Ligustrazine_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ligustrazine perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ligustrazine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.162492
CXCL8 chemokine (C-X-C motif) ligand 8 0.161259
NAMPT nicotinamide phosphoribosyltransferase 0.141052
CANX calnexin 0.10309
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.090807
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0892388
FNDC3B fibronectin type III domain containing 3B 0.0865575
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0851157
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0800765
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.074738
OGA O-GlcNAcase 0.0732766
TPR translocated promoter region, nuclear basket protein 0.0722369
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0710869
AHR aryl hydrocarbon receptor 0.0708693
ITGA1 integrin, alpha 1 0.0696798
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0659473
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0654396
CD109 CD109 molecule 0.063109
PRRC2C proline-rich coiled-coil 2C 0.0614973
FAM13A family with sequence similarity 13, member A 0.0581419
NAP1L1 nucleosome assembly protein 1-like 1 0.0570977
RICTOR RPTOR independent companion of MTOR, complex 2 0.0548701
RNF145 ring finger protein 145 0.054214
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0534826
SOD2 superoxide dismutase 2, mitochondrial 0.0530521
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0509406
SEC23A Sec23 homolog A (S. cerevisiae) 0.0509331
PTK2 protein tyrosine kinase 2 0.0485912
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0465466
HELZ helicase with zinc finger 0.0465318
SPAG9 sperm associated antigen 9 0.0464996
SMAD3 SMAD family member 3 0.0463736
EPS8 epidermal growth factor receptor pathway substrate 8 0.0460667
WAC WW domain containing adaptor with coiled-coil 0.04523
RBM39 RNA binding motif protein 39 0.0452163
ZNF292 zinc finger protein 292 0.0445501
MCTP2 multiple C2 domains, transmembrane 2 0.0445467
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0444972
ETNK1 ethanolamine kinase 1 0.0444089
MARCHF6 membrane associated ring-CH-type finger 6 0.0442477
TFG TRK-fused gene 0.0436328
RAD21 RAD21 homolog (S. pombe) 0.0433448
CEP350 centrosomal protein 350kDa 0.0413186
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0409994
KDM3A lysine (K)-specific demethylase 3A 0.0409948
BIRC3 baculoviral IAP repeat containing 3 0.0406125
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0404917
GOLGA4 golgin A4 0.0402427
TFPI2 tissue factor pathway inhibitor 2 0.0396876
TENT2 terminal nucleotidyltransferase 2 0.0395747
CDC73 cell division cycle 73 0.0391907
RUNX2 runt-related transcription factor 2 0.0391715
FNBP1 formin binding protein 1 0.039135
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0389262
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0386296
SLTM SAFB-like, transcription modulator 0.0385054
NRIP1 nuclear receptor interacting protein 1 0.0382365
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0379828
SFXN1 sideroflexin 1 0.0379188
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0371407
SUCO SUN domain containing ossification factor 0.0360266
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0357796
YME1L1 YME1-like 1 ATPase 0.034582
PNISR PNN-interacting serine/arginine-rich protein 0.0341236
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0334356
NPEPPS aminopeptidase puromycin sensitive 0.0328389
DST dystonin 0.0324569
COPA coatomer protein complex, subunit alpha 0.0322527
NUP58 nucleoporin 58 0.0322368
AFDN afadin, adherens junction formation factor 0.0320964
ARID4B AT rich interactive domain 4B (RBP1-like) 0.032021
SOS1 son of sevenless homolog 1 (Drosophila) 0.0319521
BZW1 basic leucine zipper and W2 domains 1 0.0318887
TMEM165 transmembrane protein 165 0.0317604
FTH1 ferritin, heavy polypeptide 1 0.0312976
ELL2 elongation factor, RNA polymerase II, 2 0.031062
EREG epiregulin 0.031033
TM9SF3 transmembrane 9 superfamily member 3 0.0307535
XPO1 exportin 1 0.030729
RAB8B RAB8B, member RAS oncogene family 0.0306021
IRAK3 interleukin-1 receptor-associated kinase 3 0.0302818
PTMA prothymosin, alpha 0.0299417
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0298884
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0298656
KDM6A lysine (K)-specific demethylase 6A 0.029798
COG5 component of oligomeric golgi complex 5 0.0297195
PLIN2 perilipin 2 0.0295275
RAB2A RAB2A, member RAS oncogene family 0.0291843
SMOX spermine oxidase 0.0290507
CENPF centromere protein F, 350/400kDa 0.0288055
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.028699
RB1CC1 RB1-inducible coiled-coil 1 0.0285102
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0283083
KMT2C lysine (K)-specific methyltransferase 2C 0.0282229
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.028138
