| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lipoic acid perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lipoic acid_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.259931 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0877998 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0819052 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.081693 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0747009 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0731835 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0718599 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0517984 |
| IRS2 | insulin receptor substrate 2 | 0.0515443 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.0462908 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0447312 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0421408 |
| FAT1 | FAT atypical cadherin 1 | 0.041596 |
| UBE2QL1 | ubiquitin-conjugating enzyme E2Q family-like 1 | 0.0402307 |
| SIK2 | salt-inducible kinase 2 | 0.0366469 |
| INHBA | inhibin, beta A | 0.0356221 |
| TOX | thymocyte selection-associated high mobility group box | 0.0355576 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0352453 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0321148 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0314947 |
| CDK5RAP2 | CDK5 regulatory subunit associated protein 2 | 0.0296612 |
| MAP1B | microtubule-associated protein 1B | 0.0292686 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | 0.0285068 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0285005 |
| CPE | carboxypeptidase E | 0.0279712 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0279035 |
| RNF144A | ring finger protein 144A | 0.026239 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.025131 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.0251006 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0248907 |
| NKTR | natural killer cell triggering receptor | 0.0245646 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0243627 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0242378 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0239512 |
| WDR70 | WD repeat domain 70 | 0.0239071 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.0238098 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.02368 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0233599 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0227208 |
| AOPEP | aminopeptidase O (putative) | 0.0224582 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0223273 |
| SVIL | supervillin | 0.0221047 |
| NIPSNAP2 | nipsnap homolog 2 | 0.021846 |
| STXBP5L | syntaxin binding protein 5-like | 0.0216591 |
| COA1 | cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) | 0.021284 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0212548 |
| MCM8 | minichromosome maintenance complex component 8 | 0.0211903 |
| GPRIN3 | GPRIN family member 3 | 0.0210915 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.0210545 |
| TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | 0.020948 |
| TRPA1 | transient receptor potential cation channel, subfamily A, member 1 | 0.0206946 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0206562 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.020594 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0205731 |
| SGMS2 | sphingomyelin synthase 2 | 0.0204391 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0200575 |
| LARS1 | leucyl-tRNA synthetase 1 | 0.0200331 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.019565 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0195114 |
| RIT2 | Ras-like without CAAX 2 | 0.0194518 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0193018 |
| PHF3 | PHD finger protein 3 | 0.0191271 |
| FOXP1 | forkhead box P1 | 0.0191011 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0190183 |
| TRAM1 | translocation associated membrane protein 1 | 0.0189466 |
| SCFD2 | sec1 family domain containing 2 | 0.0188635 |
| H1-0 | H1.0 linker histone | 0.0188356 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | 0.018824 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | 0.0187558 |
| DYM | dymeclin | 0.0187461 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0186903 |
| SCFD1 | sec1 family domain containing 1 | 0.0186587 |
| F2RL3 | coagulation factor II (thrombin) receptor-like 3 | 0.0186574 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0184786 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0183677 |
| NBEA | neurobeachin | 0.0183622 |
| FUBP3 | far upstream element (FUSE) binding protein 3 | 0.0183491 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.018152 |
| GPHN | gephyrin | 0.0180362 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0179982 |
| ST18 | suppression of tumorigenicity 18, zinc finger | 0.0177249 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0175587 |
| TMEM260 | transmembrane protein 260 | 0.0175261 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0174894 |
| PCM1 | pericentriolar material 1 | 0.0174868 |
| BTBD3 | BTB (POZ) domain containing 3 | 0.0174048 |
| TASOR2 | transcription activation suppressor family member 2 | 0.0172614 |
| NEK1 | NIMA-related kinase 1 | 0.0172541 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0168571 |
| DACH1 | dachshund family transcription factor 1 | 0.0167662 |
| DNER | delta/notch-like EGF repeat containing | 0.0166128 |
| KANTR | KDM5C adjacent non-coding transcript | 0.016573 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0164584 |
| ULK4 | unc-51 like kinase 4 | 0.0164086 |
| WRN | Werner syndrome, RecQ helicase-like | 0.0164016 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0163665 |
