| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lipoic acid perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lipoic acid_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.171634 |
| KYNU | kynureninase | 0.152531 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0751212 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0738972 |
| TJP1 | tight junction protein 1 | 0.0725184 |
| ANXA2 | annexin A2 | 0.0631153 |
| PRKCA | protein kinase C, alpha | 0.0605015 |
| GPC6 | glypican 6 | 0.06024 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0589319 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0575839 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0547177 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0522886 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0512871 |
| EZR | ezrin | 0.0494134 |
| MYO5B | myosin VB | 0.0492876 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0489061 |
| SETX | senataxin | 0.0483495 |
| PARD3 | par-3 family cell polarity regulator | 0.0474906 |
| VMP1 | vacuole membrane protein 1 | 0.0464465 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0463621 |
| TCF12 | transcription factor 12 | 0.0454002 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.044856 |
| INTS6 | integrator complex subunit 6 | 0.0443694 |
| RAD51B | RAD51 paralog B | 0.0443554 |
| TXNRD1 | thioredoxin reductase 1 | 0.0439445 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0438698 |
| ATP11A | ATPase, class VI, type 11A | 0.0421819 |
| HOMER1 | homer scaffolding protein 1 | 0.0418243 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0416152 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0404179 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.040061 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0398316 |
| LMO7 | LIM domain 7 | 0.0396022 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0391187 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0386853 |
| GOLGB1 | golgin B1 | 0.0379788 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0374311 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0373562 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0369911 |
| MUC16 | mucin 16, cell surface associated | 0.0367631 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.036677 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.036183 |
| MYO1E | myosin IE | 0.0357048 |
| RALGAPB | Ral GTPase activating protein, beta subunit (non-catalytic) | 0.0356197 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.0354772 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0349225 |
| ENO1 | enolase 1, (alpha) | 0.034207 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0338 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.03369 |
| RNF145 | ring finger protein 145 | 0.0334864 |
| EP300 | E1A binding protein p300 | 0.0332918 |
| STX18 | syntaxin 18 | 0.0331606 |
| SON | SON DNA binding protein | 0.0329233 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0326018 |
| STC1 | stanniocalcin 1 | 0.0323955 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0321431 |
| ANXA11 | annexin A11 | 0.0316898 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0316121 |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.0315438 |
| SLC12A6 | solute carrier family 12 (potassium/chloride transporter), member 6 | 0.0315435 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0314765 |
| OSMR | oncostatin M receptor | 0.0314599 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0312293 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0312074 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0311215 |
| MCU | mitochondrial calcium uniporter | 0.0310442 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0307862 |
| TBC1D15 | TBC1 domain family, member 15 | 0.0302917 |
| DOCK7 | dedicator of cytokinesis 7 | 0.0302232 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0301914 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0301585 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0300391 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0299902 |
| MAP7 | microtubule-associated protein 7 | 0.0298395 |
| NRG1 | neuregulin 1 | 0.0297375 |
| SLK | STE20-like kinase | 0.0294486 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.029136 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0288944 |
| ARL8B | ADP-ribosylation factor-like 8B | 0.0288265 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0288257 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | 0.0286037 |
| SRP54 | signal recognition particle 54kDa | 0.0285476 |
| PRRC2C | proline-rich coiled-coil 2C | 0.028194 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0281521 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0280618 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0280116 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0278107 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0276436 |
| CDC73 | cell division cycle 73 | 0.0275475 |
| MSN | moesin | 0.027547 |
| ETV6 | ets variant 6 | 0.0272547 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0271959 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0271728 |
| AHR | aryl hydrocarbon receptor | 0.027138 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0270475 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0269895 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0269284 |
