Ligustrazine_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ligustrazine perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Ligustrazine_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.287733
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.153464
MYH9 myosin, heavy chain 9, non-muscle 0.129926
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0980941
FNDC3B fibronectin type III domain containing 3B 0.0968839
ASPH aspartate beta-hydroxylase 0.0944289
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0938498
CANX calnexin 0.0934816
DSPP dentin sialophosphoprotein 0.0829384
AHNAK AHNAK nucleoprotein 0.0789557
LPP LIM domain containing preferred translocation partner in lipoma 0.0747932
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0733411
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0699354
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.068341
LAMC2 laminin, gamma 2 0.061919
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0609318
TPM3 tropomyosin 3 0.0601999
TRIO trio Rho guanine nucleotide exchange factor 0.0600651
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0597028
APLP2 amyloid beta (A4) precursor-like protein 2 0.0595555
CALR calreticulin 0.0589074
GRB10 growth factor receptor-bound protein 10 0.0546353
ENO1 enolase 1, (alpha) 0.052702
PLAU plasminogen activator, urokinase 0.0526384
LAMB3 laminin, beta 3 0.0519552
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0515669
NAMPT nicotinamide phosphoribosyltransferase 0.0511388
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0507031
FXR1 fragile X mental retardation, autosomal homolog 1 0.0490975
EEF2 eukaryotic translation elongation factor 2 0.0488965
PLEC plectin 0.0474091
MACF1 microtubule-actin crosslinking factor 1 0.0470028
PGK1 phosphoglycerate kinase 1 0.0469331
HSPA8 heat shock 70kDa protein 8 0.0458424
TM4SF1 transmembrane 4 L six family member 1 0.0430682
MSN moesin 0.0422211
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0420736
PTK2 protein tyrosine kinase 2 0.041997
DST dystonin 0.0416765
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.041492
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0412187
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0412087
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0411114
G0S2 G0/G1 switch 2 0.0408473
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0404735
ARRDC3 arrestin domain containing 3 0.0388972
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0385049
AKAP13 A kinase (PRKA) anchor protein 13 0.0376024
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0375098
ADAM9 ADAM metallopeptidase domain 9 0.0374734
PCBP2 poly(rC) binding protein 2 0.0370326
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0367322
MYO6 myosin VI 0.0363421
HDGF hepatoma-derived growth factor 0.0361335
CNN3 calponin 3, acidic 0.0348141
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0338334
CD47 CD47 molecule 0.0337778
NUP58 nucleoporin 58 0.0336106
PDIA6 protein disulfide isomerase family A, member 6 0.0333703
TNIP1 TNFAIP3 interacting protein 1 0.0330301
PAPOLA poly(A) polymerase alpha 0.032944
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0328518
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0327236
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0323484
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0322078
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0319612
MEF2A myocyte enhancer factor 2A 0.0317968
PDIA3 protein disulfide isomerase family A, member 3 0.0317178
IRF6 interferon regulatory factor 6 0.0316933
ANXA2 annexin A2 0.0315352
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0314418
MSI2 musashi RNA-binding protein 2 0.0306188
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0302763
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0299767
FAM13A family with sequence similarity 13, member A 0.0298835
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0291142
TFG TRK-fused gene 0.0288328
CSDE1 cold shock domain containing E1, RNA-binding 0.028646
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.027342
NAV2 neuron navigator 2 0.0267526
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0267114
TMED2 transmembrane emp24 domain trafficking protein 2 0.026638
PLS3 plastin 3 0.0265428
ATP13A3 ATPase type 13A3 0.026448
YTHDC1 YTH domain containing 1 0.026247
ANXA1 annexin A1 0.0258796
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0255802
CSNK1A1 casein kinase 1, alpha 1 0.0250731
TRA2B transformer 2 beta homolog (Drosophila) 0.0249821
CORO1C coronin, actin binding protein, 1C 0.0244737
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0243125
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0242685
IQGAP1 IQ motif containing GTPase activating protein 1 0.0239336
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0239205
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.023888
