Ligustrazine_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ligustrazine perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ligustrazine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.112022
NAMPT nicotinamide phosphoribosyltransferase 0.0997339
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0968289
ASPH aspartate beta-hydroxylase 0.0763235
TRIO trio Rho guanine nucleotide exchange factor 0.0670761
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0640411
CXCL8 chemokine (C-X-C motif) ligand 8 0.0590134
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0536479
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0503695
TFPI2 tissue factor pathway inhibitor 2 0.0491576
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0479837
GDA guanine deaminase 0.0457781
TXNRD1 thioredoxin reductase 1 0.0454259
NEK7 NIMA-related kinase 7 0.0448576
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0446122
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0440954
GRAMD1B GRAM domain containing 1B 0.040597
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0398683
LIMCH1 LIM and calponin homology domains 1 0.0383877
OGA O-GlcNAcase 0.0367137
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0334157
TM4SF1 transmembrane 4 L six family member 1 0.0314623
RTN4 reticulon 4 0.0308917
CENPF centromere protein F, 350/400kDa 0.0304035
PDE10A phosphodiesterase 10A 0.0300139
PSD3 pleckstrin and Sec7 domain containing 3 0.0295084
TNPO1 transportin 1 0.027496
DST dystonin 0.0272924
SFPQ splicing factor proline/glutamine-rich 0.0270838
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0269597
CTSC cathepsin C 0.0257934
TGFBR1 transforming growth factor, beta receptor 1 0.0240822
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0237128
MYOF myoferlin 0.0233785
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0226595
PLCB4 phospholipase C, beta 4 0.0224236
CARD16 caspase recruitment domain family, member 16 0.0220592
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0218102
KYNU kynureninase 0.0216759
BDNF brain-derived neurotrophic factor 0.0212605
ENAH enabled homolog (Drosophila) 0.0211801
SET SET nuclear proto-oncogene 0.020757
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0199955
ZNF292 zinc finger protein 292 0.019724
ARHGAP29 Rho GTPase activating protein 29 0.0196118
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0193633
SAMD4A sterile alpha motif domain containing 4A 0.0193114
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0192102
ANLN anillin, actin binding protein 0.0191825
NRCAM neuronal cell adhesion molecule 0.019074
NBAS neuroblastoma amplified sequence 0.0190632
WDR43 WD repeat domain 43 0.0189998
ANKRD36 ankyrin repeat domain 36 0.0188299
AGFG1 ArfGAP with FG repeats 1 0.0187881
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0187447
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0186415
NAP1L1 nucleosome assembly protein 1-like 1 0.0183347
MKI67 marker of proliferation Ki-67 0.0182517
ATP13A3 ATPase type 13A3 0.0179451
SERBP1 SERPINE1 mRNA binding protein 1 0.0177968
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0176164
BCAR3 breast cancer anti-estrogen resistance 3 0.0175007
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0171985
RBM39 RNA binding motif protein 39 0.0169264
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0168613
ZFC3H1 zinc finger, C3H1-type containing 0.016658
ELL2 elongation factor, RNA polymerase II, 2 0.0166429
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0165519
MFF mitochondrial fission factor 0.0165456
PUM2 pumilio RNA-binding family member 2 0.0162344
CKAP5 cytoskeleton associated protein 5 0.0161093
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0160643
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0160151
FLNB filamin B, beta 0.0159857
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0159728
ANKRD28 ankyrin repeat domain 28 0.0158991
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0157754
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0157197
COL8A1 collagen, type VIII, alpha 1 0.0155382
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.01549
AHNAK AHNAK nucleoprotein 0.0154857
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0154239
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0154209
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0153969
PNN pinin, desmosome associated protein 0.015375
CUL3 cullin 3 0.0153468
KIF5B kinesin family member 5B 0.0152561
METTL15 methyltransferase like 15 0.0152017
BRWD3 bromodomain and WD repeat domain containing 3 0.0151982
BZW1 basic leucine zipper and W2 domains 1 0.0151018
KMT2C lysine (K)-specific methyltransferase 2C 0.0149879
TNIP1 TNFAIP3 interacting protein 1 0.0148904
TPM3 tropomyosin 3 0.014671
SP3 Sp3 transcription factor 0.0145925
CDC73 cell division cycle 73 0.0145854
