| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. (Chemical Entities of Biological Interest Ontology, CHEBI_72297) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/9853053 |
| Similar Terms | |
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197 proteins with high or low expression in Lomitapide relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RNF111 | ring finger protein 111 | 2.47 |
| PER2 | period circadian clock 2 | 2.07 |
| GJC1 | gap junction protein, gamma 1, 45kDa | 1.46 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 1.06 |
| SEMG1 | semenogelin I | 0.88 |
| MSANTD2 | Myb/SANT-like DNA-binding domain containing 2 | 0.86 |
| TPM1 | tropomyosin 1 (alpha) | 0.79 |
| BLOC1S3 | biogenesis of lysosomal organelles complex-1, subunit 3 | 0.63 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | 0.6 |
| SLC37A1 | solute carrier family 37 (glucose-6-phosphate transporter), member 1 | 0.58 |
| BHLHA15 | basic helix-loop-helix family, member a15 | 0.56 |
| DNAH2 | dynein, axonemal, heavy chain 2 | 0.54 |
| ZNF367 | zinc finger protein 367 | 0.54 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.52 |
| PRELID1 | PRELI domain containing 1 | 0.52 |
| FGG | fibrinogen gamma chain | 0.46 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.45 |
| PRELID3B | PRELI domain containing 3B | 0.45 |
| SUMO2 | small ubiquitin-like modifier 2 | 0.45 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.44 |
| SON | SON DNA binding protein | 0.42 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 0.42 |
| APOB | apolipoprotein B | 0.41 |
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | 0.41 |
| PLEKHA3 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 | 0.41 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.41 |
| FXN | frataxin | 0.39 |
| GON7 | GON7 subunit of KEOPS complex | 0.38 |
| ZNF544 | zinc finger protein 544 | 0.37 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.37 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | 0.35 |
| DST | dystonin | 0.35 |
| ABHD2 | abhydrolase domain containing 2 | 0.35 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | 0.34 |
| FAM177A1 | family with sequence similarity 177, member A1 | 0.34 |
| HEXD | hexosaminidase D | 0.33 |
| EXPH5 | exophilin 5 | 0.32 |
| RGN | regucalcin | 0.32 |
| C12ORF66 | chromosome 12 open reading frame 66 | 0.32 |
| TMEM98 | transmembrane protein 98 | 0.32 |
| H3-3A | H3.3 histone A | 0.32 |
| FITM2 | fat storage-inducing transmembrane protein 2 | 0.31 |
| MPDZ | multiple PDZ domain protein | 0.31 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.31 |
| PARD6A | par-6 family cell polarity regulator alpha | 0.3 |
| CYB5D2 | cytochrome b5 domain containing 2 | 0.3 |
| PRKCH | protein kinase C, eta | 0.3 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | 0.3 |
| ROGDI | rogdi homolog (Drosophila) | 0.29 |
| DENND5A | DENN/MADD domain containing 5A | 0.29 |
| ZNF124 | zinc finger protein 124 | 0.29 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 0.29 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | 0.28 |
| TIMM23 | translocase of inner mitochondrial membrane 23 homolog (yeast) | 0.28 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | 0.28 |
| TMPO | thymopoietin | 0.28 |
| MSX2 | msh homeobox 2 | 0.28 |
| CA3 | carbonic anhydrase III | 0.28 |
| SIVA1 | SIVA1, apoptosis-inducing factor | 0.28 |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | 0.28 |
| PLD6 | phospholipase D family, member 6 | 0.28 |
| CBY1 | chibby homolog 1 (Drosophila) | 0.28 |
| TCIRG1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 0.27 |
