| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lipoic acid perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lipoic acid_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.253851 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.130659 |
| GRB10 | growth factor receptor-bound protein 10 | 0.114276 |
| FTL | ferritin, light polypeptide | 0.0948676 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0873877 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0777991 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0712372 |
| VEGFA | vascular endothelial growth factor A | 0.0627076 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0589621 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0588916 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0513791 |
| RAB7A | RAB7A, member RAS oncogene family | 0.049885 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0490946 |
| GOLGB1 | golgin B1 | 0.0483181 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0476848 |
| LDHA | lactate dehydrogenase A | 0.0458341 |
| ANXA2 | annexin A2 | 0.0449835 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0431098 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0429517 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.042778 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0422921 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0413166 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0412031 |
| EFNA5 | ephrin-A5 | 0.040481 |
| CD109 | CD109 molecule | 0.0377557 |
| DTNA | dystrobrevin, alpha | 0.0371346 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0371255 |
| FNIP1 | folliculin interacting protein 1 | 0.0370393 |
| PCBP2 | poly(rC) binding protein 2 | 0.0361819 |
| CTBP2 | C-terminal binding protein 2 | 0.0357925 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0356016 |
| ARF4 | ADP-ribosylation factor 4 | 0.0349825 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0348448 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0346897 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0346325 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0346142 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0345515 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0343757 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0314934 |
| VIM | vimentin | 0.0308097 |
| STC2 | stanniocalcin 2 | 0.0304594 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0302168 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0299301 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0297332 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0296191 |
| FNBP4 | formin binding protein 4 | 0.0291258 |
| FLNB | filamin B, beta | 0.0290078 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | 0.0287693 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0285699 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0285198 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0283703 |
| CLDN4 | claudin 4 | 0.0279555 |
| MCL1 | myeloid cell leukemia 1 | 0.0273327 |
| KIAA1217 | KIAA1217 | 0.0271952 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0269951 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0269598 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.026902 |
| RAD51B | RAD51 paralog B | 0.0267278 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0267118 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.0266714 |
| FAM13A | family with sequence similarity 13, member A | 0.0265969 |
| LOXL2 | lysyl oxidase-like 2 | 0.0263136 |
| INTS6 | integrator complex subunit 6 | 0.026268 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0261291 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0259731 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0259607 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | 0.0258737 |
| MYO1E | myosin IE | 0.0254452 |
| KLHL24 | kelch-like family member 24 | 0.0253784 |
| USP53 | ubiquitin specific peptidase 53 | 0.0252469 |
| BAG6 | BCL2-associated athanogene 6 | 0.024718 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0240252 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0240174 |
| GLRX | glutaredoxin (thioltransferase) | 0.0240008 |
| UPP1 | uridine phosphorylase 1 | 0.0238186 |
| ATOSA | atos homolog A | 0.0234901 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0234263 |
| PRKCA | protein kinase C, alpha | 0.0231216 |
| RREB1 | ras responsive element binding protein 1 | 0.0226101 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0223513 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0222789 |
| ATP11A | ATPase, class VI, type 11A | 0.0221265 |
| FBXO11 | F-box protein 11 | 0.0220106 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0219325 |
| HDAC9 | histone deacetylase 9 | 0.0217346 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0217196 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0216292 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0214234 |
| EGR1 | early growth response 1 | 0.021402 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0212866 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0212587 |
| EGFR | epidermal growth factor receptor | 0.0212438 |
| CERT1 | ceramide transporter 1 | 0.0211145 |
| SDCBP | syndecan binding protein (syntenin) | 0.0211081 |
| RPL35A | ribosomal protein L35a | 0.0209537 |
| FUS | FUS RNA binding protein | 0.0207909 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | 0.0207877 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0207339 |
