| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lipoic acid perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lipoic acid_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EHBP1 | EH domain binding protein 1 | 0.165453 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.125675 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.122837 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.119653 |
| ASPH | aspartate beta-hydroxylase | 0.118996 |
| ZNF638 | zinc finger protein 638 | 0.116271 |
| FMN1 | formin 1 | 0.114144 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.10995 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.109929 |
| DST | dystonin | 0.104811 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0927368 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0896999 |
| NPAS2 | neuronal PAS domain protein 2 | 0.089645 |
| NAV2 | neuron navigator 2 | 0.0865945 |
| FRMD5 | FERM domain containing 5 | 0.0859998 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0855096 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0839783 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0805506 |
| VIM | vimentin | 0.0775016 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0764396 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0749594 |
| RAD51B | RAD51 paralog B | 0.0711225 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0668923 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0658678 |
| EXT1 | exostosin glycosyltransferase 1 | 0.065691 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0637099 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0608378 |
| RUNX1 | runt-related transcription factor 1 | 0.0588655 |
| FN1 | fibronectin 1 | 0.0582932 |
| FLNB | filamin B, beta | 0.0559609 |
| VCL | vinculin | 0.0559257 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0554535 |
| EFNA5 | ephrin-A5 | 0.0545991 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.052971 |
| PTK2 | protein tyrosine kinase 2 | 0.0526513 |
| SQSTM1 | sequestosome 1 | 0.0516505 |
| MED13L | mediator complex subunit 13-like | 0.0513083 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0505516 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0505344 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0497167 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0486686 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0468205 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0449875 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0447186 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0441769 |
| LDHA | lactate dehydrogenase A | 0.0432427 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0400574 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.039575 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0395073 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0375287 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0370385 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0326196 |
| BPTF | bromodomain PHD finger transcription factor | 0.0324317 |
| FMNL2 | formin-like 2 | 0.032203 |
| PRRC2C | proline-rich coiled-coil 2C | 0.031633 |
| AUTS2 | autism susceptibility candidate 2 | 0.0313908 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0310746 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0282082 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0261239 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0259012 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0238615 |
| SLC38A2 | solute carrier family 38, member 2 | 0.023667 |
| RORA | RAR-related orphan receptor A | 0.0226225 |
| EXOC4 | exocyst complex component 4 | 0.0222317 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.022197 |
| SMYD3 | SET and MYND domain containing 3 | 0.0192408 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0185346 |
| VMP1 | vacuole membrane protein 1 | 0.0177259 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0151249 |
| PRELID2 | PRELI domain containing 2 | 0.0141964 |
| STC1 | stanniocalcin 1 | 0.0134686 |
| HELZ | helicase with zinc finger | 0.0133532 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.013083 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0125881 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0106704 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.00995731 |
| NCOR1 | nuclear receptor corepressor 1 | 0.00970299 |
| NKTR | natural killer cell triggering receptor | 0.00963389 |
| SMAD3 | SMAD family member 3 | 0.00954226 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.00888239 |
| CDK6 | cyclin-dependent kinase 6 | 0.00871986 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.00846935 |
| SPATA13 | spermatogenesis associated 13 | 0.00837892 |
| MYO1E | myosin IE | 0.00819791 |
| MYOF | myoferlin | 0.00791891 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0078126 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0073297 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.00719532 |
| PDE10A | phosphodiesterase 10A | 0.00645462 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.00627433 |
| GOLGA4 | golgin A4 | 0.00588006 |
| RBM39 | RNA binding motif protein 39 | 0.00546469 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.00462577 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.00349232 |
| CANX | calnexin | 0.00329896 |
| RCOR1 | REST corepressor 1 | 0.00290805 |
| ANKRD11 | ankyrin repeat domain 11 | 0.00248099 |
| USP34 | ubiquitin specific peptidase 34 | 0.00152028 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0011715 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.00105087 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.163182 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.153399 |
| SLTM | SAFB-like, transcription modulator | -0.137387 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.130596 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.107659 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0998803 |
| RPLP1 | ribosomal protein, large, P1 | -0.0913736 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.089913 |
| MT2A | metallothionein 2A | -0.0883875 |
| LAMA4 | laminin, alpha 4 | -0.0883323 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0857839 |
| TMSB10 | thymosin beta 10 | -0.081906 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0804398 |
| ITGA6 | integrin, alpha 6 | -0.0799175 |
| RSF1 | remodeling and spacing factor 1 | -0.0792051 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0769145 |
| LMO7 | LIM domain 7 | -0.0743826 |
| PKM | pyruvate kinase, muscle | -0.0725049 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0715339 |
| JMJD1C | jumonji domain containing 1C | -0.0697569 |
| OSMR | oncostatin M receptor | -0.0690808 |
| RPS6 | ribosomal protein S6 | -0.0686992 |
| PCBP2 | poly(rC) binding protein 2 | -0.0683988 |
| MYO10 | myosin X | -0.0652371 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0650301 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0620471 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0616261 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0611084 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0603841 |
| EGFR | epidermal growth factor receptor | -0.0603795 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0603177 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.059352 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0576232 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.057534 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0568672 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.056698 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.056591 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0551769 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0542528 |
| HMGA2 | high mobility group AT-hook 2 | -0.0531151 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0528185 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0516257 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0502199 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0481453 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0473778 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0473587 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0470665 |
| ENO1 | enolase 1, (alpha) | -0.0465541 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0456204 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0445963 |
| SBF2 | SET binding factor 2 | -0.0443136 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.039212 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0388683 |
| EZR | ezrin | -0.0377834 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0370991 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0361764 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0348273 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0345378 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0342809 |
| NCOA6 | nuclear receptor coactivator 6 | -0.0325807 |
| SYT1 | synaptotagmin I | -0.0316074 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0313392 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0300604 |
| PRKCA | protein kinase C, alpha | -0.0298464 |
| CD44 | CD44 molecule (Indian blood group) | -0.0287037 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0285403 |
| ATP11A | ATPase, class VI, type 11A | -0.0273865 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0272853 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0271595 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0258139 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0256833 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0251997 |
| GOLGB1 | golgin B1 | -0.0242952 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0240706 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0238896 |
| MYO1D | myosin ID | -0.0237324 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0229227 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0227531 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0222424 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0188804 |
| ATXN1 | ataxin 1 | -0.0180182 |
| SPAG9 | sperm associated antigen 9 | -0.0174677 |
| DENND1A | DENN/MADD domain containing 1A | -0.0172815 |
| B2M | beta-2-microglobulin | -0.0169042 |
| RTN4 | reticulon 4 | -0.0150315 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.014985 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0133389 |
| FNIP1 | folliculin interacting protein 1 | -0.0122707 |
| ZNF292 | zinc finger protein 292 | -0.0122457 |
| ANXA2 | annexin A2 | -0.0120982 |
| POTEF | POTE ankyrin domain family, member F | -0.011373 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0111848 |
| MCL1 | myeloid cell leukemia 1 | -0.0106954 |
| IGF2 | insulin-like growth factor 2 | -0.00684929 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.00594109 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0048237 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.00271227 |
| OXR1 | oxidation resistance 1 | -0.00225156 |
| ACTG1 | actin gamma 1 | -0.00164749 |
| NDRG1 | N-myc downstream regulated 1 | -0.00136667 |
