Liposarcoma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A malignant lipomatous neoplasm that arises in fat cells in deep soft tissue retroperitoneum.|A malignant tumor derived from primitive or embryonal lipoblastic cells. It may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid (LIPOSARCOMA, MYXOID), round-celled, or pleomorphic, usually in association with a rich network of capillaries. Recurrences are common and dedifferentiated liposarcomas metastasize to the lungs or serosal surfaces. (From Dorland, 27th ed; Stedman, 25th ed)|A usually painless malignant tumor that arises from adipose tissue. Microscopically, it may contain a spectrum of neoplastic adipocytes ranging from lipoblasts to pleomorphic malignant adipocytes. Representative morphologic variants include: well differentiated, dedifferentiated, pleomorphic, and myxoid/round cell liposarcoma. The metastatic potential is higher in less differentiated tumors. (Experimental Factor Ontology, EFO_0000569)
External Link https://www.disgenet.org/browser/0/1/0/C0023827
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Genes

293 genes associated with the disease Liposarcoma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACTB actin, beta
AFP alpha-fetoprotein
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALK anaplastic lymphoma receptor tyrosine kinase
ALPP alkaline phosphatase, placental
ANKRD36B ankyrin repeat domain 36B
APC adenomatous polyposis coli
APCS amyloid P component, serum
ASRGL1 asparaginase like 1
ATF1 activating transcription factor 1
ATF6 activating transcription factor 6
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATRNL1 attractin-like 1
AURKA aurora kinase A
BCL2 B-cell CLL/lymphoma 2
BCOR BCL6 corepressor
BRAF B-Raf proto-oncogene, serine/threonine kinase
CALR calreticulin
CAMTA1 calmodulin binding transcription activator 1
CAPN3 calpain 3, (p94)
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CAVIN1 caveolae associated protein 1
CAVIN2 caveolae associated protein 2
CBX3 chromobox homolog 3
CCDC180 coiled-coil domain containing 180
CCK cholecystokinin
CCL27 chemokine (C-C motif) ligand 27
CCND1 cyclin D1
CD274 CD274 molecule
CD34 CD34 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD38 CD38 molecule
CD6 CD6 molecule
CDK11B cyclin-dependent kinase 11B
CDK19 cyclin-dependent kinase 19
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPV centromere protein V
CHAMP1 chromosome alignment maintaining phosphoprotein 1
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CIB1 calcium and integrin binding 1 (calmyrin)
CIC capicua transcriptional repressor
CLDN6 claudin 6
COL11A2 collagen, type XI, alpha 2
CPM carboxypeptidase M
CREB3L2 cAMP responsive element binding protein 3-like 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSF1R colony stimulating factor 1 receptor
CSF3 colony stimulating factor 3 (granulocyte)
CTAG1A cancer/testis antigen 1A
CTAG1B cancer/testis antigen 1B
CTAG2 cancer/testis antigen 2
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DAXX death-domain associated protein
DDIT3 DNA-damage-inducible transcript 3
DDR2 discoidin domain receptor tyrosine kinase 2
DES desmin
DNER delta/notch-like EGF repeat containing
DNM3 dynamin 3
DUX4 double homeobox 4
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
E2F1 E2F transcription factor 1
E2F4 E2F transcription factor 4, p107/p130-binding
EBP emopamil binding protein (sterol isomerase)
EED embryonic ectoderm development
EGFR epidermal growth factor receptor
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4E eukaryotic translation initiation factor 4E
EML4 echinoderm microtubule associated protein like 4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
ERCC5 excision repair cross-complementation group 5
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ETV4 ets variant 4
EWSR1 EWS RNA-binding protein 1
FASN fatty acid synthase
FGF21 fibroblast growth factor 21
FGF23 fibroblast growth factor 23
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FLT1 fms-related tyrosine kinase 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXP1 forkhead box P1
FRS2 fibroblast growth factor receptor substrate 2
FUS FUS RNA binding protein
G0S2 G0/G1 switch 2
GDNF glial cell derived neurotrophic factor
GH1 growth hormone 1
GHR growth hormone receptor
GLI1 GLI family zinc finger 1
GNAS GNAS complex locus
GPNMB glycoprotein (transmembrane) nmb
GPS2 G protein pathway suppressor 2
GRAP2 GRB2-related adaptor protein 2
HBEGF heparin-binding EGF-like growth factor
HCCS holocytochrome c synthase
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HEATR3 HEAT repeat containing 3
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMBS hydroxymethylbilane synthase
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HOXA5 homeobox A5
