| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lipoic acid perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lipoic acid_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.210972 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.185944 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.130449 |
| ANXA2 | annexin A2 | 0.126329 |
| FTL | ferritin, light polypeptide | 0.124291 |
| TXNRD1 | thioredoxin reductase 1 | 0.105827 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0895302 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0745889 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0670065 |
| NAV2 | neuron navigator 2 | 0.0663773 |
| ERBIN | erbb2 interacting protein | 0.0632458 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0627315 |
| VEGFC | vascular endothelial growth factor C | 0.0612096 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0596227 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0586375 |
| MAP1B | microtubule-associated protein 1B | 0.0585906 |
| ATP13A3 | ATPase type 13A3 | 0.0582504 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0559756 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0520154 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0519787 |
| CALR | calreticulin | 0.0497639 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0489158 |
| VGLL3 | vestigial-like family member 3 | 0.0478409 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0471681 |
| CENPP | centromere protein P | 0.0469987 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | 0.0461926 |
| MAP4 | microtubule-associated protein 4 | 0.0441476 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0431947 |
| MKI67 | marker of proliferation Ki-67 | 0.0431946 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | 0.0431385 |
| AHNAK | AHNAK nucleoprotein | 0.0428947 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0428698 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0420104 |
| LDHA | lactate dehydrogenase A | 0.0411359 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.0409771 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0405529 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0399142 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0397293 |
| LIMA1 | LIM domain and actin binding 1 | 0.0396211 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0392553 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0392287 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0386309 |
| STC2 | stanniocalcin 2 | 0.0384828 |
| FLNB | filamin B, beta | 0.0381981 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0381731 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0378491 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0377338 |
| OGA | O-GlcNAcase | 0.0375881 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0375411 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0373108 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0372729 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0371386 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0370755 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0366979 |
| RBM39 | RNA binding motif protein 39 | 0.0357077 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0353323 |
| MECOM | MDS1 and EVI1 complex locus | 0.0352759 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0350005 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0339362 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0338309 |
| TPD52 | tumor protein D52 | 0.0336773 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0336298 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0334181 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0331396 |
| FHIT | fragile histidine triad | 0.0330012 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0328253 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0326647 |
| SDCBP | syndecan binding protein (syntenin) | 0.0324285 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.032419 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0323676 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0323357 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0322525 |
| PTK2 | protein tyrosine kinase 2 | 0.0320872 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0317315 |
| PCBP2 | poly(rC) binding protein 2 | 0.0314749 |
| CEP250 | centrosomal protein 250kDa | 0.0313849 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0312181 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0312174 |
| KLF12 | Kruppel-like factor 12 | 0.031016 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0310152 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0309351 |
| RND3 | Rho family GTPase 3 | 0.030915 |
| HDLBP | high density lipoprotein binding protein | 0.0305125 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0304089 |
| CORO1C | coronin, actin binding protein, 1C | 0.0302237 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0301724 |
| DST | dystonin | 0.0301297 |
| ATXN1 | ataxin 1 | 0.0299253 |
| SRPK2 | SRSF protein kinase 2 | 0.0298899 |
| TMOD3 | tropomodulin 3 (ubiquitous) | 0.0296558 |
| YBX1 | Y box binding protein 1 | 0.0295532 |
| KRT8 | keratin 8, type II | 0.0295106 |
| JMJD1C | jumonji domain containing 1C | 0.0292142 |
| USP3 | ubiquitin specific peptidase 3 | 0.0290924 |
| INTS6 | integrator complex subunit 6 | 0.0290543 |
| KIF13A | kinesin family member 13A | 0.0289535 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.028772 |
