Lipoic acid_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lipoic acid perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lipoic acid_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 0.0894873
ZSWIM6 zinc finger, SWIM-type containing 6 0.0688218
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0598865
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0583635
BCAR3 breast cancer anti-estrogen resistance 3 0.0506388
LMO7 LIM domain 7 0.0495906
HDAC9 histone deacetylase 9 0.0465174
TJP1 tight junction protein 1 0.0409615
MYO1E myosin IE 0.0407476
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0378674
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0345603
MYO5B myosin VB 0.0340022
SAMD4A sterile alpha motif domain containing 4A 0.0339814
PDLIM5 PDZ and LIM domain 5 0.0337857
SEPTIN9 septin 9 0.0321912
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0296435
PPARD peroxisome proliferator-activated receptor delta 0.0292387
N4BP2L2 NEDD4 binding protein 2-like 2 0.0286777
MUC4 mucin 4, cell surface associated 0.0286194
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0282343
EGFR epidermal growth factor receptor 0.0282229
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0281055
GOLGB1 golgin B1 0.0275854
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0270607
AKAP12 A kinase (PRKA) anchor protein 12 0.026513
VEGFA vascular endothelial growth factor A 0.0260231
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0251947
AREG amphiregulin 0.0247816
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0246902
SMAD3 SMAD family member 3 0.024022
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0238784
SIK3 SIK family kinase 3 0.023728
BACE2 beta-site APP-cleaving enzyme 2 0.0229928
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0226894
WWC1 WW and C2 domain containing 1 0.0216877
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0213453
JARID2 jumonji, AT rich interactive domain 2 0.0213413
NCEH1 neutral cholesterol ester hydrolase 1 0.0210726
PCNX4 pecanex 4 0.0209558
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0205305
SHB Src homology 2 domain containing adaptor protein B 0.020169
SYT14 synaptotagmin XIV 0.020037
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0197892
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0197357
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0193331
RIMKLB ribosomal modification protein rimK-like family member B 0.018902
PATJ PATJ crumbs cell polarity complex component 0.0183189
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.018231
ZC3H12C zinc finger CCCH-type containing 12C 0.0178613
PCLO piccolo presynaptic cytomatrix protein 0.017769
AKAP13 A kinase (PRKA) anchor protein 13 0.017684
MACC1 metastasis associated in colon cancer 1 0.0169354
SGMS2 sphingomyelin synthase 2 0.0169235
ZNF644 zinc finger protein 644 0.0168242
BCAS3 breast carcinoma amplified sequence 3 0.0165986
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0165795
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0165376
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0165269
CTBP2 C-terminal binding protein 2 0.0162803
MYEOV myeloma overexpressed 0.0162384
ZHX2 zinc fingers and homeoboxes 2 0.0161467
HSPA8 heat shock 70kDa protein 8 0.0160511
RPS2 ribosomal protein S2 0.0159384
RAB7A RAB7A, member RAS oncogene family 0.0159098
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0158505
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0157717
AEBP2 AE binding protein 2 0.0156986
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0156434
MACF1 microtubule-actin crosslinking factor 1 0.0152906
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.0152447
TGFB2 transforming growth factor, beta 2 0.0151279
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0150037
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.014944
LPP LIM domain containing preferred translocation partner in lipoma 0.0148842
MAST4 microtubule associated serine/threonine kinase family member 4 0.0148656
VGLL3 vestigial-like family member 3 0.0148621
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0147105
MYO6 myosin VI 0.0145631
CD59 CD59 molecule, complement regulatory protein 0.0144457
HOMER1 homer scaffolding protein 1 0.0143458
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0142978
SFPQ splicing factor proline/glutamine-rich 0.0141623
BRD2 bromodomain containing 2 0.0140659
GATAD2A GATA zinc finger domain containing 2A 0.0140653
THSD4 thrombospondin, type I, domain containing 4 0.0138386
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0138328
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.013799
LATS2 large tumor suppressor kinase 2 0.0137519
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0137313
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0136603
KYNU kynureninase 0.0133872
RPS12 ribosomal protein S12 0.0133501
RCOR1 REST corepressor 1 0.01334
PLSCR1 phospholipid scramblase 1 0.0133255
MPRIP myosin phosphatase Rho interacting protein 0.0133085
