| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lipoic acid perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lipoic acid_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.117173 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.075254 |
| INTS6 | integrator complex subunit 6 | 0.059541 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0282152 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0228894 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0224892 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0223268 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0210685 |
| LRRC23 | leucine rich repeat containing 23 | 0.020538 |
| HYOU1 | hypoxia up-regulated 1 | 0.0199618 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0188293 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.018373 |
| NEBL | nebulette | 0.017864 |
| SEC24D | SEC24 family member D | 0.0176747 |
| CTBP2 | C-terminal binding protein 2 | 0.0174421 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | 0.0173748 |
| WWOX | WW domain containing oxidoreductase | 0.0169297 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.016704 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0166283 |
| HOMER1 | homer scaffolding protein 1 | 0.0163703 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0160267 |
| GOLGB1 | golgin B1 | 0.0151598 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0151297 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0146229 |
| TGFB1 | transforming growth factor, beta 1 | 0.0145604 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0144011 |
| LARP1B | La ribonucleoprotein domain family, member 1B | 0.0139442 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0138521 |
| KLHL29 | kelch-like family member 29 | 0.0138333 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0137529 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0136306 |
| GPC5 | glypican 5 | 0.0131742 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.0130865 |
| AEBP2 | AE binding protein 2 | 0.0128773 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0127842 |
| PRKCA | protein kinase C, alpha | 0.0125139 |
| FUS | FUS RNA binding protein | 0.0120224 |
| TLN1 | talin 1 | 0.011943 |
| PGM3 | phosphoglucomutase 3 | 0.0118776 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0116433 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | 0.0115931 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0113489 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0111731 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.0110154 |
| CLIC4 | chloride intracellular channel 4 | 0.0109409 |
| NABP1 | nucleic acid binding protein 1 | 0.0108942 |
| CFAP44 | cilia and flagella associated protein 44 | 0.0108842 |
| RCC1 | regulator of chromosome condensation 1 | 0.0105341 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0105272 |
| RUNX1 | runt-related transcription factor 1 | 0.0105141 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0105099 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0103669 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0102459 |
| JAK1 | Janus kinase 1 | 0.0101257 |
| MACROD2 | MACRO domain containing 2 | 0.0101068 |
| POU2F2 | POU class 2 homeobox 2 | 0.0100592 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.00999483 |
| BAIAP2 | BAI1-associated protein 2 | 0.00994293 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0098668 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.009858 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.00985329 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.00982028 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | 0.00978406 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0097096 |
| TXNDC16 | thioredoxin domain containing 16 | 0.0095934 |
| TRIM72 | tripartite motif containing 72, E3 ubiquitin protein ligase | 0.00953641 |
| ASS1 | argininosuccinate synthase 1 | 0.00952051 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.00931762 |
| TEX14 | testis expressed 14 | 0.00895482 |
| EFNB2 | ephrin-B2 | 0.0088396 |
| CCNYL1 | cyclin Y-like 1 | 0.00877686 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | 0.00867328 |
| VEGFA | vascular endothelial growth factor A | 0.00865379 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.00851562 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.00850743 |
| SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | 0.00846454 |
| NXF1 | nuclear RNA export factor 1 | 0.00842494 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | 0.00841485 |
| IFRD1 | interferon-related developmental regulator 1 | 0.00836184 |
| COG6 | component of oligomeric golgi complex 6 | 0.00834331 |
| MYLIP | myosin regulatory light chain interacting protein | 0.0083357 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | 0.00830233 |
| ABHD5 | abhydrolase domain containing 5 | 0.00829253 |
| CALR | calreticulin | 0.00827837 |
| POLN | polymerase (DNA directed) nu | 0.00825351 |
| KIF16B | kinesin family member 16B | 0.00823033 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.00821204 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.00819538 |
| GTF2B | general transcription factor IIB | 0.00808531 |
| SPICE1 | spindle and centriole associated protein 1 | 0.00808076 |
| NCKAP5L | NCK-associated protein 5-like | 0.00807518 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0080441 |
| GCH1 | GTP cyclohydrolase 1 | 0.00798509 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.00798146 |
| RYBP | RING1 and YY1 binding protein | 0.00797857 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.00796679 |
| TUFT1 | tuftelin 1 | 0.00795322 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | 0.00794524 |