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0280766
ZMYM2 zinc finger, MYM-type 2 0.027744
RANBP2 RAN binding protein 2 0.0276582
APLP2 amyloid beta (A4) precursor-like protein 2 0.0275892
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0275804

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.288668
MT2A metallothionein 2A -0.142577
NRG1 neuregulin 1 -0.124809
NDRG1 N-myc downstream regulated 1 -0.0926135
TMSB10 thymosin beta 10 -0.0883256
FTL ferritin, light polypeptide -0.0814459
HMGA2 high mobility group AT-hook 2 -0.05396
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0514178
POTEF POTE ankyrin domain family, member F -0.0485345
ENO2 enolase 2 (gamma, neuronal) -0.0462374
EGR1 early growth response 1 -0.0441543
ZSWIM6 zinc finger, SWIM-type containing 6 -0.042356
SYT1 synaptotagmin I -0.0420526
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.041957
INTS6 integrator complex subunit 6 -0.0404407
SLC38A2 solute carrier family 38, member 2 -0.0401716
HMGA1 high mobility group AT-hook 1 -0.039183
ACTG1 actin gamma 1 -0.0381737
MRPS6 mitochondrial ribosomal protein S6 -0.03629
EFNA5 ephrin-A5 -0.0347115
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0346138
RPL35A ribosomal protein L35a -0.0343633
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0314117
MAP1B microtubule-associated protein 1B -0.0312958
RPLP1 ribosomal protein, large, P1 -0.0308315
AEBP2 AE binding protein 2 -0.0304161
RPS6 ribosomal protein S6 -0.0302408
EXT1 exostosin glycosyltransferase 1 -0.0302111
MCL1 myeloid cell leukemia 1 -0.0300885
PALLD palladin, cytoskeletal associated protein -0.0298202
RPS19 ribosomal protein S19 -0.0295259
TGFB1 transforming growth factor, beta 1 -0.0289246
RPL37A ribosomal protein L37a -0.0286535
RASAL2 RAS protein activator like 2 -0.0281206
RPS11 ribosomal protein S11 -0.0271213
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0269178
RPL28 ribosomal protein L28 -0.0267214
EGFR epidermal growth factor receptor -0.026623
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0264759
FN1 fibronectin 1 -0.0263905
IFI6 interferon, alpha-inducible protein 6 -0.0258116
SOX4 SRY (sex determining region Y)-box 4 -0.0253309
RPLP2 ribosomal protein, large, P2 -0.0250502
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0249774
RANBP17 RAN binding protein 17 -0.0248971
LIMCH1 LIM and calponin homology domains 1 -0.0244632
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.024159
NTN4 netrin 4 -0.0241145
RPS8 ribosomal protein S8 -0.0238514
RPL9 ribosomal protein L9 -0.0235932
LOC102724023 ES1 protein homolog, mitochondrial -0.023206
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0231286
GLIS3 GLIS family zinc finger 3 -0.0220219
RPS15 ribosomal protein S15 -0.0216459
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0215105
RPS29 ribosomal protein S29 -0.0214028
RPS23 ribosomal protein S23 -0.0211291
CCSER1 coiled-coil serine-rich protein 1 -0.0209342
ATP5F1B ATP synthase F1 subunit beta -0.0207668
RPL36 ribosomal protein L36 -0.0206284
STC2 stanniocalcin 2 -0.0204324
ABR active BCR-related -0.0203705
IER3 immediate early response 3 -0.0201519
BICD1 bicaudal D homolog 1 (Drosophila) -0.0200298
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0199155
NALF1 NALCN channel auxiliary factor 1 -0.0196188
NABP1 nucleic acid binding protein 1 -0.0195331
LMNA lamin A/C -0.0194385
PKM pyruvate kinase, muscle -0.0192643
WSB1 WD repeat and SOCS box containing 1 -0.0191075
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0189097
VCL vinculin -0.0188755
AUTS2 autism susceptibility candidate 2 -0.0187596
TSC22D1 TSC22 domain family, member 1 -0.0187465
DUSP6 dual specificity phosphatase 6 -0.0186184
RPL23 ribosomal protein L23 -0.0185001
LRRC23 leucine rich repeat containing 23 -0.0184561
CCND1 cyclin D1 -0.0181817
MT1X metallothionein 1X -0.0180665
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0180179
FOSL1 FOS-like antigen 1 -0.0178927
BRD2 bromodomain containing 2 -0.0177264
RPL32 ribosomal protein L32 -0.0176545
RPL31 ribosomal protein L31 -0.0175975
RPL7A ribosomal protein L7a -0.0175255
UBASH3B ubiquitin associated and SH3 domain containing B -0.0175113
GNAS GNAS complex locus -0.0174198
RPS14 ribosomal protein S14 -0.0173945
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0173222
PFN1 profilin 1 -0.0172776
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -0.0172495
RPS16 ribosomal protein S16 -0.0171276
ATN1 atrophin 1 -0.0170072
S100A9 S100 calcium binding protein A9 -0.0167385
KDM4C lysine (K)-specific demethylase 4C -0.0166566
IGF2 insulin-like growth factor 2 -0.016626
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0166061
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0165323
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0165258
SPDYA speedy/RINGO cell cycle regulator family member A -0.0164842