Lonafarnib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lonafarnib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lonafarnib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.174177
NLGN1 neuroligin 1 0.164344
PDE4D phosphodiesterase 4D, cAMP-specific 0.118409
MMP12 matrix metallopeptidase 12 0.0996637
YAP1 Yes-associated protein 1 0.0821602
DST dystonin 0.0670191
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0658112
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0630395
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0625644
PDGFC platelet derived growth factor C 0.0567506
BIRC3 baculoviral IAP repeat containing 3 0.0544583
CCN2 cellular communication network factor 2 0.0522172
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0517512
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0516089
MTAP methylthioadenosine phosphorylase 0.0509302
AHNAK AHNAK nucleoprotein 0.0506413
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0504189
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0497176
VMP1 vacuole membrane protein 1 0.0484965
TENM3 teneurin transmembrane protein 3 0.0465524
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0463059
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0461726
WWOX WW domain containing oxidoreductase 0.0453796
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0441522
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.041811
TMEM41B transmembrane protein 41B 0.0407697
NEBL nebulette 0.0403444
ANKRD12 ankyrin repeat domain 12 0.0398136
EDARADD EDAR-associated death domain 0.0396066
RRM2 ribonucleotide reductase M2 0.0395901
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0388718
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.038863
CELF2 CUGBP, Elav-like family member 2 0.0383383
RABGAP1L RAB GTPase activating protein 1-like 0.0383276
TPM3 tropomyosin 3 0.0366459
NHSL1 NHS-like 1 0.0352256
CCSER1 coiled-coil serine-rich protein 1 0.0337503
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0336549
TBC1D5 TBC1 domain family, member 5 0.0336209
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0334297
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0333384
LPP LIM domain containing preferred translocation partner in lipoma 0.0330964
USP34 ubiquitin specific peptidase 34 0.0328891
TAS2R14 taste receptor, type 2, member 14 0.032329
SMC4 structural maintenance of chromosomes 4 0.0321502
JMJD1C jumonji domain containing 1C 0.0321089
ZBTB20 zinc finger and BTB domain containing 20 0.032089
RIMS2 regulating synaptic membrane exocytosis 2 0.0318988
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0311913
IPO7 importin 7 0.0309843
NEGR1 neuronal growth regulator 1 0.0299987
RTN4 reticulon 4 0.0297162
HSPA8 heat shock 70kDa protein 8 0.0290605
CANX calnexin 0.0289442
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0289327
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.028392
SPATS2 spermatogenesis associated, serine-rich 2 0.0283499
ATP11A ATPase, class VI, type 11A 0.0282893
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0280464
NRXN3 neurexin 3 0.0277236
PCDH7 protocadherin 7 0.0272825
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0272535
RAD51B RAD51 paralog B 0.0270755
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.0270628
PCDH9 protocadherin 9 0.0263689
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0263156
ADGRG6 adhesion G protein-coupled receptor G6 0.0262196
EXOC4 exocyst complex component 4 0.0259856
XPO1 exportin 1 0.0258988
PCLO piccolo presynaptic cytomatrix protein 0.0254976
EXOC6B exocyst complex component 6B 0.025345
EPHA6 EPH receptor A6 0.0248796
ASPH aspartate beta-hydroxylase 0.0243569
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0242447
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0241836
FHIT fragile histidine triad 0.0241753
SMYD3 SET and MYND domain containing 3 0.0240609
CLTC clathrin, heavy chain (Hc) 0.0238684
PRELID2 PRELI domain containing 2 0.0236549
BCHE butyrylcholinesterase 0.0234879
EIF4A2 eukaryotic translation initiation factor 4A2 0.0232703
BABAM2 BRISC and BRCA1 A complex member 2 0.0232669
RNF213 ring finger protein 213 0.023191
FAT1 FAT atypical cadherin 1 0.0231583
ERBIN erbb2 interacting protein 0.0230284
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0228155
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0227387
SLC38A2 solute carrier family 38, member 2 0.0226928
MAP1B microtubule-associated protein 1B 0.022669
XPOT exportin, tRNA 0.0224279
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0224008
NPC1 Niemann-Pick disease, type C1 0.0221162
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0219718
LRMDA leucine rich melanocyte differentiation associated 0.0218593
IL6ST interleukin 6 signal transducer 0.0217821
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0216607