| MT1X | metallothionein 1X | 0.0287145 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0286784 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0283429 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.153121 |
| NDRG1 | N-myc downstream regulated 1 | -0.113628 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0960288 |
| FN1 | fibronectin 1 | -0.0921037 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0804207 |
| HLA-B | major histocompatibility complex, class I, B | -0.0740992 |
| ZNF841 | zinc finger protein 841 | -0.0693895 |
| TMSB4X | thymosin beta 4, X-linked | -0.067939 |
| ZNF432 | zinc finger protein 432 | -0.0671719 |
| POTEF | POTE ankyrin domain family, member F | -0.06258 |
| MT2A | metallothionein 2A | -0.0528265 |
| ACTG1 | actin gamma 1 | -0.0501314 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0489463 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0450295 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0448396 |
| SLC12A8 | solute carrier family 12, member 8 | -0.0417546 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0411908 |
| RPS2 | ribosomal protein S2 | -0.0408839 |
| CUL4B | cullin 4B | -0.0387624 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0384318 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0376972 |
| FSTL1 | follistatin-like 1 | -0.0372224 |
| DTNA | dystrobrevin, alpha | -0.0358171 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0349404 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0344389 |
| TPM1 | tropomyosin 1 (alpha) | -0.0329332 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0323783 |
| SNX14 | sorting nexin 14 | -0.0321775 |
| RBM25 | RNA binding motif protein 25 | -0.0320177 |
| SET | SET nuclear proto-oncogene | -0.0313132 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0304782 |
| CCND1 | cyclin D1 | -0.0303145 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0296287 |
| CENPF | centromere protein F, 350/400kDa | -0.0282333 |
| PGK1 | phosphoglycerate kinase 1 | -0.0278431 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0276079 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -0.0271782 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0271521 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0256632 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.02557 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0255653 |
| RPS6 | ribosomal protein S6 | -0.0254533 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0252784 |
| ACER3 | alkaline ceramidase 3 | -0.0248783 |
| RPL37 | ribosomal protein L37 | -0.0248061 |
| FLNA | filamin A, alpha | -0.0240485 |
| RPL26 | ribosomal protein L26 | -0.0239213 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0238219 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0230539 |
| ASPH | aspartate beta-hydroxylase | -0.022907 |
| MCL1 | myeloid cell leukemia 1 | -0.0227793 |
| OSMR | oncostatin M receptor | -0.0227372 |
| NAV1 | neuron navigator 1 | -0.0225464 |
| CAST | calpastatin | -0.0224851 |
| AFAP1 | actin filament associated protein 1 | -0.0224512 |
| ADM | adrenomedullin | -0.0224356 |
| WDR45B | WD repeat domain 45B | -0.0222824 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0222451 |
| TMF1 | TATA element modulatory factor 1 | -0.0221326 |
| GNAS | GNAS complex locus | -0.0217352 |
| SULF1 | sulfatase 1 | -0.0213972 |
| RPL37A | ribosomal protein L37a | -0.0211663 |
| RPS27A | ribosomal protein S27a | -0.0210578 |
| RPS12 | ribosomal protein S12 | -0.020723 |
| ANGPTL4 | angiopoietin-like 4 | -0.0206258 |
| POSTN | periostin, osteoblast specific factor | -0.0206045 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | -0.0205952 |
| LYPD6B | LY6/PLAUR domain containing 6B | -0.0205644 |
| GOLT1B | golgi transport 1B | -0.0204073 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.020349 |
| HLA-E | major histocompatibility complex, class I, E | -0.0203 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0202972 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0199879 |
| TUBB4B | tubulin, beta 4B class IVb | -0.019837 |
| POMP | proteasome maturation protein | -0.0198007 |
| CCDC80 | coiled-coil domain containing 80 | -0.0196194 |
| TBC1D23 | TBC1 domain family, member 23 | -0.0194539 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0191676 |
| RPL7 | ribosomal protein L7 | -0.0191605 |
| HMGA1 | high mobility group AT-hook 1 | -0.019009 |
| ZXDC | ZXD family zinc finger C | -0.0187352 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0186574 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0186533 |
| CLTC | clathrin, heavy chain (Hc) | -0.0184415 |
| RSF1 | remodeling and spacing factor 1 | -0.018366 |
| MTPN | myotrophin | -0.0182276 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0182246 |
| NOP58 | NOP58 ribonucleoprotein | -0.0180705 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0180287 |
| SBF2 | SET binding factor 2 | -0.0178639 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0178275 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0177724 |
| VCL | vinculin | -0.0177304 |
| CCNL1 | cyclin L1 | -0.0174854 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0174156 |
| STC1 | stanniocalcin 1 | -0.0174076 |
| ANO6 | anoctamin 6 | -0.0173634 |
| SEC22B | SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) | -0.0172484 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.017025 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.016813 |
