| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/10096344 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Linagliptin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC26A11 | solute carrier family 26 (anion exchanger), member 11 | 1.44 |
| RGN | regucalcin | 1.39 |
| MYO15A | myosin XVA | 1.35 |
| ZG16B | zymogen granule protein 16B | 1.28 |
| DES | desmin | 1.11 |
| SETDB2 | SET domain, bifurcated 2 | 1.07 |
| DIPK1B | divergent protein kinase domain 1B | 0.96 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.86 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 0.8 |
| ENO1 | enolase 1, (alpha) | 0.66 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.62 |
| HSP90AB3P | heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene | 0.6 |
| ZUP1 | zinc finger containing ubiquitin peptidase 1 | 0.59 |
| TPM2 | tropomyosin 2 (beta) | 0.53 |
| MOCOS | molybdenum cofactor sulfurase | 0.53 |
| PPCDC | phosphopantothenoylcysteine decarboxylase | 0.52 |
| TAF1L | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like | 0.49 |
| TSPAN3 | tetraspanin 3 | 0.49 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.47 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.46 |
| AP5S1 | adaptor-related protein complex 5, sigma 1 subunit | 0.44 |
| NCKAP5L | NCK-associated protein 5-like | 0.42 |
| CACNA1E | calcium channel, voltage-dependent, R type, alpha 1E subunit | 0.41 |
| PIP4P2 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | 0.41 |
| NAF1 | nuclear assembly factor 1 ribonucleoprotein | 0.4 |
| RNF111 | ring finger protein 111 | 0.39 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.39 |
| MMADHC | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria | 0.39 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.39 |
| LRRC49 | leucine rich repeat containing 49 | 0.39 |
| TMEM184B | transmembrane protein 184B | 0.38 |
| DSCAM | Down syndrome cell adhesion molecule | 0.38 |
| SGMS1 | sphingomyelin synthase 1 | 0.38 |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.38 |
| RAB26 | RAB26, member RAS oncogene family | 0.36 |
| FTL | ferritin, light polypeptide | 0.36 |
| PRKCH | protein kinase C, eta | 0.36 |
| LSM10 | LSM10, U7 small nuclear RNA associated | 0.36 |
| CYBRD1 | cytochrome b reductase 1 | 0.35 |
| AGFG2 | ArfGAP with FG repeats 2 | 0.35 |
| ATMIN | ATM interactor | 0.35 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | 0.35 |
| ZNF696 | zinc finger protein 696 | 0.34 |
| ZNF511 | zinc finger protein 511 | 0.34 |
| ASB13 | ankyrin repeat and SOCS box containing 13 | 0.34 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.34 |
| GLT8D2 | glycosyltransferase 8 domain containing 2 | 0.34 |
| RNF13 | ring finger protein 13 | 0.34 |
| PROSER3 | proline and serine rich 3 | 0.33 |
| HAS3 | hyaluronan synthase 3 | 0.33 |
| CARD10 | caspase recruitment domain family, member 10 | 0.33 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.33 |
| GK5 | glycerol kinase 5 (putative) | 0.33 |
| SET | SET nuclear proto-oncogene | 0.32 |
| NHSL1 | NHS-like 1 | 0.32 |
| GPN3 | GPN-loop GTPase 3 | 0.32 |
| C19ORF25 | chromosome 19 open reading frame 25 | 0.31 |
| FBXO42 | F-box protein 42 | 0.31 |
| ANKS6 | ankyrin repeat and sterile alpha motif domain containing 6 | 0.31 |
| CDX2 | caudal type homeobox 2 | 0.3 |
| LRRC45 | leucine rich repeat containing 45 | 0.3 |
| ZNF444 | zinc finger protein 444 | 0.3 |
| C16ORF72 | chromosome 16 open reading frame 72 | 0.3 |
| UNC13A | unc-13 homolog A (C. elegans) | 0.29 |
| COL13A1 | collagen, type XIII, alpha 1 | 0.29 |
| CDC42EP1 | CDC42 effector protein (Rho GTPase binding) 1 | 0.29 |