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0213882
MARCHF4 membrane associated ring-CH-type finger 4 0.0213505
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0211981
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0210325

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.105636
FTL ferritin, light polypeptide -0.0718155
AREG amphiregulin -0.0649233
PTMA prothymosin, alpha -0.0524321
RPL35A ribosomal protein L35a -0.0463537
RPS3 ribosomal protein S3 -0.0404719
RPS6 ribosomal protein S6 -0.0404718
MYL12B myosin, light chain 12B, regulatory -0.0386973
RPS19 ribosomal protein S19 -0.036373
RPL23 ribosomal protein L23 -0.0358689
TPT1 tumor protein, translationally-controlled 1 -0.0354389
VIM vimentin -0.0329165
RPLP1 ribosomal protein, large, P1 -0.0304292
RPS8 ribosomal protein S8 -0.0298302
RPLP2 ribosomal protein, large, P2 -0.0290635
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0287764
S100A6 S100 calcium binding protein A6 -0.0285879
HSPB1 heat shock 27kDa protein 1 -0.0283115
RPL31 ribosomal protein L31 -0.0282028
RPS27A ribosomal protein S27a -0.0281116
RPL37A ribosomal protein L37a -0.0274021
RPL34 ribosomal protein L34 -0.026976
RPS13 ribosomal protein S13 -0.0264043
RPL36 ribosomal protein L36 -0.0262332
RPL12 ribosomal protein L12 -0.0258591
SLC38A1 solute carrier family 38, member 1 -0.025191
RPS29 ribosomal protein S29 -0.0249807
RPS24 ribosomal protein S24 -0.0243723
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0236036
S100A10 S100 calcium binding protein A10 -0.0234564
RPS23 ribosomal protein S23 -0.0233294
RPL19 ribosomal protein L19 -0.0225878
RPL8 ribosomal protein L8 -0.0223582
RPL38 ribosomal protein L38 -0.0223195
RPS14 ribosomal protein S14 -0.0223053
RPL11 ribosomal protein L11 -0.0220993
RPL37 ribosomal protein L37 -0.0219586
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0219021
EEF1G eukaryotic translation elongation factor 1 gamma -0.0216556
NACA nascent polypeptide-associated complex alpha subunit -0.0216415
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0216289
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0216251
RPL9 ribosomal protein L9 -0.021308
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0211426
RPS15 ribosomal protein S15 -0.0210691
RPS16 ribosomal protein S16 -0.0210384
RPL26 ribosomal protein L26 -0.021013
CNRIP1 cannabinoid receptor interacting protein 1 -0.0199914
GNAS GNAS complex locus -0.0199635
RPS25 ribosomal protein S25 -0.0199617
WDR43 WD repeat domain 43 -0.0197739
EIF5B eukaryotic translation initiation factor 5B -0.0197183
RPL27A ribosomal protein L27a -0.019627
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0191666
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0188773
EDN1 endothelin 1 -0.0187894
RPS5 ribosomal protein S5 -0.0187093
RPLP0 ribosomal protein, large, P0 -0.0177842
RPS10 ribosomal protein S10 -0.0176769
RPL36A ribosomal protein L36a -0.0164773
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0164724
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0163839
RSL1D1 ribosomal L1 domain containing 1 -0.0162047
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0160814
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0160504
RPL13A ribosomal protein L13a -0.0160497
RPS12 ribosomal protein S12 -0.0160354
RPS20 ribosomal protein S20 -0.0159846
NOP58 NOP58 ribonucleoprotein -0.0159254
PFN1 profilin 1 -0.0157605
HMGA1 high mobility group AT-hook 1 -0.0157463
RBM39 RNA binding motif protein 39 -0.015612
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0155833
RPS17 ribosomal protein S17 -0.0153729
RPL28 ribosomal protein L28 -0.0153574
RPS11 ribosomal protein S11 -0.0152887
ATP5F1B ATP synthase F1 subunit beta -0.0147559
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0146831
ZC3H15 zinc finger CCCH-type containing 15 -0.01451
EIF1 eukaryotic translation initiation factor 1 -0.0144599
LRRC23 leucine rich repeat containing 23 -0.0143615
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0143563
RAB2A RAB2A, member RAS oncogene family -0.0140679
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0139772
RPL7A ribosomal protein L7a -0.0131161
S100A11 S100 calcium binding protein A11 -0.0129105
PA2G4 proliferation-associated 2G4, 38kDa -0.0128803
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0128461
GPBP1 GC-rich promoter binding protein 1 -0.0126567
RSL24D1 ribosomal L24 domain containing 1 -0.0126384
GCG glucagon -0.0125973
VDAC1 voltage-dependent anion channel 1 -0.0124777
PARK7 parkinson protein 7 -0.0124141
RPL5 ribosomal protein L5 -0.0123533
PNISR PNN-interacting serine/arginine-rich protein -0.0123359
RPL35 ribosomal protein L35 -0.0123176
NEMF nuclear export mediator factor -0.0121564
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.011948
S100A9 S100 calcium binding protein A9 -0.0119309
RPS21 ribosomal protein S21 -0.0118272