| COPA | coatomer protein complex, subunit alpha | 0.0268339 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0267526 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0266587 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.15168 |
| FTL | ferritin, light polypeptide | -0.139113 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.101127 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0873019 |
| RPL35A | ribosomal protein L35a | -0.0836491 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0797366 |
| ATOSA | atos homolog A | -0.0777099 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0737137 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0715827 |
| TMSB10 | thymosin beta 10 | -0.0695101 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0665278 |
| MXD1 | MAX dimerization protein 1 | -0.0607035 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.060559 |
| FAM13A | family with sequence similarity 13, member A | -0.0597806 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0592385 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0577098 |
| PTMA | prothymosin, alpha | -0.0563534 |
| RPL26 | ribosomal protein L26 | -0.0562858 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0517455 |
| SQSTM1 | sequestosome 1 | -0.049809 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0494246 |
| SRPK2 | SRSF protein kinase 2 | -0.0492941 |
| PKM | pyruvate kinase, muscle | -0.0491939 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0487299 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0483225 |
| CD2AP | CD2-associated protein | -0.0480792 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0479883 |
| NPTN | neuroplastin | -0.0456513 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0452261 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0451711 |
| XPO1 | exportin 1 | -0.0437038 |
| RIOK3 | RIO kinase 3 | -0.043058 |
| RPLP1 | ribosomal protein, large, P1 | -0.0429745 |
| PDE8A | phosphodiesterase 8A | -0.0428762 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.042857 |
| RPL38 | ribosomal protein L38 | -0.0427777 |
| RPL23 | ribosomal protein L23 | -0.0426704 |
| PTK2 | protein tyrosine kinase 2 | -0.0419308 |
| LASP1 | LIM and SH3 protein 1 | -0.0416769 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0409361 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0408199 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0400507 |
| ZNF638 | zinc finger protein 638 | -0.0394401 |
| FLNB | filamin B, beta | -0.0391269 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | -0.0382704 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0382698 |
| TAOK3 | TAO kinase 3 | -0.0381313 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0378781 |
| HMGA2 | high mobility group AT-hook 2 | -0.0377893 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.037442 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0369624 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.0369032 |
| TMEM165 | transmembrane protein 165 | -0.0366237 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0364789 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0362859 |
| RSF1 | remodeling and spacing factor 1 | -0.0362482 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0360511 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.035815 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0357791 |
| ATF6 | activating transcription factor 6 | -0.035694 |
| TXNIP | thioredoxin interacting protein | -0.035481 |
| FMNL2 | formin-like 2 | -0.0353393 |
| TLK1 | tousled-like kinase 1 | -0.0348035 |
| ADM | adrenomedullin | -0.0347089 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0342504 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0332799 |
| ATP13A3 | ATPase type 13A3 | -0.0332788 |
| RPS8 | ribosomal protein S8 | -0.0323622 |
| HDLBP | high density lipoprotein binding protein | -0.0321435 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0318517 |
| RPL37A | ribosomal protein L37a | -0.0317988 |
| RPS19 | ribosomal protein S19 | -0.0317545 |
| RAI14 | retinoic acid induced 14 | -0.0314493 |
| MMP1 | matrix metallopeptidase 1 | -0.0314254 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0314124 |
| RPL18 | ribosomal protein L18 | -0.0312501 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0311486 |
| S100A11 | S100 calcium binding protein A11 | -0.0311242 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0306975 |
| RPL5 | ribosomal protein L5 | -0.0302051 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0300807 |
| RPS29 | ribosomal protein S29 | -0.0292777 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | -0.0288674 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | -0.0283494 |
| RBM25 | RNA binding motif protein 25 | -0.0281414 |
| RPS27A | ribosomal protein S27a | -0.0277717 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0277368 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0277087 |
| B2M | beta-2-microglobulin | -0.0275902 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0275537 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0275428 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0275349 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0275062 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0273329 |
| CDK17 | cyclin-dependent kinase 17 | -0.0272131 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0270634 |
| IER3 | immediate early response 3 | -0.0270267 |
| S100A6 | S100 calcium binding protein A6 | -0.0270123 |
| RPS12 | ribosomal protein S12 | -0.0269223 |
| RPS6 | ribosomal protein S6 | -0.0268748 |
