| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lipoic acid perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lipoic acid_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.319028 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.165534 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.098233 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0890708 |
| LDHA | lactate dehydrogenase A | 0.0836652 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0765048 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0641152 |
| ASPH | aspartate beta-hydroxylase | 0.0610897 |
| LOX | lysyl oxidase | 0.0600164 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0580696 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0576372 |
| GOLGB1 | golgin B1 | 0.0560687 |
| CALD1 | caldesmon 1 | 0.0527356 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0525219 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0495306 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0476959 |
| NAV3 | neuron navigator 3 | 0.0438379 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0434169 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0423676 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0420007 |
| TNS3 | tensin 3 | 0.0407671 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.038015 |
| COL5A1 | collagen, type V, alpha 1 | 0.0377706 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0376072 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.0371812 |
| COL12A1 | collagen, type XII, alpha 1 | 0.0349707 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0345885 |
| STC1 | stanniocalcin 1 | 0.0339266 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0332261 |
| IGF2 | insulin-like growth factor 2 | 0.0331018 |
| NRXN3 | neurexin 3 | 0.0330341 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0323907 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0323752 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0320479 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0315972 |
| VEGFA | vascular endothelial growth factor A | 0.0312144 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0312087 |
| TAOK1 | TAO kinase 1 | 0.0309719 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | 0.0309487 |
| MYLK | myosin light chain kinase | 0.0303779 |
| CLIC4 | chloride intracellular channel 4 | 0.0287556 |
| PCNX4 | pecanex 4 | 0.0285863 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0282821 |
| GNG12 | guanine nucleotide binding protein (G protein), gamma 12 | 0.0279671 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0275719 |
| EGFR | epidermal growth factor receptor | 0.0272141 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.027211 |
| ZNF804A | zinc finger protein 804A | 0.0270195 |
| MAGT1 | magnesium transporter 1 | 0.0268111 |
| CD44 | CD44 molecule (Indian blood group) | 0.0267255 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0266221 |
| RASA2 | RAS p21 protein activator 2 | 0.0263061 |
| CEP95 | centrosomal protein 95kDa | 0.0261286 |
| SETX | senataxin | 0.0260976 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0257502 |
| CALN1 | calneuron 1 | 0.0254565 |
| NABP1 | nucleic acid binding protein 1 | 0.0253888 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0253127 |
| LOXL2 | lysyl oxidase-like 2 | 0.0251242 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0251099 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.025049 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0249616 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0248218 |
| SLC14A1 | solute carrier family 14 (urea transporter), member 1 (Kidd blood group) | 0.024661 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0242817 |
| TENM1 | teneurin transmembrane protein 1 | 0.0241209 |
| HMGA2 | high mobility group AT-hook 2 | 0.0239982 |
| STXBP1 | syntaxin binding protein 1 | 0.0235623 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0233571 |
| EGR1 | early growth response 1 | 0.0233535 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | 0.0233504 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0229932 |
| GPATCH2L | G patch domain containing 2-like | 0.0229796 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0227248 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0227208 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0225947 |
| CHRM3 | cholinergic receptor, muscarinic 3 | 0.0225185 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0222951 |
| OLA1 | Obg-like ATPase 1 | 0.0222861 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0221746 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0221208 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0220928 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0220692 |
| MAGED1 | melanoma antigen family D1 | 0.0218355 |
| PRPSAP1 | phosphoribosyl pyrophosphate synthetase-associated protein 1 | 0.0216526 |
| ARF1 | ADP-ribosylation factor 1 | 0.0213662 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0212847 |
| SHISA5 | shisa family member 5 | 0.0210378 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0209802 |
| SEM1 | SEM1 26S proteasome subunit | 0.0208521 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.0205409 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0202844 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0202411 |
| GOSR2 | golgi SNAP receptor complex member 2 | 0.0201477 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0198423 |
| PLAGL1 | pleiomorphic adenoma gene-like 1 | 0.0195862 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0195159 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0193072 |
