Lipoic acid_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lipoic acid perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lipoic acid_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0937516
LMO7 LIM domain 7 0.07074
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0552558
KLF5 Kruppel-like factor 5 (intestinal) 0.0426701
LDHA lactate dehydrogenase A 0.0380167
HSPA8 heat shock 70kDa protein 8 0.0363958
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0341769
MYO1E myosin IE 0.0341725
INTS6 integrator complex subunit 6 0.0323432
GOLGB1 golgin B1 0.0321985
ASPH aspartate beta-hydroxylase 0.0319575
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0285216
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0281793
CTBP2 C-terminal binding protein 2 0.0262784
TMED3 transmembrane emp24 protein transport domain containing 3 0.0259384
RPL4 ribosomal protein L4 0.0241666
LRRC23 leucine rich repeat containing 23 0.0241493
FAT1 FAT atypical cadherin 1 0.0238943
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0231938
ANXA2 annexin A2 0.0231457
PRELID2 PRELI domain containing 2 0.0221472
ITPRID2 ITPR interacting domain containing 2 0.021275
EXT1 exostosin glycosyltransferase 1 0.0207339
AHNAK AHNAK nucleoprotein 0.0203299
HDLBP high density lipoprotein binding protein 0.0202438
DSG2 desmoglein 2 0.019913
RPL6 ribosomal protein L6 0.0193845
MAML3 mastermind-like 3 (Drosophila) 0.0193654
DSPP dentin sialophosphoprotein 0.0188633
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.018135
PDE4D phosphodiesterase 4D, cAMP-specific 0.0179653
EIF4A2 eukaryotic translation initiation factor 4A2 0.0178495
TMED2 transmembrane emp24 domain trafficking protein 2 0.0176776
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0175299
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0174363
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0173877
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0172036
LOC105378220 macrophage receptor MARCO-like 0.0171605
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0170337
RPL14 ribosomal protein L14 0.0168726
UGDH UDP-glucose 6-dehydrogenase 0.0168164
ANKLE2 ankyrin repeat and LEM domain containing 2 0.0167669
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0166189
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.016241
AHNAK2 AHNAK nucleoprotein 2 0.0160374
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0159963
MTAP methylthioadenosine phosphorylase 0.0158247
RPL13A ribosomal protein L13a 0.0154024
DSC3 desmocollin 3 0.0153283
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0150797
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0150064
RCC1 regulator of chromosome condensation 1 0.0149622
PDZD8 PDZ domain containing 8 0.0147988
PSD3 pleckstrin and Sec7 domain containing 3 0.0147966
LGALS12 lectin, galactoside-binding, soluble, 12 0.0143215
POF1B premature ovarian failure, 1B 0.0143082
CLIC5 chloride intracellular channel 5 0.0142557
XAF1 XIAP associated factor 1 0.0140916
BZW1 basic leucine zipper and W2 domains 1 0.0140424
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0136253
BHLHE40 basic helix-loop-helix family, member e40 0.0136051
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0134884
COG6 component of oligomeric golgi complex 6 0.0133644
IFRD1 interferon-related developmental regulator 1 0.0132481
H1-0 H1.0 linker histone 0.0132352
PGM3 phosphoglucomutase 3 0.0129485
SERINC5 serine incorporator 5 0.0128688
AGR2 anterior gradient 2 0.0126942
TMEM263 transmembrane protein 263 0.0126335
CLTC clathrin, heavy chain (Hc) 0.0126148
GOLM2 golgi membrane protein 2 0.0125799
PALLD palladin, cytoskeletal associated protein 0.012578
LAMB3 laminin, beta 3 0.0124704
HLA-C major histocompatibility complex, class I, C 0.0123683
RPS7 ribosomal protein S7 0.0122391
SEPTIN9 septin 9 0.012226
FTL ferritin, light polypeptide 0.0121461
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0121354
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0121099
MYH9 myosin, heavy chain 9, non-muscle 0.012108
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.012099
EIF4B eukaryotic translation initiation factor 4B 0.0120645
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0119236
PDIA4 protein disulfide isomerase family A, member 4 0.0119231
PMM2 phosphomannomutase 2 0.0118644
ARHGAP21 Rho GTPase activating protein 21 0.0118518
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0117488
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0117184
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0117067
KDM3A lysine (K)-specific demethylase 3A 0.0116895
SNX14 sorting nexin 14 0.011677
CRYBG1 crystallin beta-gamma domain containing 1 0.0116697
ZNF770 zinc finger protein 770 0.0116511
MKI67 marker of proliferation Ki-67 0.0116456
DST dystonin 0.0114746
