Lipoic acid_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lipoic acid perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lipoic acid_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.10834
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.103889
BAIAP2L1 BAI1-associated protein 2-like 1 0.0836184
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0648684
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0644411
FMNL2 formin-like 2 0.0564438
EFNA5 ephrin-A5 0.0507043
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0491869
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0478803
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0473748
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0473604
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0462941
SAMD4A sterile alpha motif domain containing 4A 0.0451282
MCL1 myeloid cell leukemia 1 0.0446164
TRIO trio Rho guanine nucleotide exchange factor 0.0439378
INTS6 integrator complex subunit 6 0.0433356
PPARD peroxisome proliferator-activated receptor delta 0.0414284
TGM2 transglutaminase 2 0.0395182
SMAD3 SMAD family member 3 0.0387182
HMGA2 high mobility group AT-hook 2 0.0374156
POTEF POTE ankyrin domain family, member F 0.0372879
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0366009
ERBIN erbb2 interacting protein 0.0362355
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0348155
FNDC3B fibronectin type III domain containing 3B 0.034475
GRB10 growth factor receptor-bound protein 10 0.0336246
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0332493
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0312314
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0305965
NRIP1 nuclear receptor interacting protein 1 0.0304768
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0297712
BMP6 bone morphogenetic protein 6 0.029505
NDRG1 N-myc downstream regulated 1 0.0291065
CLMP CXADR-like membrane protein 0.0284891
ANKRD11 ankyrin repeat domain 11 0.0284203
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0283065
PLEC plectin 0.0280519
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0279315
HDAC9 histone deacetylase 9 0.0274009
APLP2 amyloid beta (A4) precursor-like protein 2 0.0269328
YAP1 Yes-associated protein 1 0.0264754
EXT1 exostosin glycosyltransferase 1 0.0263331
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0262803
GREB1L growth regulation by estrogen in breast cancer-like 0.0256487
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.025571
PDLIM5 PDZ and LIM domain 5 0.0253573
MSN moesin 0.025174
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0244922
RUNX1 runt-related transcription factor 1 0.0244442
TRRAP transformation/transcription domain-associated protein 0.0242724
MPRIP myosin phosphatase Rho interacting protein 0.0236314
MBNL1 muscleblind-like splicing regulator 1 0.0232227
CD44 CD44 molecule (Indian blood group) 0.0227799
KMT2E lysine (K)-specific methyltransferase 2E 0.0227695
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0227411
MOSMO modulator of smoothened 0.0227153
USP53 ubiquitin specific peptidase 53 0.0226206
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0224
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.022126
NCOR2 nuclear receptor corepressor 2 0.0220642
ABTB3 ankyrin repeat and BTB domain containing 3 0.0214586
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0213807
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0211635
GLS2 glutaminase 2 (liver, mitochondrial) 0.0208848
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.020815
THSD4 thrombospondin, type I, domain containing 4 0.0207371
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0206582
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0200578
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0198955
VEGFA vascular endothelial growth factor A 0.0190492
SETX senataxin 0.0190411
ATXN1 ataxin 1 0.019039
COPA coatomer protein complex, subunit alpha 0.0190277
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0190198
PCBP2 poly(rC) binding protein 2 0.0189762
SEPTIN9 septin 9 0.0189205
N4BP2L2 NEDD4 binding protein 2-like 2 0.0189193
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0188664
ANO6 anoctamin 6 0.0188321
CMIP c-Maf inducing protein 0.0186794
ZMIZ1 zinc finger, MIZ-type containing 1 0.018525
RBM39 RNA binding motif protein 39 0.0184738
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0182996
FTL ferritin, light polypeptide 0.0182875
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0181202
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0179677
AHRR aryl-hydrocarbon receptor repressor 0.0178071
RASAL2 RAS protein activator like 2 0.0177573
TTC3 tetratricopeptide repeat domain 3 0.0177264
PTK2 protein tyrosine kinase 2 0.0176655
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0175632
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0174996
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0174568
JARID2 jumonji, AT rich interactive domain 2 0.0173382
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0172571
