Lipoic acid_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lipoic acid perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lipoic acid_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MACF1 microtubule-actin crosslinking factor 1 0.0603252
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0399058
FNDC3B fibronectin type III domain containing 3B 0.0373598
DST dystonin 0.0317961
FMNL2 formin-like 2 0.0316685
MBNL2 muscleblind-like splicing regulator 2 0.0295887
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0283953
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0280037
ELL2 elongation factor, RNA polymerase II, 2 0.0279107
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0261702
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0245166
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0235738
ATXN1 ataxin 1 0.0233088
SMAD3 SMAD family member 3 0.0223556
DPYD dihydropyrimidine dehydrogenase 0.0219035
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.021075
PDE4D phosphodiesterase 4D, cAMP-specific 0.0193811
RASAL2 RAS protein activator like 2 0.0193068
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0189024
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0187729
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.018639
ANO6 anoctamin 6 0.0180874
ANKRD28 ankyrin repeat domain 28 0.0177781
FBXL17 F-box and leucine-rich repeat protein 17 0.0177703
DSCAM Down syndrome cell adhesion molecule 0.0177295
GPR39 G protein-coupled receptor 39 0.0175818
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0174949
TAS2R14 taste receptor, type 2, member 14 0.0173911
RNF217 ring finger protein 217 0.016971
BIRC3 baculoviral IAP repeat containing 3 0.0168163
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0166586
NFE2L1 nuclear factor, erythroid 2-like 1 0.0166085
SLC38A2 solute carrier family 38, member 2 0.0165857
BICD1 bicaudal D homolog 1 (Drosophila) 0.0165017
PRR16 proline rich 16 0.0162747
WNK1 WNK lysine deficient protein kinase 1 0.0162667
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0162293
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0161833
ZC3H12B zinc finger CCCH-type containing 12B 0.0159821
BIRC2 baculoviral IAP repeat containing 2 0.0158114
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0157292
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.015694
BCAR3 breast cancer anti-estrogen resistance 3 0.0153365
SVIL supervillin 0.0152898
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0152041
ITCH itchy E3 ubiquitin protein ligase 0.0149986
ADGRG6 adhesion G protein-coupled receptor G6 0.0148832
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0146564
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0144495
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0144492
GSK3B glycogen synthase kinase 3 beta 0.0143902
HDLBP high density lipoprotein binding protein 0.0141439
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0140814
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0140632
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0140356
PCLO piccolo presynaptic cytomatrix protein 0.0139972
SATB2 SATB homeobox 2 0.0139058
CDK17 cyclin-dependent kinase 17 0.013799
RAD50 RAD50 homolog (S. cerevisiae) 0.0137606
NDEL1 nudE neurodevelopment protein 1-like 1 0.0137327
ATXN7L1 ataxin 7-like 1 0.0137183
TTC3 tetratricopeptide repeat domain 3 0.0134391
CD44 CD44 molecule (Indian blood group) 0.0134386
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0134061
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0134004
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0133403
CEP112 centrosomal protein 112kDa 0.0132315
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0131867
SAMD4A sterile alpha motif domain containing 4A 0.0131709
ASXL1 additional sex combs like transcriptional regulator 1 0.013166
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0131645
ERBIN erbb2 interacting protein 0.0130796
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0130345
LNPEP leucyl/cystinyl aminopeptidase 0.0130196
AKAP9 A kinase (PRKA) anchor protein 9 0.0130089
NAV3 neuron navigator 3 0.0128457
PUM2 pumilio RNA-binding family member 2 0.012836
ANXA2 annexin A2 0.0127993
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0127856
FNDC3A fibronectin type III domain containing 3A 0.012675
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0126272
DOCK5 dedicator of cytokinesis 5 0.0125972
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0124909
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0124418
AHNAK AHNAK nucleoprotein 0.0123604
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0122081
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0121418
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0120828
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0120617
TIAM1 T-cell lymphoma invasion and metastasis 1 0.0120386
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0118283
PDIA4 protein disulfide isomerase family A, member 4 0.0117647
