| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lipoic acid perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lipoic acid_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0854154 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0696357 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0624249 |
| GLIS3 | GLIS family zinc finger 3 | 0.0475473 |
| MSN | moesin | 0.0392689 |
| FAT1 | FAT atypical cadherin 1 | 0.039056 |
| VEGFA | vascular endothelial growth factor A | 0.0369577 |
| TXNRD1 | thioredoxin reductase 1 | 0.0346406 |
| NRP2 | neuropilin 2 | 0.0342118 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0332046 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0320007 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0317324 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0305032 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0303455 |
| SEPTIN9 | septin 9 | 0.0296514 |
| TRAM1 | translocation associated membrane protein 1 | 0.0290233 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0289798 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0282046 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.027242 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0268793 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0265632 |
| RAI14 | retinoic acid induced 14 | 0.0265152 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0256771 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0255564 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0255251 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0253022 |
| TGM2 | transglutaminase 2 | 0.0248852 |
| IFI44L | interferon-induced protein 44-like | 0.0243778 |
| HPCAL1 | hippocalcin-like 1 | 0.0243685 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | 0.0242684 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0241673 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.0238096 |
| PTK2 | protein tyrosine kinase 2 | 0.0236192 |
| GPC6 | glypican 6 | 0.0234486 |
| METTL15 | methyltransferase like 15 | 0.0234391 |
| DIAPH3 | diaphanous-related formin 3 | 0.0230313 |
| PAX8 | paired box 8 | 0.0228357 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0223486 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0220776 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0220067 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0217155 |
| SMAD3 | SMAD family member 3 | 0.0216836 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0216651 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0216133 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0215881 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0215347 |
| USP47 | ubiquitin specific peptidase 47 | 0.0213103 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0208027 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0207179 |
| EHBP1 | EH domain binding protein 1 | 0.0206841 |
| NRP1 | neuropilin 1 | 0.0202685 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0201634 |
| SLTM | SAFB-like, transcription modulator | 0.019986 |
| ERBIN | erbb2 interacting protein | 0.0194377 |
| TGFB2 | transforming growth factor, beta 2 | 0.019418 |
| OPTN | optineurin | 0.0192453 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0191363 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0189091 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.018904 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | 0.018778 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0185806 |
| CPAP | centrosome assembly and centriole elongation protein | 0.0182986 |
| MKI67 | marker of proliferation Ki-67 | 0.0182317 |
| PFN1 | profilin 1 | 0.0180726 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0176852 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0176594 |
| MSR1 | macrophage scavenger receptor 1 | 0.0175848 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0175248 |
| CTBP2 | C-terminal binding protein 2 | 0.0172898 |
| EGFR | epidermal growth factor receptor | 0.0172796 |
| NUP58 | nucleoporin 58 | 0.0171171 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.0171102 |
| GOLGA4 | golgin A4 | 0.0170159 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0169943 |
| MSH6 | mutS homolog 6 | 0.0169665 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0169132 |
| COPA | coatomer protein complex, subunit alpha | 0.0168885 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0168679 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0168416 |
| PGM3 | phosphoglucomutase 3 | 0.0168059 |
| HOMER2 | homer scaffolding protein 2 | 0.0164852 |
| ITGAV | integrin, alpha V | 0.0164355 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0163714 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.016336 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.0163151 |
| JAK1 | Janus kinase 1 | 0.0162837 |
| WASL | Wiskott-Aldrich syndrome-like | 0.0160754 |
| MAP1B | microtubule-associated protein 1B | 0.0160093 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.0159815 |
| ASPH | aspartate beta-hydroxylase | 0.0159621 |
| CLTC | clathrin, heavy chain (Hc) | 0.0158753 |
| PFKP | phosphofructokinase, platelet | 0.0155742 |
| UBN2 | ubinuclein 2 | 0.0154787 |
| FAM3C | family with sequence similarity 3, member C | 0.0153958 |
| EFNA5 | ephrin-A5 | 0.0153908 |
| SMC5 | structural maintenance of chromosomes 5 | 0.0153856 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0153259 |
| TUSC3 | tumor suppressor candidate 3 | 0.0152959 |