HOXC13 homeobox C13
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IFI44 interferon-induced protein 44
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP5 insulin-like growth factor binding protein 5
IL22 interleukin 22
IL4R interleukin 4 receptor
IL6 interleukin 6
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
INTS1 integrator complex subunit 1
INTS13 integrator complex subunit 13
JAZF1 JAZF zinc finger 1
JUN jun proto-oncogene
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KL klotho
KLF6 Kruppel-like factor 6
KNTC1 kinetochore associated 1
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
LBR lamin B receptor
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPP LIM domain containing preferred translocation partner in lipoma
LRP1 low density lipoprotein receptor-related protein 1
LRRC4 leucine rich repeat containing 4
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MBTPS1 membrane-bound transcription factor peptidase, site 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MEPE matrix extracellular phosphoglycoprotein
MET MET proto-oncogene, receptor tyrosine kinase
MIB1 mindbomb E3 ubiquitin protein ligase 1
MKI67 marker of proliferation Ki-67
MLANA melan-A
MLH1 mutL homolog 1
MMP2 matrix metallopeptidase 2
MOV10L1 Mov10 RISC complex RNA helicase like 1
MSH2 mutS homolog 2
MSRA methionine sulfoxide reductase A
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOCD myocardin
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NANS N-acetylneuraminic acid synthase
NAT10 N-acetyltransferase 10 (GCN5-related)
NF1 neurofibromin 1
NNAT neuronatin
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUP107 nucleoporin 107kDa
OSBP oxysterol binding protein
PALM paralemmin
PARP1 poly (ADP-ribose) polymerase 1
PAX8 paired box 8
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDIK1L PDLIM1 interacting kinase 1 like
PDLIM3 PDZ and LIM domain 3
PER1 period circadian clock 1
PER2 period circadian clock 2
PGF placental growth factor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLAG1 pleiomorphic adenoma gene 1
PLIN1 perilipin 1
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PML promyelocytic leukemia
PNPLA2 patatin-like phospholipase domain containing 2
PNPLA3 patatin-like phospholipase domain containing 3
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
PPARG peroxisome proliferator-activated receptor gamma
PRAME preferentially expressed antigen in melanoma
PRG4 proteoglycan 4
PRUNE1 prune exopolyphosphatase 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTK7 protein tyrosine kinase 7 (inactive)
PTPRA protein tyrosine phosphatase, receptor type, A
PTX3 pentraxin 3, long
RASA2 RAS p21 protein activator 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RET ret proto-oncogene
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPP14 ribonuclease P/MRP 14kDa subunit
RPS14 ribosomal protein S14
RPSA ribosomal protein SA
S100A1 S100 calcium binding protein A1
S100A4 S100 calcium binding protein A4
S100A9 S100 calcium binding protein A9
S100B S100 calcium binding protein B
SBF1 SET binding factor 1
SDC1 syndecan 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SF3B6 splicing factor 3b, subunit 6, 14kDa
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SOD1 superoxide dismutase 1, soluble
SOX10 SRY (sex determining region Y)-box 10
SOX2 SRY (sex determining region Y)-box 2
SOX21 SRY (sex determining region Y)-box 21
SPIN1 spindlin 1
SPPL3 signal peptide peptidase like 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
SS18 synovial sarcoma translocation, chromosome 18
SSX2 synovial sarcoma, X breakpoint 2
SSX2B synovial sarcoma, X breakpoint 2B
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
SUB1 SUB1 homolog (S. cerevisiae)
SYT1 synaptotagmin I
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAL1 T-cell acute lymphocytic leukemia 1
TARDBP TAR DNA binding protein
TAZ tafazzin
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TERT telomerase reverse transcriptase
TFE3 transcription factor binding to IGHM enhancer 3
THPO thrombopoietin
THRSP thyroid hormone responsive
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP4 TIMP metallopeptidase inhibitor 4
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP53INP2 tumor protein p53 inducible nuclear protein 2
TRIO trio Rho guanine nucleotide exchange factor
TSN translin
TSPAN31 tetraspanin 31
TYRO3 TYRO3 protein tyrosine kinase
UBASH3A ubiquitin associated and SH3 domain containing A
VIM vimentin
WNT1 wingless-type MMTV integration site family, member 1
WWTR1 WW domain containing transcription regulator 1
XPO1 exportin 1
YAP1 Yes-associated protein 1
YBX1 Y box binding protein 1
YEATS4 YEATS domain containing 4
ZEB1 zinc finger E-box binding homeobox 1
ZIC1 Zic family member 1
ZNF654 zinc finger protein 654