Liver Failure Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C0085605
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Genes

283 genes associated with the disease Liver Failure in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACAD9 acyl-CoA dehydrogenase family, member 9
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACVRL1 activin A receptor type II-like 1
ADAM17 ADAM metallopeptidase domain 17
AFP alpha-fetoprotein
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AHCY adenosylhomocysteinase
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
AKR1D1 aldo-keto reductase family 1, member D1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
ALG6 ALG6, alpha-1,3-glucosyltransferase
ALG8 ALG8, alpha-1,3-glucosyltransferase
ALG9 ALG9, alpha-1,2-mannosyltransferase
AMACR alpha-methylacyl-CoA racemase
ARG1 arginase 1
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASL argininosuccinate lyase
ASPG asparaginase
ASS1 argininosuccinate synthase 1
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATRX alpha thalassemia/mental retardation syndrome X-linked
AVP arginine vasopressin
BCHE butyrylcholinesterase
BDNF brain-derived neurotrophic factor
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BTBD8 BTB (POZ) domain containing 8
BTNL2 butyrophilin-like 2
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAVIN1 caveolae associated protein 1
CCK cholecystokinin
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CCL4L1 chemokine (C-C motif) ligand 4-like 1
CCL4L2 chemokine (C-C motif) ligand 4-like 2
CD163 CD163 molecule
CEL carboxyl ester lipase
CHN1 chimerin 1
CHUK conserved helix-loop-helix ubiquitous kinase
CISH cytokine inducible SH2-containing protein
COL11A2 collagen, type XI, alpha 2
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPT1A carnitine palmitoyltransferase 1A (liver)
CPT2 carnitine palmitoyltransferase 2
CRP C-reactive protein, pentraxin-related
CTC1 CTS telomere maintenance complex component 1
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DAXX death-domain associated protein
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DGUOK deoxyguanosine kinase
DKC1 dyskeratosis congenita 1, dyskerin
DLAT dihydrolipoamide S-acetyltransferase
DLD dihydrolipoamide dehydrogenase
EDN1 endothelin 1
EGFR epidermal growth factor receptor
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENG endoglin
EPCAM epithelial cell adhesion molecule
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EPX eosinophil peroxidase
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F13A1 coagulation factor XIII, A1 polypeptide
F13B coagulation factor XIII, B polypeptide
F2 coagulation factor II (thrombin)
F3 coagulation factor III (thromboplastin, tissue factor)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBL fibrillarin
FECH ferrochelatase
FGFR4 fibroblast growth factor receptor 4
FH fumarate hydratase
FLT1 fms-related tyrosine kinase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO3 forkhead box O3
FOXP3 forkhead box P3
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GALT galactose-1-phosphate uridylyltransferase
GAST gastrin
GBA glucosidase, beta, acid
GBE1 glucan (1,4-alpha-), branching enzyme 1
GDF2 growth differentiation factor 2
GFER growth factor, augmenter of liver regeneration
GFM1 G elongation factor, mitochondrial 1
GLUL glutamate-ammonia ligase
GPBAR1 G protein-coupled bile acid receptor 1
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GSTK1 glutathione S-transferase kappa 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GSTZ1 glutathione S-transferase zeta 1
HAVCR1 hepatitis A virus cellular receptor 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HMGB1 high mobility group box 1
HNF4A hepatocyte nuclear factor 4, alpha
HPGDS hematopoietic prostaglandin D synthase
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
HSPA1L heat shock 70kDa protein 1-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNG interferon, gamma
IFT122 intraflagellar transport 122
IFT172 intraflagellar transport 172
IL10 interleukin 10
IL12A interleukin 12A
IL12RB1 interleukin 12 receptor, beta 1
IL17A interleukin 17A
IL17F interleukin 17F
IL18 interleukin 18
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL21R interleukin 21 receptor
IL2RA interleukin 2 receptor, alpha
IL33 interleukin 33
IL6 interleukin 6
IRF5 interferon regulatory factor 5
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JAG1 jagged 1