| MKRN1 | makorin ring finger protein 1 | 0.0152566 |
| TGFA | transforming growth factor, alpha | 0.0152296 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.216489 |
| TMSB10 | thymosin beta 10 | -0.161279 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.115814 |
| UBC | ubiquitin C | -0.101399 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0943544 |
| RPS27A | ribosomal protein S27a | -0.087642 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.081031 |
| HLA-B | major histocompatibility complex, class I, B | -0.0809852 |
| PTMA | prothymosin, alpha | -0.0768852 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0760088 |
| CP | ceruloplasmin (ferroxidase) | -0.0739509 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0711991 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0692826 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0649964 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0646079 |
| JUN | jun proto-oncogene | -0.0635064 |
| CALU | calumenin | -0.0599102 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.0593977 |
| RPL23 | ribosomal protein L23 | -0.0587964 |
| CAVIN1 | caveolae associated protein 1 | -0.0578131 |
| FTL | ferritin, light polypeptide | -0.0554673 |
| HLA-E | major histocompatibility complex, class I, E | -0.0536139 |
| AHNAK | AHNAK nucleoprotein | -0.0511085 |
| RRBP1 | ribosome binding protein 1 | -0.0510499 |
| APP | amyloid beta (A4) precursor protein | -0.0510359 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0507096 |
| S100A6 | S100 calcium binding protein A6 | -0.0496726 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0487087 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0484098 |
| TPM4 | tropomyosin 4 | -0.0478185 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.047079 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0437561 |
| G0S2 | G0/G1 switch 2 | -0.0434072 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0432496 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0423177 |
| ACTG1 | actin gamma 1 | -0.0423167 |
| RPS8 | ribosomal protein S8 | -0.0417 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0416333 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0411154 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0399343 |
| SDCBP | syndecan binding protein (syntenin) | -0.0396529 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0395658 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0393561 |
| RPL34 | ribosomal protein L34 | -0.0389401 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0388927 |
| RPL35A | ribosomal protein L35a | -0.0380769 |
| CALR | calreticulin | -0.03803 |
| RPS24 | ribosomal protein S24 | -0.0376543 |
| FRMD4A | FERM domain containing 4A | -0.0370185 |
| CD82 | CD82 molecule | -0.036931 |
| FAM107B | family with sequence similarity 107, member B | -0.0368428 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0360159 |
| GNAS | GNAS complex locus | -0.0357719 |
| MT2A | metallothionein 2A | -0.0357085 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0351179 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0349721 |
| S100A10 | S100 calcium binding protein A10 | -0.0348634 |
| RPL37A | ribosomal protein L37a | -0.0340609 |
| STK17A | serine/threonine kinase 17a | -0.0338896 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0335073 |
| CD63 | CD63 molecule | -0.033414 |
| RPL19 | ribosomal protein L19 | -0.033333 |
| RPLP1 | ribosomal protein, large, P1 | -0.0333083 |
| RPL31 | ribosomal protein L31 | -0.0331272 |
| HLA-C | major histocompatibility complex, class I, C | -0.0331126 |
| CANX | calnexin | -0.0329163 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.0324771 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0323721 |
| ENO1 | enolase 1, (alpha) | -0.0321394 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0321161 |
| RPL9 | ribosomal protein L9 | -0.0317277 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0317029 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0316937 |
| RPLP2 | ribosomal protein, large, P2 | -0.0315821 |
| LAMB3 | laminin, beta 3 | -0.0307855 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0307805 |
| SEPTIN7 | septin 7 | -0.030511 |
| FUS | FUS RNA binding protein | -0.0305077 |
| LMNA | lamin A/C | -0.0304995 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0300793 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0300208 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0300179 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0294463 |
| CADM1 | cell adhesion molecule 1 | -0.0292808 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0292278 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.029171 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0291205 |
| RPLP0 | ribosomal protein, large, P0 | -0.0289926 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0284034 |
| RPL26 | ribosomal protein L26 | -0.0279432 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0277155 |
| HMGB1 | high mobility group box 1 | -0.0274803 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.0274668 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0273976 |
| ADM | adrenomedullin | -0.0271289 |
| PLIN2 | perilipin 2 | -0.0270821 |
| TPM1 | tropomyosin 1 (alpha) | -0.0270044 |
| RPL30 | ribosomal protein L30 | -0.0267726 |
| NDRG1 | N-myc downstream regulated 1 | -0.0266918 |
| MMP7 | matrix metallopeptidase 7 | -0.0264511 |