DSCAM Down syndrome cell adhesion molecule 0.0238274
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0237695
SCEL sciellin 0.0232256
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0232116
CDC73 cell division cycle 73 0.0231264

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.343163
FTL ferritin, light polypeptide -0.220782
ACTG1 actin gamma 1 -0.188645
TMSB10 thymosin beta 10 -0.112263
RPLP1 ribosomal protein, large, P1 -0.0969823
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0770907
S100A6 S100 calcium binding protein A6 -0.0764413
HMGA1 high mobility group AT-hook 1 -0.0738553
MT2A metallothionein 2A -0.072625
RPL35A ribosomal protein L35a -0.0700667
TMSB4X thymosin beta 4, X-linked -0.0574529
PTMA prothymosin, alpha -0.0541698
SLC38A1 solute carrier family 38, member 1 -0.0537729
LOC112694756 uncharaterized LOC112694756 -0.0534504
RPL34 ribosomal protein L34 -0.0534128
RPS19 ribosomal protein S19 -0.0522306
RAB7A RAB7A, member RAS oncogene family -0.0487095
POTEF POTE ankyrin domain family, member F -0.0456717
RPL8 ribosomal protein L8 -0.0451905
GNAS GNAS complex locus -0.043196
IFITM3 interferon induced transmembrane protein 3 -0.0424495
CDCP1 CUB domain containing protein 1 -0.0400406
RPL30 ribosomal protein L30 -0.0349804
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0344657
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0339834
RPLP2 ribosomal protein, large, P2 -0.0334016
TSC22D2 TSC22 domain family, member 2 -0.032319
RPL28 ribosomal protein L28 -0.0317845
S100A10 S100 calcium binding protein A10 -0.0317035
SDC4 syndecan 4 -0.0315375
FTH1 ferritin, heavy polypeptide 1 -0.0313149
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0313102
EGR1 early growth response 1 -0.0308048
TXNIP thioredoxin interacting protein -0.030771
RPLP0 ribosomal protein, large, P0 -0.0306399
RPL27A ribosomal protein L27a -0.0305875
CCNI cyclin I -0.0304736
ARF1 ADP-ribosylation factor 1 -0.0302382
RPS13 ribosomal protein S13 -0.0301447
TUBB4B tubulin, beta 4B class IVb -0.0299676
SOX4 SRY (sex determining region Y)-box 4 -0.0291538
NPEPPS aminopeptidase puromycin sensitive -0.0289549
S100A9 S100 calcium binding protein A9 -0.0288021
BLZF1 basic leucine zipper nuclear factor 1 -0.0282746
NPC2 Niemann-Pick disease, type C2 -0.0281784
LOC102724023 ES1 protein homolog, mitochondrial -0.0281203
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0277434
RPS14 ribosomal protein S14 -0.0276421
RACK1 receptor for activated C kinase 1 -0.0275097
RPS21 ribosomal protein S21 -0.0269113
RPS8 ribosomal protein S8 -0.0264497
NDRG1 N-myc downstream regulated 1 -0.0262098
IFITM1 interferon induced transmembrane protein 1 -0.0260949
EIF1 eukaryotic translation initiation factor 1 -0.025715
LMAN1 lectin, mannose-binding, 1 -0.025586
RPS5 ribosomal protein S5 -0.0254605
TAPBP TAP binding protein (tapasin) -0.0252917
RPS23 ribosomal protein S23 -0.0252314
RBM25 RNA binding motif protein 25 -0.0250525
HMGB1 high mobility group box 1 -0.0249903
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0247253
RPL9 ribosomal protein L9 -0.0246232
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0245008
VIM vimentin -0.024254
RRBP1 ribosome binding protein 1 -0.0242514
TMEM263 transmembrane protein 263 -0.023613
RPS20 ribosomal protein S20 -0.0235852
BASP1 brain abundant, membrane attached signal protein 1 -0.0232669
RPL15 ribosomal protein L15 -0.0230795
CSTB cystatin B (stefin B) -0.0228996
RPS16 ribosomal protein S16 -0.0228332
FBXO11 F-box protein 11 -0.0227448
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0225188
RPS24 ribosomal protein S24 -0.0224197
PHLDA2 pleckstrin homology-like domain, family A, member 2 -0.0221615
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0219679
DUSP6 dual specificity phosphatase 6 -0.0218767
ISG15 ISG15 ubiquitin-like modifier -0.0218534
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0218499
VDAC1 voltage-dependent anion channel 1 -0.0216579
UBE2B ubiquitin-conjugating enzyme E2B -0.0215624
LY6E lymphocyte antigen 6 complex, locus E -0.0213801
RPL36A ribosomal protein L36a -0.0212482
ASTN2 astrotactin 2 -0.0211029
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0210051
BRD2 bromodomain containing 2 -0.020637
NPR2 natriuretic peptide receptor 2 -0.0206248
CLDN4 claudin 4 -0.0204302
RPS27 ribosomal protein S27 -0.0203264
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0202882
CTSD cathepsin D -0.0202269
RPS15 ribosomal protein S15 -0.0202268
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0200768
RPS29 ribosomal protein S29 -0.0200375
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0197526
DCP1A decapping mRNA 1A -0.0197199
ACBD3 acyl-CoA binding domain containing 3 -0.0197115
KLHL24 kelch-like family member 24 -0.0197089
RAB1A RAB1A, member RAS oncogene family -0.0195689
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0193127