Lipoic acid_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lipoic acid perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lipoic acid_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.122894
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.119017
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.104681
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0982807
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0978704
KMT2C lysine (K)-specific methyltransferase 2C 0.0825516
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0758687
COL5A2 collagen, type V, alpha 2 0.0749336
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0696815
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0566439
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0547291
EEF2 eukaryotic translation elongation factor 2 0.0538774
DST dystonin 0.0524499
PCBP2 poly(rC) binding protein 2 0.0501038
LDHA lactate dehydrogenase A 0.0500366
NUP58 nucleoporin 58 0.0482674
PCM1 pericentriolar material 1 0.0461721
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0451082
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0446999
KMT2E lysine (K)-specific methyltransferase 2E 0.0404433
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0398999
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0398733
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0395799
HELZ helicase with zinc finger 0.0389317
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0377549
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0372624
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0371391
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0370804
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0370508
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0365651
FXR1 fragile X mental retardation, autosomal homolog 1 0.0364693
SFPQ splicing factor proline/glutamine-rich 0.0363918
AKAP9 A kinase (PRKA) anchor protein 9 0.0362334
CABIN1 calcineurin binding protein 1 0.0360584
KDM6A lysine (K)-specific demethylase 6A 0.0358728
PIAS2 protein inhibitor of activated STAT, 2 0.0354135
SIK3 SIK family kinase 3 0.0349244
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0340665
TOP2B topoisomerase (DNA) II beta 180kDa 0.0335982
BRWD1 bromodomain and WD repeat domain containing 1 0.0334933
ENO1 enolase 1, (alpha) 0.0332936
MACF1 microtubule-actin crosslinking factor 1 0.032942
JARID2 jumonji, AT rich interactive domain 2 0.0328764
BBX bobby sox homolog (Drosophila) 0.0327225
PDIA6 protein disulfide isomerase family A, member 6 0.0325503
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0323514
MKI67 marker of proliferation Ki-67 0.0322446
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0320854
PDIA3 protein disulfide isomerase family A, member 3 0.0319768
SERTAD2 SERTA domain containing 2 0.0319332
APLP2 amyloid beta (A4) precursor-like protein 2 0.0318707
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0317438
XPO1 exportin 1 0.0316869
KIF1B kinesin family member 1B 0.0313278
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0309764
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.03096
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.030584
ZCCHC7 zinc finger, CCHC domain containing 7 0.0303056
TOP2A topoisomerase (DNA) II alpha 170kDa 0.030102
PHIP pleckstrin homology domain interacting protein 0.0300901
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.030034
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0299776
KDM2A lysine (K)-specific demethylase 2A 0.0295885
HSPA8 heat shock 70kDa protein 8 0.029238
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0291641
SOX5 SRY (sex determining region Y)-box 5 0.0289635
GOLGA4 golgin A4 0.0288548
HELLS helicase, lymphoid-specific 0.0288006
TTC3 tetratricopeptide repeat domain 3 0.0287888
TAOK1 TAO kinase 1 0.0287374
GIGYF2 GRB10 interacting GYF protein 2 0.0285631
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0281699
ATRN attractin 0.0279571
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0279361
ZNF638 zinc finger protein 638 0.0276973
FAM168A family with sequence similarity 168, member A 0.0276034
ALKBH5 AlkB family member 5, RNA demethylase 0.02757
MYH10 myosin, heavy chain 10, non-muscle 0.0273047
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0272766
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0272728
UBA6 ubiquitin-like modifier activating enzyme 6 0.0271725
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.027153
KDM1A lysine (K)-specific demethylase 1A 0.0270851
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0269695
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0268601
RPL3 ribosomal protein L3 0.0268577
RCOR1 REST corepressor 1 0.0265041
CENPF centromere protein F, 350/400kDa 0.0264689
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0262264
BRD2 bromodomain containing 2 0.0261588
PDE7A phosphodiesterase 7A 0.0259732
MBNL1 muscleblind-like splicing regulator 1 0.0259118
DENND1A DENN/MADD domain containing 1A 0.0258957
