Lipoic acid_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lipoic acid perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lipoic acid_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.114682
DSPP dentin sialophosphoprotein 0.0901723
SVIL supervillin 0.0835589
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0689628
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0680917
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0609395
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0513088
TNS1 tensin 1 0.0500823
FN1 fibronectin 1 0.0489295
SAMD4A sterile alpha motif domain containing 4A 0.0399614
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0376456
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0370165
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0362481
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0313356
NDRG1 N-myc downstream regulated 1 0.0303784
VEGFA vascular endothelial growth factor A 0.0302881
FAT1 FAT atypical cadherin 1 0.026628
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.0243733
LDHA lactate dehydrogenase A 0.0241366
NFE2L1 nuclear factor, erythroid 2-like 1 0.0239718
ARFGEF3 ARFGEF family member 3 0.0220863
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.022049
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0217462
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0216953
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0211398
CRLS1 cardiolipin synthase 1 0.0209821
EIF4B eukaryotic translation initiation factor 4B 0.020982
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0209444
BAG6 BCL2-associated athanogene 6 0.0204406
FRK fyn-related Src family tyrosine kinase 0.0203684
PER2 period circadian clock 2 0.0200149
RPL3 ribosomal protein L3 0.0199208
OPTN optineurin 0.01985
FAM13A family with sequence similarity 13, member A 0.019849
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0194644
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0191725
TMF1 TATA element modulatory factor 1 0.0185874
KYNU kynureninase 0.018557
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0185284
TF transferrin 0.018482
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0179882
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0178287
GSE1 Gse1 coiled-coil protein 0.0176301
ASPH aspartate beta-hydroxylase 0.0173944
APLP2 amyloid beta (A4) precursor-like protein 2 0.0173678
SPAG9 sperm associated antigen 9 0.0171584
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 0.0169135
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0166594
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 0.0165492
MXI1 MAX interactor 1, dimerization protein 0.0162787
NGLY1 N-glycanase 1 0.0161945
BIRC2 baculoviral IAP repeat containing 2 0.0160695
RAD51B RAD51 paralog B 0.0160276
EEF2 eukaryotic translation elongation factor 2 0.0158517
EGLN1 egl-9 family hypoxia-inducible factor 1 0.015794
JAG1 jagged 1 0.0156535
LCOR ligand dependent nuclear receptor corepressor 0.0156206
ADAM17 ADAM metallopeptidase domain 17 0.0151482
BRD4 bromodomain containing 4 0.0150498
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0150419
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0150081
KMT2C lysine (K)-specific methyltransferase 2C 0.014992
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.014983
SLK STE20-like kinase 0.0148384
MXRA7 matrix-remodelling associated 7 0.0147256
RSRC2 arginine/serine-rich coiled-coil 2 0.0145607
DSG2 desmoglein 2 0.0144432
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0142171
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0141639
USP47 ubiquitin specific peptidase 47 0.0139542
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0139315
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0138353
CRY1 cryptochrome circadian clock 1 0.0136358
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0136333
KIF1B kinesin family member 1B 0.0134905
BIRC3 baculoviral IAP repeat containing 3 0.0134654
ZFC3H1 zinc finger, C3H1-type containing 0.0134312
MTSS1 metastasis suppressor 1 0.0134276
CEP250 centrosomal protein 250kDa 0.0134031
TCIM transcriptional and immune response regulator 0.0133834
SYBU syntabulin (syntaxin-interacting) 0.0132783
WWC2 WW and C2 domain containing 2 0.0132321
RPS7 ribosomal protein S7 0.0132138
STC2 stanniocalcin 2 0.0132069
ELL2 elongation factor, RNA polymerase II, 2 0.0131004
TXNIP thioredoxin interacting protein 0.013037
PAPOLA poly(A) polymerase alpha 0.0130132
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.0129788
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0128771
AHR aryl hydrocarbon receptor 0.0128433
GOLGB1 golgin B1 0.0128181
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.0127954
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 0.0125622
TPD52 tumor protein D52 0.0124852
ESYT2 extended synaptotagmin-like protein 2 0.0123725