EXOC6B exocyst complex component 6B 0.0172531
CAPRIN2 caprin family member 2 0.0170625
PSD3 pleckstrin and Sec7 domain containing 3 0.017029
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.016955
SVIL supervillin 0.0168045

decreased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 -0.196231
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.188639
TMSB10 thymosin beta 10 -0.120462
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.114528
TPT1 tumor protein, translationally-controlled 1 -0.113672
AKAP12 A kinase (PRKA) anchor protein 12 -0.1081
LMO7 LIM domain 7 -0.102536
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0824409
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.070589
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0688345
PGK1 phosphoglycerate kinase 1 -0.061952
S100A10 S100 calcium binding protein A10 -0.0614535
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0592825
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0579181
TM4SF1 transmembrane 4 L six family member 1 -0.0562326
DSG2 desmoglein 2 -0.0561987
SACK1A scaffolding CK1 anchoring protein A -0.0553711
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0539524
VIM vimentin -0.053415
UBC ubiquitin C -0.053246
LOC112694756 uncharaterized LOC112694756 -0.0502398
RPL12 ribosomal protein L12 -0.0482333
S100A6 S100 calcium binding protein A6 -0.0479248
CD59 CD59 molecule, complement regulatory protein -0.047388
RAD21 RAD21 homolog (S. pombe) -0.0468749
VCAN versican -0.0463073
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0462902
EZR ezrin -0.043918
KLF6 Kruppel-like factor 6 -0.0436122
B2M beta-2-microglobulin -0.0422574
BZW1 basic leucine zipper and W2 domains 1 -0.0418677
EMP1 epithelial membrane protein 1 -0.0414651
PTPRR protein tyrosine phosphatase, receptor type, R -0.0404052
TXNRD1 thioredoxin reductase 1 -0.0403205
CD2AP CD2-associated protein -0.0380072
LY6E lymphocyte antigen 6 complex, locus E -0.0369879
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0366812
S100A4 S100 calcium binding protein A4 -0.0366358
KLK10 kallikrein-related peptidase 10 -0.0361275
RPL34 ribosomal protein L34 -0.03566
RIOK3 RIO kinase 3 -0.0355358
F3 coagulation factor III (thromboplastin, tissue factor) -0.035526
MYL12B myosin, light chain 12B, regulatory -0.0354354
RPS24 ribosomal protein S24 -0.0344615
SDC4 syndecan 4 -0.033931
PLAUR plasminogen activator, urokinase receptor -0.0338478
GOLGA4 golgin A4 -0.0337152
FAM107B family with sequence similarity 107, member B -0.0336846
PTMA prothymosin, alpha -0.0334262
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0331777
RPL26 ribosomal protein L26 -0.0330863
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.032858
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0322682
RPS21 ribosomal protein S21 -0.0314141
GNAS GNAS complex locus -0.0304305
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0294872
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0294008
PRSS3 protease, serine, 3 -0.0292469
KDM3A lysine (K)-specific demethylase 3A -0.0290906
CALU calumenin -0.0288699
EPCAM epithelial cell adhesion molecule -0.0284702
PERP PERP, TP53 apoptosis effector -0.028366
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0282574
TMSB4X thymosin beta 4, X-linked -0.0265371
KRT18 keratin 18, type I -0.0265199
RPL30 ribosomal protein L30 -0.0264149
EIF1 eukaryotic translation initiation factor 1 -0.0261894
FTH1 ferritin, heavy polypeptide 1 -0.0260208
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0259928
SREK1IP1 SREK1-interacting protein 1 -0.0257271
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0256652
RPLP0 ribosomal protein, large, P0 -0.0255026
AHNAK AHNAK nucleoprotein -0.025462
HLA-E major histocompatibility complex, class I, E -0.0251187
TPM4 tropomyosin 4 -0.0250163
SP100 SP100 nuclear antigen -0.0248859
STAT1 signal transducer and activator of transcription 1, 91kDa -0.024539
UBE2B ubiquitin-conjugating enzyme E2B -0.0242038
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0241941
TMEM263 transmembrane protein 263 -0.0241452
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0239162
SQSTM1 sequestosome 1 -0.023595
RPL36A ribosomal protein L36a -0.0234889
ITPRID2 ITPR interacting domain containing 2 -0.0234523
RSL1D1 ribosomal L1 domain containing 1 -0.0234043
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0232739
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0229673
S100A11 S100 calcium binding protein A11 -0.0229623
MUC17 mucin 17, cell surface associated -0.0228662
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0228045
FLNB filamin B, beta -0.0222995
CD63 CD63 molecule -0.0219244
RPL8 ribosomal protein L8 -0.0219193
SMNDC1 survival motor neuron domain containing 1 -0.0216463
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.021526
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.021456
DSC3 desmocollin 3 -0.0214453
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0213192
AFF4 AF4/FMR2 family, member 4 -0.0212729
FERMT1 fermitin family member 1 -0.0209267