| FN1 | fibronectin 1 | 0.27 |
| HOXB4 | homeobox B4 | 0.27 |
| B4GALT3 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 | 0.27 |
| EVL | Enah/Vasp-like | 0.26 |
| CADPS | Ca++-dependent secretion activator | 0.26 |
| ASB1 | ankyrin repeat and SOCS box containing 1 | 0.26 |
| SPIRE2 | spire-type actin nucleation factor 2 | 0.26 |
| MYBPC1 | myosin binding protein C, slow type | 0.26 |
| MPV17L2 | MPV17 mitochondrial membrane protein-like 2 | 0.26 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | 0.26 |
| RAB30 | RAB30, member RAS oncogene family | 0.25 |
| SPRTN | SprT-like N-terminal domain | 0.25 |
| GDF15 | growth differentiation factor 15 | 0.25 |
| SCRN3 | secernin 3 | 0.25 |
| RGS20 | regulator of G-protein signaling 20 | 0.25 |
| MAZ | MYC-associated zinc finger protein (purine-binding transcription factor) | 0.25 |
| ITPKB | inositol-trisphosphate 3-kinase B | 0.25 |
| USP33 | ubiquitin specific peptidase 33 | 0.25 |
| GABPB1 | GA binding protein transcription factor, beta subunit 1 | 0.25 |
| BSDC1 | BSD domain containing 1 | 0.25 |
| TIMM17A | translocase of inner mitochondrial membrane 17 homolog A (yeast) | 0.25 |
| CCDC110 | coiled-coil domain containing 110 | 0.25 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.24 |
| H1-4 | H1.4 linker histone, cluster member | 0.24 |
| COMMD5 | COMM domain containing 5 | 0.24 |
| SNRPD1 | small nuclear ribonucleoprotein D1 polypeptide 16kDa | 0.24 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.24 |
| PICK1 | protein interacting with PRKCA 1 | 0.24 |
| FGA | fibrinogen alpha chain | 0.24 |
| NET1 | neuroepithelial cell transforming 1 | 0.23 |
| H2AFX | H2A histone family, member X | 0.23 |
| PRDX4 | peroxiredoxin 4 | 0.23 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.23 |
| FICD | FIC domain containing | 0.23 |
| ACTBL2 | actin, beta-like 2 | 0.23 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.23 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CNTRL | centriolin | -1.85 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | -1.25 |
| DAP | death-associated protein | -0.75 |
| GK5 | glycerol kinase 5 (putative) | -0.74 |
| RECK | reversion-inducing-cysteine-rich protein with kazal motifs | -0.7 |
| NAAA | N-acylethanolamine acid amidase | -0.68 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.65 |
| PLIN2 | perilipin 2 | -0.62 |
| MR1 | major histocompatibility complex, class I-related | -0.62 |
| DBNL | drebrin-like | -0.59 |
| MYH1 | myosin, heavy chain 1, skeletal muscle, adult | -0.53 |
| PDGFC | platelet derived growth factor C | -0.53 |
| ABHD18 | abhydrolase domain containing 18 | -0.52 |
| RILPL2 | Rab interacting lysosomal protein-like 2 | -0.51 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | -0.51 |
| RNF145 | ring finger protein 145 | -0.51 |
| TUB | tubby bipartite transcription factor | -0.5 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.48 |
| GLT8D1 | glycosyltransferase 8 domain containing 1 | -0.46 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.45 |
| MUC16 | mucin 16, cell surface associated | -0.44 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.44 |
| LIPA | lipase A, lysosomal acid, cholesterol esterase | -0.43 |
| PLSCR1 | phospholipid scramblase 1 | -0.43 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -0.42 |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) | -0.41 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | -0.41 |
| RABAC1 | Rab acceptor 1 (prenylated) | -0.39 |
| E2F1 | E2F transcription factor 1 | -0.39 |
| HAL | histidine ammonia-lyase | -0.39 |
