Ligustrazine_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ligustrazine perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ligustrazine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.274034
TFPI2 tissue factor pathway inhibitor 2 0.206108
COL6A3 collagen, type VI, alpha 3 0.116817
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0585929
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0523024
NAV2 neuron navigator 2 0.049871
MYH9 myosin, heavy chain 9, non-muscle 0.0473718
CXCL8 chemokine (C-X-C motif) ligand 8 0.0472628
ANLN anillin, actin binding protein 0.0448096
NAMPT nicotinamide phosphoribosyltransferase 0.0445499
KMT2E lysine (K)-specific methyltransferase 2E 0.0432685
FMNL2 formin-like 2 0.0428009
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0410619
FLNA filamin A, alpha 0.0407153
MKI67 marker of proliferation Ki-67 0.0402476
ARRDC3 arrestin domain containing 3 0.0369754
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0367607
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.035475
ANXA2 annexin A2 0.0346368
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0343632
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0339855
FAM13A family with sequence similarity 13, member A 0.0332047
BIRC3 baculoviral IAP repeat containing 3 0.0327147
METTL15 methyltransferase like 15 0.0326149
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0321049
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0316092
MORC3 MORC family CW-type zinc finger 3 0.0314783
NF1 neurofibromin 1 0.030949
COL1A1 collagen, type I, alpha 1 0.0305661
TENT5A terminal nucleotidyltransferase 5A 0.0305209
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0304519
PTBP2 polypyrimidine tract binding protein 2 0.0303435
B2M beta-2-microglobulin 0.0303147
PTMA prothymosin, alpha 0.0299669
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0299138
CKAP2 cytoskeleton associated protein 2 0.02976
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0293315
IGFBP7 insulin-like growth factor binding protein 7 0.028403
CDCA2 cell division cycle associated 2 0.0283521
LGALS1 lectin, galactoside-binding, soluble, 1 0.0283461
SMC3 structural maintenance of chromosomes 3 0.0283139
KIF2C kinesin family member 2C 0.0282088
DST dystonin 0.028024
VIM vimentin 0.0279564
ZNF160 zinc finger protein 160 0.027927
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.0268606
CCDC14 coiled-coil domain containing 14 0.0268205
GCC2 GRIP and coiled-coil domain containing 2 0.026787
GRB10 growth factor receptor-bound protein 10 0.0267818
ELL elongation factor RNA polymerase II 0.026383
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0257725
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0255248
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0251631
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0251625
LAMB3 laminin, beta 3 0.0249902
COPG1 coatomer protein complex, subunit gamma 1 0.0249096
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.02478
LEPROT leptin receptor overlapping transcript 0.0245697
TTC17 tetratricopeptide repeat domain 17 0.0245184
SLMAP sarcolemma associated protein 0.0244938
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0243875
TXNIP thioredoxin interacting protein 0.0243549
SYPL1 synaptophysin-like 1 0.0241279
SET SET nuclear proto-oncogene 0.0239016
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0235608
COL5A2 collagen, type V, alpha 2 0.0234959
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0234025
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0233353
TNIP1 TNFAIP3 interacting protein 1 0.0231504
MORF4L1 mortality factor 4 like 1 0.0230287
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.0230055
IL1R1 interleukin 1 receptor, type I 0.0229809
PUM2 pumilio RNA-binding family member 2 0.0220709
NIBAN2 niban apoptosis regulator 2 0.0219268
APLP2 amyloid beta (A4) precursor-like protein 2 0.0219224
RPS14 ribosomal protein S14 0.0218897
XRN2 5'-3' exoribonuclease 2 0.0217053
WDR26 WD repeat domain 26 0.0215504
ARID4A AT rich interactive domain 4A (RBP1-like) 0.0215092
FANCC Fanconi anemia, complementation group C 0.021491
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0214803
CD44 CD44 molecule (Indian blood group) 0.0213821
IGFBP6 insulin-like growth factor binding protein 6 0.0213787
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0213112
RB1CC1 RB1-inducible coiled-coil 1 0.0212291
ITM2B integral membrane protein 2B 0.0212276
RPLP2 ribosomal protein, large, P2 0.0211993
MACF1 microtubule-actin crosslinking factor 1 0.0210823
HP1BP3 heterochromatin protein 1, binding protein 3 0.0210759
FLNB filamin B, beta 0.0210545
RPS2 ribosomal protein S2 0.0209836
TXN2 thioredoxin 2 0.0209663
PTK2 protein tyrosine kinase 2 0.0208731
SGO2 shugoshin 2 0.0208616
TMEM184B transmembrane protein 184B 0.0208425
ETV6 ets variant 6 0.0208083
KIAA1217 KIAA1217 0.0207247
SDK1 sidekick cell adhesion molecule 1 0.0207073
MYOF myoferlin 0.0206452
RPL35A ribosomal protein L35a 0.0204832

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.263306