| ZNF644 | zinc finger protein 644 | 0.016289 |
| FAM120B | family with sequence similarity 120B | 0.0162777 |
| VGF | VGF nerve growth factor inducible | 0.0162341 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | 0.0161783 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.228863 |
| TENM1 | teneurin transmembrane protein 1 | -0.148468 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.135512 |
| ESRRG | estrogen-related receptor gamma | -0.115373 |
| GPC6 | glypican 6 | -0.107038 |
| NCKAP5 | NCK-associated protein 5 | -0.0843715 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0798112 |
| NDRG1 | N-myc downstream regulated 1 | -0.0796401 |
| ACTG1 | actin gamma 1 | -0.0791691 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0729818 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0727054 |
| RORA | RAR-related orphan receptor A | -0.0724918 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0716908 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0696003 |
| DTNA | dystrobrevin, alpha | -0.0657453 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.06199 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0619752 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0591238 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.056452 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0558223 |
| ENO1 | enolase 1, (alpha) | -0.0549181 |
| SNTG1 | syntrophin, gamma 1 | -0.0542614 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0527933 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -0.0525826 |
| NLGN1 | neuroligin 1 | -0.0512654 |
| RPS27A | ribosomal protein S27a | -0.0489965 |
| PTCHD4 | patched domain containing 4 | -0.0462215 |
| EFNA5 | ephrin-A5 | -0.0443844 |
| SMYD3 | SET and MYND domain containing 3 | -0.0437116 |
| NELL1 | NEL-like 1 (chicken) | -0.042627 |
| UBC | ubiquitin C | -0.041941 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0412709 |
| PTMA | prothymosin, alpha | -0.0398458 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0390378 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0387581 |
| NAV1 | neuron navigator 1 | -0.0372471 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0369754 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0360015 |
| FTL | ferritin, light polypeptide | -0.0351369 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0348917 |
| RPL26 | ribosomal protein L26 | -0.0342271 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0341363 |
| LSAMP | limbic system-associated membrane protein | -0.03399 |
| CADM1 | cell adhesion molecule 1 | -0.0338753 |
| MYT1L | myelin transcription factor 1-like | -0.0335624 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0334389 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0333745 |
| GPC5 | glypican 5 | -0.0324818 |
| RPS21 | ribosomal protein S21 | -0.032288 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0320287 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | -0.0317289 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0315054 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0308311 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0306175 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0300756 |
| ZMAT4 | zinc finger, matrin-type 4 | -0.0296594 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.029221 |
| LRFN2 | leucine rich repeat and fibronectin type III domain containing 2 | -0.0283578 |
| CNTNAP2 | contactin associated protein-like 2 | -0.028003 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0277158 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0272078 |
| RPL37A | ribosomal protein L37a | -0.0270198 |
| APP | amyloid beta (A4) precursor protein | -0.025378 |
| AGBL4 | ATP/GTP binding protein-like 4 | -0.0251775 |
| KIF26B | kinesin family member 26B | -0.0249588 |
| TMSB4X | thymosin beta 4, X-linked | -0.024868 |
| SQSTM1 | sequestosome 1 | -0.0248623 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.024505 |
| RPL23 | ribosomal protein L23 | -0.0243068 |
| UNC5D | unc-5 homolog D (C. elegans) | -0.0242324 |
| FBXO34 | F-box protein 34 | -0.0240799 |
| EXOC4 | exocyst complex component 4 | -0.0239462 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0239155 |
| MT2A | metallothionein 2A | -0.0237076 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0237052 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0236673 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | -0.0234847 |
| JAM3 | junctional adhesion molecule 3 | -0.0232671 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | -0.0231024 |
| SGO2 | shugoshin 2 | -0.0229589 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0229243 |
| RAD51B | RAD51 paralog B | -0.0228986 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0228537 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0228277 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0228218 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0227088 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0226716 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0225919 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0224992 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.022419 |
| SON | SON DNA binding protein | -0.0223343 |
| MCL1 | myeloid cell leukemia 1 | -0.0222682 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0219378 |
| PRELID2 | PRELI domain containing 2 | -0.0219199 |
| POTEF | POTE ankyrin domain family, member F | -0.0218432 |
| POU2F1 | POU class 2 homeobox 1 | -0.0218295 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0216578 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0213966 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0213089 |
| RNF213 | ring finger protein 213 | -0.0212411 |
