| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ligustrazine perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ligustrazine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.137152 |
| PDE10A | phosphodiesterase 10A | 0.135207 |
| STC1 | stanniocalcin 1 | 0.110775 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0962572 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.089021 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0866711 |
| RORA | RAR-related orphan receptor A | 0.0814101 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0761687 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0717942 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0702679 |
| NOP58 | NOP58 ribonucleoprotein | 0.0651074 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0611729 |
| ZNF292 | zinc finger protein 292 | 0.0598901 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0581141 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0575971 |
| MCL1 | myeloid cell leukemia 1 | 0.0568269 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0566015 |
| ENO1 | enolase 1, (alpha) | 0.0555329 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0538883 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0538479 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.052677 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0522018 |
| RPL19 | ribosomal protein L19 | 0.0517827 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0497894 |
| EFNA5 | ephrin-A5 | 0.0496074 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0482571 |
| RPS12 | ribosomal protein S12 | 0.0462915 |
| RACK1 | receptor for activated C kinase 1 | 0.0461765 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0458115 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0437464 |
| RPS8 | ribosomal protein S8 | 0.0435981 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0432476 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.0425687 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0412178 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0406782 |
| RNF145 | ring finger protein 145 | 0.0361776 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0361111 |
| PDE8A | phosphodiesterase 8A | 0.0359013 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0357 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0352709 |
| MYOF | myoferlin | 0.0352621 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0352147 |
| SEC61G | Sec61 gamma subunit | 0.0351769 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0336717 |
| MED13L | mediator complex subunit 13-like | 0.0336411 |
| RPL23 | ribosomal protein L23 | 0.03345 |
| PTK2 | protein tyrosine kinase 2 | 0.0327357 |
| VMP1 | vacuole membrane protein 1 | 0.0325808 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0319012 |
| HDLBP | high density lipoprotein binding protein | 0.0317601 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0315831 |
| TPR | translocated promoter region, nuclear basket protein | 0.0313467 |
| ANXA2 | annexin A2 | 0.0308163 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0303717 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0292473 |
| RPL26 | ribosomal protein L26 | 0.0289668 |
| RPL31 | ribosomal protein L31 | 0.02876 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0276016 |
| MT2A | metallothionein 2A | 0.0273509 |
| GPC6 | glypican 6 | 0.0271992 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0269165 |
| GNAS | GNAS complex locus | 0.026532 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0258422 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0257114 |
| HELZ | helicase with zinc finger | 0.0254678 |
| PARD3 | par-3 family cell polarity regulator | 0.0252797 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.025181 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0248248 |
| RPL15 | ribosomal protein L15 | 0.0248155 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0247701 |
| DST | dystonin | 0.0246451 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0242983 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0238906 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0237867 |
| JAK1 | Janus kinase 1 | 0.0237263 |
| FLNB | filamin B, beta | 0.0236172 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0226839 |
| RPS29 | ribosomal protein S29 | 0.0226839 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0224702 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0223494 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0220933 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0218765 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0212195 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0208829 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 0.0208492 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0208404 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0206768 |
| NRG1 | neuregulin 1 | 0.0204271 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0201839 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0198457 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0198269 |
| RPL5 | ribosomal protein L5 | 0.0197715 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0196345 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0188419 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0188011 |
| WWOX | WW domain containing oxidoreductase | 0.0187906 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0176454 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0173929 |
| MATR3 | matrin 3 | 0.0168552 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0162005 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.284549 |
| FN1 | fibronectin 1 | -0.201425 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.180399 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.145576 |
| LMO7 | LIM domain 7 | -0.107373 |
| ASPH | aspartate beta-hydroxylase | -0.0935613 |
| RPL35A | ribosomal protein L35a | -0.0837046 |
| NAV2 | neuron navigator 2 | -0.0815484 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0741349 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0734579 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0722658 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0708785 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0667288 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0648863 |
| TNS3 | tensin 3 | -0.0619698 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0615987 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0607548 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0590974 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0583584 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0575968 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0573158 |
| HMGA2 | high mobility group AT-hook 2 | -0.0546468 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.053636 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0534904 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0529576 |
| INTS6 | integrator complex subunit 6 | -0.0472998 |
| PRKCA | protein kinase C, alpha | -0.0468918 |
| RPS6 | ribosomal protein S6 | -0.0465828 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0464954 |
| CDH13 | cadherin 13 | -0.0458864 |
| VIM | vimentin | -0.0440899 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0440532 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0440484 |
| TMSB10 | thymosin beta 10 | -0.0402681 |
| MED13 | mediator complex subunit 13 | -0.0392165 |
| GRAMD1B | GRAM domain containing 1B | -0.0382515 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0376659 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.037225 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0360026 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0356285 |
| FAM13A | family with sequence similarity 13, member A | -0.0349714 |
| RPL37A | ribosomal protein L37a | -0.0344614 |
| EZR | ezrin | -0.0334292 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0334269 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0328562 |
| TPM4 | tropomyosin 4 | -0.0323244 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0322311 |
| ACTG1 | actin gamma 1 | -0.0315491 |
| FMNL2 | formin-like 2 | -0.0303838 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0287892 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0279742 |
| SPAG9 | sperm associated antigen 9 | -0.0277925 |
| VCL | vinculin | -0.0277887 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0275004 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0258073 |
| RAD51B | RAD51 paralog B | -0.0257493 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.025715 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0256325 |
| USP34 | ubiquitin specific peptidase 34 | -0.0249324 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0249307 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0248377 |
| CANX | calnexin | -0.0236265 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.022999 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0228644 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0216692 |
| GOLGA4 | golgin A4 | -0.0214127 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0211376 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0208916 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.02079 |
| SETD5 | SET domain containing 5 | -0.0205185 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0201909 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0194319 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0192408 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0190617 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.018667 |
| PKM | pyruvate kinase, muscle | -0.0181908 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0178766 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0172719 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0160615 |
| SMAD3 | SMAD family member 3 | -0.013312 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.013106 |
| RUNX1 | runt-related transcription factor 1 | -0.0130488 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0129814 |
| B2M | beta-2-microglobulin | -0.0115133 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0113251 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0109282 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0108719 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0102259 |
| OGA | O-GlcNAcase | -0.00995568 |
| PGK1 | phosphoglycerate kinase 1 | -0.00982873 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0093298 |
| RPS3 | ribosomal protein S3 | -0.00901824 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.00805961 |
| CCNI | cyclin I | -0.00698825 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.00668596 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.00567067 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.00421304 |
| AFF4 | AF4/FMR2 family, member 4 | -0.00393882 |
| JMJD1C | jumonji domain containing 1C | -0.00333436 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0027216 |
