| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lipoic acid perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lipoic acid_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | 0.13967 |
| DST | dystonin | 0.113165 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0995523 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0754292 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0631452 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0608194 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0447716 |
| PDE10A | phosphodiesterase 10A | 0.0438934 |
| EFNA5 | ephrin-A5 | 0.0423989 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0418168 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0414037 |
| KYNU | kynureninase | 0.040793 |
| INTS6 | integrator complex subunit 6 | 0.0398441 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.038025 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0376231 |
| GRAMD1B | GRAM domain containing 1B | 0.0367108 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0351372 |
| GDA | guanine deaminase | 0.0341264 |
| DNER | delta/notch-like EGF repeat containing | 0.0339271 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0326246 |
| COL5A2 | collagen, type V, alpha 2 | 0.0322097 |
| FMNL2 | formin-like 2 | 0.0318012 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0303439 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0303319 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0299745 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0291792 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0276107 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0268691 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.024585 |
| PRELID2 | PRELI domain containing 2 | 0.0245032 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0244096 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.024045 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0239358 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.0234229 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0233868 |
| BDNF | brain-derived neurotrophic factor | 0.0227501 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0223172 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0223107 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0221009 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.020961 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0208142 |
| MALT1 | MALT1 paracaspase | 0.0204184 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0198641 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0196872 |
| DOCK5 | dedicator of cytokinesis 5 | 0.019672 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0193476 |
| PCBP2 | poly(rC) binding protein 2 | 0.0192987 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0192843 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0192537 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0191657 |
| CTBP2 | C-terminal binding protein 2 | 0.0186468 |
| DNMBP | dynamin binding protein | 0.0183297 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0178093 |
| CLTC | clathrin, heavy chain (Hc) | 0.017668 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0175408 |
| ATXN7 | ataxin 7 | 0.0174951 |
| PTEN | phosphatase and tensin homolog | 0.0174913 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0174559 |
| DISP1 | dispatched homolog 1 (Drosophila) | 0.0170877 |
| MARCHF1 | membrane associated ring-CH-type finger 1 | 0.0167705 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0167142 |
| RPS2 | ribosomal protein S2 | 0.0166962 |
| RAD51B | RAD51 paralog B | 0.0166295 |
| GLCCI1 | glucocorticoid induced 1 | 0.0165398 |
| SCARA5 | scavenger receptor class A, member 5 | 0.0164185 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | 0.0162338 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0160629 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0160227 |
| GLRX | glutaredoxin (thioltransferase) | 0.0159718 |
| MSN | moesin | 0.0158554 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0157338 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0154772 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0154161 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0153705 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0152594 |
| CTSC | cathepsin C | 0.0151392 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0151245 |
| GPC6 | glypican 6 | 0.015103 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.015081 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.0150069 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.014907 |
| TOP1 | topoisomerase (DNA) I | 0.014842 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.014649 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0145946 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0145424 |
| HEATR1 | HEAT repeat containing 1 | 0.0142844 |
| HYOU1 | hypoxia up-regulated 1 | 0.0141851 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0140236 |
| FLNB | filamin B, beta | 0.0139375 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0138947 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0138686 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0135865 |
| MOSMO | modulator of smoothened | 0.013584 |
| PYGB | phosphorylase, glycogen; brain | 0.0135619 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0135065 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.0134796 |
| RNF145 | ring finger protein 145 | 0.013478 |
| CUL3 | cullin 3 | 0.0132254 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0131735 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0131643 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.307049 |
| FN1 | fibronectin 1 | -0.190986 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.162921 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.134027 |
| VIM | vimentin | -0.123772 |
| PTMA | prothymosin, alpha | -0.113169 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0992229 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0822471 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0780058 |
| TMSB10 | thymosin beta 10 | -0.0738177 |
| RPLP1 | ribosomal protein, large, P1 | -0.0638688 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0602733 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0585615 |
| RPS24 | ribosomal protein S24 | -0.055698 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0533489 |
| MYOF | myoferlin | -0.0525426 |
| INHBA | inhibin, beta A | -0.051918 |
| IL6 | interleukin 6 | -0.0516219 |
| RPL35A | ribosomal protein L35a | -0.0509976 |
| RPS6 | ribosomal protein S6 | -0.0502872 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0497797 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0488072 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0485267 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0472673 |
| PGK1 | phosphoglycerate kinase 1 | -0.0471356 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0469851 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0465291 |
| CD109 | CD109 molecule | -0.0464042 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0463249 |
| CDH13 | cadherin 13 | -0.0460554 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0459214 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0451417 |
| S100A6 | S100 calcium binding protein A6 | -0.0450752 |
| STC1 | stanniocalcin 1 | -0.0420552 |
| HLA-B | major histocompatibility complex, class I, B | -0.0409801 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0401448 |
| SPAG9 | sperm associated antigen 9 | -0.0394336 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0387319 |
| CANX | calnexin | -0.0384884 |
| IER3 | immediate early response 3 | -0.0384542 |
| CTSL | cathepsin L | -0.0381076 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0374453 |
| SMYD3 | SET and MYND domain containing 3 | -0.0373548 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0372796 |
| RPLP0 | ribosomal protein, large, P0 | -0.0370622 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0369716 |
| PCBP3 | poly(rC) binding protein 3 | -0.0367683 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0365004 |
| B2M | beta-2-microglobulin | -0.0359668 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.0358543 |
| GNAS | GNAS complex locus | -0.0356501 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0352044 |
| RPS27A | ribosomal protein S27a | -0.0348563 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0347273 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0347273 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0346948 |
| RPL26 | ribosomal protein L26 | -0.0346346 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0344504 |
| S100A10 | S100 calcium binding protein A10 | -0.0339912 |
| RPL19 | ribosomal protein L19 | -0.0339336 |
| FTL | ferritin, light polypeptide | -0.0334786 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0330172 |
| PTGR1 | prostaglandin reductase 1 | -0.0329445 |
| HLA-A | major histocompatibility complex, class I, A | -0.032791 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0324218 |
| RPL38 | ribosomal protein L38 | -0.0322297 |
| NCKAP5 | NCK-associated protein 5 | -0.0322114 |
| TMSB4X | thymosin beta 4, X-linked | -0.0313396 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0311937 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.031088 |
| RPL7A | ribosomal protein L7a | -0.0310719 |
| OSMR | oncostatin M receptor | -0.0310549 |
| RPL12 | ribosomal protein L12 | -0.0309676 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0307984 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0302842 |
| ENO1 | enolase 1, (alpha) | -0.0296941 |
| ESM1 | endothelial cell-specific molecule 1 | -0.0296386 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0294829 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0292875 |
| ASPH | aspartate beta-hydroxylase | -0.0292221 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0289752 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0289024 |
| SLC16A6 | solute carrier family 16, member 6 | -0.0288561 |
| RPL37A | ribosomal protein L37a | -0.0288317 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.02872 |
| RPL34 | ribosomal protein L34 | -0.0286779 |
| TPM4 | tropomyosin 4 | -0.0280557 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0277991 |
| BMERB1 | bMERB domain containing 1 | -0.0275758 |
| RPL31 | ribosomal protein L31 | -0.0270963 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.0269518 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0266795 |
| ABLIM1 | actin binding LIM protein 1 | -0.0263676 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0261209 |
| PRSS23 | protease, serine, 23 | -0.0259596 |
| RPL36A | ribosomal protein L36a | -0.0258461 |
| ACTG1 | actin gamma 1 | -0.0256153 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0256034 |
| RPL9 | ribosomal protein L9 | -0.0254899 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0252389 |
