Ligustrazine_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ligustrazine perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ligustrazine_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0834384
ADAM10 ADAM metallopeptidase domain 10 0.0753034
GOLGA4 golgin A4 0.0750484
DSCAM Down syndrome cell adhesion molecule 0.0682202
ZNF292 zinc finger protein 292 0.0681325
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0667292
CAMTA1 calmodulin binding transcription activator 1 0.0638349
KDM3A lysine (K)-specific demethylase 3A 0.0593075
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.059212
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0569816
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.054594
NAMPT nicotinamide phosphoribosyltransferase 0.0540882
FLNB filamin B, beta 0.0535098
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0533939
NUP58 nucleoporin 58 0.0491237
ECT2 epithelial cell transforming 2 0.0486935
NBAS neuroblastoma amplified sequence 0.0469159
TXNIP thioredoxin interacting protein 0.0423758
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0414258
EIF4A2 eukaryotic translation initiation factor 4A2 0.0380961
KMT2E lysine (K)-specific methyltransferase 2E 0.037599
GSK3B glycogen synthase kinase 3 beta 0.0371411
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.036931
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0367863
ELOVL5 ELOVL fatty acid elongase 5 0.0365061
NCKAP1 NCK-associated protein 1 0.0359799
XPO1 exportin 1 0.0357122
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0356687
YEATS2 YEATS domain containing 2 0.035531
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0355234
TGFBR3 transforming growth factor, beta receptor III 0.0351872
OGA O-GlcNAcase 0.0347524
ADAM9 ADAM metallopeptidase domain 9 0.0347517
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0347469
KDM6A lysine (K)-specific demethylase 6A 0.0335517
RNF145 ring finger protein 145 0.0335331
PTBP2 polypyrimidine tract binding protein 2 0.0334305
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0328432
PGK1 phosphoglycerate kinase 1 0.0325955
RBM39 RNA binding motif protein 39 0.0323873
CCNL1 cyclin L1 0.0322194
TFG TRK-fused gene 0.0321067
CDC73 cell division cycle 73 0.0318714
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0317971
KMT2C lysine (K)-specific methyltransferase 2C 0.03133
ANKRD36 ankyrin repeat domain 36 0.0311328
RTN4 reticulon 4 0.03021
EEF2 eukaryotic translation elongation factor 2 0.0301121
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0299958
CD47 CD47 molecule 0.0295823
PICALM phosphatidylinositol binding clathrin assembly protein 0.0294444
COG5 component of oligomeric golgi complex 5 0.0292215
ZFAND3 zinc finger, AN1-type domain 3 0.0288826
SMNDC1 survival motor neuron domain containing 1 0.0284506
PTK2 protein tyrosine kinase 2 0.0278715
EZR ezrin 0.0278021
FNDC3B fibronectin type III domain containing 3B 0.0269789
MON2 MON2 homolog (S. cerevisiae) 0.0269692
UBA6 ubiquitin-like modifier activating enzyme 6 0.026835
PRELID2 PRELI domain containing 2 0.026787
TOP2B topoisomerase (DNA) II beta 180kDa 0.0259829
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0258776
COPA coatomer protein complex, subunit alpha 0.0258418
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0253847
SEC23A Sec23 homolog A (S. cerevisiae) 0.0253518
GARS1 glycyl-tRNA synthetase 1 0.0248736
WAC WW domain containing adaptor with coiled-coil 0.024739
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0246138
YTHDC1 YTH domain containing 1 0.0244239
RPL3 ribosomal protein L3 0.0243931
TMF1 TATA element modulatory factor 1 0.0243533
SET SET nuclear proto-oncogene 0.0243181
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0241525
BRWD1 bromodomain and WD repeat domain containing 1 0.0239515
NCOR1 nuclear receptor corepressor 1 0.0238806
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.023755
SPAG9 sperm associated antigen 9 0.0235184
USP24 ubiquitin specific peptidase 24 0.0234817
ZFC3H1 zinc finger, C3H1-type containing 0.0234439
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0233773
QKI QKI, KH domain containing, RNA binding 0.0233708
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.023318
CASC3 cancer susceptibility candidate 3 0.0233088
FAT1 FAT atypical cadherin 1 0.0230992
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0230836
ELP2 elongator acetyltransferase complex subunit 2 0.0229204
SQSTM1 sequestosome 1 0.0222085
PRPF38B pre-mRNA processing factor 38B 0.0221083
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0220841
HELZ helicase with zinc finger 0.0220524
EIF4B eukaryotic translation initiation factor 4B 0.022008
SERINC1 serine incorporator 1 0.0219971
TMEM39A transmembrane protein 39A 0.0217744
