Lipoic acid_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lipoic acid perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lipoic acid_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZCCHC7 zinc finger, CCHC domain containing 7 0.117838
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.105021
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.104732
COPA coatomer protein complex, subunit alpha 0.0911553
EEF2 eukaryotic translation elongation factor 2 0.085435
MCL1 myeloid cell leukemia 1 0.0741671
BRD2 bromodomain containing 2 0.0710367
EGR1 early growth response 1 0.0636853
INTS6 integrator complex subunit 6 0.0598543
ELL2 elongation factor, RNA polymerase II, 2 0.0586399
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0568436
PCBP2 poly(rC) binding protein 2 0.0556019
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0510914
PRKCE protein kinase C, epsilon 0.0504438
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0493677
AEBP2 AE binding protein 2 0.0489493
WNK1 WNK lysine deficient protein kinase 1 0.0478996
TLN1 talin 1 0.047385
AKAP9 A kinase (PRKA) anchor protein 9 0.046843
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0462276
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0462111
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0445442
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0444823
KDM2A lysine (K)-specific demethylase 2A 0.044431
SND1 staphylococcal nuclease and tudor domain containing 1 0.0439182
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0428057
ZSWIM6 zinc finger, SWIM-type containing 6 0.0409746
WNT2B wingless-type MMTV integration site family, member 2B 0.0404114
SETX senataxin 0.0401697
PDLIM5 PDZ and LIM domain 5 0.0394632
ZNF638 zinc finger protein 638 0.0385839
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0384437
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0383396
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0365925
RAB7A RAB7A, member RAS oncogene family 0.0362492
PDE4D phosphodiesterase 4D, cAMP-specific 0.0361571
RAD51B RAD51 paralog B 0.0360003
SEC31A SEC31 homolog A (S. cerevisiae) 0.0355013
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0354426
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0348607
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0343561
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0341791
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0341042
HYOU1 hypoxia up-regulated 1 0.033051
CAMKMT calmodulin-lysine N-methyltransferase 0.0329845
UBN2 ubinuclein 2 0.032363
PDIA6 protein disulfide isomerase family A, member 6 0.0321665
BRD4 bromodomain containing 4 0.032088
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0317701
PRELID2 PRELI domain containing 2 0.0317538
VMP1 vacuole membrane protein 1 0.0316255
TPM3 tropomyosin 3 0.0316207
RICTOR RPTOR independent companion of MTOR, complex 2 0.0316097
GOLGB1 golgin B1 0.0314842
CANX calnexin 0.0312021
CSNK1A1 casein kinase 1, alpha 1 0.0309073
AFF3 AF4/FMR2 family, member 3 0.030353
HOMER1 homer scaffolding protein 1 0.030266
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0301009
PMM2 phosphomannomutase 2 0.0299879
SFPQ splicing factor proline/glutamine-rich 0.0298388
BPTF bromodomain PHD finger transcription factor 0.0296205
GON4L gon-4-like (C. elegans) 0.0295391
MEF2D myocyte enhancer factor 2D 0.0292879
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0292317
ATF6 activating transcription factor 6 0.0287868
GPATCH2L G patch domain containing 2-like 0.028635
WWOX WW domain containing oxidoreductase 0.0285483
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0284043
POTEF POTE ankyrin domain family, member F 0.0278329
EXOC6B exocyst complex component 6B 0.0276924
PDIA3 protein disulfide isomerase family A, member 3 0.0275792
FXR1 fragile X mental retardation, autosomal homolog 1 0.0275593
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0272555
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0268838
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0267448
SRRM2 serine/arginine repetitive matrix 2 0.0266614
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0266547
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0264801
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0262807
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.025937
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0258052
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0257615
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0257098
CAMTA1 calmodulin binding transcription activator 1 0.0256435
MYH9 myosin, heavy chain 9, non-muscle 0.0255154
RAB1A RAB1A, member RAS oncogene family 0.0254234
ANKRD11 ankyrin repeat domain 11 0.0253258
ADIPOR2 adiponectin receptor 2 0.0251125
DCAF8 DDB1 and CUL4 associated factor 8 0.0245901
HELZ helicase with zinc finger 0.0243259
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.0243139
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.023844
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0237136