RUNX1 runt-related transcription factor 1 0.0145373
NGLY1 N-glycanase 1 0.0144463
NIPBL Nipped-B homolog (Drosophila) 0.014406
PSME4 proteasome (prosome, macropain) activator subunit 4 0.014309
WRN Werner syndrome, RecQ helicase-like 0.0140894

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.274795
FN1 fibronectin 1 -0.188419
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.152139
TMSB10 thymosin beta 10 -0.0990776
VIM vimentin -0.0977006
PDE4D phosphodiesterase 4D, cAMP-specific -0.0780612
RPS6 ribosomal protein S6 -0.066847
FTL ferritin, light polypeptide -0.0651264
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0572034
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0554952
RPL37A ribosomal protein L37a -0.0506749
TPT1 tumor protein, translationally-controlled 1 -0.0472949
P3H2 prolyl 3-hydroxylase 2 -0.0468801
RPS19 ribosomal protein S19 -0.0467995
RPLP1 ribosomal protein, large, P1 -0.0459293
RPL35A ribosomal protein L35a -0.0439076
HLA-A major histocompatibility complex, class I, A -0.0415134
RPS3 ribosomal protein S3 -0.0414588
IGFBP3 insulin-like growth factor binding protein 3 -0.0405452
RPL31 ribosomal protein L31 -0.0404252
RPS23 ribosomal protein S23 -0.0399065
B2M beta-2-microglobulin -0.0398482
HLA-B major histocompatibility complex, class I, B -0.0395037
EGR1 early growth response 1 -0.0378693
NDRG1 N-myc downstream regulated 1 -0.0373446
CDH13 cadherin 13 -0.0371027
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0362473
RPS12 ribosomal protein S12 -0.0361138
MAP7 microtubule-associated protein 7 -0.035488
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0352633
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0352613
RPL19 ribosomal protein L19 -0.0351772
PTMA prothymosin, alpha -0.0348113
WARS1 tryptophanyl-tRNA synthetase 1 -0.0338498
RPS8 ribosomal protein S8 -0.0327455
RPL37 ribosomal protein L37 -0.0316
WSB1 WD repeat and SOCS box containing 1 -0.0315715
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0314141
RPL9 ribosomal protein L9 -0.0301621
BASP1 brain abundant, membrane attached signal protein 1 -0.0300247
RPL36 ribosomal protein L36 -0.0298982
RPS29 ribosomal protein S29 -0.0297567
NALF1 NALCN channel auxiliary factor 1 -0.0297542
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0293982
IL6 interleukin 6 -0.0288091
UBC ubiquitin C -0.0285467
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0284055
RPS14 ribosomal protein S14 -0.0283656
S100A6 S100 calcium binding protein A6 -0.028016
FNDC3A fibronectin type III domain containing 3A -0.0276122
SOX4 SRY (sex determining region Y)-box 4 -0.0270918
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0267024
RPL7A ribosomal protein L7a -0.0260323
MCL1 myeloid cell leukemia 1 -0.0259456
PKM pyruvate kinase, muscle -0.025484
AUTS2 autism susceptibility candidate 2 -0.0254514
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0253524
RPS13 ribosomal protein S13 -0.0252891
LAMA5 laminin, alpha 5 -0.0252773
RPL12 ribosomal protein L12 -0.0249068
RPS27 ribosomal protein S27 -0.024697
SLC38A2 solute carrier family 38, member 2 -0.0245451
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0240827
PRKN parkin RBR E3 ubiquitin protein ligase -0.0240336
LSAMP limbic system-associated membrane protein -0.0237943
RPL36A ribosomal protein L36a -0.0232946
RPS4X ribosomal protein S4, X-linked -0.0232636
ACTG1 actin gamma 1 -0.0232277
IFIH1 interferon induced with helicase C domain 1 -0.0231457
LMNA lamin A/C -0.0231014
RPS27A ribosomal protein S27a -0.0230716
RPS25 ribosomal protein S25 -0.0230561
PM20D1 peptidase M20 domain containing 1 -0.0229479
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0227515
RPLP2 ribosomal protein, large, P2 -0.0225524
OASL 2'-5'-oligoadenylate synthetase-like -0.022475
RACK1 receptor for activated C kinase 1 -0.0221183
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0219144
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0216009
FTH1 ferritin, heavy polypeptide 1 -0.0214171
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0212551
CUX1 cut-like homeobox 1 -0.0211716
CTSL cathepsin L -0.0209113
RPS16 ribosomal protein S16 -0.0208655
CHL1 cell adhesion molecule L1-like -0.0208619
MT2A metallothionein 2A -0.020746
RPL35 ribosomal protein L35 -0.0206944
AGTPBP1 ATP/GTP binding protein 1 -0.02058
ENO2 enolase 2 (gamma, neuronal) -0.0204787
STC1 stanniocalcin 1 -0.0203363
RPL32 ribosomal protein L32 -0.0202858
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0202705
S100A10 S100 calcium binding protein A10 -0.0202476
TTC28 tetratricopeptide repeat domain 28 -0.0200376
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0200018
RPL26 ribosomal protein L26 -0.0199725
RPL34 ribosomal protein L34 -0.0198678
ADGRD1 adhesion G protein-coupled receptor D1 -0.0196793
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0195755
RPL13A ribosomal protein L13a -0.0189602