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.16402
TGFBI transforming growth factor, beta-induced, 68kDa -0.139538
FN1 fibronectin 1 -0.125891
LOX lysyl oxidase -0.0957949
SEC31A SEC31 homolog A (S. cerevisiae) -0.0697197
NDRG1 N-myc downstream regulated 1 -0.0686502
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0677462
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0643075
HLA-B major histocompatibility complex, class I, B -0.0628914
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0601597
COL6A2 collagen, type VI, alpha 2 -0.0561463
AKAP12 A kinase (PRKA) anchor protein 12 -0.0550156
STC1 stanniocalcin 1 -0.0534285
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0532658
COL6A1 collagen, type VI, alpha 1 -0.0524164
F3 coagulation factor III (thromboplastin, tissue factor) -0.0512766
RAI14 retinoic acid induced 14 -0.0491377
EXT1 exostosin glycosyltransferase 1 -0.0486319
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0473404
ARF4 ADP-ribosylation factor 4 -0.0466462
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.046178
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0457899
IL6 interleukin 6 -0.0457584
SDC4 syndecan 4 -0.0445937
ECE1 endothelin converting enzyme 1 -0.0418142
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0417745
FBXO11 F-box protein 11 -0.0417473
CANX calnexin -0.0411837
PRRC1 proline-rich coiled-coil 1 -0.0409784
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0405351
VCL vinculin -0.0402114
RUNX1 runt-related transcription factor 1 -0.0401849
NBEAL1 neurobeachin-like 1 -0.0396341
SEC24D SEC24 family member D -0.0389734
BIRC6 baculoviral IAP repeat containing 6 -0.0384965
UBC ubiquitin C -0.0381266
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0373412
PDLIM5 PDZ and LIM domain 5 -0.0371902
GOLGA4 golgin A4 -0.0368612
COG6 component of oligomeric golgi complex 6 -0.0366589
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0364625
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0364159
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0362785
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0354773
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0354072
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0352229
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0350243
RTN4 reticulon 4 -0.0347286
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.034703
PRSS23 protease, serine, 23 -0.0343219
CLIC4 chloride intracellular channel 4 -0.0342577
HLA-C major histocompatibility complex, class I, C -0.034058
NUMB numb homolog (Drosophila) -0.0337566
HMGA2 high mobility group AT-hook 2 -0.0334926
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -0.0334754
ZFAND3 zinc finger, AN1-type domain 3 -0.0333816
FAM3C family with sequence similarity 3, member C -0.0333613
CLTC clathrin, heavy chain (Hc) -0.0329782
QKI QKI, KH domain containing, RNA binding -0.0328831
TNS3 tensin 3 -0.0327403
GLIS3 GLIS family zinc finger 3 -0.0318511
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0314558
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0310269
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0309834
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0304232
HIP1 huntingtin interacting protein 1 -0.0301951
SPDYA speedy/RINGO cell cycle regulator family member A -0.0300563
KMT2C lysine (K)-specific methyltransferase 2C -0.0292384
VDAC1 voltage-dependent anion channel 1 -0.029187
HDLBP high density lipoprotein binding protein -0.0288999
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0288
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0285294
MAP1B microtubule-associated protein 1B -0.0282626
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0280975
FNDC3A fibronectin type III domain containing 3A -0.0280078
COPB1 coatomer protein complex, subunit beta 1 -0.0278382
EGR1 early growth response 1 -0.0277929
SYNPO synaptopodin -0.0277621
WASF2 WAS protein family, member 2 -0.0275135
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0274846
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0274529
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0273483
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0271807
RASAL2 RAS protein activator like 2 -0.0269905
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0269011
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0267274
RAB2A RAB2A, member RAS oncogene family -0.0267245
SLC38A2 solute carrier family 38, member 2 -0.0258033
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0256659
TPM1 tropomyosin 1 (alpha) -0.0256124
KAT6B K(lysine) acetyltransferase 6B -0.0253036
CDK13 cyclin-dependent kinase 13 -0.0251631
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0250489
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0249742
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0249152
NRP1 neuropilin 1 -0.0247558
VEGFA vascular endothelial growth factor A -0.024753
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0246438
IARS1 isoleucyl-tRNA synthetase 1 -0.0245753