Lipoic acid_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lipoic acid perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lipoic acid_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.102212
PDE4D phosphodiesterase 4D, cAMP-specific 0.0997718
ZSWIM6 zinc finger, SWIM-type containing 6 0.092222
EGFR epidermal growth factor receptor 0.083494
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0831316
INTS6 integrator complex subunit 6 0.0739991
EFNA5 ephrin-A5 0.072728
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0666195
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0637739
DOCK5 dedicator of cytokinesis 5 0.063495
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0632924
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0612342
MCL1 myeloid cell leukemia 1 0.0549264
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0533188
GOLGB1 golgin B1 0.0528478
AUTS2 autism susceptibility candidate 2 0.0525691
MAML3 mastermind-like 3 (Drosophila) 0.0495866
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0495137
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0492583
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0473872
ZCCHC7 zinc finger, CCHC domain containing 7 0.0466939
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0465933
AADAC arylacetamide deacetylase 0.0464167
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0441616
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0436189
PDLIM5 PDZ and LIM domain 5 0.0429481
HMGA2 high mobility group AT-hook 2 0.0425917
SAMD4A sterile alpha motif domain containing 4A 0.04204
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0413294
ALCAM activated leukocyte cell adhesion molecule 0.0395024
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0379996
THSD4 thrombospondin, type I, domain containing 4 0.037295
SP100 SP100 nuclear antigen 0.0364414
CTBP2 C-terminal binding protein 2 0.0359495
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 0.0355984
VCL vinculin 0.03543
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0352318
ZBTB20 zinc finger and BTB domain containing 20 0.0349021
MED13 mediator complex subunit 13 0.0338585
EPAS1 endothelial PAS domain protein 1 0.0332782
FNIP1 folliculin interacting protein 1 0.0326619
AKAP13 A kinase (PRKA) anchor protein 13 0.0323463
IGFBP3 insulin-like growth factor binding protein 3 0.0318781
RHCG Rh family, C glycoprotein 0.0317113
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0314876
PKM pyruvate kinase, muscle 0.0309978
USP47 ubiquitin specific peptidase 47 0.0307772
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0295244
FBXO11 F-box protein 11 0.0294301
PALLD palladin, cytoskeletal associated protein 0.0294054
VMP1 vacuole membrane protein 1 0.0290242
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0289164
UBASH3B ubiquitin associated and SH3 domain containing B 0.028913
PRKCA protein kinase C, alpha 0.0287393
LMO7 LIM domain 7 0.0287193
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0286302
LDHA lactate dehydrogenase A 0.0284675
CUX1 cut-like homeobox 1 0.0282431
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0282269
RAD51B RAD51 paralog B 0.0282158
AKAP9 A kinase (PRKA) anchor protein 9 0.0280875
NDRG1 N-myc downstream regulated 1 0.027882
NLK nemo-like kinase 0.0276819
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0275583
TNS1 tensin 1 0.027294
POTEF POTE ankyrin domain family, member F 0.027048
GPATCH2L G patch domain containing 2-like 0.0270054
SETX senataxin 0.0267943
PEAK1 pseudopodium-enriched atypical kinase 1 0.0265344
ZNF638 zinc finger protein 638 0.0257852
EXT1 exostosin glycosyltransferase 1 0.0256749
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0256662
WNK1 WNK lysine deficient protein kinase 1 0.0255717
MON2 MON2 homolog (S. cerevisiae) 0.0255163
FAT1 FAT atypical cadherin 1 0.0254132
MACF1 microtubule-actin crosslinking factor 1 0.0253828
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0253376
LIMCH1 LIM and calponin homology domains 1 0.0252731
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0251382
NABP1 nucleic acid binding protein 1 0.0251158
UBAP2 ubiquitin associated protein 2 0.0250518
CDK13 cyclin-dependent kinase 13 0.0248617
MSN moesin 0.0247172
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0246905
SVIL supervillin 0.0246664
RCOR1 REST corepressor 1 0.0244153
COPA coatomer protein complex, subunit alpha 0.024229
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0238766
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0235846
CREBBP CREB binding protein 0.0234013
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0229827
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.022884
RPS23 ribosomal protein S23 0.0228016
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0227416
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0226853
BPTF bromodomain PHD finger transcription factor 0.0226057
DUSP16 dual specificity phosphatase 16 0.0225305
PRKCE protein kinase C, epsilon 0.0222987
CSNK1A1 casein kinase 1, alpha 1 0.022292
ERBIN erbb2 interacting protein 0.0222655

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.122139