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0236726
COG6 component of oligomeric golgi complex 6 0.023602
ZNF207 zinc finger protein 207 0.0235987
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0235384
AGO3 argonaute RISC catalytic component 3 0.023438
PRH1 proline-rich protein HaeIII subfamily 1 0.0232739

decreased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 -0.185507
TMSB10 thymosin beta 10 -0.0935206
PTMA prothymosin, alpha -0.0899955
TXNRD1 thioredoxin reductase 1 -0.0865134
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0839522
TPT1 tumor protein, translationally-controlled 1 -0.0732026
VIM vimentin -0.0706264
MYL12B myosin, light chain 12B, regulatory -0.0693261
RPL35A ribosomal protein L35a -0.0536939
AKAP12 A kinase (PRKA) anchor protein 12 -0.0534327
RPL37 ribosomal protein L37 -0.0526679
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0513482
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.05009
TM4SF1 transmembrane 4 L six family member 1 -0.0496964
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0482205
RPL12 ribosomal protein L12 -0.0475081
RPS21 ribosomal protein S21 -0.0469853
RPL26 ribosomal protein L26 -0.0451189
RPS24 ribosomal protein S24 -0.0446956
THSD4 thrombospondin, type I, domain containing 4 -0.0431799
AHNAK AHNAK nucleoprotein -0.0420244
GRAMD1B GRAM domain containing 1B -0.0394817
OSMR oncostatin M receptor -0.0392212
NCOA7 nuclear receptor coactivator 7 -0.0391014
NAP1L1 nucleosome assembly protein 1-like 1 -0.0389305
RPS8 ribosomal protein S8 -0.0387971
RPLP0 ribosomal protein, large, P0 -0.0384445
RPS27A ribosomal protein S27a -0.0383894
RPL19 ribosomal protein L19 -0.0382898
KPNB1 karyopherin (importin) beta 1 -0.0378922
RPL34 ribosomal protein L34 -0.037611
TPI1 triosephosphate isomerase 1 -0.0373779
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0373615
MT2A metallothionein 2A -0.0368707
KLF6 Kruppel-like factor 6 -0.0364807
RPL38 ribosomal protein L38 -0.0364771
SINHCAF SIN3-HDAC complex associated factor -0.0363796
KDM3A lysine (K)-specific demethylase 3A -0.0356096
HLA-B major histocompatibility complex, class I, B -0.0347296
TRIO trio Rho guanine nucleotide exchange factor -0.0346132
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.034602
PGK1 phosphoglycerate kinase 1 -0.0345707
BASP1 brain abundant, membrane attached signal protein 1 -0.0343163
SMAD3 SMAD family member 3 -0.0337149
ACTG1 actin gamma 1 -0.0337082
IFI6 interferon, alpha-inducible protein 6 -0.0327296
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0326905
RPS29 ribosomal protein S29 -0.0325386
RTN4 reticulon 4 -0.0313523
PLSCR1 phospholipid scramblase 1 -0.0308155
CCND2 cyclin D2 -0.0303814
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0299895
ZFR zinc finger RNA binding protein -0.0299733
RPL37A ribosomal protein L37a -0.0298078
RPL23 ribosomal protein L23 -0.0293002
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0291094
KTN1 kinectin 1 (kinesin receptor) -0.0291021
CD2AP CD2-associated protein -0.0290366
ADGRG6 adhesion G protein-coupled receptor G6 -0.028952
ZNF217 zinc finger protein 217 -0.0287756
IER3 immediate early response 3 -0.0287722
VDAC1 voltage-dependent anion channel 1 -0.0284942
RAD21 RAD21 homolog (S. pombe) -0.0282617
RPL32 ribosomal protein L32 -0.0276888
RPL11 ribosomal protein L11 -0.0274959
ZNFX1 zinc finger, NFX1-type containing 1 -0.0270238
S100A6 S100 calcium binding protein A6 -0.0269574
RPS3 ribosomal protein S3 -0.0262112
RPS15 ribosomal protein S15 -0.0262086
RPL9 ribosomal protein L9 -0.0261098
CLDN1 claudin 1 -0.0257928
ANKRD12 ankyrin repeat domain 12 -0.0256603
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0255938
RPS16 ribosomal protein S16 -0.0252502
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0252018
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0251326
ZNF292 zinc finger protein 292 -0.0249883
CAVIN1 caveolae associated protein 1 -0.0247658
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0247498
EML4 echinoderm microtubule associated protein like 4 -0.0247079
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0243838
RPLP1 ribosomal protein, large, P1 -0.0243812
HMGA2 high mobility group AT-hook 2 -0.0243156
ZMYND8 zinc finger, MYND-type containing 8 -0.0242974
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0240459
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0239856
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0239376
RPL7L1 ribosomal protein L7-like 1 -0.0233739
IGF1R insulin-like growth factor 1 receptor -0.0232659
RPL30 ribosomal protein L30 -0.0231926
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0229045
SMC4 structural maintenance of chromosomes 4 -0.0228923
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 -0.0228699
H3-3B H3.3 histone B -0.0228159
XPO1 exportin 1 -0.0227442
CD44 CD44 molecule (Indian blood group) -0.0225132
S100A10 S100 calcium binding protein A10 -0.0223476
CCND1 cyclin D1 -0.0223178
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0221639
TNPO1 transportin 1 -0.0220263