SRRM2 serine/arginine repetitive matrix 2 0.0258231
YBX1 Y box binding protein 1 0.0257588
AUTS2 autism susceptibility candidate 2 0.0256839
UBAP2 ubiquitin associated protein 2 0.0256263
SRSF4 serine/arginine-rich splicing factor 4 0.0256118
CNOT1 CCR4-NOT transcription complex, subunit 1 0.025544
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0252102

decreased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B -0.136889
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.102142
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0949464
TENM3 teneurin transmembrane protein 3 -0.0901887
NPAS3 neuronal PAS domain protein 3 -0.0763431
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0583686
RPS24 ribosomal protein S24 -0.0578077
SOX4 SRY (sex determining region Y)-box 4 -0.0518234
PDE4D phosphodiesterase 4D, cAMP-specific -0.0516662
TPT1 tumor protein, translationally-controlled 1 -0.0500412
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0491762
IFI6 interferon, alpha-inducible protein 6 -0.046418
RPLP2 ribosomal protein, large, P2 -0.0438015
RPL35A ribosomal protein L35a -0.0391672
RPS8 ribosomal protein S8 -0.0389847
GRID2 glutamate receptor, ionotropic, delta 2 -0.0377565
RPL19 ribosomal protein L19 -0.0363119
RPL36A ribosomal protein L36a -0.0351759
RPL34 ribosomal protein L34 -0.0351049
EFNA5 ephrin-A5 -0.0350266
RPS6 ribosomal protein S6 -0.0347726
HMGB1 high mobility group box 1 -0.0347424
RPLP1 ribosomal protein, large, P1 -0.0346472
RPL26 ribosomal protein L26 -0.0340573
RPS19 ribosomal protein S19 -0.0339771
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0336706
CADM2 cell adhesion molecule 2 -0.0336158
TMSB10 thymosin beta 10 -0.0331204
RPL9 ribosomal protein L9 -0.0330874
SHROOM3 shroom family member 3 -0.0323166
GJA1 gap junction protein, alpha 1, 43kDa -0.0322324
RIGI RNA sensor RIG-I -0.0320067
RAP1B RAP1B, member of RAS oncogene family -0.0314681
RPL37A ribosomal protein L37a -0.0314478
MYL12B myosin, light chain 12B, regulatory -0.0313805
RPL12 ribosomal protein L12 -0.0310448
RPS27A ribosomal protein S27a -0.0307754
SLF1 SMC5-SMC6 complex localization factor 1 -0.0301744
RPS5 ribosomal protein S5 -0.0298975
ZNF33A zinc finger protein 33A -0.0295691
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0293517
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0292713
PTMA prothymosin, alpha -0.0291732
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0288959
ZNF217 zinc finger protein 217 -0.0286144
RBM25 RNA binding motif protein 25 -0.028257
RPL23 ribosomal protein L23 -0.0279264
ACTG1 actin gamma 1 -0.0273992
SOX2 SRY (sex determining region Y)-box 2 -0.0271859
RPL11 ribosomal protein L11 -0.0270551
RPL31 ribosomal protein L31 -0.026899
TPD52 tumor protein D52 -0.0264399
RPS28 ribosomal protein S28 -0.026304
PNISR PNN-interacting serine/arginine-rich protein -0.026235
EGR1 early growth response 1 -0.0258275
ARB2A ARB2 cotranscriptional regulator A -0.0257438
RPL37 ribosomal protein L37 -0.0254678
OSBPL10 oxysterol binding protein-like 10 -0.0252805
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0252655
HLA-B major histocompatibility complex, class I, B -0.0248003
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0246276
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0242321
TMEM41B transmembrane protein 41B -0.0238224
RPL38 ribosomal protein L38 -0.023633
RPS23 ribosomal protein S23 -0.0235462
ZNFX1 zinc finger, NFX1-type containing 1 -0.0231045
RPS16 ribosomal protein S16 -0.023066
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0230445
TNPO1 transportin 1 -0.0225239
RPL4 ribosomal protein L4 -0.0222915
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0217737
HLA-C major histocompatibility complex, class I, C -0.0215398
RPS29 ribosomal protein S29 -0.0213625
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0212342
DNAH14 dynein, axonemal, heavy chain 14 -0.0208522
SLIT2 slit homolog 2 (Drosophila) -0.0207658
RPL5 ribosomal protein L5 -0.0205836
LOC112694756 uncharaterized LOC112694756 -0.0204887
RPL13A ribosomal protein L13a -0.0203435
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0203021
RPS11 ribosomal protein S11 -0.02005
SEPTIN10 septin 10 -0.0199486
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -0.0196721
RPL7A ribosomal protein L7a -0.0193751
RPS21 ribosomal protein S21 -0.019137
EXT1 exostosin glycosyltransferase 1 -0.0189097
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0188532
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0186753
MATR3 matrin 3 -0.0186154
RPL27A ribosomal protein L27a -0.0185342
HHIP hedgehog interacting protein -0.0184891
RPL32 ribosomal protein L32 -0.0183941
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0177142
NT5C2 5'-nucleotidase, cytosolic II -0.0176397
ATXN10 ataxin 10 -0.0175918
MCTP1 multiple C2 domains, transmembrane 1 -0.0173746
TXNL1 thioredoxin-like 1 -0.0173702
COL11A1 collagen, type XI, alpha 1 -0.0168855
ATP5F1E ATP synthase F1 subunit epsilon -0.0168727
BTG3 BTG family, member 3 -0.0167926