AKAP12 A kinase (PRKA) anchor protein 12 -0.0991509
MT2A metallothionein 2A -0.0970152
MT1X metallothionein 1X -0.0965974
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0848421
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0798044
USP3 ubiquitin specific peptidase 3 -0.0749884
NAMPT nicotinamide phosphoribosyltransferase -0.0738467
BASP1 brain abundant, membrane attached signal protein 1 -0.0659103
KCTD9 potassium channel tetramerization domain containing 9 -0.0637576
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0619379
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0609774
TXNRD1 thioredoxin reductase 1 -0.0594204
ARHGAP26 Rho GTPase activating protein 26 -0.0589227
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0543174
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0493119
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0474912
OSMR oncostatin M receptor -0.0472614
NCOA7 nuclear receptor coactivator 7 -0.0470537
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0467906
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0467251
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0463135
C15ORF48 chromosome 15 open reading frame 48 -0.0439341
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0434732
FTL ferritin, light polypeptide -0.0432491
PTMA prothymosin, alpha -0.0420559
TM4SF1 transmembrane 4 L six family member 1 -0.0419266
TKT transketolase -0.0418286
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0401057
IGFBP4 insulin-like growth factor binding protein 4 -0.0391743
PGK1 phosphoglycerate kinase 1 -0.0387085
DGKD diacylglycerol kinase, delta 130kDa -0.0367685
FNDC3B fibronectin type III domain containing 3B -0.0363238
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0360152
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0345566
VEZT vezatin, adherens junctions transmembrane protein -0.033663
RPL12 ribosomal protein L12 -0.0336002
RPLP0 ribosomal protein, large, P0 -0.0334583
RRBP1 ribosome binding protein 1 -0.0331952
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0328803
TMSB4X thymosin beta 4, X-linked -0.0327526
DENND4C DENN/MADD domain containing 4C -0.0327261
KDM3A lysine (K)-specific demethylase 3A -0.0327171
AGFG1 ArfGAP with FG repeats 1 -0.0325968
KLF6 Kruppel-like factor 6 -0.0323784
NPEPPS aminopeptidase puromycin sensitive -0.0321675
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.032028
HELZ helicase with zinc finger -0.0309694
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0309474
RTN4 reticulon 4 -0.0309398
S100A6 S100 calcium binding protein A6 -0.0302695
SPAG9 sperm associated antigen 9 -0.0302297
AKR1C2 aldo-keto reductase family 1, member C2 -0.029911
CA12 carbonic anhydrase XII -0.0297622
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0296624
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0292661
EIF1 eukaryotic translation initiation factor 1 -0.0291293
RPL32 ribosomal protein L32 -0.0282088
FAM107B family with sequence similarity 107, member B -0.0281314
EREG epiregulin -0.027646
NAP1L1 nucleosome assembly protein 1-like 1 -0.027635
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0275682
FTH1 ferritin, heavy polypeptide 1 -0.0272255
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0271438
SOD2 superoxide dismutase 2, mitochondrial -0.0270692
ARL5B ADP-ribosylation factor-like 5B -0.0269751
STC1 stanniocalcin 1 -0.026875
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0267442
EVA1C eva-1 homolog C (C. elegans) -0.0267405
RPS24 ribosomal protein S24 -0.0265909
RASA2 RAS p21 protein activator 2 -0.026174
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0256843
PTBP3 polypyrimidine tract binding protein 3 -0.0253498
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0250461
WDR45B WD repeat domain 45B -0.0249928
RB1CC1 RB1-inducible coiled-coil 1 -0.0248676
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0248632
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0247054
BMAL2 basic helix-loop-helix ARNT like 2 -0.0245809
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0244092
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0241049
AOPEP aminopeptidase O (putative) -0.0238548
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0236832
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0236711
RNF24 ring finger protein 24 -0.0233465
SSH1 slingshot protein phosphatase 1 -0.0233307
YBX3 Y box binding protein 3 -0.0231175
RPL26 ribosomal protein L26 -0.0227423
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.022668
OLA1 Obg-like ATPase 1 -0.0224613
NUP58 nucleoporin 58 -0.0224241
RPLP1 ribosomal protein, large, P1 -0.0223968
TRIO trio Rho guanine nucleotide exchange factor -0.0223076
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0221014
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0218061
NPC1 Niemann-Pick disease, type C1 -0.0217112
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0215606
BHLHE40 basic helix-loop-helix family, member e40 -0.0214931
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0214385
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0212306