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0216499
ANK2 ankyrin 2, neuronal 0.0214557
SBF2 SET binding factor 2 0.0212467
ZMYM2 zinc finger, MYM-type 2 0.0212414
ANKRD12 ankyrin repeat domain 12 0.0212213
COG6 component of oligomeric golgi complex 6 0.021085
ZNF608 zinc finger protein 608 0.0209966

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.21743
PTMA prothymosin, alpha -0.194592
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.120072
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.100134
RPS6 ribosomal protein S6 -0.0973905
FOXP1 forkhead box P1 -0.0939377
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0913189
ACTG1 actin gamma 1 -0.0849596
PKM pyruvate kinase, muscle -0.0747643
BMP10 bone morphogenetic protein 10 -0.0712811
RPL35A ribosomal protein L35a -0.0679626
RPLP1 ribosomal protein, large, P1 -0.0590109
RPS8 ribosomal protein S8 -0.0544948
HSPB1 heat shock 27kDa protein 1 -0.051885
GLI3 GLI family zinc finger 3 -0.0507245
S100A4 S100 calcium binding protein A4 -0.0501784
CCND1 cyclin D1 -0.0498159
PDE4B phosphodiesterase 4B, cAMP-specific -0.0490237
PFN1 profilin 1 -0.0445145
RPL34 ribosomal protein L34 -0.0433506
RPL31 ribosomal protein L31 -0.0427178
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0421861
ZMYND8 zinc finger, MYND-type containing 8 -0.0404572
PDE4D phosphodiesterase 4D, cAMP-specific -0.0402058
DLG1 discs, large homolog 1 (Drosophila) -0.0401643
RPS19 ribosomal protein S19 -0.0392304
RPS13 ribosomal protein S13 -0.0383962
ARL4C ADP-ribosylation factor-like 4C -0.0382552
POTEF POTE ankyrin domain family, member F -0.0371647
RPLP2 ribosomal protein, large, P2 -0.0349712
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0341055
TMSB10 thymosin beta 10 -0.033485
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0334013
RPL7A ribosomal protein L7a -0.0329201
DUSP6 dual specificity phosphatase 6 -0.0329048
RPL19 ribosomal protein L19 -0.0327812
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0322076
LOC102724023 ES1 protein homolog, mitochondrial -0.0321838
DIAPH3 diaphanous-related formin 3 -0.0317842
S100A9 S100 calcium binding protein A9 -0.031309
NPAS2 neuronal PAS domain protein 2 -0.0310226
RPS23 ribosomal protein S23 -0.030318
CUX1 cut-like homeobox 1 -0.0301649
CAMKMT calmodulin-lysine N-methyltransferase -0.0300504
RPL28 ribosomal protein L28 -0.0298847
RPS14 ribosomal protein S14 -0.0298434
NBEA neurobeachin -0.0293954
PDE7B phosphodiesterase 7B -0.0293025
RPL23 ribosomal protein L23 -0.0286234
RPL36 ribosomal protein L36 -0.0285494
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0285155
PRUNE2 prune homolog 2 (Drosophila) -0.0282342
LOC112694756 uncharaterized LOC112694756 -0.0281351
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0279833
RPS21 ribosomal protein S21 -0.0279044
RPS25 ribosomal protein S25 -0.0278984
RPL12 ribosomal protein L12 -0.027803
RPL26 ribosomal protein L26 -0.0270434
RPS24 ribosomal protein S24 -0.0268948
RPS16 ribosomal protein S16 -0.0265746
DPYD dihydropyrimidine dehydrogenase -0.0264784
RPS27A ribosomal protein S27a -0.0264471
SMC4 structural maintenance of chromosomes 4 -0.0263573
TUBB4B tubulin, beta 4B class IVb -0.0260786
RPL9 ribosomal protein L9 -0.025887
RPS3 ribosomal protein S3 -0.0257125
RPS29 ribosomal protein S29 -0.0252073
RPL37A ribosomal protein L37a -0.0248991
RACK1 receptor for activated C kinase 1 -0.0247608
S100A10 S100 calcium binding protein A10 -0.0245434
GNAS GNAS complex locus -0.0245021
RPL32 ribosomal protein L32 -0.0243556
RPLP0 ribosomal protein, large, P0 -0.0243277
NAV2 neuron navigator 2 -0.0243016
MT2A metallothionein 2A -0.0242108
EGFR epidermal growth factor receptor -0.0239842
GSE1 Gse1 coiled-coil protein -0.0236375
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0236291
S100A6 S100 calcium binding protein A6 -0.0235789
FTL ferritin, light polypeptide -0.0234198
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0233698
HMGB1 high mobility group box 1 -0.0232065
SDK1 sidekick cell adhesion molecule 1 -0.0229773
EMP3 epithelial membrane protein 3 -0.0229087
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0228768
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0226368
BPTF bromodomain PHD finger transcription factor -0.0224921
MKI67 marker of proliferation Ki-67 -0.022425
IFITM3 interferon induced transmembrane protein 3 -0.0220698
RPL36A ribosomal protein L36a -0.0219505
ASTN2 astrotactin 2 -0.0219503
VCL vinculin -0.0213234
PRDX2 peroxiredoxin 2 -0.0213079
RPL8 ribosomal protein L8 -0.0211602
RPS5 ribosomal protein S5 -0.0211088
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -0.0209827
ZNF438 zinc finger protein 438 -0.0206417
PKP4 plakophilin 4 -0.0204749
IFI6 interferon, alpha-inducible protein 6 -0.0203987
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0203539