| ZC3H12A | zinc finger CCCH-type containing 12A | 0.29 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.29 |
| KCTD21 | potassium channel tetramerization domain containing 21 | 0.29 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.29 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | 0.29 |
| RASSF5 | Ras association (RalGDS/AF-6) domain family member 5 | 0.28 |
| AUNIP | aurora kinase A and ninein interacting protein | 0.28 |
| PALB2 | partner and localizer of BRCA2 | 0.28 |
| SGSM3 | small G protein signaling modulator 3 | 0.28 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | 0.28 |
| MPZL2 | myelin protein zero-like 2 | 0.28 |
| PRAME | preferentially expressed antigen in melanoma | 0.28 |
| ZNF775 | zinc finger protein 775 | 0.28 |
| AAMP | angio-associated, migratory cell protein | 0.28 |
| IL13RA1 | interleukin 13 receptor, alpha 1 | 0.27 |
| ALOXE3 | arachidonate lipoxygenase 3 | 0.27 |
| REEP1 | receptor accessory protein 1 | 0.27 |
| TAF11 | TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa | 0.27 |
| DST | dystonin | 0.27 |
| CENPJ | centromere protein J | 0.27 |
| ZNF593 | zinc finger protein 593 | 0.27 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.27 |
| AASS | aminoadipate-semialdehyde synthase | 0.27 |
| SH2B3 | SH2B adaptor protein 3 | 0.27 |
| ILF2 | interleukin enhancer binding factor 2 | 0.27 |
| PES1 | pescadillo ribosomal biogenesis factor 1 | 0.26 |
| ARMC7 | armadillo repeat containing 7 | 0.26 |
| CHKA | choline kinase alpha | 0.26 |
| FAM161A | family with sequence similarity 161, member A | 0.26 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | 0.26 |
| KIF3B | kinesin family member 3B | 0.26 |
| FAR1 | fatty acyl CoA reductase 1 | 0.26 |
| FAM110A | family with sequence similarity 110, member A | 0.26 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HELQ | helicase, POLQ-like | -3.65 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | -0.7 |
| DMD | dystrophin | -0.66 |
| SNRNP35 | small nuclear ribonucleoprotein 35kDa (U11/U12) | -0.57 |
| CCDC102A | coiled-coil domain containing 102A | -0.55 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.52 |
| HBA1 | hemoglobin, alpha 1 | -0.51 |
| B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | -0.51 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | -0.48 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | -0.48 |
| TMEM179B | transmembrane protein 179B | -0.47 |
| LMX1B | LIM homeobox transcription factor 1, beta | -0.46 |
| CLTCL1 | clathrin, heavy chain-like 1 | -0.45 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | -0.45 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.45 |
| FHIT | fragile histidine triad | -0.44 |
| TBC1D7 | TBC1 domain family, member 7 | -0.43 |
| CCDC158 | coiled-coil domain containing 158 | -0.42 |
| SLC25A44 | solute carrier family 25, member 44 | -0.41 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.4 |
| MARCKSL1 | MARCKS-like 1 | -0.39 |
| CENPK | centromere protein K | -0.38 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.38 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | -0.37 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | -0.37 |
| KIAA0586 | KIAA0586 | -0.37 |
| MBP | myelin basic protein | -0.37 |
| CES3 | carboxylesterase 3 | -0.36 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.35 |
| CNTNAP1 | contactin associated protein 1 | -0.35 |
| CRIP2 | cysteine-rich protein 2 | -0.34 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.34 |
| TMEM159 | transmembrane protein 159 | -0.34 |