| ATXN1 | ataxin 1 | 0.0205878 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0204221 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.17381 |
| ASPH | aspartate beta-hydroxylase | -0.137477 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.127462 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.125775 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.113107 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.110971 |
| S100A6 | S100 calcium binding protein A6 | -0.105735 |
| TMSB4X | thymosin beta 4, X-linked | -0.103657 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0974861 |
| LAMC2 | laminin, gamma 2 | -0.094287 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0925198 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0924331 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0770306 |
| HMGB2 | high mobility group box 2 | -0.0757321 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0719737 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0704835 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0684986 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.067917 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0650339 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0642861 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0629192 |
| PGK1 | phosphoglycerate kinase 1 | -0.058286 |
| ACTG1 | actin gamma 1 | -0.0567174 |
| PTMA | prothymosin, alpha | -0.0554222 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0552261 |
| TFG | TRK-fused gene | -0.0541889 |
| UBC | ubiquitin C | -0.0541883 |
| TMSB10 | thymosin beta 10 | -0.0513713 |
| S100A10 | S100 calcium binding protein A10 | -0.0495901 |
| MSMO1 | methylsterol monooxygenase 1 | -0.0484803 |
| RPL32 | ribosomal protein L32 | -0.0481675 |
| DSG2 | desmoglein 2 | -0.0470163 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0469626 |
| RPL34 | ribosomal protein L34 | -0.0462129 |
| RPS2 | ribosomal protein S2 | -0.0457523 |
| KRT18 | keratin 18, type I | -0.0456257 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0442948 |
| CD2AP | CD2-associated protein | -0.0441596 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0438206 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0431585 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0431049 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0427638 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0420728 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0408933 |
| RPL19 | ribosomal protein L19 | -0.0403222 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0402866 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0398018 |
| TKT | transketolase | -0.038817 |
| ADAR | adenosine deaminase, RNA-specific | -0.0383004 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.038046 |
| RPS24 | ribosomal protein S24 | -0.0376258 |
| RPL11 | ribosomal protein L11 | -0.0374037 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | -0.0373318 |
| TMEM123 | transmembrane protein 123 | -0.0373037 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0366296 |
| RPL4 | ribosomal protein L4 | -0.0361788 |
| GPX4 | glutathione peroxidase 4 | -0.0361138 |
| SDC4 | syndecan 4 | -0.0359497 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.0357407 |
| ANLN | anillin, actin binding protein | -0.0354972 |
| MKI67 | marker of proliferation Ki-67 | -0.0353362 |
| KRT7 | keratin 7, type II | -0.0349963 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0349579 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0347485 |
| TXNRD1 | thioredoxin reductase 1 | -0.0342978 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0342798 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0342188 |
| RACK1 | receptor for activated C kinase 1 | -0.0341742 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.034174 |
| CLINT1 | clathrin interactor 1 | -0.0341687 |
| CCND1 | cyclin D1 | -0.0341629 |
| RPL7 | ribosomal protein L7 | -0.0341483 |
| RPS21 | ribosomal protein S21 | -0.033955 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0338862 |
| RPL12 | ribosomal protein L12 | -0.0331745 |
| RPL15 | ribosomal protein L15 | -0.0327924 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.0325681 |
| CDK17 | cyclin-dependent kinase 17 | -0.0322811 |
| PAPOLA | poly(A) polymerase alpha | -0.0320898 |
| POTEF | POTE ankyrin domain family, member F | -0.0319816 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0319117 |
| YBX3 | Y box binding protein 3 | -0.031633 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0314682 |
| RPLP0 | ribosomal protein, large, P0 | -0.0312789 |
| TPX2 | TPX2, microtubule-associated | -0.0310363 |
| EPCAM | epithelial cell adhesion molecule | -0.0308042 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0305094 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | -0.0303402 |
| TUBA1B | tubulin, alpha 1b | -0.0297511 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0295832 |
| RPL26 | ribosomal protein L26 | -0.0295748 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0295394 |
| MATR3 | matrin 3 | -0.0295206 |
| PEG10 | paternally expressed 10 | -0.029403 |
| RPLP2 | ribosomal protein, large, P2 | -0.0293268 |
| RPS12 | ribosomal protein S12 | -0.0292822 |
| RYBP | RING1 and YY1 binding protein | -0.0287 |
| H3-3B | H3.3 histone B | -0.0285062 |
| RPS23 | ribosomal protein S23 | -0.0284242 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0282994 |