| CFAP44 | cilia and flagella associated protein 44 | 0.0192218 |
| MARCHF1 | membrane associated ring-CH-type finger 1 | 0.0191024 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.167464 |
| GRB10 | growth factor receptor-bound protein 10 | -0.14159 |
| NLGN1 | neuroligin 1 | -0.0947212 |
| RUNX1 | runt-related transcription factor 1 | -0.0774035 |
| B2M | beta-2-microglobulin | -0.0653682 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0650717 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0650205 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0604455 |
| TMSB10 | thymosin beta 10 | -0.0573498 |
| MKI67 | marker of proliferation Ki-67 | -0.0560116 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0545654 |
| CENPF | centromere protein F, 350/400kDa | -0.0543487 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0532157 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0530821 |
| SYT1 | synaptotagmin I | -0.0516317 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0505742 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0500466 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0499439 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0491309 |
| DIAPH3 | diaphanous-related formin 3 | -0.0480143 |
| SBF2 | SET binding factor 2 | -0.0466592 |
| LYPD6B | LY6/PLAUR domain containing 6B | -0.0459147 |
| PDE10A | phosphodiesterase 10A | -0.0436097 |
| PTK2 | protein tyrosine kinase 2 | -0.0434901 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0431803 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0430636 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0429389 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0425179 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0417812 |
| SPAG9 | sperm associated antigen 9 | -0.040904 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0408849 |
| TXNRD1 | thioredoxin reductase 1 | -0.0404345 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0399401 |
| AOPEP | aminopeptidase O (putative) | -0.0389862 |
| GPC6 | glypican 6 | -0.0388028 |
| USP34 | ubiquitin specific peptidase 34 | -0.0387579 |
| PTMA | prothymosin, alpha | -0.0384711 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.0373136 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0372887 |
| KIF4A | kinesin family member 4A | -0.0372198 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0370613 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.036363 |
| CHD6 | chromodomain helicase DNA binding protein 6 | -0.0359948 |
| MT2A | metallothionein 2A | -0.0358086 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0355339 |
| SEPTIN7 | septin 7 | -0.0353441 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.035267 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0352564 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0350396 |
| PRKCE | protein kinase C, epsilon | -0.0348008 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0347827 |
| SNX13 | sorting nexin 13 | -0.0347697 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0342998 |
| USP3 | ubiquitin specific peptidase 3 | -0.0340119 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0335849 |
| NAV2 | neuron navigator 2 | -0.0332792 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0331244 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0329333 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.032345 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0322008 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0321553 |
| JMJD1C | jumonji domain containing 1C | -0.0319251 |
| ATP13A3 | ATPase type 13A3 | -0.0318439 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0317809 |
| CEP128 | centrosomal protein 128kDa | -0.031588 |
| POM121 | POM121 transmembrane nucleoporin | -0.0314859 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0312289 |
| WWOX | WW domain containing oxidoreductase | -0.0309541 |
| GLCCI1 | glucocorticoid induced 1 | -0.0308757 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.03082 |
| MCL1 | myeloid cell leukemia 1 | -0.0307797 |
| AUTS2 | autism susceptibility candidate 2 | -0.030593 |
| CENPE | centromere protein E, 312kDa | -0.0305716 |
| ATXN1 | ataxin 1 | -0.0303559 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0302328 |
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | -0.0299565 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.029915 |
| ANLN | anillin, actin binding protein | -0.0296105 |
| RPLP1 | ribosomal protein, large, P1 | -0.029446 |
| ANO6 | anoctamin 6 | -0.029386 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0293518 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.029079 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0290734 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | -0.0289739 |
| HS6ST3 | heparan sulfate 6-O-sulfotransferase 3 | -0.0289645 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0289062 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0287627 |
| VIM | vimentin | -0.0287571 |
| TCF12 | transcription factor 12 | -0.028628 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0284765 |
| THOC2 | THO complex 2 | -0.0284591 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0283013 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0281324 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0279486 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0279357 |
| GRAMD1B | GRAM domain containing 1B | -0.0278945 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0278766 |
| NDRG1 | N-myc downstream regulated 1 | -0.0278727 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0277864 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0277055 |