| MEST | mesoderm specific transcript | -0.34 |
| DAP | death-associated protein | -0.34 |
| SESN1 | sestrin 1 | -0.33 |
| AMDHD1 | amidohydrolase domain containing 1 | -0.33 |
| AFG1L | AFG1 like ATPase | -0.33 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.33 |
| MTSS2 | MTSS I-BAR domain containing 2 | -0.33 |
| GRTP1 | growth hormone regulated TBC protein 1 | -0.33 |
| HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 | -0.33 |
| SPHK2 | sphingosine kinase 2 | -0.32 |
| EED | embryonic ectoderm development | -0.32 |
| PUM2 | pumilio RNA-binding family member 2 | -0.32 |
| TMEM41B | transmembrane protein 41B | -0.32 |
| KLC3 | kinesin light chain 3 | -0.31 |
| GLI4 | GLI family zinc finger 4 | -0.3 |
| SLC35F3 | solute carrier family 35, member F3 | -0.3 |
| RIN3 | Ras and Rab interactor 3 | -0.3 |
| CECR2 | cat eye syndrome chromosome region, candidate 2 | -0.3 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.3 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.29 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | -0.29 |
| S100A5 | S100 calcium binding protein A5 | -0.29 |
| LARGE2 | LARGE xylosyl- and glucuronyltransferase 2 | -0.29 |
| METTL22 | methyltransferase like 22 | -0.29 |
| ALG6 | ALG6, alpha-1,3-glucosyltransferase | -0.29 |
| METTL7A | methyltransferase like 7A | -0.28 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.28 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.28 |
| ATP1A1 | ATPase, Na+/K+ transporting, alpha 1 polypeptide | -0.28 |
| MEGF8 | multiple EGF-like-domains 8 | -0.28 |
| SLC38A5 | solute carrier family 38, member 5 | -0.27 |
| SON | SON DNA binding protein | -0.27 |
| ZNF672 | zinc finger protein 672 | -0.27 |
| ACSM3 | acyl-CoA synthetase medium-chain family member 3 | -0.27 |
| ZC3H6 | zinc finger CCCH-type containing 6 | -0.27 |
| SLC16A6 | solute carrier family 16, member 6 | -0.27 |
| PUS10 | pseudouridylate synthase 10 | -0.27 |
| RNASET2 | ribonuclease T2 | -0.27 |
| HECA | headcase homolog (Drosophila) | -0.27 |
| VTN | vitronectin | -0.26 |
| GLRX | glutaredoxin (thioltransferase) | -0.26 |
| HTD2 | hydroxyacyl-thioester dehydratase type 2 | -0.26 |
| ENSA | endosulfine alpha | -0.26 |
| CDIPT | CDP-diacylglycerol--inositol 3-phosphatidyltransferase | -0.26 |
| SIMC1 | SUMO-interacting motifs containing 1 | -0.26 |
| SERINC5 | serine incorporator 5 | -0.26 |
| ADGRE2 | adhesion G protein-coupled receptor E2 | -0.26 |
| CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa | -0.26 |
| TNNI3 | troponin I type 3 (cardiac) | -0.26 |
| CYLD | cylindromatosis (turban tumor syndrome) | -0.25 |
| PRMT2 | protein arginine methyltransferase 2 | -0.25 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.25 |
| TMUB1 | transmembrane and ubiquitin-like domain containing 1 | -0.25 |
| BRD7 | bromodomain containing 7 | -0.25 |
| C2ORF76 | chromosome 2 open reading frame 76 | -0.24 |
| PLPP6 | phospholipid phosphatase 6 | -0.24 |
| BCAM | basal cell adhesion molecule (Lutheran blood group) | -0.24 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.24 |
| ADIRF | adipogenesis regulatory factor | -0.24 |
| CYB5D2 | cytochrome b5 domain containing 2 | -0.24 |
| PKHD1 | polycystic kidney and hepatic disease 1 (autosomal recessive) | -0.24 |
| APOE | apolipoprotein E | -0.24 |
| FBXL16 | F-box and leucine-rich repeat protein 16 | -0.24 |
| BCL6 | B-cell CLL/lymphoma 6 | -0.23 |
| FAM219B | family with sequence similarity 219, member B | -0.23 |
| ERH | enhancer of rudimentary homolog (Drosophila) | -0.23 |
| ABCC10 | ATP-binding cassette, sub-family C (CFTR/MRP), member 10 | -0.23 |
