| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lipoic acid perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lipoic acid_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.19708 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.101224 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0855476 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0733562 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0671257 |
| HDAC9 | histone deacetylase 9 | 0.0642521 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0625872 |
| GOLGB1 | golgin B1 | 0.0585899 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0561709 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0540524 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0456938 |
| H1-0 | H1.0 linker histone | 0.0454888 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0448498 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0432481 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0424084 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0416243 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0412463 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0411224 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0406251 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0403276 |
| ASPH | aspartate beta-hydroxylase | 0.0388454 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0364437 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0359595 |
| EGR1 | early growth response 1 | 0.0357428 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0355325 |
| INTS6 | integrator complex subunit 6 | 0.0349821 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0346532 |
| PTK2 | protein tyrosine kinase 2 | 0.03434 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0327005 |
| KYNU | kynureninase | 0.0326652 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0326541 |
| CDK13 | cyclin-dependent kinase 13 | 0.0325003 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0320703 |
| CUL3 | cullin 3 | 0.0311464 |
| DST | dystonin | 0.0311181 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.031014 |
| SMYD3 | SET and MYND domain containing 3 | 0.0308962 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0304047 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0303256 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0298645 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0297855 |
| MYO9A | myosin IXA | 0.0293351 |
| ANXA2 | annexin A2 | 0.0287847 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0285269 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0284649 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0281674 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0279578 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0278773 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.0273326 |
| TOP1 | topoisomerase (DNA) I | 0.0270573 |
| RBM39 | RNA binding motif protein 39 | 0.0268875 |
| CLINT1 | clathrin interactor 1 | 0.0268293 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0267811 |
| HDLBP | high density lipoprotein binding protein | 0.026719 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.02665 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0264231 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0264173 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0262789 |
| CTSB | cathepsin B | 0.0261809 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.025892 |
| NAV2 | neuron navigator 2 | 0.025088 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0250723 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0249801 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0248117 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0246065 |
| SDCBP | syndecan binding protein (syntenin) | 0.024486 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0244363 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.024393 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0243507 |
| DENND4A | DENN/MADD domain containing 4A | 0.0243172 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0242733 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0241255 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0237758 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0237087 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0236604 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0234486 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0234236 |
| SMAD3 | SMAD family member 3 | 0.023257 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0231807 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0230196 |
| CRY1 | cryptochrome circadian clock 1 | 0.0229882 |
| NUMB | numb homolog (Drosophila) | 0.02282 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0226355 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0225697 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0225145 |
| RAD51B | RAD51 paralog B | 0.0224972 |
| GOLGA4 | golgin A4 | 0.0224922 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.022332 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.022314 |
| RPS3 | ribosomal protein S3 | 0.0222381 |
| APP | amyloid beta (A4) precursor protein | 0.0222361 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0221777 |
| PMM2 | phosphomannomutase 2 | 0.021821 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0218036 |
| KIAA1217 | KIAA1217 | 0.021704 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0216448 |
| TUT7 | terminal uridylyl transferase 7 | 0.0216438 |
| THBS1 | thrombospondin 1 | 0.0215532 |
| PGM3 | phosphoglucomutase 3 | 0.0215351 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.021451 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A2 | collagen, type I, alpha 2 | -0.147913 |
| COL1A1 | collagen, type I, alpha 1 | -0.115906 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.112994 |
| NDRG1 | N-myc downstream regulated 1 | -0.0847203 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0778844 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0736259 |
| TMSB10 | thymosin beta 10 | -0.0658103 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0586372 |
| HLA-B | major histocompatibility complex, class I, B | -0.0583913 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0522376 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0518473 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.051574 |
| PGK1 | phosphoglycerate kinase 1 | -0.0504763 |
| STC1 | stanniocalcin 1 | -0.0487018 |
| FTL | ferritin, light polypeptide | -0.0482936 |
| MEF2A | myocyte enhancer factor 2A | -0.0468147 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.044563 |
| CD109 | CD109 molecule | -0.0433621 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0432602 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0432022 |
| NRP1 | neuropilin 1 | -0.0415685 |
| FN1 | fibronectin 1 | -0.0394025 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0392963 |
| SETD5 | SET domain containing 5 | -0.0351062 |
| MT2A | metallothionein 2A | -0.0349278 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0348969 |
| SSH1 | slingshot protein phosphatase 1 | -0.0342453 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0342027 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0338834 |
| VIM | vimentin | -0.0336768 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0333774 |
| FNDC3B | fibronectin type III domain containing 3B | -0.033059 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.032763 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0318632 |
| RTN4 | reticulon 4 | -0.0315779 |
| EML5 | echinoderm microtubule associated protein like 5 | -0.0312066 |
| PFN1 | profilin 1 | -0.0309273 |
| ZNF148 | zinc finger protein 148 | -0.03068 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0305365 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0300463 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0295518 |
| S100A6 | S100 calcium binding protein A6 | -0.0294213 |
| PLIN2 | perilipin 2 | -0.0286758 |
| MYO1B | myosin IB | -0.0278902 |
| FRMD4A | FERM domain containing 4A | -0.0271991 |
| XPO1 | exportin 1 | -0.0270657 |
| CDH13 | cadherin 13 | -0.0265405 |
| HLA-C | major histocompatibility complex, class I, C | -0.0260478 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0259082 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0256743 |
| EHD2 | EH-domain containing 2 | -0.0252145 |
| COLEC10 | collectin sub-family member 10 (C-type lectin) | -0.0247918 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0243989 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0236466 |
| MX1 | MX dynamin-like GTPase 1 | -0.0234663 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.023464 |
| INHBA | inhibin, beta A | -0.0233974 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0233231 |
| CCNL1 | cyclin L1 | -0.0229588 |
| CHSY1 | chondroitin sulfate synthase 1 | -0.0226562 |
| GNAS | GNAS complex locus | -0.0225753 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0224661 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0224481 |
| TFG | TRK-fused gene | -0.0220011 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0219561 |
| MX2 | MX dynamin-like GTPase 2 | -0.0219278 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0216864 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0216538 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0215058 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0215055 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.0214773 |
| TRAM2 | translocation associated membrane protein 2 | -0.0214178 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0213696 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0213613 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0212596 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0208483 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0206555 |
| RNF213 | ring finger protein 213 | -0.0204593 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0203774 |
| DIAPH3 | diaphanous-related formin 3 | -0.0202601 |
| CENPF | centromere protein F, 350/400kDa | -0.0199985 |
| CLMP | CXADR-like membrane protein | -0.0199426 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0199143 |
| FAM162A | family with sequence similarity 162, member A | -0.0198531 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0197675 |
| RSF1 | remodeling and spacing factor 1 | -0.0194001 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0193702 |
| FOSL1 | FOS-like antigen 1 | -0.0193344 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0192518 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.0192427 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.0190679 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0189856 |
| RNF24 | ring finger protein 24 | -0.0187272 |
| AFDN | afadin, adherens junction formation factor | -0.0187043 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0186012 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | -0.0185943 |
| TMEM123 | transmembrane protein 123 | -0.0184761 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0184332 |
| MMP12 | matrix metallopeptidase 12 | -0.0181717 |
| PHIP | pleckstrin homology domain interacting protein | -0.0180535 |