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0117547
KIAA1328 KIAA1328 0.0117372
PARD3B par-3 family cell polarity regulator beta 0.0117073
FTO fat mass and obesity associated 0.0117071
IL6ST interleukin 6 signal transducer 0.0116414
NR2C2 nuclear receptor subfamily 2, group C, member 2 0.0116345
BCAS3 breast carcinoma amplified sequence 3 0.0115508
GLS2 glutaminase 2 (liver, mitochondrial) 0.011452

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.228018
PTMA prothymosin, alpha -0.136896
VIM vimentin -0.133945
TPT1 tumor protein, translationally-controlled 1 -0.103609
TMSB10 thymosin beta 10 -0.0887708
RPLP1 ribosomal protein, large, P1 -0.0624098
GNAS GNAS complex locus -0.0548532
RPL35A ribosomal protein L35a -0.0498235
RPS8 ribosomal protein S8 -0.0446494
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0440228
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0417018
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0408076
RPL23 ribosomal protein L23 -0.0406746
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0406116
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0405454
RPL31 ribosomal protein L31 -0.0373919
LDHA lactate dehydrogenase A -0.0373136
RPL36 ribosomal protein L36 -0.0366512
RPS13 ribosomal protein S13 -0.036578
RPS23 ribosomal protein S23 -0.0364268
RPS6 ribosomal protein S6 -0.0353499
HILPDA hypoxia inducible lipid droplet-associated -0.0351571
RPS17 ribosomal protein S17 -0.0347626
ENO2 enolase 2 (gamma, neuronal) -0.0345176
RPL37 ribosomal protein L37 -0.0344013
RPS3 ribosomal protein S3 -0.0338722
FTH1 ferritin, heavy polypeptide 1 -0.0336617
OASL 2'-5'-oligoadenylate synthetase-like -0.0334461
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0326983
B2M beta-2-microglobulin -0.0326421
RPL19 ribosomal protein L19 -0.0325492
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0322835
IER3 immediate early response 3 -0.0320242
RPL37A ribosomal protein L37a -0.0316424
PKM pyruvate kinase, muscle -0.0316219
S100A9 S100 calcium binding protein A9 -0.0314416
IGFBP3 insulin-like growth factor binding protein 3 -0.0305745
LOC102724023 ES1 protein homolog, mitochondrial -0.0292849
RPL27A ribosomal protein L27a -0.0289182
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0288721
DEK DEK proto-oncogene -0.0288027
EGR1 early growth response 1 -0.028182
EIF1 eukaryotic translation initiation factor 1 -0.0280911
RPS21 ribosomal protein S21 -0.0279726
POTEF POTE ankyrin domain family, member F -0.0279011
MT2A metallothionein 2A -0.0278448
RPL12 ribosomal protein L12 -0.0275782
IFITM3 interferon induced transmembrane protein 3 -0.0274482
RPS25 ribosomal protein S25 -0.0264656
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0261371
H3-3B H3.3 histone B -0.0258849
RPL15 ribosomal protein L15 -0.0256515
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0254453
FTL ferritin, light polypeptide -0.0253044
RPL26 ribosomal protein L26 -0.0251223
HLA-A major histocompatibility complex, class I, A -0.0249773
ENO1 enolase 1, (alpha) -0.0242356
RPS27A ribosomal protein S27a -0.0242012
RPLP0 ribosomal protein, large, P0 -0.0239363
TPM4 tropomyosin 4 -0.0238
HLA-B major histocompatibility complex, class I, B -0.023534
SDC4 syndecan 4 -0.0232129
SEPTIN7 septin 7 -0.0232099
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.023185
RPS29 ribosomal protein S29 -0.0231513
RPS12 ribosomal protein S12 -0.0230959
S100A10 S100 calcium binding protein A10 -0.0230342
RPLP2 ribosomal protein, large, P2 -0.0229032
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0228567
RPL32 ribosomal protein L32 -0.022833
RPS15 ribosomal protein S15 -0.0227927
UBB ubiquitin B -0.0226042
RPS24 ribosomal protein S24 -0.0225916
RSRC2 arginine/serine-rich coiled-coil 2 -0.0221398
VDAC1 voltage-dependent anion channel 1 -0.0220035
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0219861
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0218279
IGF2 insulin-like growth factor 2 -0.0215812
RPL30 ribosomal protein L30 -0.0213349
UBC ubiquitin C -0.0212487
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0210125
RPL5 ribosomal protein L5 -0.0209586
DLG1 discs, large homolog 1 (Drosophila) -0.020883
NIPBL Nipped-B homolog (Drosophila) -0.0208424
RPL11 ribosomal protein L11 -0.0207897
RPS20 ribosomal protein S20 -0.0207236
RACK1 receptor for activated C kinase 1 -0.020685
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0206607
SRPK2 SRSF protein kinase 2 -0.0206603
RPS16 ribosomal protein S16 -0.0202276
RNF213 ring finger protein 213 -0.0201824
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0196806
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0194726
BASP1 brain abundant, membrane attached signal protein 1 -0.0194704
RAI14 retinoic acid induced 14 -0.019359
SETD5 SET domain containing 5 -0.0191993
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0191945
NDRG1 N-myc downstream regulated 1 -0.0190203
HMGA1 high mobility group AT-hook 1 -0.0189201
RPL7A ribosomal protein L7a -0.0186627