| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ligustrazine perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ligustrazine_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.17826 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.117375 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.113616 |
| NTM | neurotrimin | 0.0891518 |
| HDAC9 | histone deacetylase 9 | 0.0859098 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0823668 |
| THBS1 | thrombospondin 1 | 0.0774535 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0743665 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0741153 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0715117 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0687644 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0662486 |
| TPM3 | tropomyosin 3 | 0.0623356 |
| UPP1 | uridine phosphorylase 1 | 0.0620378 |
| PCBP2 | poly(rC) binding protein 2 | 0.0605313 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0598921 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0588786 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0588744 |
| MKI67 | marker of proliferation Ki-67 | 0.0561761 |
| PRR16 | proline rich 16 | 0.0558378 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0549055 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0535283 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0508519 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0500244 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0499936 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0499491 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.04952 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0475594 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0457556 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0451779 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0446978 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0442077 |
| FNBP1L | formin binding protein 1-like | 0.0438782 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0426875 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0420033 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.0416609 |
| ANKRD33B | ankyrin repeat domain 33B | 0.041581 |
| ZNF217 | zinc finger protein 217 | 0.041218 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0409763 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0408138 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0405836 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0405192 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0404116 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0395376 |
| CANX | calnexin | 0.0395191 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0391776 |
| SBF2 | SET binding factor 2 | 0.0390897 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0390091 |
| MBIP | MAP3K12 binding inhibitory protein 1 | 0.0388646 |
| EMP1 | epithelial membrane protein 1 | 0.0385731 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0379984 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0379375 |
| TCP1 | t-complex 1 | 0.0379068 |
| NFIB | nuclear factor I/B | 0.0378346 |
| SET | SET nuclear proto-oncogene | 0.0376815 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0376651 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.037547 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0372577 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0368175 |
| CALR | calreticulin | 0.0366776 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0363169 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0362069 |
| GANAB | glucosidase, alpha; neutral AB | 0.0360978 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0358101 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.035231 |
| NOC2L | nucleolar complex associated 2 homolog (S. cerevisiae) | 0.0351497 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0350968 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0338668 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0337544 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | 0.0333142 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0330966 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0328995 |
| FAM171B | family with sequence similarity 171, member B | 0.0328465 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0328298 |
| TOP1 | topoisomerase (DNA) I | 0.0327206 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.032353 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0323256 |
| USP53 | ubiquitin specific peptidase 53 | 0.0322419 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0319658 |
| RPL3 | ribosomal protein L3 | 0.0315981 |
| ANXA2 | annexin A2 | 0.0314693 |
| PDGFC | platelet derived growth factor C | 0.0314126 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0312761 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0311998 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0310521 |
| SERINC1 | serine incorporator 1 | 0.0310294 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0310291 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0310258 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | 0.030731 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0303931 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0303003 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0301717 |
| RREB1 | ras responsive element binding protein 1 | 0.030139 |
| SPAG9 | sperm associated antigen 9 | 0.0301213 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0299744 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0297773 |
| COL5A2 | collagen, type V, alpha 2 | 0.0296079 |
| MEMO1 | mediator of cell motility 1 | 0.0295695 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0291402 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0289694 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.109321 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.107961 |
| FOXP2 | forkhead box P2 | -0.10311 |
| VIM | vimentin | -0.0775721 |
| SMYD3 | SET and MYND domain containing 3 | -0.0635699 |
| RPLP1 | ribosomal protein, large, P1 | -0.0618864 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0611279 |
| ACTG1 | actin gamma 1 | -0.0607432 |
| RBM39 | RNA binding motif protein 39 | -0.0591469 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0554628 |
| RPS16 | ribosomal protein S16 | -0.0546045 |
| PFN1 | profilin 1 | -0.053818 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0533511 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0524718 |
| CADM2 | cell adhesion molecule 2 | -0.050443 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0498518 |
| MEIS2 | Meis homeobox 2 | -0.0480757 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.047179 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0464053 |
| PEG10 | paternally expressed 10 | -0.0463909 |
| RPS8 | ribosomal protein S8 | -0.0434395 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0431847 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0418517 |
| ZNF292 | zinc finger protein 292 | -0.040242 |
| COL1A2 | collagen, type I, alpha 2 | -0.0402364 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.040084 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0395736 |
| CAVIN1 | caveolae associated protein 1 | -0.0376892 |
| S100A10 | S100 calcium binding protein A10 | -0.037138 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0358558 |
| NPR2 | natriuretic peptide receptor 2 | -0.0350242 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0347541 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0337616 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0337319 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0336404 |
| MAP1B | microtubule-associated protein 1B | -0.0335855 |
| FTL | ferritin, light polypeptide | -0.0331775 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0331316 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0319655 |
| ACTN4 | actinin, alpha 4 | -0.0312845 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0312369 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0311039 |
| HMGA2 | high mobility group AT-hook 2 | -0.0309426 |
| RPL19 | ribosomal protein L19 | -0.0307173 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0304382 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0301444 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0299846 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0297889 |
| CLIC4 | chloride intracellular channel 4 | -0.029754 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0290899 |
| AK1 | adenylate kinase 1 | -0.0286664 |
| RPS27A | ribosomal protein S27a | -0.0282848 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0282538 |
| RPS19 | ribosomal protein S19 | -0.0282041 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0281345 |
| RPL35A | ribosomal protein L35a | -0.028041 |
| MED13L | mediator complex subunit 13-like | -0.027583 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0273899 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.0273522 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -0.0273029 |
| RIGI | RNA sensor RIG-I | -0.0272181 |
| RAB31 | RAB31, member RAS oncogene family | -0.0270329 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0269358 |
| DEK | DEK proto-oncogene | -0.0267611 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0267495 |
| ATXN2 | ataxin 2 | -0.0266153 |
| PRKD1 | protein kinase D1 | -0.0265309 |
| RPS13 | ribosomal protein S13 | -0.0262956 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0261446 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0260149 |
| NF1 | neurofibromin 1 | -0.0256469 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0255673 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0255612 |
| ASTN2 | astrotactin 2 | -0.0255178 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0253301 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0252673 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.0251314 |
| NBEAL1 | neurobeachin-like 1 | -0.0248854 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0248354 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0247351 |
| PDSS2 | prenyl (decaprenyl) diphosphate synthase, subunit 2 | -0.0245977 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | -0.0245533 |
| HDLBP | high density lipoprotein binding protein | -0.024507 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0242551 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0240645 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0238396 |
| RACK1 | receptor for activated C kinase 1 | -0.0238384 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.023449 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0234422 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | -0.0233923 |
| RPL36 | ribosomal protein L36 | -0.0233875 |
| SERF2 | small EDRK-rich factor 2 | -0.0232577 |
| FIGN | fidgetin | -0.0232075 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | -0.0231294 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0230108 |
| GLG1 | golgi glycoprotein 1 | -0.0229087 |
| WIPF2 | WAS/WASL interacting protein family, member 2 | -0.0226624 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0224001 |
| RPL36A | ribosomal protein L36a | -0.0223953 |
| RPL37A | ribosomal protein L37a | -0.0223796 |