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.0114641
RPL41 ribosomal protein L41 0.0114089
GOLGA3 golgin A3 0.0113164
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0112998
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.0112533

decreased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 -0.185438
TMSB10 thymosin beta 10 -0.16409
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.15101
RPLP1 ribosomal protein, large, P1 -0.150972
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.143505
RPS19 ribosomal protein S19 -0.128575
RPL34 ribosomal protein L34 -0.0821129
CALB1 calbindin 1, 28kDa -0.0818209
RPL23 ribosomal protein L23 -0.0754675
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0739082
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0707847
RPS21 ribosomal protein S21 -0.0705698
RPLP2 ribosomal protein, large, P2 -0.0687626
FLNB filamin B, beta -0.067637
F3 coagulation factor III (thromboplastin, tissue factor) -0.0639803
RPL35A ribosomal protein L35a -0.0619889
RPL36 ribosomal protein L36 -0.0610304
MX1 MX dynamin-like GTPase 1 -0.0586372
IFI27 interferon, alpha-inducible protein 27 -0.0573502
CLDN4 claudin 4 -0.0569395
RPS14 ribosomal protein S14 -0.0562979
PTMA prothymosin, alpha -0.0558595
RPL11 ribosomal protein L11 -0.0542255
ITGA6 integrin, alpha 6 -0.0528538
RBM25 RNA binding motif protein 25 -0.0514272
EZR ezrin -0.0513729
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0497131
RPLP0 ribosomal protein, large, P0 -0.0493613
RPL18 ribosomal protein L18 -0.0490991
IFI6 interferon, alpha-inducible protein 6 -0.0488833
RAP1B RAP1B, member of RAS oncogene family -0.0471117
HLA-B major histocompatibility complex, class I, B -0.0469108
C6ORF132 chromosome 6 open reading frame 132 -0.0446129
S100A6 S100 calcium binding protein A6 -0.0438816
ACTN4 actinin, alpha 4 -0.0436795
PLAC8 placenta-specific 8 -0.0436444
RPS8 ribosomal protein S8 -0.042748
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0423484
LAMA4 laminin, alpha 4 -0.0412438
DSG3 desmoglein 3 -0.0411765
RNF213 ring finger protein 213 -0.0406105
RIGI RNA sensor RIG-I -0.0398594
ISG15 ISG15 ubiquitin-like modifier -0.0397973
RPL8 ribosomal protein L8 -0.0393628
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0388012
DIAPH1 diaphanous-related formin 1 -0.0381707
UBE2H ubiquitin-conjugating enzyme E2H -0.0377535
PCBP2 poly(rC) binding protein 2 -0.0376394
RPL21 ribosomal protein L21 -0.0374214
RPL35 ribosomal protein L35 -0.0373976
YBX3 Y box binding protein 3 -0.0367441
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0355992
ANXA11 annexin A11 -0.0355037
RNF145 ring finger protein 145 -0.0353641
RPL32 ribosomal protein L32 -0.0349525
POTEF POTE ankyrin domain family, member F -0.034915
RAD51B RAD51 paralog B -0.0347287
TJP1 tight junction protein 1 -0.0346547
RPL36A ribosomal protein L36a -0.0342452
HMGA1 high mobility group AT-hook 1 -0.0342263
JUP junction plakoglobin -0.0340567
RPS27 ribosomal protein S27 -0.0336484
PIAS1 protein inhibitor of activated STAT, 1 -0.0331207
PFN1 profilin 1 -0.0328573
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0324931
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0322489
PKM pyruvate kinase, muscle -0.0320451
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0319204
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0317712
RPL5 ribosomal protein L5 -0.03175
AKAP13 A kinase (PRKA) anchor protein 13 -0.0315816
RPS25 ribosomal protein S25 -0.0311143
RPS5 ribosomal protein S5 -0.0308886
CBX3 chromobox homolog 3 -0.0308027
KTN1 kinectin 1 (kinesin receptor) -0.0307734
RPL28 ribosomal protein L28 -0.0305191
PTPRK protein tyrosine phosphatase, receptor type, K -0.0305056
PLSCR1 phospholipid scramblase 1 -0.0303188
RPL27A ribosomal protein L27a -0.0299566
IFITM3 interferon induced transmembrane protein 3 -0.0298645
BACE2 beta-site APP-cleaving enzyme 2 -0.0297093
MSI2 musashi RNA-binding protein 2 -0.0294155
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.029165
OASL 2'-5'-oligoadenylate synthetase-like -0.0291524
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0291194
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0287193
PTPRG protein tyrosine phosphatase, receptor type, G -0.0282296
PTBP3 polypyrimidine tract binding protein 3 -0.0281362
RPL19 ribosomal protein L19 -0.0281335
VCL vinculin -0.0281144
EPHA2 EPH receptor A2 -0.0276818
GARS1 glycyl-tRNA synthetase 1 -0.0273102
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0272407
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0268926
ETNK1 ethanolamine kinase 1 -0.0268475
RPS13 ribosomal protein S13 -0.0268219
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0265694
RPL9 ribosomal protein L9 -0.026341
GPBP1 GC-rich promoter binding protein 1 -0.0261773
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0260958