| GSTA1 | glutathione S-transferase alpha 1 | -0.39 |
| HECW2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | -0.38 |
| TMX2 | thioredoxin-related transmembrane protein 2 | -0.38 |
| B9D1 | B9 protein domain 1 | -0.38 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.37 |
| ALDH1L1 | aldehyde dehydrogenase 1 family, member L1 | -0.37 |
| POLE4 | polymerase (DNA-directed), epsilon 4, accessory subunit | -0.37 |
| CUTA | cutA divalent cation tolerance homolog (E. coli) | -0.36 |
| TMEM184A | transmembrane protein 184A | -0.36 |
| ZNF189 | zinc finger protein 189 | -0.35 |
| ABHD17C | abhydrolase domain containing 17C | -0.35 |
| BCL6 | B-cell CLL/lymphoma 6 | -0.35 |
| TTYH3 | tweety family member 3 | -0.35 |
| PSAP | prosaposin | -0.35 |
| ALDH1L2 | aldehyde dehydrogenase 1 family, member L2 | -0.35 |
| CREBZF | CREB/ATF bZIP transcription factor | -0.33 |
| TGOLN2 | trans-golgi network protein 2 | -0.33 |
| TSPAN31 | tetraspanin 31 | -0.32 |
| ACTN2 | actinin, alpha 2 | -0.32 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | -0.32 |
| COX10 | COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor | -0.31 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.31 |
| FGB | fibrinogen beta chain | -0.31 |
| ANGPTL4 | angiopoietin-like 4 | -0.31 |
| DCLRE1B | DNA cross-link repair 1B | -0.3 |
| NPHP3 | nephronophthisis 3 (adolescent) | -0.3 |
| ADAM22 | ADAM metallopeptidase domain 22 | -0.3 |
| ADGRE2 | adhesion G protein-coupled receptor E2 | -0.29 |
| LAMP2 | lysosomal-associated membrane protein 2 | -0.29 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.29 |
| GID8 | GID complex subunit 8 | -0.29 |
| MARVELD3 | MARVEL domain containing 3 | -0.29 |
| PCTP | phosphatidylcholine transfer protein | -0.29 |
| SYT17 | synaptotagmin XVII | -0.28 |
| MTRF1L | mitochondrial translational release factor 1-like | -0.28 |
| MSX1 | msh homeobox 1 | -0.28 |
| ARL8A | ADP-ribosylation factor-like 8A | -0.28 |
| NDRG2 | NDRG family member 2 | -0.28 |
| SH2B3 | SH2B adaptor protein 3 | -0.28 |
| ITFG2 | integrin alpha FG-GAP repeat containing 2 | -0.28 |
| ADIRF | adipogenesis regulatory factor | -0.28 |
| RMI2 | RecQ mediated genome instability 2 | -0.28 |
| FAM110A | family with sequence similarity 110, member A | -0.28 |
| NME6 | NME/NM23 nucleoside diphosphate kinase 6 | -0.28 |
| ARSG | arylsulfatase G | -0.28 |
| EPN3 | epsin 3 | -0.28 |
| R3HCC1L | R3H domain and coiled-coil containing 1-like | -0.28 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | -0.27 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.27 |
| BCAM | basal cell adhesion molecule (Lutheran blood group) | -0.27 |
| F10 | coagulation factor X | -0.27 |
| ZNF417 | zinc finger protein 417 | -0.27 |
| LZTS1 | leucine zipper, putative tumor suppressor 1 | -0.27 |
| PPIP5K1 | diphosphoinositol pentakisphosphate kinase 1 | -0.27 |
| LIPT1 | lipoyltransferase 1 | -0.27 |
| HMBOX1 | homeobox containing 1 | -0.26 |
| OTC | ornithine carbamoyltransferase | -0.26 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -0.26 |
| TMEM63A | transmembrane protein 63A | -0.26 |
| INO80B | INO80 complex subunit B | -0.26 |
| STARD10 | StAR-related lipid transfer (START) domain containing 10 | -0.26 |
| HTD2 | hydroxyacyl-thioester dehydratase type 2 | -0.26 |
| ACTL8 | actin-like 8 | -0.25 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.25 |
| MLYCD | malonyl-CoA decarboxylase | -0.25 |
| CRCP | CGRP receptor component | -0.25 |
| PLEKHG5 | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 | -0.25 |
| PPT1 | palmitoyl-protein thioesterase 1 | -0.25 |