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KMT2D lysine (K)-specific methyltransferase 2D
KRT8 keratin 8, type II
LECT2 leukocyte cell-derived chemotaxin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
MARS1 methionyl-tRNA synthetase 1
MET MET proto-oncogene, receptor tyrosine kinase
MLN motilin
MMEL1 membrane metallo-endopeptidase-like 1
MOGS mannosyl-oligosaccharide glucosidase
MPI mannose phosphate isomerase
MPO myeloperoxidase
MPV17 MpV17 mitochondrial inner membrane protein
MRPS7 mitochondrial ribosomal protein S7
MSC musculin
MT-ATP6 ATP synthase F0 subunit 6
MT-ND2 MTND2
MT-ND3 NADH dehydrogenase, subunit 3 (complex I)
MT-ND4 NADH dehydrogenase, subunit 4 (complex I)
MT-ND5 NADH dehydrogenase, subunit 5 (complex I)
MT-ND6 NADH dehydrogenase, subunit 6 (complex I)
NBAS neuroblastoma amplified sequence
ND1
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFE2L2 nuclear factor, erythroid 2-like 2
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1
NHP2 NHP2 ribonucleoprotein
NLRP3 NLR family, pyrin domain containing 3
NOP10 NOP10 ribonucleoprotein
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5C2 5'-nucleotidase, cytosolic II
NUP210 nucleoporin 210kDa
ORM1 orosomucoid 1
OSTM1 osteopetrosis associated transmembrane protein 1
OTC ornithine carbamoyltransferase
PARN poly(A)-specific ribonuclease
PARP1 poly (ADP-ribose) polymerase 1
PARP9 poly (ADP-ribose) polymerase family, member 9
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEX1 peroxisomal biogenesis factor 1
PEX10 peroxisomal biogenesis factor 10
PEX11B peroxisomal biogenesis factor 11 beta
PEX12 peroxisomal biogenesis factor 12
PEX13 peroxisomal biogenesis factor 13
PEX14 peroxisomal biogenesis factor 14
PEX16 peroxisomal biogenesis factor 16
PEX19 peroxisomal biogenesis factor 19
PEX2 peroxisomal biogenesis factor 2
PEX26 peroxisomal biogenesis factor 26
PEX3 peroxisomal biogenesis factor 3
PEX5 peroxisomal biogenesis factor 5
PEX6 peroxisomal biogenesis factor 6
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAU plasminogen activator, urokinase
PLRG1 pleiotropic regulator 1
PNPLA3 patatin-like phospholipase domain containing 3
POLG polymerase (DNA directed), gamma
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
PPARG peroxisome proliferator-activated receptor gamma
PRDX4 peroxiredoxin 4
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PROL1 proline rich, lacrimal 1
PTK2B protein tyrosine kinase 2 beta
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RBM45 RNA binding motif protein 45
REG3A regenerating islet-derived 3 alpha
RETN resistin
RIPK3 receptor-interacting serine-threonine kinase 3
RORA RAR-related orphan receptor A
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RPS10 ribosomal protein S10
RPS6 ribosomal protein S6
RPS9 ribosomal protein S9
RTEL1 regulator of telomere elongation helicase 1
SC5D sterol-C5-desaturase
SCN1A sodium channel, voltage gated, type I alpha subunit
SCO1 SCO1 cytochrome c oxidase assembly protein
SCYL1 SCY1-like 1 (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SETD2 SET domain containing 2
SLA2 Src-like-adaptor 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLCO6A1 solute carrier organic anion transporter family, member 6A1
SMAD4 SMAD family member 4
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SOCS1 suppressor of cytokine signaling 1
SOD1 superoxide dismutase 1, soluble
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SQSTM1 sequestosome 1
SST somatostatin
TALDO1 transaldolase 1
TANK TRAF family member-associated NFKB activator
TERT telomerase reverse transcriptase
TFAM transcription factor A, mitochondrial
TGFB1 transforming growth factor, beta 1
THPO thrombopoietin
TIMELESS timeless circadian clock
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TIPE2 TNF alpha induced protein 8 like 2
TJP2 tight junction protein 2
TK2 thymidine kinase 2, mitochondrial
TLR1 toll-like receptor 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNPO3 transportin 3
TP53 tumor protein p53
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TTC37 tetratricopeptide repeat domain 37
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UQCRC2 ubiquinol-cytochrome c reductase core protein II
USB1 U6 snRNA biogenesis 1
USP8 ubiquitin specific peptidase 8
VEGFA vascular endothelial growth factor A
WARS1 tryptophanyl-tRNA synthetase 1
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
WNT5A wingless-type MMTV integration site family, member 5A
WRAP53 WD repeat containing, antisense to TP53