repeat containing 6 0.0260406
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0257362
UBE2H ubiquitin-conjugating enzyme E2H 0.0255726
PDIA6 protein disulfide isomerase family A, member 6 0.0254805
CHD1 chromodomain helicase DNA binding protein 1 0.0254302
PDIA4 protein disulfide isomerase family A, member 4 0.0253117
NBAS neuroblastoma amplified sequence 0.0252961
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0250822
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0250617
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0249963

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.223398
TMSB10 thymosin beta 10 -0.118384
EGR1 early growth response 1 -0.111918
MT2A metallothionein 2A -0.0604915
ACTG1 actin gamma 1 -0.0593799
RPL35A ribosomal protein L35a -0.0589242
POTEF POTE ankyrin domain family, member F -0.0577791
RPLP1 ribosomal protein, large, P1 -0.0538766
YBX3 Y box binding protein 3 -0.0510521
HLA-B major histocompatibility complex, class I, B -0.0493551
RPS21 ribosomal protein S21 -0.0474797
MYL12B myosin, light chain 12B, regulatory -0.0473229
VIM vimentin -0.0435762
IGF2 insulin-like growth factor 2 -0.0423504
PFN1 profilin 1 -0.0416992
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0357779
IFI6 interferon, alpha-inducible protein 6 -0.0350374
S100A11 S100 calcium binding protein A11 -0.0326924
ATP5F1B ATP synthase F1 subunit beta -0.0311469
LOC102724023 ES1 protein homolog, mitochondrial -0.0307986
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0306711
FTL ferritin, light polypeptide -0.0290253
RPL28 ribosomal protein L28 -0.0282651
RPS6 ribosomal protein S6 -0.0280975
MT1X metallothionein 1X -0.0266813
RPL8 ribosomal protein L8 -0.0265481
ATP5F1E ATP synthase F1 subunit epsilon -0.0262052
STC1 stanniocalcin 1 -0.0256504
VDAC1 voltage-dependent anion channel 1 -0.0247087
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0244102
RPL31 ribosomal protein L31 -0.0239747
RPL37 ribosomal protein L37 -0.0235951
RPS29 ribosomal protein S29 -0.02349
RPS15 ribosomal protein S15 -0.0232193
TPI1 triosephosphate isomerase 1 -0.0230605
IER3 immediate early response 3 -0.0226532
RPLP2 ribosomal protein, large, P2 -0.0226501
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0220536
RPL5 ribosomal protein L5 -0.0219319
RAB7A RAB7A, member RAS oncogene family -0.0215439
RPS19 ribosomal protein S19 -0.0215122
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0210428
TAPBP TAP binding protein (tapasin) -0.0207463
RPS4X ribosomal protein S4, X-linked -0.0204245
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0203653
RACK1 receptor for activated C kinase 1 -0.0200644
RPS24 ribosomal protein S24 -0.0198348
S100A6 S100 calcium binding protein A6 -0.0195901
SEC61G Sec61 gamma subunit -0.0194059
RPS27 ribosomal protein S27 -0.0193612
RPS14 ribosomal protein S14 -0.0193581
RPS10 ribosomal protein S10 -0.0190197
RPL39 ribosomal protein L39 -0.0185317
HMGA1 high mobility group AT-hook 1 -0.0184963
RPS8 ribosomal protein S8 -0.0183873
TUBA1B tubulin, alpha 1b -0.0181611
FTH1 ferritin, heavy polypeptide 1 -0.018004
RPL36A ribosomal protein L36a -0.017825
RPL30 ribosomal protein L30 -0.0178176
BSG basigin (Ok blood group) -0.0178162
UBB ubiquitin B -0.0177824
PRH1 proline-rich protein HaeIII subfamily 1 -0.0176944
RPL36 ribosomal protein L36 -0.0174953
RANBP17 RAN binding protein 17 -0.0173999
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0173754
RPL35 ribosomal protein L35 -0.0172495
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0171848
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.016984
RPLP0 ribosomal protein, large, P0 -0.0166728
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0166636
CCND1 cyclin D1 -0.0165838
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0164833
S100A10 S100 calcium binding protein A10 -0.016449
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0164458
CBX3 chromobox homolog 3 -0.0164248
RPS16 ribosomal protein S16 -0.0161427
RPL34 ribosomal protein L34 -0.0160987
MAGEA4 melanoma antigen family A4 -0.0159513
B2M beta-2-microglobulin -0.0158684
LOC112694756 uncharaterized LOC112694756 -0.015615
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0155972
PMP22 peripheral myelin protein 22 -0.015575
RPL9 ribosomal protein L9 -0.0154453
PABPN1 poly(A) binding protein, nuclear 1 -0.0153924
SRSF3 serine/arginine-rich splicing factor 3 -0.0153891
COX5B cytochrome c oxidase subunit Vb -0.0153666
RIMS2 regulating synaptic membrane exocytosis 2 -0.0153173
MIDN midnolin -0.0153069
RPS20 ribosomal protein S20 -0.0151213
PRDX1 peroxiredoxin 1 -0.0150886
RPS23 ribosomal protein S23 -0.0149436
ICAM1 intercellular adhesion molecule 1 -0.0146513
DEK DEK proto-oncogene -0.0145436
RPL27 ribosomal protein L27 -0.0143701
TUBB4B tubulin, beta 4B class IVb -0.0143216
PHF14 PHD finger protein 14 -0.01429
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0141901
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.014182
MYO9B myosin IXB -0.0141212
OSMR oncostatin M receptor -0.0140344