ARRDC3 arrestin domain containing 3 0.0121705
EFL1 elongation factor like GTPase 1 0.0119859
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0118833
MYH9 myosin, heavy chain 9, non-muscle 0.0118808
PRELID2 PRELI domain containing 2 0.0118543

decreased expression

Symbol Name Standardized Value
GPC3 glypican 3 -0.160645
APOA2 apolipoprotein A-II -0.152097
SLC38A2 solute carrier family 38, member 2 -0.137973
APOB apolipoprotein B -0.137766
TPT1 tumor protein, translationally-controlled 1 -0.137033
MT2A metallothionein 2A -0.125113
EHBP1 EH domain binding protein 1 -0.102736
TMSB10 thymosin beta 10 -0.100722
C3 complement component 3 -0.099944
FBF1 Fas (TNFRSF6) binding factor 1 -0.084145
TM4SF1 transmembrane 4 L six family member 1 -0.0823194
ITGAV integrin, alpha V -0.077983
AHSG alpha-2-HS-glycoprotein -0.0774006
VCL vinculin -0.0759622
RPS24 ribosomal protein S24 -0.0734334
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0734044
GPC6 glypican 6 -0.0710434
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0710369
NPAS2 neuronal PAS domain protein 2 -0.0691972
TRIM26 tripartite motif containing 26 -0.0668479
RPL35A ribosomal protein L35a -0.066654
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0660428
NKD1 naked cuticle homolog 1 (Drosophila) -0.0656843
PTCHD4 patched domain containing 4 -0.0647209
RPL11 ribosomal protein L11 -0.0644131
GMDS GDP-mannose 4,6-dehydratase -0.0621958
RPS6 ribosomal protein S6 -0.0617756
GNAS GNAS complex locus -0.0594096
RNF213 ring finger protein 213 -0.0580479
RPS19 ribosomal protein S19 -0.0577162
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0573601
RPLP1 ribosomal protein, large, P1 -0.0568814
AMBP alpha-1-microglobulin/bikunin precursor -0.0562948
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0557838
SDC4 syndecan 4 -0.0544972
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0535589
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.053398
RPL37A ribosomal protein L37a -0.0521265
RPS27A ribosomal protein S27a -0.0505961
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0493109
NPR2 natriuretic peptide receptor 2 -0.0488722
TPM4 tropomyosin 4 -0.048629
FRMD5 FERM domain containing 5 -0.0476491
APOE apolipoprotein E -0.047636
RPL23 ribosomal protein L23 -0.0468763
EGR1 early growth response 1 -0.0468387
ACTN4 actinin, alpha 4 -0.0465819
IER3 immediate early response 3 -0.0454365
MAML2 mastermind-like 2 (Drosophila) -0.0453371
CCL20 chemokine (C-C motif) ligand 20 -0.0451026
FNDC3B fibronectin type III domain containing 3B -0.0450454
RPL31 ribosomal protein L31 -0.0448755
RPL34 ribosomal protein L34 -0.0447871
TRIO trio Rho guanine nucleotide exchange factor -0.044367
ZBTB20 zinc finger and BTB domain containing 20 -0.0440609
DLC1 DLC1 Rho GTPase activating protein -0.0433123
A2M alpha-2-macroglobulin -0.0431271
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0428924
PDLIM5 PDZ and LIM domain 5 -0.0416264
MYO1E myosin IE -0.0414936
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.041456
RPS21 ribosomal protein S21 -0.0414375
RPS8 ribosomal protein S8 -0.0411679
FTL ferritin, light polypeptide -0.0410194
PTMA prothymosin, alpha -0.0409955
RPS29 ribosomal protein S29 -0.0404358
LYZ lysozyme -0.0403799
STAU1 staufen double-stranded RNA binding protein 1 -0.0402942
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0402173
ZNF644 zinc finger protein 644 -0.040075
COL27A1 collagen, type XXVII, alpha 1 -0.0397746
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0395946
TMEM123 transmembrane protein 123 -0.0395188
RPL19 ribosomal protein L19 -0.039417
LRMDA leucine rich melanocyte differentiation associated -0.0390225
GK glycerol kinase -0.0389725
KRT18 keratin 18, type I -0.0389153
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0384364
SLC38A1 solute carrier family 38, member 1 -0.0383162
ACTG1 actin gamma 1 -0.0378429
CP ceruloplasmin (ferroxidase) -0.0377542
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0370881
ISG15 ISG15 ubiquitin-like modifier -0.0369193
RPL12 ribosomal protein L12 -0.0367862
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0362621
PERP PERP, TP53 apoptosis effector -0.0361715
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0361558
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0359181
HMGA1 high mobility group AT-hook 1 -0.0350874
EML4 echinoderm microtubule associated protein like 4 -0.0347654
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0347018
PEG3 paternally expressed 3 -0.0346955
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0346705
MSI2 musashi RNA-binding protein 2 -0.0343856
ZFHX3 zinc finger homeobox 3 -0.0341136
DNAH17 dynein, axonemal, heavy chain 17 -0.0338622
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0337835
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.033367
RPS11 ribosomal protein S11 -0.0328085
AHNAK AHNAK nucleoprotein -0.0324395