Lipoic acid_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lipoic acid perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lipoic acid_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.186176
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.178314
DTNA dystrobrevin, alpha 0.106274
LSAMP limbic system-associated membrane protein 0.0800978
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0711504
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0671106
MACF1 microtubule-actin crosslinking factor 1 0.0668241
NDRG1 N-myc downstream regulated 1 0.0662197
PBX3 pre-B-cell leukemia homeobox 3 0.0628642
TRIO trio Rho guanine nucleotide exchange factor 0.0598579
DST dystonin 0.0579912
ASPH aspartate beta-hydroxylase 0.0560453
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0545078
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0537415
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0496147
PRKCE protein kinase C, epsilon 0.0446485
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0439004
RUNX1 runt-related transcription factor 1 0.0438428
MYO10 myosin X 0.0437288
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0426996
JARID2 jumonji, AT rich interactive domain 2 0.0420459
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0411166
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0410421
PHACTR1 phosphatase and actin regulator 1 0.0396726
AKAP12 A kinase (PRKA) anchor protein 12 0.0390492
PTPRD protein tyrosine phosphatase, receptor type, D 0.0387055
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0370904
LIMCH1 LIM and calponin homology domains 1 0.0350825
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0347871
RPS2 ribosomal protein S2 0.0346879
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0346101
FMNL2 formin-like 2 0.0344934
PRELID2 PRELI domain containing 2 0.0328164
ZCCHC7 zinc finger, CCHC domain containing 7 0.0324605
PTPRG protein tyrosine phosphatase, receptor type, G 0.0323803
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0319657
KDM4C lysine (K)-specific demethylase 4C 0.0316933
NALF1 NALCN channel auxiliary factor 1 0.0316567
UBA6 ubiquitin-like modifier activating enzyme 6 0.0302861
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0302657
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0302174
RPS12 ribosomal protein S12 0.0299874
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0299025
GOLGA4 golgin A4 0.0294486
GPHN gephyrin 0.0286948
FGFR1 fibroblast growth factor receptor 1 0.0284123
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0283729
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0279689
DOCK5 dedicator of cytokinesis 5 0.0278169
TTC3 tetratricopeptide repeat domain 3 0.0271828
TXNIP thioredoxin interacting protein 0.0271243
PCBP2 poly(rC) binding protein 2 0.0267485
MSN moesin 0.0263133
SSH2 slingshot protein phosphatase 2 0.0253826
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0250195
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0248751
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0248001
KDM2A lysine (K)-specific demethylase 2A 0.0247143
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0246553
ZNF638 zinc finger protein 638 0.0246091
PDE8A phosphodiesterase 8A 0.0242415
ANO6 anoctamin 6 0.0242391
ESYT2 extended synaptotagmin-like protein 2 0.0241206
RBMS3 RNA binding motif, single stranded interacting protein 3 0.024106
EEF2 eukaryotic translation elongation factor 2 0.0239114
RPS3 ribosomal protein S3 0.023713
RPS6 ribosomal protein S6 0.0236537
GOLGB1 golgin B1 0.0231323
BRD4 bromodomain containing 4 0.0228271
HOOK2 hook microtubule-tethering protein 2 0.0227739
PTK2 protein tyrosine kinase 2 0.0226904
KDM4B lysine (K)-specific demethylase 4B 0.0225795
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0225371
ARFGEF3 ARFGEF family member 3 0.0224559
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0222993
HILPDA hypoxia inducible lipid droplet-associated 0.0221597
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0221241
COPA coatomer protein complex, subunit alpha 0.0220315
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0215362
NBAS neuroblastoma amplified sequence 0.0214211
HSPH1 heat shock 105kDa/110kDa protein 1 0.0212054
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0210182
MCL1 myeloid cell leukemia 1 0.020976
INTS6 integrator complex subunit 6 0.0207757
HMGA2 high mobility group AT-hook 2 0.0206827
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0206222
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0205906
CDH13 cadherin 13 0.0205404
CALU calumenin 0.0204062
ZEB2 zinc finger E-box binding homeobox 2 0.0203578
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0201883
RIC1 RAB6A GEF complex partner 1 0.0201823
GRAMD1B GRAM domain containing 1B 0.0201562
SMYD3 SET and MYND domain containing 3 0.020082
HSPA8 heat shock 70kDa protein 8 0.0198367
