Limb Ischemia Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C2945695
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Genes

158 genes associated with the disease Limb Ischemia in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACKR3 atypical chemokine receptor 3
ACOT7 acyl-CoA thioesterase 7
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTBL2 actin, beta-like 2
ACTG1 actin gamma 1
ACTG2 actin, gamma 2, smooth muscle, enteric
AGER advanced glycosylation end product-specific receptor
AGGF1 angiogenic factor with G patch and FHA domains 1
AIF1 allograft inflammatory factor 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALOX15 arachidonate 15-lipoxygenase
ANGPT1 angiopoietin 1
ANGPTL6 angiopoietin-like 6
APC adenomatous polyposis coli
APOE apolipoprotein E
ATN1 atrophin 1
ATOX1 antioxidant 1 copper chaperone
ATXN1 ataxin 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BDNF brain-derived neurotrophic factor
BEST1 bestrophin 1
BGN biglycan
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CAMP cathelicidin antimicrobial peptide
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CD34 CD34 molecule
CDK9 cyclin-dependent kinase 9
CHRM3 cholinergic receptor, muscarinic 3
CLCN3 chloride channel, voltage-sensitive 3
COL18A1 collagen, type XVIII, alpha 1
CUX1 cut-like homeobox 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40
DUSP5 dual specificity phosphatase 5
EDIL3 EGF-like repeats and discoidin I-like domains 3
EDN1 endothelin 1
EFNB2 ephrin-B2
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF3E eukaryotic translation initiation factor 3, subunit E
EPAS1 endothelial PAS domain protein 1
EPHB4 EPH receptor B4
EPO erythropoietin
ESM1 endothelial cell-specific molecule 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FAM3A family with sequence similarity 3, member A
FGF1 fibroblast growth factor 1 (acidic)
FGF13 fibroblast growth factor 13
FGF2 fibroblast growth factor 2 (basic)
FGFR1 fibroblast growth factor receptor 1
FHL5 four and a half LIM domains 5
FSTL3 follistatin-like 3 (secreted glycoprotein)
FURIN furin (paired basic amino acid cleaving enzyme)
FXYD5 FXYD domain containing ion transport regulator 5
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GDE1 glycerophosphodiester phosphodiesterase 1
GDF11 growth differentiation factor 11
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPI glucose-6-phosphate isomerase
GRK2 G protein-coupled receptor kinase 2
HABP2 hyaluronan binding protein 2
HCLS1 hematopoietic cell-specific Lyn substrate 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10 interleukin 10
IL1B interleukin 1, beta
IL2RB interleukin 2 receptor, beta
IL6 interleukin 6
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB5 integrin, beta 5
KDR kinase insert domain receptor
KHSRP KH-type splicing regulatory protein
KLF2 Kruppel-like factor 2
KLK1 kallikrein 1
LEP leptin
LEPR leptin receptor
LOC105371045 uncharacterized LOC105371045
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MEF2A myocyte enhancer factor 2A
MOK MOK protein kinase
MPO myeloperoxidase
MSC musculin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYD88 myeloid differentiation primary response 88
NAP1L4 nucleosome assembly protein 1-like 4
NEUROG1 neurogenin 1
NFE2L2 nuclear factor, erythroid 2-like 2
NGF nerve growth factor (beta polypeptide)
NLRP1 NLR family, pyrin domain containing 1
NLRP3 NLR family, pyrin domain containing 3
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPB natriuretic peptide B
NPR1 natriuretic peptide receptor 1
NTF3 neurotrophin 3
NTSR1 neurotensin receptor 1 (high affinity)
OGN osteoglycin
PADI4 peptidyl arginine deiminase, type IV
PEAR1 platelet endothelial aggregation receptor 1
PEX2 peroxisomal biogenesis factor 2
PGPEP1 pyroglutamyl-peptidase I
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLAU plasminogen activator, urokinase
POTEM POTE ankyrin domain family, member M
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRAP1 proline-rich acidic protein 1
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PROK2 prokineticin 2
PSIP1 PC4 and SFRS1 interacting protein 1
QKI QKI, KH domain containing, RNA binding
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RBBP6 retinoblastoma binding protein 6
S100A1 S100 calcium binding protein A1
SCG2 secretogranin II
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SIGLEC5 sialic acid binding Ig-like lectin 5
SIGLEC7 sialic acid binding Ig-like lectin 7
SOAT1 sterol O-acyltransferase 1
SPP1 secreted phosphoprotein 1
SPRTN SprT-like N-terminal domain
TACR1 tachykinin receptor 1
TCF3 transcription factor 3
TEK TEK tyrosine kinase, endothelial
TFRC transferrin receptor
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TRERF1 transcriptional regulating factor 1
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TSPO translocator protein (18kDa)
TXNIP thioredoxin interacting protein
VCAN versican
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VWF von Willebrand factor
ZNF415 zinc finger protein 415