UBAP2 ubiquitin associated protein 2 0.0132335
FAM107B family with sequence similarity 107, member B 0.013219
MCL1 myeloid cell leukemia 1 0.0130483
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0127684
NABP1 nucleic acid binding protein 1 0.0127565

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.307486
PTMA prothymosin, alpha -0.150723
TMSB4X thymosin beta 4, X-linked -0.126178
TMSB10 thymosin beta 10 -0.108323
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.106707
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0929746
AHNAK AHNAK nucleoprotein -0.0894054
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0874603
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0772748
PGK1 phosphoglycerate kinase 1 -0.0743339
CD2AP CD2-associated protein -0.0717785
EMP1 epithelial membrane protein 1 -0.0667724
KRT19 keratin 19, type I -0.0652257
TMEM123 transmembrane protein 123 -0.0652044
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0636203
NPEPPS aminopeptidase puromycin sensitive -0.0623089
EZR ezrin -0.0621384
RUNX1 runt-related transcription factor 1 -0.0620303
RPLP1 ribosomal protein, large, P1 -0.057175
CANX calnexin -0.0568655
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0567056
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0564943
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0561957
F3 coagulation factor III (thromboplastin, tissue factor) -0.0553189
ANLN anillin, actin binding protein -0.0550624
KRT18 keratin 18, type I -0.0546047
NDRG1 N-myc downstream regulated 1 -0.0528514
S100A6 S100 calcium binding protein A6 -0.0518231
DLG1 discs, large homolog 1 (Drosophila) -0.0511142
LOC112694756 uncharaterized LOC112694756 -0.0497014
LY6E lymphocyte antigen 6 complex, locus E -0.0491862
S100A10 S100 calcium binding protein A10 -0.0490473
HMGA1 high mobility group AT-hook 1 -0.0489779
FN1 fibronectin 1 -0.0476689
TSC22D2 TSC22 domain family, member 2 -0.0475819
LAMA4 laminin, alpha 4 -0.0466001
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0465014
TPI1 triosephosphate isomerase 1 -0.0463371
KRT7 keratin 7, type II -0.0459573
KRT17 keratin 17, type I -0.0457048
MKI67 marker of proliferation Ki-67 -0.0450088
RNF213 ring finger protein 213 -0.0444095
RPL35A ribosomal protein L35a -0.0442872
TPM4 tropomyosin 4 -0.0432155
HLA-B major histocompatibility complex, class I, B -0.0430953
RLF rearranged L-myc fusion -0.0428032
ANXA2 annexin A2 -0.0420111
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0417423
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0417416
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0412394
CAV1 caveolin 1, caveolae protein, 22kDa -0.0411772
H1-0 H1.0 linker histone -0.0411748
SMC4 structural maintenance of chromosomes 4 -0.040631
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0404977
FCHSD2 FCH and double SH3 domains 2 -0.0389905
KDM3A lysine (K)-specific demethylase 3A -0.0389639
LDHA lactate dehydrogenase A -0.0386265
DEK DEK proto-oncogene -0.0382935
RAD21 RAD21 homolog (S. pombe) -0.0376244
FTH1 ferritin, heavy polypeptide 1 -0.0373334
FOSL1 FOS-like antigen 1 -0.0373143
HLA-A major histocompatibility complex, class I, A -0.0370292
PKM pyruvate kinase, muscle -0.0367849
IFI27 interferon, alpha-inducible protein 27 -0.0364468
TXNIP thioredoxin interacting protein -0.0363645
WSB1 WD repeat and SOCS box containing 1 -0.0363305
FNDC3B fibronectin type III domain containing 3B -0.0362282
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0361796
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0357482
NAMPT nicotinamide phosphoribosyltransferase -0.0357148
WDR45B WD repeat domain 45B -0.0357134
RPL19 ribosomal protein L19 -0.0351698
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0351317
DDIT4 DNA-damage-inducible transcript 4 -0.0348416
ECT2 epithelial cell transforming 2 -0.034629
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0345391
MT2A metallothionein 2A -0.0342846
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.034026
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0340247
XPO1 exportin 1 -0.0338324
DIAPH3 diaphanous-related formin 3 -0.0336997
EHF ets homologous factor -0.0334178
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0333352
RPS19 ribosomal protein S19 -0.0332827
PRRC2C proline-rich coiled-coil 2C -0.0329086
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0327799
HLA-E major histocompatibility complex, class I, E -0.0319647
OGA O-GlcNAcase -0.0319035
TXNRD1 thioredoxin reductase 1 -0.0313134
KPNB1 karyopherin (importin) beta 1 -0.03125
HLA-C major histocompatibility complex, class I, C -0.0307738
RBM25 RNA binding motif protein 25 -0.0307136
CALR calreticulin -0.0305964
TM4SF1 transmembrane 4 L six family member 1 -0.0304475
ACTN4 actinin, alpha 4 -0.0301331
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0299901
RPS6 ribosomal protein S6 -0.0299071
NT5C2 5'-nucleotidase, cytosolic II -0.0296542
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0294689
ANKRD10 ankyrin repeat domain 10 -0.0290232