| CYP20A1 | cytochrome P450, family 20, subfamily A, polypeptide 1 | 0.00789003 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.00788047 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FAT1 | FAT atypical cadherin 1 | -0.152263 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.126025 |
| PTMA | prothymosin, alpha | -0.110834 |
| AHNAK | AHNAK nucleoprotein | -0.0889187 |
| MKI67 | marker of proliferation Ki-67 | -0.0565079 |
| TXNRD1 | thioredoxin reductase 1 | -0.0526717 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0516499 |
| ENO1 | enolase 1, (alpha) | -0.0478212 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.047579 |
| TMSB10 | thymosin beta 10 | -0.0456627 |
| TPM4 | tropomyosin 4 | -0.042966 |
| EZR | ezrin | -0.0419395 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0397792 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0395148 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0370881 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0370548 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.037032 |
| PGK1 | phosphoglycerate kinase 1 | -0.0361529 |
| KRT18 | keratin 18, type I | -0.0358689 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0357398 |
| CENPF | centromere protein F, 350/400kDa | -0.035529 |
| TENM3 | teneurin transmembrane protein 3 | -0.0353329 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0351031 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0345944 |
| MED13L | mediator complex subunit 13-like | -0.0344489 |
| NF1 | neurofibromin 1 | -0.0344086 |
| NDRG1 | N-myc downstream regulated 1 | -0.0335097 |
| SERINC5 | serine incorporator 5 | -0.0334342 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0322616 |
| RPS6 | ribosomal protein S6 | -0.0319239 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0313804 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0310311 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0305096 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0301427 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0300641 |
| JMJD1C | jumonji domain containing 1C | -0.0299146 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0289862 |
| KPNB1 | karyopherin (importin) beta 1 | -0.028963 |
| LDHA | lactate dehydrogenase A | -0.0288797 |
| HMGB2 | high mobility group box 2 | -0.0283201 |
| EPCAM | epithelial cell adhesion molecule | -0.0279629 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0279375 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.027641 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0270187 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0269786 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0263984 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0262234 |
| ACTG1 | actin gamma 1 | -0.0261043 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0257596 |
| CD2AP | CD2-associated protein | -0.0255852 |
| PKP2 | plakophilin 2 | -0.025403 |
| KRT8 | keratin 8, type II | -0.0253982 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0253781 |
| NOP58 | NOP58 ribonucleoprotein | -0.0249544 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.024798 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0247757 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0246532 |
| PRRC2B | proline-rich coiled-coil 2B | -0.02449 |
| VCL | vinculin | -0.0243879 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0242382 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0238346 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0237309 |
| MSI2 | musashi RNA-binding protein 2 | -0.0236864 |
| TUBA1B | tubulin, alpha 1b | -0.0236124 |
| PKM | pyruvate kinase, muscle | -0.0235851 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0235308 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0230238 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0228653 |
| POTEF | POTE ankyrin domain family, member F | -0.022739 |
| TMEM87A | transmembrane protein 87A | -0.0227207 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0221863 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0220452 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.021808 |
| FRMD5 | FERM domain containing 5 | -0.0215216 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0214107 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0211252 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0211236 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0211225 |
| BPTF | bromodomain PHD finger transcription factor | -0.0210504 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0210322 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0210228 |
| MYOF | myoferlin | -0.0208789 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0208601 |
| KLF6 | Kruppel-like factor 6 | -0.0207125 |
| VMP1 | vacuole membrane protein 1 | -0.0206834 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0206792 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0206559 |
| RACK1 | receptor for activated C kinase 1 | -0.0204352 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0202886 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0202656 |
| SON | SON DNA binding protein | -0.0202005 |
| APP | amyloid beta (A4) precursor protein | -0.0201552 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0199029 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0198009 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0196432 |
| TUBB | tubulin, beta class I | -0.0196198 |
| FDPS | farnesyl diphosphate synthase | -0.0195934 |
| MATR3 | matrin 3 | -0.0195368 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.019404 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0191019 |