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0195571
EGFR epidermal growth factor receptor 0.0195036
KTN1 kinectin 1 (kinesin receptor) 0.0194143
ITGA6 integrin, alpha 6 0.0193627
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0192791

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.262409
TMSB10 thymosin beta 10 -0.145922
VIM vimentin -0.110714
VCL vinculin -0.0946022
AHNAK AHNAK nucleoprotein -0.0896135
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0797985
LOC112694756 uncharaterized LOC112694756 -0.0683676
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.063424
RTN4 reticulon 4 -0.0623142
CALD1 caldesmon 1 -0.0573183
ACTG1 actin gamma 1 -0.0560494
PTMA prothymosin, alpha -0.053977
RAD21 RAD21 homolog (S. pombe) -0.0535212
ADAM19 ADAM metallopeptidase domain 19 -0.0495039
OSMR oncostatin M receptor -0.0456209
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0436231
PTCHD4 patched domain containing 4 -0.0426804
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0417875
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0412557
APP amyloid beta (A4) precursor protein -0.0409246
NAMPT nicotinamide phosphoribosyltransferase -0.0405644
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0403452
NTM neurotrimin -0.040216
CTSB cathepsin B -0.0396827
EIF1 eukaryotic translation initiation factor 1 -0.0394784
PDE4D phosphodiesterase 4D, cAMP-specific -0.0391456
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0389546
RPS24 ribosomal protein S24 -0.0381332
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0334103
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0334024
MCTP1 multiple C2 domains, transmembrane 1 -0.0331557
MT2A metallothionein 2A -0.0329396
FRMD6 FERM domain containing 6 -0.0328235
NABP1 nucleic acid binding protein 1 -0.0320346
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0319811
CD44 CD44 molecule (Indian blood group) -0.0315074
NPC1 Niemann-Pick disease, type C1 -0.0306725
CDK17 cyclin-dependent kinase 17 -0.0303281
ACTN1 actinin, alpha 1 -0.0302205
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0301267
NF1 neurofibromin 1 -0.0296788
ERBIN erbb2 interacting protein -0.029611
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0294846
PKM pyruvate kinase, muscle -0.0293268
TPM4 tropomyosin 4 -0.0291618
RPLP0 ribosomal protein, large, P0 -0.0291311
RPLP1 ribosomal protein, large, P1 -0.0290716
H1-0 H1.0 linker histone -0.0289312
BTG1 B-cell translocation gene 1, anti-proliferative -0.0289131
ABI1 abl-interactor 1 -0.028713
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0285976
GNAS GNAS complex locus -0.0285948
RPL35A ribosomal protein L35a -0.0274939
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.02736
KYNU kynureninase -0.0273185
TPI1 triosephosphate isomerase 1 -0.0272285
TNNC1 troponin C type 1 (slow) -0.026557
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0258122
EIF3H eukaryotic translation initiation factor 3, subunit H -0.025782
ANKRD28 ankyrin repeat domain 28 -0.0252703
RPL32 ribosomal protein L32 -0.0252625
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0250242
ENKUR enkurin, TRPC channel interacting protein -0.0249746
JMJD1C jumonji domain containing 1C -0.0248709
ZNF217 zinc finger protein 217 -0.0248487
WDR26 WD repeat domain 26 -0.0248185
RPL19 ribosomal protein L19 -0.0244278
HLA-E major histocompatibility complex, class I, E -0.0241515
RPL27A ribosomal protein L27a -0.0240492
MAML2 mastermind-like 2 (Drosophila) -0.0239759
ITGAV integrin, alpha V -0.0235161
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0234433
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0233653
RPL4 ribosomal protein L4 -0.0232757
GLIPR1 GLI pathogenesis-related 1 -0.0231869
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0229711
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0228762
TUBB tubulin, beta class I -0.0228003
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0227759
TPT1 tumor protein, translationally-controlled 1 -0.0227447
PGK1 phosphoglycerate kinase 1 -0.0227329
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0227308
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0224649
HMGA1 high mobility group AT-hook 1 -0.0224372
CFAP299 cilia and flagella associated protein 299 -0.0223347
RPL23 ribosomal protein L23 -0.0219626
STC1 stanniocalcin 1 -0.0218426
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0217
TMEM123 transmembrane protein 123 -0.0214633
PMP22 peripheral myelin protein 22 -0.0214401
WDR43 WD repeat domain 43 -0.0213803
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0212515
GPC6 glypican 6 -0.0212272
FOXP1 forkhead box P1 -0.0211264
EMP1 epithelial membrane protein 1 -0.020952
STK17A serine/threonine kinase 17a -0.0208707
VDAC1 voltage-dependent anion channel 1 -0.0206345
SPAG9 sperm associated antigen 9 -0.020605
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0204243
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0204164